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UMC Repository: Recent submissions

Now showing items 21181-21200 of 40729

Learning to better understand: Novel bioinformatics algorithms for cancer research

Nieboer, Marleentje Martha (Utrecht University, 2021-08-31)

In this thesis, we focused on developing new bioinformatics algorithms with the ultimate aim of creating a better understanding of cancer. Our research targeted 3 unsolved problems. First, a main difficulty in treating ...
Mandibular range of motion in children with juvenile idiopathic arthritis with and without clinically established temporomandibular joint involvement and in healthy children; a cross-sectional study

Sonnaville, Willemijn F. C. de; Speksnijder, Caroline M.; Zuithoff, Nicolaas P. A.; Verkouteren, Daan R. C.; Wulffraat, Nico W.; Steenks, Michel H.; Rosenberg, Antoine J. W. P. (BMC, 2021-06-03)

Background: Recognition of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis (JIA) has gained increasing attention in the past decade. The clinical assessment of mandibular range ...
Maximum bite force in children with juvenile idiopathic arthritis with and without clinical established temporomandibular joint involvement and in healthy children: a cross-sectional study

Sonnaville, Willemijn F. C. de; Speksnijder, Caroline M.; Zuithoff, Nicolaas P. A.; Verkouteren, Daan R. C.; Wulffraat, Nico W.; Steenks, Michel H.; Rosenberg, Antoine J. W. P. (Wiley, 2021-03-29)

Background: In children with juvenile idiopathic arthritis (JIA), the temporomandibular joint (TMJ) can be involved, resulting in dysfunction of the masticatory system. Bite force is one of the variables that reflects the ...
Plasmid mediated resistance to β-lactam antibiotics in Enterobacteriaceae: mechanisms and detection of plasmid transmission

Stohr, Joep Johan Jacob Mark (Utrecht University, 2021-08-24)

This thesis describes various studies investigating the relationship between plasmids and β-lactam resistance development, the detection of β-lactam resistance in short-read sequence data and the genetic diversity of ...
Immunology, imaging and treatment of advanced penile carcinoma

Ottenhof, Sarah Rosanne (Utrecht University, 2021-07-08)

Penile cancer is introduced in chapter 1. Chapter 2 and 3 describe immunohistochemical studies. First, we looked at PD-L1 expression in different areas and patterns in the tumour-microenvironment. Forty-eight percent ...
Disinvestment decisions in healthcare : An exploration of mechanisms and considerations

Rotteveel, Adriënne Henderika (Utrecht University, 2021-07-08)

Fully or partially withdrawing the reimbursement of healthcare interventions that are currently being used and reimbursed in the healthcare system but that are unsafe, ineffective or do not provide value for money (i.e. ...
The infant gut microbiome and resistome in health and disease

Reyman, Marta (Utrecht University, 2021-07-01)

In this thesis, we describe the development of the infant gut microbiome and resistome, identify important environmental and nutritional drivers of this development and study the gut microbiome and microbial networks in ...
Sarcopenia in head and neck cancer: Towards personalized medicine

Chargi, Najiba (Utrecht University, 2021-07-08)

This thesis showed that low skeletal muscle mass (sarcopenia) is a prevalent problem which occurs in approximately 55% of patients. Skeletal muscle mass can be easily assessed on a single slice at the level of C3 (or L3) ...
Towards the treatment of Cantú syndrome. Drug repurposing for rare genetic diseases

Roessler, Helen Isabel (Utrecht University, 2021-07-06)

Individually, rare genetic diseases affect a small number of individuals. However, collectively they represent an important public health burden by impacting 8% of the EU population. Many rare genetic diseases have a large ...
Focal therapy for (recurrent) prostate cancer. Treat the lesion, preserve the man?

Son, Marieke Juliet van (Utrecht University, 2021-07-01)

The current thesis describes the role of focal therapy for localized prostate cancer in two settings: the primary treatment setting and the salvage treatment setting. Besides a general outline, the use of high-dose-rate ...
Wheelchair Mobility Skills in youth using a manual wheelchair : From Test to Training

Sol, Marleen Elisabeth (Utrecht University, 2021-07-07)

MAIN FINDINGS o The newly developed Utrecht Pediatric Wheelchair Mobility Skills Test (UP-WMST 2.0) is a reliable and valid outcome measure to assess WMS in youth using a manual wheelchair (chapter 2 and 3). o The ...
Letting go of the dichotomy between psoriasis and psoriatic arthritis

Leijten, Emmerik Frederick Adriaan (Utrecht University, 2021-06-29)

Psoriasis and PsA have predominantly shared genetic background and overlapping immunologic signature, confirming their denomination as falling within a spectrum of one single disease. Local tissue factors induce a ...
Vascular cell and extracellular matrix interactions: Implications for vascular regeneration and disease modeling

Dijk, Christian Gerardus Marinus van (Utrecht University, 2021-06-22)

The human body depends on a specialized perfused blood vessel (vascular) network to provide all cells with oxygen and nutrients. Via the complex process of angiogenesis, formation of new small blood vessels from existing ...
Minimally invasive approach to diseases of the breast and contemporary factors affecting breast cancer surgery

Filipe, Mando Dyko (Utrecht University, 2021-06-17)

Pathological nipple discharge is defined as unilateral outflow from the breast. In case of negative imaging, surgery is often recommended in which the milk duct (s) are removed. This operation is under general anaesthesia ...
Unravelling adherence and flourishing acceptance in people with haemophilia

Hoefnagels, Johanna Wilhelmina (Utrecht University, 2021-07-15)

Haemophilia is a rare congenital bleeding disorder that generally affects men. A lack of clotting factor increases the risk of bleeding, which can be prevented and treated with regular, prophylactic, intravenous clotting ...
Knee joint distraction: moving forward

Jansen, Mylène Paulien (Utrecht University, 2021-06-15)

Knee joint distraction (KJD) is a joint-preserving technique for younger (<65 years) patients with knee osteoarthritis (OA). In joint distraction, the two bony ends of a joint are temporarily (6-9 weeks) placed at a certain ...
The DUX4 cytotoxic cascade, and CRISPR mitigation methods

Ashoti, Ator Rafael Odisho (Utrecht University, 2021-06-17)

Facioscapulohumeral muscular dystrophy (FSHD) is a muscle degenerative disease that disproportionally affects the muscles of the face, shoulder girdle and upper arms. FSHD is caused by the ectopic expression of Double ...
Cardiovascular risk and disease management in diabetes : differences between women and men

Jong, Marit, de (Utrecht University, 2021-06-03)

Diabetes is one of the most common chronic diseases worldwide. Individuals with diabetes are at increased risk of developing a wide variety of complications, including cardiovascular diseases (CVD). CVD consist of a group ...
Risk factors for violent behavior in people with psychotic disorders

Lamsma, Jelle (Utrecht University, 2021-06-15)

This dissertation has expanded knowledge of violent behavior in people with schizophrenia and other psychotic disorders by showing that: (a) it is often illness-related; (b) the role that cognition and brain structure play ...
The brain at risk: Detection and quantification of cerebrovascular disease

Hespen, Kees Marijn van (Utrecht University, 2021-05-11)

Cerebrovascular disease results in morphological and functional alterations in the intracranial macro- and microvasculature. Early detection of such alterations is key for better understanding of cerebrovascular disease ...

Now showing items 21181-21200 of 40729