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UMC Repository: Recent submissions

  • Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels 
    Rahmati, Negah; Hoebeek, Freek E; Peter, Saša; De Zeeuw, Chris I (Frontiers Media S. A., 2018-05-01)
    The intraneuronal ionic composition is an important determinant of brain functioning. There is growing evidence that aberrant homeostasis of the intracellular concentration of Cl- ([Cl-]i) evokes, in addition to that of ...
  • Achieved LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia: A model that explores the efficacy of conventional and novel lipid-lowering therapy 
    Hartgers, Merel L.; Besseling, Joost; Stroes, Erik S.; Wittekoek, Janneke; Rutten, Joost H.W.; de Graaf, Jacqueline; Visseren, Frank L.J.; Imholz, Ben P.M.; Roeters van Lennep, Jeanine E.; Huijgen, Roeland; Kastelein, John J.P.; Hovingh, G. Kees (Elsevier, 2018-07-01)
    Background: A large proportion of patients with heterozygous familial hypercholesterolemia (heFH) do not reach low-density lipoprotein cholesterol (LDL-c) levels advocated by international guidelines (<70 mg/dL or <100 ...
  • The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease 
    Schrover, Ilse M.; van der Graaf, Yolanda; Spiering, Wilko; Visseren, Frank L.J.; SMART Study Group (Oxford University Press, 2018-09-01)
    Introduction: We evaluated the relationship between adipokine plasma concentrations and body fat distribution and the metabolic syndrome. Methods: In a cohort of 1215 patients with clinically manifest vascular disease the ...
  • Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1-syndrome 
    van der Tuin, Karin; de Kock, Leanne; Kamping, Eveline J; Hannema, Sabine E; Pouwels, Marie-Jose M; Niedziela, Marek; van Wezel, Tom; Hes, Frederik J; Jongmans, Marjolijn C; Foulkes, William D; Morreau, Hans (Endocrine Society, 2019-02-01)
    Context DICER1 syndrome is a rare autosomal-dominantly inherited disorder that predisposes to a variety of cancerous and noncancerous tumors of mostly pediatric and adolescent onset, including differentiated thyroid carcinoma ...
  • Weight-bearing or non-weight-bearing after surgical treatment of ankle fractures: a multicenter randomized controlled trial 
    Smeeing, Diederik Pieter Johan; Houwert, Roderick Marijn; Briet, Jan Paul; Groenwold, Rolf Hendrik Herman; Lansink, Koen Willem Wouter; Leenen, Luke Petrus Hendrikus; van der Zwaal, Peer; Hoogendoorn, Jochem Maarten; van Heijl, Mark; Verleisdonk, Egbert Jan; Segers, Michiel Joseph Marie; Hietbrink, Falco (Springer International Publishing AG, 2020-02-01)
    PURPOSE: The goal of this study was to assess if unprotected weight-bearing as tolerated is superior to protected weight-bearing and unprotected non-weight-bearing in terms of functional outcome and complications after ...
  • The impact of family centred care interventions in a neonatal or paediatric intensive care unit on parents’ satisfaction and length of stay: A systematic review 
    Segers, Elisabeth; Ockhuijsen, Henrietta; Baarendse, Petra; van Eerden, Irene; van den Hoogen, Agnes (Churchill Livingstone, 2019-02-01)
    Objective: To explore the impact of family centred care interventions on parents’ satisfaction and length of stay for patients admitted to a paediatric intensive care unit or a neonatal intensive care unit. Methods: A ...
  • Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group 
    Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T.; Bøen, Erlend; Bonnin, Caterina del Mar; Busatto, Geraldo F.; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Dannlowski, Udo; Díaz-Zuluaga, Ana M.; Dietsche, Bruno; Doan, Nhat Trung; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Emden, Daniel; Eyler, Lisa T.; Fatjó-Vilas, Mar; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Glahn, David C.; Goikolea, Jose M.; Grotegerd, Dominik; Hahn, Tim; Henry, Chantal; Hibar, Derrek P.; Houenou, Josselin; Howells, Fleur M.; Jahanshad, Neda; Kaufmann, Tobias; Kenney, Joanne; Kircher, Tilo T.J.; Krug, Axel; Lagerberg, Trine V.; Lenroot, Rhoshel K.; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; Malt, Ulrik F.; McDonald, Colm; Mitchell, Philip B.; van Haren, Neeltje E.M.; for the ENIGMA Bipolar Disorders Working Group (Springer Nature, 2020-09)
    Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings ...
  • Saliva oxytocin, cortisol, and testosterone levels in adolescent boys with autism spectrum disorder, oppositional defiant disorder/conduct disorder and typically developing individuals 
    Bakker-Huvenaars, M. J.; Greven, C. U.; Herpers, P.; Wiegers, E.; Jansen, A.; van der Steen, R.; van Herwaarden, A. E.; Baanders, A. N.; Nijhof, K. S.; Scheepers, F.; Rommelse, N.; Glennon, J. C.; Buitelaar, J. K. (Elsevier, 2020-01)
    The aim of the current study was to compare levels of oxytocin, cortisol, and testosterone in adolescents with either autism spectrum disorder (ASD), or oppositional defiant disorder (ODD)/conduct disorder (CD), and in ...
  • Anatomical and Functional Computed Tomography for Diagnosing Hemodynamically Significant Coronary Artery Disease: A Meta-Analysis 
    Celeng, Csilla; Leiner, Tim; Maurovich-Horvat, Pál; Merkely, Béla; de Jong, Pim; Dankbaar, Jan W; van Es, Hendrik W; Ghoshhajra, Brian B; Hoffmann, Udo; Takx, Richard A P (Elsevier, 2019-07)
    OBJECTIVES: This meta-analysis determined the diagnostic performance of coronary computed tomography (CT) angiography (CTA), CT myocardial perfusion (CTP), fractional flow reserve CT (FFRCT), the transluminal attenuation ...
  • Results of next-generation sequencing gene panel diagnostics including copy-number variation analysis in 810 patients suspected of heritable thoracic aortic disorders 
    Overwater, Eline; Marsili, Luisa; Baars, Marieke J.H.; Baas, Annette F.; van de Beek, Irma; Dulfer, Eelco; van Hagen, Johanna M.; Hilhorst-Hofstee, Yvonne; Kempers, Marlies; Krapels, Ingrid P.; Menke, Leonie A.; Verhagen, Judith M.A.; Yeung, Kak K.; Zwijnenburg, Petra J.G.; Groenink, Maarten; van Rijn, Peter; Weiss, Marjan M.; Voorhoeve, Els; van Tintelen, J. Peter; Houweling, Arjan C.; Maugeri, Alessandra (John Wiley & Sons Inc., 2018-09-01)
    Simultaneous analysis of multiple genes using next-generation sequencing (NGS) technology has become widely available. Copy-number variations (CNVs) in disease-associated genes have emerged as a cause for several hereditary ...
  • Risk Factors for Necrotizing Enterocolitis: A Prospective Multicenter Case-Control Study 
    Berkhout, Daniel J.C.; Klaassen, Patrick; Niemarkt, Hendrik J.; de Boode, Willem P.; Cossey, Veerle; van Goudoever, Johannes B.; Hulzebos, Christiaan V.; Andriessen, Peter; van Kaam, Anton H.; Kramer, Boris W.; van Lingen, Richard A.; Vijlbrief, Daniel C.; van Weissenbruch, Mirjam M.; Benninga, Marc; de Boer, Nanne K.H.; de Meij, Tim G.J. (S. Karger AG, 2018)
    Background: The identification of independent clinical risk factors for necrotizing enterocolitis (NEC) may contribute to early selection of infants at risk, allowing for the development of targeted strategies aimed at the ...
  • Recovery of puborectalis muscle after vaginal delivery: an ultrasound study 
    Van de Waarsenburg, M K; Verberne, E A; van der Vaart, C H; Withagen, M I J (John Wiley & Sons Inc., 2018-09)
    Objectives: To assess change in levator hiatal dimensions between pregnancy and different timepoints after vaginal delivery, and map recovery of the hiatus in order to contribute to secondary prevention of symptoms of ...
  • Predicting the cumulative chance of live birth over multiple complete cycles of in vitro fertilization: An external validation study 
    Leijdekkers, J. A.; Eijkemans, M. J.C.; Van Tilborg, T. C.; Oudshoorn, S. C.; McLernon, D. J.; Bhattacharya, S.; Mol, B. W.J.; Broekmans, F. J.M.; Torrance, H. L.; OPTIMIST (Oxford University Press, 2018-09)
    STUDY QUESTION: Are the published pre-treatment and post-treatment McLernon models, predicting cumulative live birth rates (LBR) over multiple complete IVF cycles, valid in a different context? SUMMARY ANSWER: With minor ...
  • Cardio-oncology: an overview on outpatient management and future developments 
    Teske, A. J.; Linschoten, M.; Kamphuis, J. A.M.; Naaktgeboren, W. R.; Leiner, T.; van der Wall, E.; Kuball, J.; van Rhenen, A.; Doevendans, P. A.; Cramer, M. J.; Asselbergs, F. W. (Bohn Stafleu van Loghum, 2018-11-01)
    Recent advances in the early detection and treatment of cancer have led to increasing numbers of cancer survivors worldwide. Nonetheless, despite major improvements in the outcome of these patients, long-term side effects ...
  • Linking the Heart and the Brain: Neurodevelopmental Disorders In Patients With Catecholaminergic Polymorphic Ventricular Tachycardia 
    Lieve, Krystien V.V.; Verhagen, Judith M.A.; Wei, Jinhong; Bos, J. Martijn; van der Werf, Christian; Rosés i Noguer, Ferran; Mancini, Grazia M.S.; Guo, Wenting; Wang, Ruiwu; van den Heuvel, Freek; Frohn-Mulder, Ingrid M.E.; Shimizu, Wataru; Nogami, Akihiko; Horigome, Hitoshi; Roberts, Jason D.; Leenhardt, Antoine; Crijns, Harry J.G.; Blank, Andreas C.; Aiba, Takeshi; Wiesfeld, Ans C.P.; Blom, Nico A.; Sumitomo, Naokata; Till, Jan; Ackerman, Michael J.; Chen, S. R.Wayne; van de Laar, Ingrid M.B.H.; Wilde, Arthur A.M. (Elsevier, 2019-02-01)
    Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an uncommon inherited arrhythmia disorder characterized by adrenergically evoked ventricular arrhythmias. Mutations in the cardiac calcium release ...
  • Estrogen deprivation and cardiovascular disease risk in primary ovarian insufficiency 
    Christ, Jacob P.; Gunning, Marlise N.; Palla, Giulia; Eijkemans, Marinus J.C.; Lambalk, Cornelis B.; Laven, Joop S.E.; Fauser, Bart C.J.M. (Elsevier, 2018-04-01)
    Objective: To evaluate the association between estrogen (E) exposure and deficiency and cardiovascular disease (CVD) risk among women with primary ovarian insufficiency (POI). Design: Cross-sectional study conducted between ...
  • Neurodevelopment After Perinatal Arterial Ischemic Stroke 
    Wagenaar, Nienke; Martinez-Biarge, Miriam; van der Aa, Niek E; van Haastert, Ingrid C; Groenendaal, Floris; Benders, Manon J N L; Cowan, Frances M; de Vries, Linda S (American Academy of Pediatrics, 2018-09)
    BACKGROUND AND OBJECTIVES: Perinatal arterial ischemic stroke (PAIS) leads to cerebral palsy in ∼30% of affected children and has other neurologic sequelae. Authors of most outcome studies focus on middle cerebral artery ...
  • Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns 
    Negro, Simona; Benders, Manon J N L; Tataranno, Maria Luisa; Coviello, Caterina; de Vries, Linda S; van Bel, Frank; Groenendaal, Floris; Longini, Mariangela; Proietti, Fabrizio; Belvisi, Elisa; Buonocore, Giuseppe; Perrone, Serafina (Hindawi Publishing Corporation, 2018)
    This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation ...
  • The burden of systemic juvenile idiopathic arthritis for patients and caregivers: An international survey and retrospective chart review 
    Shenoi, Susan; Horneff, Gerd; Cidon, Michal; Ramanan, Athimalaipet V.; Kimura, Yukiko; Quartier, Pierre; Foeldvari, Ivan; Zeft, Andrew; Lomax, Kathleen G.; Gregson, Jill; Abma, Tineke; Campbell-Hill, Sarah; Weiss, Jeffrey; Patel, Dony; Marinsek, Nina; Wulffraat, Nico (Clinical and Experimental Rheumatology S.A.S., 2018-09-01)
    Objective To investigate the burden of systemic juvenile idiopathic arthritis (SJIA) on health-related quality of life (HRQOL) and resource use of patients and caregivers (families) on biologic therapy. Methods This ...
  • Osteochondritis Dissecans in the Knee of Skeletally Immature Patients: Rates of Persistent Pain, Osteoarthritis, and Arthroplasty at Mean 14-Years’ Follow-Up 
    Hevesi, Mario; Sanders, Thomas L.; Pareek, Ayoosh; Milbrandt, Todd A.; Levy, Bruce A.; Stuart, Michael J.; Saris, Daniel B.F.; Krych, Aaron J. (SAGE Publications Inc., 2020-07)
    Objective: Osteochondritis dissecans (OCD) is a knee disorder of predominately pediatric populations. Because of low incidence, it has traditionally been difficult to study OCD. The purpose of this study was to report ...