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Now showing items 21501-21520 of 40729

What do Future Hospice Patients Expect of Hospice Care: Expectations of Patients in the Palliative Phase Who Might be in Need of Hospice Care in the Future: A Qualitative Exploration

van Klinken, Merel; de Graaf, Everlien; Bressers, Rick; Koorn, Remco; van der Baan, Frederieke; Teunissen, Saskia (Sage Publications, 2020-06-01)

Introduction: Hospice care (HC) in the Netherlands is available for patients with life expectancies <3 months. Little is known about expectations of patients who might be in need of HC. This study aims to gain insight into ...
[Zr-89]Zr-cetuximab PET/CT as biomarker for cetuximab monotherapy in patients with RAS wild-type advanced colorectal cancer

van Helden, E J; Elias, S G; Gerritse, S L; van Es, S C; Boon, E; Huisman, M C; van Grieken, N C T; Dekker, H; van Dongen, G A M S; Vugts, D J; Boellaard, R; van Herpen, C M L; de Vries, E G E; Oyen, W J G; Brouwers, A H; Verheul, H M W; Hoekstra, O S; Menke-van der Houven van Oordt, C W (Springer-Verlag, 2020-04)

PURPOSE: One-third of patients with RAS wild-type mCRC do not benefit from anti-EGFR monoclonal antibodies. This might be a result of variable pharmacokinetics and insufficient tumor targeting. We evaluated cetuximab tumor ...
Quality of life in primary care patients with moderate medically unexplained physical symptoms

Van Westrienen, P. E.; Pisters, M. F.; Toonders, S. A. J.; Gerrits, M.; De Wit, N. J.; Veenhof, C. (Springer Netherlands, 2020-03)

Purpose: Medically Unexplained Physical Symptoms (MUPS) have a large impact on patient’s quality of life. Most studies have been limited to chronic MUPS and thus, little is known about moderate MUPS. Improved knowledge ...
Show yourself, experiences of patients with bipolar disorder recording a film to show their "euthymic being": A qualitative study

Goossens, Peter J J; Daggenvoorde, Thea H; Groot Lipman, Melanie H G; van Bendegem, Micha A; Kars, Marijke C (Wiley-Blackwell, 2020-04)

PURPOSE: To examine the experiences of outpatients with bipolar disorder recording a 10-minute film to show their "being" in a euthymic mood state. DESIGN AND METHODS: A multicenter qualitative study, in the context of a ...
Impact of risk minimisation measures on the use of strontium ranelate in Europe: a multi-national cohort study in 5 EU countries by the EU-ADR Alliance

Berencsi, K; Sami, A; Ali, M S; Marinier, K; Deltour, N; Perez-Guthann, S; Pedersen, L; Rijnbeek, P; Van der Lei, J; Lapi, F; Simonetti, M; Reyes, C; Sturkenboom, M C J M; Prieto-Alhambra, D (Springer Science and Business Media Deutschland GmbH, 2020-04)

INTRODUCTION: In May 2013 and March 2014, the European Medicines Agency (EMA) issued two decisions restricting the use of strontium ranelate (SR). These risk minimisation measures (RMM) introduced new contraindications and ...
Survey of paediatricians caring for children with life-limiting conditions found that they were involved in advance care planning

Fahner, Jurrianne C; Rietjens, Judith A C; van der Heide, Agnes; van Delden, Johannes J M; Kars, Marijke C (Wiley-Blackwell, 2020-05)

Aim: Advance care planning (ACP) is a strategy to align future care and treatment with preferences of patients and families. This study assesses the experiences of ACP among paediatricians caring for children with life-limiting ...
Antithrombotic Therapy and Major Adverse Limb Events in Patients With Chronic Lower Extremity Arterial Disease: systematic review and meta-analysis from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy in Collaboration with the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases

Savarese, Gianluigi; Reiner, Martin F; Uijl, Alicia; D Amario, Domenico; Agewall, Stefan; Atar, Dan; Baumgartner, Iris; Borghi, Claudio; De Carlo, Marco; Drexel, Heinz; Kaski, Juan Carlos; Kjeldsen, Keld P; Kucher, Nils; Lund, Lars H; Niessner, Alexander; Semb, Anne Grete; Schmidt, Thomas A; Sulzgruber, Patrick; Tamargo, Juan; Vitale, Cristiana; Wassmann, Sven; Aboyans, Victor; Lewis, Basil S (Oxford University Press, 2020-04-01)

AIMS: The role and selection of antithrombotic therapy to improve limb outcomes in chronic lower extremity artery disease (LEAD) is still debated. We conducted a meta-analysis to examine the efficacy and safety of ...
One-stop routing for surgical interventions: a cost-analysis of endoscopic groin repair

van Hessen, Coen; Roos, Marleen; Frederix, Geert; Verleisdonk, Egbert Jan; Clevers, Geert Jan; Davids, Paul; Burgmans, Josephina (Springer New York, 2020-05-01)

Background: Single-visit (SV) totally extraperitoneal (TEP) inguinal hernia repair is an efficient service without impairment of safety or complication rate. Data on the economic impact of this approach are rare. The aim ...
Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk : A two-sample Mendelian Randomization study

Zwakenberg, Sabine R; Burgess, Stephen; Sluijs, Ivonne; Weiderpass, Elisabete; Beulens, Joline W J; van der Schouw, Yvonne T (Churchill Livingstone, 2020-04-01)

BACKGROUND AND AIMS: Multiple observational studies and small-scale intervention studies suggest that high vitamin K intake is associated with improved markers for cardiovascular health. Circulating phylloquinone solely ...
Growth Hormone Receptor Interacting Proteins

Schantl, J.A. (Utrecht University, 2003-01-21)

Growth hormone (GH) promotes muscle strength, fights infections, accelerates wound healing and accelerates recovery after bone fractures. In addition, children with delayed growth can be treated with GH. Recently, the ...
Phosphorylation and ubiquitination in Growth Hormone Receptor endocytosis and signalling

Putters, J. (Utrecht University, 2010-04-06)

In her thesis Joyce Putters has described how cells of the body regulate the sensitivity for growth hormone. This is important because growth hormone promotes muscle strength, fights infections, accelerates wound healing ...
Incidence of Occult Lymph Node Metastasis in Primary Larynx Squamous Cell Carcinoma, by Subsite, T Classification and Neck Level: A Systematic Review

Sanabria, Alvaro; Shah, Jatin P; Medina, Jesus E; Olsen, Kerry D; Robbins, K Thomas; Silver, Carl E; Rodrigo, Juan P; Suárez, Carlos; Coca-Pelaz, Andrés; Shaha, Ashok R; Mäkitie, Antti A; Rinaldo, Alessandra; de Bree, Remco; Strojan, Primož; Hamoir, Marc; Takes, Robert P; Sjögren, Elisabeth V; Cannon, Trinitia; Kowalski, Luiz P; Ferlito, Alfio (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-24)

BACKGROUND: Larynx cancer is a common site for tumors of the upper aerodigestive tract. In cases with a clinically negative neck, the indications for an elective neck treatment are still debated. The objective is to define ...
Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T

van Rijssel, Michael J.; Pluim, Josien P.W.; Chan, Hui Shan M.; van den Wildenberg, Lieke; Schmitz, Alexander M.Th; Luijten, Peter R.; Gilhuijs, Kenneth G.A.; Klomp, Dennis W.J. (John Wiley & Sons Inc., 2020-08-01)

PURPOSE: Inhomogeneous excitation at ultrahigh field strengths (7T and above) compromises the reliability of quantified dynamic contrast-enhanced breast MRI. This can hamper the introduction of ultrahigh field MRI into the ...
Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment

De Maar, Josanne Sophia; Sofias, Alexandros Marios; Siegel, Tiffany Porta; Vreeken, Rob J.; Moonen, Chrit; Bos, Clemens; Deckers, Roel (Ivyspring International Publisher, 2020-01-01)

Genetic and phenotypic tumour heterogeneity is an important cause of therapy resistance. Moreover, non-uniform spatial drug distribution in cancer treatment may cause pseudo-resistance, meaning that a treatment is ineffective ...
Short-term immunogenicity and safety of hepatitis-A and varicella vaccines in HIV-exposed uninfected and HIV-unexposed South African children

Mutsaerts, Eleonora A.M.L.; Nunes, Marta C.; Bhikha, Sutika; Ikulinda, Benit T.; Jose, Lisa; Koen, Anthonet; Moultrie, Andrew; Grobbee, Diederick E.; Klipstein-Grobusch, Kerstin; Weinberg, Adriana; Madhi, Shabir A. (Elsevier, 2020-05-08)

Background: HIV-exposed uninfected (HEU) children have increased risk of infectious morbidity during early childhood. We evaluated the short-term immunogenicity and safety of single dose inactivated hepatitis-A virus (HAV) ...
Association between heart failure aetiology and magnitude of echocardiographic remodelling and outcome of cardiac resynchronization therapy

Kloosterman, Mariëlle; van Stipdonk, Antonius M.W.; ter Horst, Iris; Rienstra, Michiel; Van Gelder, Isabelle C.; Vos, Marc A.; Prinzen, Frits W.; Meine, Matthias; Vernooy, Kevin; Maass, Alexander H. (John Wiley & Sons Inc., 2020-04)

AIMS: Echocardiographic response after cardiac resynchronization therapy (CRT) is often lesser in ischaemic cardiomyopathy (ICM) than non-ischaemic dilated cardiomyopathy (NIDCM) patients. We assessed the association of ...
Occurrence and Risk Factors of Chronic Pain After Critical Illness

Koster-Brouwer, Maria E.; Rijsdijk, Mienke; Van Os, Wouter K.M.; Soliman, Ivo W.; Slooter, Arjen J.C.; De Lange, Dylan W.; Van Dijk, Diederik; Bonten, Marc J.M.; Cremer, Olaf L. (Lippincott Williams & Wilkins, 2020-05)

Objectives: Occurrence, risk factors, and impact on daily life of chronic pain after critical illness have not been systematically studied. Design: Cohort study. Setting: A tertiary ICU in The Netherlands. Patients: We ...
A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

Tessadori, Federico; Rehman, Atteeq U; Giltay, Jacques C; Xia, Fan; Streff, Haley; Duran, Karen; Bakkers, Jeroen; Lalani, Seema R; van Haaften, Gijs (Springer Nature, 2020-05)

We report here a de novo missense variant in HIST1H4J resulting in a complex syndrome combining growth delay, microcephaly and intellectual disability. Trio whole exome sequencing (WES) revealed that the proband was ...
Preferences to receive unsolicited findings of germline genome sequencing in a large population of patients with cancer

Bijlsma, Rhode; Wouters, Roel; Wessels, Hester; Sleijfer, Stefan; Beerepoot, Laurens; Ten Bokkel Huinink, Daan; Cruijsen, Hester; Heijns, Joan; Lolkema, Martijn P; Steeghs, Neeltje; van Voorthuizen, Theo; Vulink, Annelie; Witteveen, Els; Ausems, Margreet; Bredenoord, Annelien; May, Anne M; Voest, Emile (Elsevier, 2020-04)

BACKGROUND: In precision medicine, somatic and germline DNA sequencing are essential to make genome-guided treatment decisions in patients with cancer. However, it can also uncover unsolicited findings (UFs) in germline ...
Healthcare Costs of Metastatic Cutaneous Melanoma in the Era of Immunotherapeutic and Targeted Drugs

Leeneman, Brenda; Uyl-de Groot, Carin A; Aarts, Maureen J B; van Akkooi, Alexander C J; van den Berkmortel, Franchette W P J; van den Eertwegh, Alfons J M; de Groot, Jan Willem B; Herbschleb, Karin H; van der Hoeven, Jacobus J M; Hospers, Geke A P; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Rozemarijn S; Suijkerbuijk, Karijn P M; Ten Tije, Albert J; van der Veldt, Astrid A M; Vreugdenhil, Gerard; Wouters, Michel W J M; Haanen, John B A G; Franken, Margreet G (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-18)

Immunotherapeutic and targeted drugs improved survival of patients with metastatic melanoma. There is, however, a lack of evidence regarding their healthcare costs in clinical practice. The aim of our study was to provide ...

Now showing items 21501-21520 of 40729