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UMC Repository: Recent submissions

  • The multi-biomarker disease activity score tracks response to rituximab treatment in rheumatoid arthritis patients: a post hoc analysis of three cohort studies 
    Roodenrijs, Nadia M.T.; de Hair, Maria J.H.; Wheater, Gill; Elshahaly, Mohsen; Tekstra, Janneke; Teng, Y. K.Onno; Lafeber, Floris P.J.G.; Hwang, Ching Chang; Liu, Xinyu; Sasso, Eric H.; van Laar, Jacob M. (BioMed Central Ltd., 2018-11-20)
    BACKGROUND: A multi-biomarker disease activity (MBDA) score has been validated as an objective measure of disease activity in rheumatoid arthritis (RA) and shown to track response to treatment with several disease-modifying ...
  • Safety of intradiscal delivery of triamcinolone acetonide by a poly(esteramide) microsphere platform in a large animal model of intervertebral disc degeneration 
    Rudnik-Jansen, Imke; Tellegen, Anna; Beukers, Martijn; Öner, Fetullah; Woike, Nina; Mihov, George; Thies, Jens; Meij, Björn; Tryfonidou, Marianna; Creemers, Laura (Elsevier, 2019-05)
    BACKGROUND CONTEXT: Local corticosteroids have been used to relieve symptoms of chronic low back pain, although treatment effects have been shown to wear off relatively fast. Prolonging corticosteroid presence by controlled ...
  • Predictive Role of Urinary Metabolic Profile for Abnormal MRI Score in Preterm Neonates 
    Tataranno, Maria Luisa; Perrone, Serafina; Longini, Mariangela; Coviello, Caterina; Tassini, Maria; Vivi, Antonio; Calderisi, Marco; de Vries, Linda S.; Groenendaal, Floris; Buonocore, Giuseppe; Benders, Manon J.N.L. (IOS Press, 2018-01-01)
    Background and Objective: Early identification of neonates at risk for brain injury is important to start appropriate intervention. Urinary metabolomics is a source of potential, noninvasive biomarkers of brain disease. ...
  • Multiscale modelling and homogenisation of fibre-reinforced hydrogels for tissue engineering 
    Chen, M. J.; Kimpton, L. S.; Whiteley, J. P.; Castilho, M.; Malda, J.; Please, C. P.; Waters, S. L.; Byrne, H. M. (Cambridge University Press, 2020-02)
    Tissue engineering aims to grow artificial tissues in vitro to replace those in the body that have been damaged through age, trauma or disease. A recent approach to engineer artificial cartilage involves seeding cells ...
  • SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase 
    Holt-Danborg, Lasse; Vodopiutz, Julia; Nonboe, Annika W.; De Laffolie, Jan; Skovbjerg, Signe; Wolters, Victorien M.; Müller, Thomas; Hetzer, Benjamin; Querfurt, Alexander; Zimmer, Klaus Peter; Jensen, Jan K.; Entenmann, Andreas; Heinz-Erian, Peter; Vogel, Lotte K.; Janecke, Andreas R. (Oxford University Press, 2019-03-01)
    The syndromic form of congenital sodium diarrhea (SCSD) is caused by bi-allelic mutations in SPINT2, which encodes a Kunitz-type serine protease inhibitor (HAI-2). We report three novel SCSD patients, two novel SPINT2 ...
  • Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome 
    Teede, Helena J.; Misso, Marie L.; Costello, Michael F.; Dokras, Anuja; Laven, Joop; Moran, Lisa; Piltonen, Terhi; Norman, Robert J.; Andersen, Marianne; Azziz, Ricardo; Balen, Adam; Baye, Estifanos; Boyle, Jacqueline; Brennan, Leah; Broekmans, Frank; Dabadghao, Preeti; Devoto, Luigi; Dewailly, Didier; Downes, Linda; Fauser, Bart; Franks, Stephen; Garad, Rhonda M.; Gibson-Helm, Melanie; Harrison, Cheryce; Hart, Roger; Hawkes, Rachel; Hirschberg, Angelica; Hoeger, Kathleen; Hohmann, Femke; Hutchison, Samantha; Joham, Anju; Johnson, Louise; Jordan, Cailin; Kulkarni, Jayashri; Legro, Richard S.; Li, Rong; Lujan, Marla; Malhotra, Jaideep; Mansfield, Darren; Marsh, Kate; McAllister, Veryan; Mocanu, Edgar; Mol, Ben W.; Ng, Ernest; Oberfield, Sharon; Ottey, Sasha; Peña, Alexia; Qiao, Jie; Redman, Leanne; Rodgers, Raymond; on behalf of the International PCOS Network (Oxford University Press, 2018-09-01)
    STUDY QUESTION: What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise and consumer preference? SUMMARY ANSWER: International ...
  • Deep learning enables automatic quantitative assessment of puborectalis muscle and urogenital hiatus in plane of minimal hiatal dimensions 
    van den Noort, F; van der Vaart, C H; Grob, A T M; van de Waarsenburg, M K; Slump, C H; van Stralen, M (John Wiley & Sons Inc., 2019-08)
    Objectives: To measure the length, width and area of the urogenital hiatus (UH), and the length and mean echogenicity (MEP) of the puborectalis muscle (PRM), automatically and observer-independently, in the plane of minimal ...
  • Determinants of successful lifestyle change during a 6-month preconception lifestyle intervention in women with obesity and infertility 
    Karsten, Matty D.A.; van Oers, Anne M.; Groen, Henk; Mutsaerts, Meike A.Q.; van Poppel, Mireille N.M.; Geelen, Anouk; van de Beek, Cornelieke; Painter, Rebecca C.; Mol, Ben W.J.; Roseboom, Tessa J.; Hoek, Annemieke; Burggraaff, J. M.; Kuchenbecker, W. K.H.; Perquin, D. A.M.; Koks, C. A.M.; van Golde, R.; Kaaijk, E. M.; Schierbeek, J. M.; Oosterhuis, G. J.E.; Broekmans, F. J.; Vogel, N. E.A.; Lambalk, C. B.; van der Veen, F.; Klijn, N. F.; Mercelina, P. E.A.M.; van Kasteren, Y. M.; Nap, A. W.; Mulder, R. J.A.B.; Gondrie, E. T.C.M.; de Bruin, J. P.; the LIFEstyle study group (Springer Science and Business Media Deutschland GmbH, 2019-09-01)
    PURPOSE: To identify demographic, (bio)physical, behavioral, and psychological determinants of successful lifestyle change and program completion by performing a secondary analysis of the intervention arm of a randomized ...
  • Follicle stimulating hormone versus clomiphene citrate in intrauterine insemination for unexplained subfertility: a randomized controlled trial 
    Danhof, N A; van Wely, M; Repping, S; Koks, C; Verhoeve, H R; de Bruin, J P; Verberg, M F G; van Hooff, M H A; Cohlen, B J; van Heteren, C F; Fleischer, K; Gianotten, J; van Disseldorp, J; Visser, J; Broekmans, F J M; Mol, B W J; van der Veen, F; Mochtar, M H; SUPER study group (Oxford University Press, 2018-10-01)
    STUDY QUESTION: Is FSH or clomiphene citrate (CC) the most effective stimulation regimen in terms of ongoing pregnancies in couples with unexplained subfertility undergoing IUI with adherence to strict cancellation criteria ...
  • Displaced medial clavicle fractures: operative treatment with locking compression plate fixation 
    Frima, Herman; Houwert, Roderick M.; Sommer, Christoph (Springer International Publishing AG, 2020-02-01)
    Objectives: Medial clavicle fractures are rare injuries and historically treated non-operatively. Displaced medial clavicle fractures, however, have a higher incidence of delayed- or non-union compared to non- displaced ...
  • Altered organization of the visual cortex in FHONDA syndrome 
    Ahmadi, Khazar; Fracasso, Alessio; van Dijk, Jelle A.; Kruijt, Charlotte; van Genderen, Maria; Dumoulin, Serge O.; Hoffmann, Michael B. (Academic Press Inc., 2019-04-15)
    A fundamental scheme in the organization of the early visual cortex is the retinotopic representation of the contralateral visual hemifield on each hemisphere. We determined the cortical organization in a novel congenital ...
  • Fast technetium-99m liver SPECT for evaluation of the pretreatment procedure for radioembolization dosimetry 
    van der Velden, Sandra; Dietze, Martijn M A; Viergever, Max A; de Jong, Hugo W A M (John Wiley & Sons Inc., 2019-01)
    Purpose: The efficiency of radioembolization procedures could be greatly enhanced if results of the 99m Tc-MAA pretreatment procedure were immediately available in the interventional suite, enabling 1-day procedures as a ...
  • Strategies for intrapartum foetal surveillance in low- and middle-income countries: A systematic review 
    Housseine, Natasha; Punt, Marieke C.; Browne, Joyce L.; Meguid, Tarek; Klipstein-Grobusch, Kerstin; Kwast, Barbara E.; Franx, Arie; Grobbee, Diederick E.; Rijken, Marcus J. (Public Library of Science, 2018-10-26)
    Background The majority of the five million perinatal deaths worldwide take place in low-resource settings. In contrast to high-resource settings, almost 50% of stillbirths occur intrapartum. The aim of this study was to ...
  • Development of a real-time patient-reported outcome measure for symptom assessment in patients with functional dyspepsia using the experience sampling method 
    Smeets, Fabiënne G.M.; Keszthelyi, Daniel; Vork, Lisa; Tack, Jan; Talley, Nicholas J.; Simren, Magnus; Aziz, Qasim; Ford, Alexander C.; Conchillo, José M.; Kruimel, Joanna W.; Van Os, Jim; Masclee, Ad A.M. (Wiley-Blackwell, 2019-02)
    Background: Patient-reported outcome measures (PROMs) are used to assess symptoms in patients with functional dyspepsia (FD). Current end-of-day questionnaires have several limitations including sensitivity to recall and ...
  • Diagnosing Nonfunctional Pancreatic NETs in MEN1: The Evidence Base 
    van Treijen, Mark J. C.; van Beek, Dirk-Jan; van Leeuwaarde, Rachel S.; Vriens, Menno R.; Valk, Gerlof D. (Endocrine Society, 2018-09-01)
    In multiple endocrine neoplasia type 1 (MEN1), nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) are the most frequently diagnosed NETs and a leading cause of MEN1-related death. The high prevalence and malignant ...
  • Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology 
    Teitsma, Xavier M; Yang, Wei; Jacobs, Johannes W G; Pethö-Schramm, Attila; Borm, Michelle E A; Harms, Amy C; Hankemeier, Thomas; van Laar, Jacob M; Bijlsma, Johannes W J; Lafeber, Floris P J G (BioMed Central Ltd., 2018)
    BACKGROUND: We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with achieving sustained drug-free remission (sDFR) after ...
  • Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet 
    Kozijn, A. E.; Tartjiono, M. T.; Ravipati, S.; van der Ham, F.; Barrett, D. A.; Mastbergen, S. C.; Korthagen, N. M.; Lafeber, F. P.J.G.; Zuurmond, A. M.; Bobeldijk, I.; Weinans, H.; Stoop, R. (W.B. Saunders Ltd, 2019-01)
    Objective: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and ...
  • SNX3-retromer requires an evolutionary conserved MON2: DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion 
    McGough, Ian J.; de Groot, Reinoud E.A.; Jellett, Adam P.; Betist, Marco C.; Varandas, Katherine C.; Danson, Chris M.; Heesom, Kate J.; Korswagen, Hendrik C.; Cullen, Peter J. (Nature Publishing Group, 2018-12-01)
    Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent ...
  • Physiotherapists’ experiences with a blended osteoarthritis intervention: a mixed methods study 
    Kloek, Corelien J.J.; Bossen, Daniël; de Vries, Herman J.; de Bakker, Dinny H.; Veenhof, Cindy; Dekker, Joost (Informa Healthcare, 2020-05-03)
    Introduction: E-Exercise is an effective 12-week blended intervention consisting of around five face-to-face physiotherapy sessions and a web-based application for patients with hip/knee osteoarthritis. In order to facilitate ...
  • Differentiating Cerebellar Impact on Thalamic Nuclei 
    Gornati, Simona V; Schäfer, Carmen B; Eelkman Rooda, Oscar H J; Nigg, Alex L; De Zeeuw, Chris I; Hoebeek, Freek E (Cell Press, 2018-05-29)
    The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of ...