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Now showing items 20721-20740 of 40729

Generalizability of Randomized Controlled Trials in Heart Failure

Lim, Yvonne Mei Fong (Utrecht University, 2023-09-27)

In the first part of this thesis, we explored the differences between trial participants and registry cohorts to explain the mismatch between heart failure trial participants and patient registry populations to identify ...
Efficacious application of laboratory testing in internal medicine

Vrijsen, Bram Evert Luciën (Utrecht University, 2023-10-26)

Laboratory testing plays a major role in internal medicine, especially in diagnosing diseases. In order to use laboratory testing most effectively, several conditions need to be met. Firstly, only tests that contribute ...
Drug and device testing in a preclinical model sensitive to cardiac arrhythmias

Bavel, Joanne Johanne Arianne van (Utrecht University, 2023-09-28)

Sudden cardiac death is still the leading cause of mortality worldwide and in 50-70% of the cases related to ventricular tachyarrhythmia. The process of initiation and perpetuation of ventricular arrhythmias is complex and ...
Optimal care/treatment of patients with atopic dermatitis at the edge of a new era of advanced systemic treatments

Ariëns, Lieneke Francis Marleen (Utrecht University, 2023-09-21)

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide with an increasing prevalence up to 20% in children and 10% in adults in developed countries. Atopic dermatitis is associated with many ...
Cardiotoxicity in childhood cancer survivors: risk of low dose cancer treatment, added value of ECG in surveillance and prevention by dexrazoxane

Baat, Esmée Christina de (Utrecht University, 2023-10-12)

Long-term health effects in the growing population of childhood cancer survivors are of major concern. Cardiac disease, because of treatment with anthracyclines, mitoxantrone or radiotherapy involving the heart region, can ...
Make or brake it: On the roles of the cohesin acetylation cycle

Ruiten, Marjon Suzanne van (Utrecht University, 2023-10-03)

Human chromosomes are centimeters in length, but are structured to fit into a micrometer- scale nucleus. Key to this organization are structural maintenance of chromosomes complexes, which includes the cohesin complex. ...
All roads lead to SHP2

Mulero-Sánchez, Antonio (Utrecht University, 2023-10-19)

It is clear by now that CRISPR screens are a useful tool to identify and validate novel targets for the treatment of various malignancies. Furthermore, genetic screens have allowed the identification of not only the usual ...
Therapeutic strategies to rescue damaged heart

Fang, Juntao (Utrecht University, 2023-09-18)

Heart failure is a complex and common condition with a poor prognosis and increasing incidence. Unfortunately, end-stage heart failure can only be treated with heart replacement therapy or mechanical support devices, which ...
Learning from patients: Understanding student experiences with patient involvement in medical education

Eijkelboom, Marie Charlotte Leonie (Utrecht University, 2023-09-13)

Moving towards person-centred care requires a solid role for patients in the education of healthcare professionals. Patient involvement is the active involvement and engagement of patients in health professions education. ...
Reconstructing AMR plasmids: New methods to track the dissemination of mobile genetic elements in ICUs

Paganini, Julian Andrés (Utrecht University, 2023-09-27)

Antimicrobial resistance (AMR) is a pressing global concern, posing a significant threat to human health worldwide. Each year, the incidence of infections caused by resistant bacteria continues to rise, imposing a significant ...
Wearable wireless continuous vital signs monitoring on the general ward: a technological innovation in nursing

Leenen, Jobbe Pierre Lucien (Utrecht University, 2023-09-25)

Patients on general wards are at risk of complications, often associated with deviations in vital signs. Unfortunately, the currently used manual method of intermittently measuring vital signs is not optimal, potentially ...
Plasticity of neural networks: Diagnostic and therapeutic transcranial magnetic stimulation of healthy and infarcted brains

Vink, Jord Jan-Teunis (Utrecht University, 2023-09-27)

Despite improvements in acute stroke therapies and rehabilitation strategies, many stroke patients are left with long-term upper limb motor impairment, making stroke the leading cause of adult disability. Repetitive ...
Saving Private Macrophage: Alternative therapeutic options for Staphylococcus aureus implant-associated infections

Cecotto, Leonardo (Utrecht University, 2023-09-11)

Breaking a bone is not a pleasant experience. It might get worse if an implant is needed to repair the fracture. In 1 to 5% of the cases, Staphylococcus aureus might use the implant to enter and colonize our organism. This ...
Brainwaves and Breakdowns - Tracking Brain Dynamics in Epilepsy and Migraine

Helling, Robert Martijn (Utrecht University, 2023-09-12)

Epilepsy is a chronic disorder characterized by recurring and unpredictable seizures that disrupt normal brain function. These seizures, stemming from abnormal neuronal activity, can severely impact the quality of life for ...
Glial Cells in Alzheimer’s Disease: Insights from Patient-Derived Models

Verkerke, Marie Louise (Utrecht University, 2023-09-26)

The human brain is responsible for information processing and functions at various levels, ranging from movement to language and creativity. It consists of neurons and glial cells, including astrocytes and microglia. ...
Thumb Carpometacarpal Osteoarthritis: New insights & Treatment opportunities

Ottenhoff, Janna Sophie Eugenia (Utrecht University, 2023-09-14)

Osteoarthritis of the basal thumb joint is part of normal human aging: everyone gets it if we live long enough. Thumb pain can cause reduced pinch strength and impaired hand capability such as difficulty opening jars or ...
Subsequent breast cancer risk in childhood cancer survivors and survivorship care

Wang, Yuehan (Utrecht University, 2023-09-14)

Survival rates for childhood cancer have improved markedly over the last decades. Unfortunately, the life expectancy and quality of life of long-term survivors are compromised by long-term adverse effects such as subsequent ...
The occurrence and prevention of CSF leakage: Application of a patch in different neurosurgical indications

Slot, Emma Marie Heleen (Utrecht University, 2023-10-17)

This Ph.D. thesis describes further applications of a novel dural sealant patch to prevent cerebrospinal fluid (CSF) leakage. CSF leakage is a well-known complication after neurosurgical procedures. To mitigate the risk ...
Management of Inflammatory Bowel Disease: a long-term perspective

Mahmoud, Remi (Utrecht University, 2023-09-28)

Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBD), characterized by relapsing-remitting inflammation of the gastrointestinal tract. IBD patients may experience abdominal pain, diarrhea, rectal ...
Rheumatic heart disease in Tanzania: insight in clinical aspects and outcome

Mutagaywa, Reuben Kato (Utrecht University, 2023-08-29)

Chapter 1 is the general introduction and an outline of this thesis. Part 1 of the thesis assessed RHD in special populations. In the first part of chapter 2, we reported on the influence of gender in the management ...

Now showing items 20721-20740 of 40729