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The Association Between Marital Status, Coronary Computed Tomography Imaging Biomarkers, and Mortality in a Lung Cancer Screening Population

Celeng, Csilla; Takx, Richard A P; Lessmann, Nikolas; Maurovich-Horvat, Pál; Leiner, Tim; Išgum, Ivana; de Jong, Pim A (Lippincott Williams & Wilkins, 2020-05-01)

PURPOSE: The purpose of this study was to elucidate the impact of being unmarried on coronary computed tomography (CT) imaging biomarkers and mortality in a lung cancer screening population. MATERIALS AND METHODS: In this ...
Contrast leakage distant from the hematoma in patients with spontaneous ICH: A 7 T MRI study

Jolink, Wilmar MT; Lindenholz, Arjen; van Etten, Ellis S; van Nieuwenhuizen, Koen M; Schreuder, Floris Hbm; Kuijf, Hugo J; van Osch, Matthias Jp; Hendrikse, Jeroen; Rinkel, Gabriel Je; Wermer, Marieke JH; Klijn, Catharina JM (SAGE Publications Inc., 2020-05-01)

Disruption of the blood-brain barrier (BBB) might play a role in the pathophysiology of cerebral small vessel disease-related ICH. The aim of this study was to assess presence and extent of contrast agent leakage distant ...
Cost-effectiveness of routine transoesophageal echocardiography during cardiac surgery: a discrete-event simulation study

Dieleman, Jan M; Myles, Paul S; Bulfone, Liliana; Younie, Sandra; van Zaane, Bas; McGiffin, David; Moodie, Marj; Gao, Lan (Oxford University Press, 2020-02)

BACKGROUND: The aim of this study was to simulate and compare the healthcare and economic outcomes associated with routine use of intraoperative transoesophageal echocardiography (TOE) in patients undergoing cardiac surgery ...
Diagnostic Accuracy of Procalcitonin and C-reactive Protein Is Insufficient to Predict Proven Infection: A Retrospective Cohort Study in Critically Ill Patients Fulfilling the Sepsis-3 Criteria

van Oers, Jos A H; de Jong, Evelien; Kemperman, Hans; Girbes, Armand R J; de Lange, Dylan W (Oxford University Press, 2020-01)

Background: New Sepsis-3 definitions facilitate early recognition of patients with sepsis. In this study we investigated whether a single initial determination of procalcitonin (PCT) or C-reactive protein (CRP) in plasma ...
Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort

de Savornin Lohman, Elise; de Bitter, Tessa; Verhoeven, Rob; van der Geest, Lydia; Hagendoorn, Jeroen; Mohammad, Nadia Haj; Daams, Freek; Heinz-Josef Klümpen, Klümpen; van Gulik, Thomas; Erdmann, Joris; de Boer, Marieke; Hoogwater, Frederik; Koerkamp, Bas Groot; Braat, Andries; Verheij, Joanne; Nagtegaal, Iris; van Laarhoven, Cornelis; van den Boezem, Peter; van der Post, Rachel; de Reuver, Philip (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-09)

Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a ...
Impact of nationwide enhanced implementation of best practices in pancreatic cancer care (PACAP-1): a multicenter stepped-wedge cluster randomized controlled trial

Dutch Pancreatic Cancer Group (BioMed Central, 2020-04-16)

BACKGROUND: Pancreatic cancer has a very poor prognosis. Best practices for the use of chemotherapy, enzyme replacement therapy, and biliary drainage have been identified but their implementation in daily clinical practice ...
The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger, Georg A; Lissendorp, Fianne; Franken, Ingrid A; van Hillegersberg, Richard; Ruurda, Jelle P; Clevers, Hans; de Maat, Michiel F G (Royal Society Publishing, 2020-04)

The incidence of adenocarcinoma at the gastrooesophageal junction increased over the last years. Curative treatment for patients with upper gastrointestinal (UGI) malignancies, such as oesophageal and gastric tumours, is ...
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

van Geel, Robin M J M; van Brummelen, Emilie M J; Eskens, Ferry A L M; Huijberts, Sanne C F A; de Vos, Filip Y F L; Lolkema, Martijn P J K; Devriese, Lot A; Opdam, Frans L; Marchetti, Serena; Steeghs, Neeltje; Monkhorst, Kim; Thijssen, Bas; Rosing, Hilde; Huitema, Alwin D R; Beijnen, Jos H; Bernards, René; Schellens, Jan H M (Springer Nature, 2020-04-14)

BACKGROUND: Mutations in KRAS result in a constitutively activated MAPK pathway. In KRAS-mutant tumours existing treatment options, e.g. MEK inhibition, have limited efficacy due to resistance through feedback activation ...
2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)

Konstantinides, Stavros V.; Meyer, Guy; Bueno, Hector; Galié, Nazzareno; Gibbs, J. Simon R.; Ageno, Walter; Agewall, Stefan; Almeida, Ana G.; Andreotti, Felicita; Barbato, Emanuele; Baumbach, Andreas; Beygui, Farzin; Carlsen, Jørn; De Carlo, Marco; Delcroix, Marion; Subias, Pilar Escribano; Gaine, Sean; Goldhaber, Samuel Z.; Gopalan, Deepa; Habib, Gilbert; Jenkins, David; Kjellström, Barbro; Lainscak, Mitja; Lee, Geraldine; Le Gal, Grégoire; Messas, Emmanuel; Morais, Joao; Piepoli, Massimo Francesco; Price, Susanna; Salvi, Aldo; Sanchez, Olivier; Stortecky, Stefan; Thielmann, Matthias; Noordegraaf, Anton Vonk; Becattini, Cecilia; Bueno, Héctor; Geersing, Geert Jan; Harjola, Veli Pekka; Huisman, Menno V.; Humbert, Marc; Jennings, Catriona Sian; Jiménez, David; Kucher, Nils; Lang, Irene Marthe; Lankeit, Mareike; Lorusso, Roberto; Mazzolai, Lucia; Meneveau, Nicolas; Áinle, Fionnuala Ní; Prandoni, Paolo; Pruszczyk, Piotr; Righini, Marc; Torbicki, Adam; Van Belle, Eric; Zamorano, José Luis; Windecker, Stephan; Aboyans, Victor; Baigent, Colin; Collet, Jean Philippe; Dean, Veronica; Delgado, Victoria; Fitzsimons, Donna; Gale, Chris P.; Grobbee, Diederick E.; Hindricks, Gerhard; Iung, Bernard; Jüni, Peter; Katus, Hugo A.; Landmesser, Ulf; Leclercq, Christophe; Lettino, Maddalena; Lewis, Basil S.; Merkely, Bela; Mueller, Christian; Petersen, Steffen E.; Petronio, Anna Sonia; Richter, Dimitrios J.; Roffi, Marco; Shlyakhto, Evgeny; Simpson, Iain A.; Sousa-Uva, Miguel; Touyz, Rhian M.; Hammoudi, Naima; Hayrapetyan, Hamlet; Mascherbauer, Julia; Ibrahimov, Firdovsi; Polonetsky, Oleg; Lancellotti, Patrizio; Tokmakova, Mariya; Skoric, Bosko; Michaloliakos, Ioannis; Hutyra, Martin; Mellemkjaer, Søren; Mansour, Mostafa; Reinmets, Julia; Jääskeläinen, Pertti; Angoulvant, Denis; Bauersachs, Johann; Giannakoulas, George; Zima, Endre; Vizza, Carmine Dario; Sugraliyev, Akhmetzhan; Bytyçi, Ibadete; Maca, Aija; Ereminiene, Egle; Huijnen, Steve; Xuereb, Robert; Diaconu, Nadejda; Bulatovic, Nebojsa; Asfalou, Ilyasse; Bosevski, Marijan; Halvorsen, Sigrun; Sobkowicz, Bozena; Ferreira, Daniel; Petris, Antoniu Octavian; Moiseeva, Olga; Zavatta, Marco; Obradovic, Slobodan; Šimkova, Iveta; Radsel, Peter; Ibanez, Borja; Wikström, Gerhard; Aujesky, Drahomir; Kaymaz, Cihangir; Parkhomenko, Alexander; Pepke-Zaba, Joanna (Oxford University Press, 2020-01-21)

Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their ...
Use of viral load to improve survey estimates of known HIV-positive status and antiretroviral treatment coverage

Young, Peter W; Zielinski-Gutierrez, Emily; Wamicwe, Joyce; Mukui, Irene; Kim, Andrea A; Waruru, Anthony; Zeh, Clement; Kretzschmar, Mirjam E; De Cock, Kevin M (Lippincott Williams & Wilkins, 2020-03-15)

Objective:To compare alternative methods of adjusting self-reported knowledge of HIV-positive status and antiretroviral (ARV) therapy use based on undetectable viral load (UVL) and ARV detection in blood.Design:Post hoc ...
Diagnostic criteria and symptom grading for delayed gastric conduit emptying after esophagectomy for cancer : international expert consensus based on a modified Delphi process

Konradsson, M; van Berge Henegouwen, M I; Bruns, C; Chaudry, M A; Cheong, E; Cuesta, M A; Darling, G E; Gisbertz, S S; Griffin, S M; Gutschow, C A; van Hillegersberg, R; Hofstetter, W; Hölscher, A H; Kitagawa, Y; van Lanschot, J J B; Lindblad, M; Ferri, L E; Low, D E; Luyer, M D P; Ndegwa, N; Mercer, S; Moorthy, K; Morse, C R; Nafteux, P; Nieuwehuijzen, G A P; Pattyn, P; Rosman, C; Ruurda, J P; Räsänen, J; Schneider, P M; Schröder, W; Sgromo, B; Van Veer, H; Wijnhoven, B P L; Nilsson, M (Wiley-Blackwell, 2020-04-15)

Delayed gastric conduit emptying (DGCE) after esophagectomy for cancer is associated with adverse outcomes and troubling symptoms. Widely accepted diagnostic criteria and a symptom grading tool for DGCE are missing. This ...
Stereotactic radiotherapy concurrent to immune or targeted therapy for oligometastatic NSCLC: Clinical scenarios affecting survival

Kroeze, S G C; Fritz, C; Kaul, D; Blanck, O; Kahl, K; Roeder, F; Siva, S; Verhoeff, J J C; Grosu, A L; Schymalla, M M; Glatzer, M; Szuecs, M; Geier, M; Skazikis, G; Sackerer, I; Lohaus, F; Eckert, F; Guckenberger, M (Oxford University Press, 2019-04)
3-Dimensional target coverage assessment for MRI guided esophageal cancer radiotherapy

Boekhoff, M. R.; Defize, I. L.; Borggreve, A. S.; Takahashi, N.; van Lier, A. L.H.M.W.; Ruurda, J. P.; van Hillegersberg, R.; Lagendijk, J. J.W.; Mook, S.; Meijer, G. J. (Elsevier Ireland Ltd, 2020-06-01)

Purpose: This study aimed to quantify the coverage probability for esophageal cancer radiotherapy as a function of a preset margin for online MR-guided and (CB)CT-guided radiotherapy. Methods: Thirty esophageal cancer ...
Preterm infants with isolated cerebellar hemorrhage show bilateral cortical alterations at term equivalent age

Dijkshoorn, Aicha B C; Turk, Elise; Hortensius, Lisa M; van der Aa, Niek E; Hoebeek, Freek E; Groenendaal, Floris; Benders, Manon J N L; Dudink, Jeroen (Nature Publishing Group, 2020-03-24)

The cerebellum is connected to numerous regions of the contralateral side of the cerebrum. Motor and cognitive deficits following neonatal cerebellar hemorrhages (CbH) in extremely preterm neonates may be related to remote ...
Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people

Jaspers, Nicole E.M.; Blaha, Michael J.; Matsushita, Kunihiro; Van Der Schouw, Yvonne T.; Wareham, Nicholas J.; Khaw, Kay Tee; Geisel, Marie H.; Lehmann, Nils; Erbel, Raimund; Jöckel, Karl Heinz; Van Der Graaf, Yolanda; Verschuren, W. M.Monique; Boer, Jolanda M.A.; Nambi, Vijay; Visseren, Frank L.J.; Dorresteijn, Jannick A.N. (Oxford University Press, 2020-03-14)

Aims: The benefit an individual can expect from preventive therapy varies based on risk-factor burden, competing risks, and treatment duration. We developed and validated the LIFEtime-perspective CardioVascular Disease ...
Anti-Müllerian hormone levels and risk of cancer: A systematic review

Verdiesen, Renée M.G.; van Gils, Carla H.; van der Schouw, Yvonne T.; Onland-Moret, N. Charlotte (Elsevier Ireland Ltd, 2020-05)

Experimental research suggests that anti-Müllerian hormone (AMH) inhibits tumor growth. Conversely, epidemiological studies suggest that higher AMH concentrations increase breast cancer risk, while associations with other ...
Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants

UCLEB Consortium** (Wiley-Blackwell, 2020-03-03)

Background We aimed at investigating the association of circulating fatty acids with coronary heart disease (CHD) and stroke risk. Methods and Results We conducted an individual-participant data meta-analysis of 5 UK-based ...
Outcome of mechanical circulatory support at the University Medical Centre Utrecht

Felix, S. E.A.; Ramjankhan, F. Z.; Buijsrogge, M. P.; Jacob, K. A.; Asselbergs, F. W.; Oerlemans, M. I.F.; Kirkels, J. H.; van Laake, L. W.; Oppelaar, A. M.C.; Suyker, W. J.L.; de Jonge, N. (Bohn Stafleu van Loghum, 2020-04-01)

Background: The prevalence of heart failure (HF) is increasing substantially and, despite improvements in medical therapy, HF still carries a poor prognosis. Mechanical circulatory support (MCS) by a continuous-flow left ...
Perioperative Antibiotics in Clean-Contaminated Head and Neck Surgery: A Systematic Review and Meta-Analysis

Vander Poorten, Vincent; Uyttebroek, Saartje; Robbins, K Thomas; Rodrigo, Juan P; de Bree, Remco; Laenen, Annouschka; F Saba, Nabil; Suarez, Carlos; Mäkitie, Antti; Rinaldo, Alessandra; Ferlito, Alfio (Springer, 2020-04)

BACKGROUND: The optimal evidence-based prophylactic antibiotic regimen for surgical site infections following major head and neck surgery remains a matter of debate. METHODS: Medline, Cochrane, and Embase were searched for ...
Improving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study

SIMPLIFY Study Group (Elsevier, 2020-06)

PURPOSE: Drug-drug interactions (DDIs) may cause adverse outcomes in patients admitted to the Intensive Care Unit (ICU). Computerized decision support systems (CDSSs) may help prevent DDIs by timely showing relevant warning ...

Now showing items 21521-21540 of 40729