Rhabdomyosarcomas (RMS) are the most common tumors of the soft tissues (sarcomas) in children and adolescents. RMS grow aggressively and show a propensity to spread in the body (metastasize). Treatment is harsh and consists ...

Osteoarthritis (OA) is a joint disease that causes pain and limitations in mobility. Current treatment of OA is focused on management of symptoms and joint replacement surgery at end stage disease, and no curative or ...

This thesis aimed to explore clinical and genetic features of a telomere syndrome in patients with idiopathic pulmonary fibrosis (IPF). IPF is thought to represent a chronic disease process, but the initial stages of disease ...

Our healthcare system is under increasing pressure, both in terms of financial and human capacity, which forces us into difficult choices. Value-based healthcare offers a theory in which the outcomes of care that matter ...

For the implementation of valuable prediction models in clinical practice, properly conducted and well reported studies on early stages of model development and validation are essential. We systematically reviewed the ...

Over the past years, the druggable genome has expanded rapidly which has led to an increase in the number and complexity of biomarkers that need to be assessed in each single patient. The current increase in numbers and ...

In this thesis, the ultimate goal has been to strive towards (automatic) computer assisted planning of reconstructive osteotomies. However, the quality of the output of such a workflow depends on the quality of all the ...

Accumulating evidence shows that metabolism, cellular signaling and epigenetics are highly intertwined. Metabolic alterations, therefore, affect cellular behavior. This thesis focuses on deepening our understanding of ...

During the last decade, the use of holmium-166 (166Ho) microspheres as radioembolization device has been increasing throughout Europe. Chapter 1 presented the use of 166Ho microspheres as an alternative to 90Y for ...