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Now showing items 21841-21860 of 40729

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry

Ariëns, Lieneke F M; van der Schaft, Jorien; Bakker, Daphne S; Balak, Deepak; Romeijn, Margreet L E; Kouwenhoven, Tessa; Kamsteeg, Marijke; Giovannone, Barbara; Drylewicz, Julia; van Amerongen, Cynthia Catalina Aurora; Delemarre, Evelien M; Knol, Edward F; van Wijk, Femke; Nierkens, Stefan; Thijs, Judith L; Schuttelaar, Marie L A; de Bruin-Weller, Marjolein S (Wiley-Blackwell, 2020-01-01)

INTRODUCTION: Dupilumab has recently been approved for the treatment of moderate to severe atopic dermatitis (AD) in adults. Daily practice data on dupilumab treatment are scarce. OBJECTIVE: To study the effect of 16-week ...
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

Freisling, Heinz; Viallon, Vivian; Lennon, Hannah; Bagnardi, Vincenzo; Ricci, Cristian; Butterworth, Adam S; Sweeting, Michael; Muller, David; Romieu, Isabelle; Bazelle, Pauline; Kvaskoff, Marina; Arveux, Patrick; Severi, Gianluca; Bamia, Christina; Kühn, Tilman; Kaaks, Rudolf; Bergmann, Manuela; Boeing, Heiner; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Dahm, Christina C; Menéndez, Virginia; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Santiuste, Carmen; Gurrea, Aurelio Barricarte; Tong, Tammy Y N; Schmidt, Julie A; Tzoulaki, Ioanna; Tsilidis, Konstantinos K; Ward, Heather; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Picavet, H Susan J; Bakker, Marije; Monninkhof, Evelyn; Nilsson, Peter; Manjer, Jonas; Rolandsson, Olov; Thysell, Elin; Weiderpass, Elisabete; Jenab, Mazda; Riboli, Elio; Vineis, Paolo; Danesh, John; Wareham, Nick J; Gunter, Marc J; Ferrari, Pietro (BioMed Central Ltd., 2020-01-10)

BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely ...
Health-related quality of life after prophylactic cranial irradiation for stage III non-small cell lung cancer patients: Results from the NVALT-11/DLCRG-02 phase III study

Witlox, W J A; Ramaekers, B L T; Joore, M A; Dingemans, A-M C; Praag, J; Belderbos, J; Tissing-Tan, C; Herder, G; Haitjema, T; Ubbels, J F; Lagerwaard, J; El Sharouni, S Y; Stigt, J A; Smit, E F; van Tinteren, H; van der Noort, V; Groen, H J M; De Ruysscher, D K M (Elsevier Ireland Ltd, 2020-03-01)

BACKGROUND AND PURPOSE: The NVALT-11/DLCRG-02 phase III trial (clinicaltrials.gov identifier: NCT01282437) showed that, after standard curative intent treatment, prophylactic cranial irradiation (PCI) decreased the incidence ...
Vasomotor menopausal symptoms and cardiovascular disease risk in midlife: A longitudinal study

Dam, V.; Dobson, A. J.; Onland-Moret, N. C.; van der Schouw, Y. T.; Mishra, G. D. (Elsevier Ireland Ltd, 2020-03-01)

Objective: To ascertain the association between vasomotor menopausal symptoms (VSM), hot flushes and night sweats, and cardiovascular disease, coronary heart disease and cerebrovascular disease. Study design: The study ...
Lipid lowering and Alzheimer disease risk: A mendelian randomization study

Williams, Dylan M.; Finan, Chris; Schmidt, Amand F.; Burgess, Stephen; Hingorani, Aroon D. (John Wiley & Sons Inc., 2020-01-01)

Objective: To examine whether genetic variation affecting the expression or function of lipid-lowering drug targets is associated with Alzheimer disease (AD) risk, to evaluate the potential impact of long-term exposure to ...
Efficacy and tolerability of tremelimumab in locally advanced or metastatic urothelial carcinoma patients who have failed first-line platinum-based chemotherapy

Sharma, Padmanee; Sohn, Joohyuk; Shin, Sang Joon; Oh, Do Youn; Keam, Bhumsuk; Lee, Hyo Jin; Gizzi, Marco; Kalinka, Ewa; de Vos, Filip Y.F.L.; Ruscica, Dario; Ferro, Salvatore; Xiao, Feng; Baverel, Paul; Chen, Cecil Chi Keung; Asubonteng, Kobby; Morsli, Nassim; Dirix, Luc (American Association for Cancer Research Inc., 2020-01-01)

Purpose: Patients with advanced urothelial carcinoma who fail platinum-containing chemotherapy (treatment fails) have a poor prognosis and limited treatment options. Recent approvals of immune-checkpoint inhibitors confirmed ...
Vulvar and vaginal neoplasia in women with inflammatory bowel disease

The Dutch Workgroup on IBD and Vulvovaginal neoplasia (Elsevier, 2020-02)

Immunosuppressive drugs are the cornerstone in the treatment of inflammatory bowel disease (IBD), however they are associated with an increased risk of extra-intestinal cancer. Whether the risk for female genital tract ...
Mortality after hospital admission for heart failure: improvement over time, equally strong in women as in men

Queen of Hearts and RECONNECT investigators (BioMed Central, 2020-01-10)

BACKGROUND: To assess the trend in age- and sex-stratified mortality after hospitalization for heart failure (HF) in the Netherlands. METHODS: Two nationwide cohorts of patients, hospitalized for new onset heart failure ...
Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study

on behalf of the LATER Study Group (Mosby Inc., 2020-01-01)

Background: Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic ...
A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial

Ahmadi, Michael; Laumeier, Inga; Ihl, Thomas; Steinicke, Maureen; Ferse, Caroline; Endres, Matthias; Grau, Armin; Hastrup, Sidsel; Poppert, Holger; Palm, Frederick; Schoene, Martin; Seifert, Christian L.; Kandil, Farid I.; Weber, Joachim E.; von Weitzel-Mudersbach, Paul; Wimmer, Martin L. J.; Algra, Ale; Amarenco, Pierre; Greving, Jacoba P.; Busse, Otto; Kohler, Friedrich; Marx, Peter; Audebert, Heinrich J. (Elsevier Limited, 2020-01)

Background: Patients with recent stroke or transient ischaemic attack are at high risk for a further vascular event, possibly leading to permanent disability or death. Although evidence-based treatments for secondary ...
Redefining the core values and tasks of GPs in the Netherlands (Woudschoten 2019)

van der Horst, Henriette E.; de Wit, Niek (Royal College of General Practitioners, 2020-01)
Biallelic variants in POLR3GL cause endosteal hyperostosis and oligodontia

Terhal, Paulien A; Vlaar, Judith M; Middelkamp, Sjors; Nievelstein, Rutger A J; Nikkels, Peter G J; Ross, Jamila; Créton, Marijn; Bos, Jeroen W; Voskuil-Kerkhof, Elsbeth S M; Cuppen, Edwin; Knoers, Nine; van Gassen, Koen L I (Springer Nature, 2020-01)

RNA polymerase III (Pol III) is an essential 17-subunit complex responsible for the transcription of small housekeeping RNAs such as transfer RNAs and 5S ribosomal RNA. Biallelic variants in four genes (POLR3A, POLR3B, and ...
Neonatal cardiac hypertrophy: the role of hyperinsulinism—a review of literature

Paauw, Nina D.; Stegeman, Raymond; de Vroede, Monique A.M.J.; Termote, Jacqueline U.M.; Freund, Matthias W.; Breur, Johannes M.P.J. (Springer-Verlag, 2020-01)

Hypertrophic cardiomyopathy (HCM) in neonates is a rare and heterogeneous disorder which is characterized by hypertrophy of heart with histological and functional disruption of the myocardial structure/composition. The ...
Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration

Karel, Peter; Van der Toorn, Annette; Vanderschuren, Louk; Guo, Chao; Sadighi Alvandi, Mina; Reneman, Liesbeth; Dijkhuizen, Rick; Verheij, Michel M.M.; Homberg, Judith R. (Wiley-Blackwell, 2020-01-01)

Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor ...
Nationwide trends in incidence, treatment and survival of pancreatic ductal adenocarcinoma

Dutch Pancreatic Cancer Group (Elsevier Limited, 2020-01-01)

Background: In recent years, new treatment options have become available for pancreatic ductal adenocarcinoma (PDAC) including 5-fluorouracil, leucovorin, irinotecan and oxaliplatin. The impact hereof has not been assessed ...
Etidronate halts systemic arterial calcification in pseudoxanthoma elasticum

Bartstra, Jonas W.; de Jong, Pim A.; Kranenburg, Guido; Wolterink, Jelmer M.; Isgum, Ivana; Wijsman, Alayna; Wolf, Bas; den Harder, Annemarie M.; Mali, Willem P.Th M.; Spiering, Wilko (Elsevier, 2020-01-01)

Background and aims: In pseudoxanthoma elasticum (PXE), low levels of inorganic pyrophosphate result in extensive arterial calcification. Recently, the treatment of ectopic mineralization in the PXE (TEMP) trial showed ...
Acardius anceps with neck cyst and cleft palate: Three dimensional skeletal computed tomography reconstruction with discussion of the literature

van Gemert, Martin J.C.; Streekstra, Geert J.; Vandenbussche, Frank P.H.A.; Nikkels, Peter G.J.; van den Wijngaard, Jeroen P.H.M. (John Wiley & Sons Inc., 2020-01-15)

Acardiac twinning is a rare anomaly of monochorionic twin pregnancies. Acardiac fetuses lack a functional heart but are passively perfused by arterial blood from their pump co-twin causing the acardiac body to be hypoxemic. ...
A comparison of the beta-geometric model with landmarking for dynamic prediction of time to pregnancy

van Eekelen, Rik; Putter, Hein; McLernon, David J; Eijkemans, Marinus J; van Geloven, Nan (Wiley-VCH Verlag, 2020-01)

We conducted a simulation study to compare two methods that have been recently used in clinical literature for the dynamic prediction of time to pregnancy. The first is landmarking, a semi-parametric method where predictions ...
Human papillomavirus infection and cervical dysplasia in HIV-positive women: potential role of the vaginal microbiota

HARP Study Group (Lippincott Williams & Wilkins, 2020-01-01)

OBJECTIVES: To assess the associations between microbiological markers of vaginal dysbiosis and incident/cleared/type-swap/persistent high-risk human papillomavirus (hrHPV) infection; and incident/cured/cleared/persistent ...
Authors' reply re: Lactobacilli-containing vaginal probiotics to cure or prevent bacterial or fungal vaginal dysbiosis: a systematic review and recommendations for future trial designs

van de Wijgert, Janneke Hhm; Verwijs, Marijn C (Wiley-Blackwell, 2020-01-01)

Now showing items 21841-21860 of 40729