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UMC Repository: Recent submissions

  • Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases 
    Klarić, Lucija; Tsepilov, Yakov A; Stanton, Chloe M; Mangino, Massimo; Sikka, Timo Tõnis; Esko, Tõnu; Pakhomov, Eugene; Salo, Perttu; Deelen, Joris; McGurnaghan, Stuart J; Keser, Toma; Vučković, Frano; Ugrina, Ivo; Krištić, Jasminka; Gudelj, Ivan; Štambuk, Jerko; Plomp, Rosina; Pučić-Baković, Maja; Pavić, Tamara; Vilaj, Marija; Trbojević-Akmačić, Irena; Drake, Camilla; Dobrinić, Paula; Mlinarec, Jelena; Jelušić, Barbara; Richmond, Anne; Timofeeva, Maria; Grishchenko, Alexander K; Dmitrieva, Julia; Bermingham, Mairead L; Sharapov, Sodbo Zh; Farrington, Susan M; Theodoratou, Evropi; Uh, Hae-Won; Beekman, Marian; Slagboom, Eline P; Louis, Edouard; Georges, Michel; Wuhrer, Manfred; Colhoun, Helen M; Dunlop, Malcolm G; Perola, Markus; Fischer, Krista; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Wilson, James F; Zoldoš, Vlatka; Vitart, Veronique; Spector, Tim; Aulchenko, Yurii S; Lauc, Gordan; Hayward, Caroline (American Association for the Advancement of Science, 2020-02-19)
    Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little ...
  • Big Data in the Assessment of Pediatric Medication Safety 
    McMahon, Ann W; Cooper, William O; Brown, Jeffrey S; Carleton, Bruce; Doshi-Velez, Finale; Kohane, Isaac; Goldman, Jennifer L; Hoffman, Mark A; Kamaleswaran, Rishikesan; Sakiyama, Michiyo; Sekine, Shohko; Sturkenboom, Miriam C J M; Turner, Mark A; Califf, Robert M (American Academy of Pediatrics, 2020-02)
    Big data (BD) in pediatric medication safety research provides many opportunities to improve the safety and health of children. The number of pediatric medication and device trials has increased in part because of the past ...
  • From registration to publication: A study on Dutch academic randomized controlled trials 
    Huiskens, Joost; Kool, Boudewijn R J; Bakker, Jean-Michel; Bruns, Emma R J; de Jonge, Stijn W; Olthof, Pim B; van Rosmalen, Belle V; van Gulik, Thomas M; Hooft, Lotty; Punt, Cornelis J A (John Wiley & Sons Inc., 2020-03)
    INTRODUCTION: Registration of clinical trials has been initiated in order to assess adherence of the reported results to the original trial protocol. This study aimed to investigate the publication rates, timely dissemination ...
  • Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis 
    Papadimitriou, Nikos; Dimou, Niki; Tsilidis, Konstantinos K; Banbury, Barbara; Martin, Richard M; Lewis, Sarah J; Kazmi, Nabila; Robinson, Timothy M; Albanes, Demetrius; Aleksandrova, Krasimira; Berndt, Sonja I; Timothy Bishop, D; Brenner, Hermann; Buchanan, Daniel D; Bueno-de-Mesquita, Bas; Campbell, Peter T; Castellví-Bel, Sergi; Chan, Andrew T; Chang-Claude, Jenny; Ellingjord-Dale, Merete; Figueiredo, Jane C; Gallinger, Steven J; Giles, Graham G; Giovannucci, Edward; Gruber, Stephen B; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia; Harrison, Tabitha A; Hoffmeister, Michael; Hopper, John L; Hsu, Li; María Huerta, José; Huyghe, Jeroen R; Jenkins, Mark A; Keku, Temitope O; Kühn, Tilman; La Vecchia, Carlo; Le Marchand, Loic; Li, Christopher I; Li, Li; Lindblom, Annika; Lindor, Noralane M; Lynch, Brigid; Markowitz, Sanford D; Masala, Giovanna; May, Anne M; Milne, Roger; Monninkhof, Evelyn; Moreno, Lorena; Moreno, Victor; Newcomb, Polly A; Offit, Kenneth; Perduca, Vittorio; Pharoah, Paul D P; Platz, Elizabeth A; Potter, John D; Rennert, Gad; Riboli, Elio; Sánchez, Maria-Jose; Schmit, Stephanie L; Schoen, Robert E; Severi, Gianluca; Sieri, Sabina; Slattery, Martha L; Song, Mingyang; Tangen, Catherine M; Thibodeau, Stephen N; Travis, Ruth C; Trichopoulou, Antonia; Ulrich, Cornelia M; van Duijnhoven, Franzel J B; Van Guelpen, Bethany; Vodicka, Pavel; White, Emily; Wolk, Alicja; Woods, Michael O; Wu, Anna H; Peters, Ulrike; Gunter, Marc J; Murphy, Neil (Nature Publishing Group, 2020-01-30)
    Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation ...
  • Adaptive trial designs in diagnostic accuracy research 
    Zapf, Antonia; Stark, Maria; Gerke, Oke; Ehret, Christoph; Benda, Norbert; Bossuyt, Patrick; Deeks, Jon; Reitsma, Johannes; Alonzo, Todd; Friede, Tim (John Wiley & Sons Inc., 2020-02-28)
    The aim of diagnostic accuracy studies is to evaluate how accurately a diagnostic test can distinguish diseased from nondiseased individuals. Depending on the research question, different study designs and accuracy measures ...
  • Tongue function and its influence on masticatory performance in patients treated for oral cancer: a five-year prospective study 
    de Groot, Reilly J.; Merkx, Matthias A.W.; Hamann, Merel N.S.; Brand, Henk S.; de Haan, Anton F.J.; Rosenberg, Antoine J.W.P.; Speksnijder, Caroline M. (Springer-Verlag, 2020-03-01)
    Purpose: The purpose of this study was to observe the impact of oral oncological treatment, including the recovery of several tongue functions (force, mobility, and sensory functions), and to determine the influence of ...
  • Loss of skeletal muscle index and survival in patients with metastatic colorectal cancer: Secondary analysis of the phase 3 CAIRO3 trial 
    Kurk, Sophie A; Peeters, Petra H M; Dorresteijn, Bram; de Jong, Pim A; Jourdan, Marion; Creemers, Geert-Jan M; Erdkamp, Frans L G; de Jongh, Felix E; Kint, Peter A M; Poppema, Boelo J; Radema, Sandra A; Simkens, Lieke H J; Tanis, Bea C; Tjin-A-Ton, Manuel L R; Van Der Velden, Ankie; Punt, Cornelis J A; Koopman, Miriam; May, Anne M (John Wiley & Sons Inc., 2020-02)
    BACKGROUND: Low skeletal muscle index (SMI) in metastatic colorectal cancer (mCRC) patients is associated with poor outcomes. The prognostic impact of SMI changes during consecutive palliative systemic treatments is unknown. ...
  • Impact of oral metronidazole treatment on the vaginal microbiota and correlates of treatment failure 
    Verwijs, Marijn C; Agaba, Stephen K; Darby, Alistair C; van de Wijgert, Janneke H H M (Mosby Inc., 2020-02)
    Background: Metronidazole is the first-line treatment for bacterial vaginosis, but cure rates are suboptimal and recurrence rates high. Objectives: To evaluate the impact of a standard course of oral metronidazole treatment ...
  • The 2016 Joint European Prevention Guidelines and the uses of polypills: Time to update the evidence 
    Webster, Ruth; Grobbee, Diederick; Rodgers, Anthony (Oxford University Press, 2020-03-01)
  • Individual participant data meta-analysis of intervention studies with time-to-event outcomes: A review of the methodology and an applied example 
    de Jong, Valentijn M T; Moons, Karel G M; Riley, Richard D; Smith, Catrin Tudur; Marson, Anthony G; Eijkemans, Marinus J C; Debray, Thomas P A (John Wiley & Sons Inc., 2020-03)
    Many randomized trials evaluate an intervention effect on time-to-event outcomes. Individual participant data (IPD) from such trials can be obtained and combined in a so-called IPD meta-analysis (IPD-MA), to summarize the ...
  • Clinical research study implementation of case-finding strategies for heart failure and chronic obstructive pulmonary disease in the elderly with reduced exercise tolerance or dyspnea: A cluster randomized trial 
    van Mourik, Yvonne; Rutten, Frans H; Bertens, Loes C M; Cramer, Maarten J M; Lammers, Jan-Willem J; Gohar, Aisha; Reitsma, Johannes B; Moons, Karel G M; Hoes, Arno W (Mosby Inc., 2020-02)
    BACKGROUND: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) often remain undiagnosed in older individuals, although both disorders inhibit functionality and impair health. The aim of the study was to ...
  • TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample 
    Pries, Lotta-Katrin; Snijders, Clara; Menne-Lothmann, Claudia; Decoster, Jeroen; van Winkel, Ruud; Collip, Dina; Delespaul, Philippe; De Hert, Marc; Derom, Catherine; Thiery, Evert; Jacobs, Nele; Wichers, Marieke; Guloksuz, Sinan; van Os, Jim; Rutten, Bart P F (Cambridge University Press, 2019-12)
    Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are ...
  • Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium 
    on behalf of the PROG-IMT study group (Oxford University Press, 2020-02-01)
    Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for ...
  • Illness perceptions associated with patient burden with musculoskeletal pain in outpatient physical therapy practice, a cross-sectional study 
    de Raaij, E J; Ostelo, R W J G; Maissan, J F; Pool, J; Westers, P; Wittink, H (Elsevier, 2020-02-01)
    INTRODUCTION: Musculoskeletal pain (MSP) is a burden to patients and to society. In addition to well-known prognostic factors, illness perceptions (IPs) may be associated with pain intensity and physical functioning in MSP ...
  • Risk factors of mortality in older patients with dementia in psychiatric care 
    Goluke, Nienke M S; Geerlings, Mirjam I; van de Vorst, Irene E; Vaartjes, Ilonca H; de Jonghe, Annemarieke; Bots, Michiel L; Koek, Huiberdina L (John Wiley & Sons Inc., 2020-02)
    Objective: To examine the mortality risk, and its risk factors, of older patients with dementia in psychiatric care. Methods: We constructed a cohort of dementia patients through data linkage of four Dutch registers: the ...
  • Off to a good start after a cancer diagnosis: implementation of a time out consultation in primary care before cancer treatment decision 
    Noteboom, Eveline A.; de Wit, Niek J.; van Asseldonk, Ingrid J.E.M.; Janssen, Monique C.A.M.; Lam-Wong, Wai Yee; Linssen, Rob H.P.J.; Pepels, Manon J.A.E.; Schrama, Natascha A.W.P.; Trompper, Mariëlle E.H.; Veldhuizen, L. Maaike; Wijtvliet, Anne P.; Zeldenrust, Ed G.F.; Hendrikx, Ans M.; van de Boomen, Wil A.; Elbersen, Dorothé M.; Jacobs, Esther M.G.; van der Wall, Elsken; Helsper, Charles W. (Springer, 2020-02-01)
    Purpose: Supportive care for cancer patients may benefit from improving treatment decisions and optimal use of the family physicians’ and specialists’ strengths. To improve shared decision-making (SDM) and facilitate ...
  • Faecal carriage, risk factors, acquisition and persistence of ESBL-producing Enterobacteriaceae in dogs and cats and co-carriage with humans belonging to the same household 
    van den Bunt, G; Fluit, A C; Spaninks, M P; Timmerman, A J; Geurts, Y; Kant, A; Scharringa, J; Mevius, D; Wagenaar, J A; Bonten, M J M; van Pelt, W; Hordijk, J (Oxford University Press, 2020-02-01)
    BACKGROUND: ESBL-producing Enterobacteriaceae (ESBL-E) are observed in many reservoirs. Pets might play an important role in the dissemination of ESBL-E to humans since they live closely together. OBJECTIVES: To identify ...
  • Hair cortisol and inhaled corticosteroid use in asthmatic children 
    Baan, Esmé J; van den Akker, Erica L T; Engelkes, Marjolein; de Rijke, Yolanda B; de Jongste, Johan C; Sturkenboom, Miriam C J M; Verhamme, Katia M; Janssens, Hettie M (John Wiley & Sons Inc., 2020-02)
    BACKGROUND: Adrenal suppression is a side effect of long-term use of inhaled corticosteroids (ICS). Hair cortisol concentration (HCC) measurement is a noninvasive tool for measuring adrenal function that may be useful for ...
  • Gastro-esophageal reflux after laparoscopic gastrostomy placement in children 
    Franken, Josephine; Stellato, Rebecca K; Tytgat, Stefaan H A J; Van der Zee, David C; Mauritz, Femke A; Lindeboom, Maud Y A (Lippincott Williams & Wilkins, 2020-02-01)
    OBJECTIVES: Gastrostomy placement is frequently performed in pediatric patients who require long-term enteral tube feeding. Evidence on the influence of gastrostomy placement on gastro-oesophageal reflux disease has been ...
  • Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data 
    van Vulpen, Jonna K; Sweegers, Maike G; Peeters, Petra H M; Courneya, Kerry S; Newton, Robert U; Aaronson, Neil K; Jacobsen, Paul B; Galvão, Daniel A; Chinapaw, Mai J; Steindorf, Karen; Irwin, Melinda L; Stuiver, Martijn M; Hayes, Sandi; Griffith, Kathleen A; Mesters, Ilse; Knoop, Hans; Goedendorp, Martine M; Mutrie, Nanette; Daley, Amanda J; McConnachie, Alex; Bohus, Martin; Thorsen, Lene; Schulz, Karl-Heinz; Short, Camille E; James, Erica L; Plotnikoff, Ronald C; Schmidt, Martina E; Ulrich, Cornelia M; van Beurden, Marc; Oldenburg, Hester S; Sonke, Gabe S; van Harten, Wim H; Schmitz, Kathryn H; Winters-Stone, Kerri M; Velthuis, Miranda J; Taaffe, Dennis R; van Mechelen, Willem; Kersten, Marie José; Nollet, Frans; Wenzel, Jennifer; Wiskemann, Joachim; Verdonck-de Leeuw, Irma M; Brug, Johannes; May, Anne M; Buffart, Laurien M (Lippincott Williams & Wilkins, 2020-02)
    PURPOSE: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a ...