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UMC Repository: Recent submissions

  • Is Ulcerative Colitis Associated With Primary Sclerosing Cholangitis an Undertreated Condition? 
    Van Der Have, Mike; Oldenburg, Bas (John Wiley & Sons Inc., 2020-05)
  • Exploring the clinical utility of two staging models for bipolar disorder 
    van der Markt, Afra; Klumpers, Ursula M.H.; Dols, Annemiek; Draisma, Stasja; Boks, Marco P.; van Bergen, Annet; Ophoff, Roel A.; Beekman, Aartjan T.F.; Kupka, Ralph W. (Blackwell Munksgaard, 2020-02)
    OBJECTIVE: To assess the clinical utility of two staging models for bipolar disorder by examining distribution, correlation, and the relationship to external criteria. These are primarily defined by the recurrence of mood ...
  • Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect 
    Krebs, Catharine E.; Ori, Anil P.S.; Vreeker, Annabel; Wu, Timothy; Cantor, Rita M.; Boks, Marco P.M.; Kahn, Rene S.; Olde Loohuis, Loes M.; Ophoff, Roel A. (Cambridge University Press, 2020-11)
    Background Bipolar disorder (BD) is a highly heritable mood disorder with complex genetic architecture and poorly understood etiology. Previous transcriptomic BD studies have had inconsistent findings due to issues such ...
  • Antibiotic treatment for 6 days versus 12 days in patients with severe cellulitis: a multicentre randomized, double-blind, placebo-controlled, non-inferiority trial 
    Cranendonk, Duncan R; Opmeer, Brent C; van Agtmael, Michiel A; Branger, Judith; Brinkman, Kees; Hoepelman, Andy I M; Lauw, Fanny N; Oosterheert, Jan Jelrik; Pijlman, Annemarie H; Sankatsing, Sanjay U C; Soetekouw, Robin; Veenstra, Jan; de Vries, Peter J; Prins, Jan M; Wiersinga, W Joost (Elsevier, 2020-05)
    Objectives: To investigate whether antibiotic treatment of 6 days' duration is non-inferior to treatment for 12 days in patients hospitalized for cellulitis. Methods: This multicentre, randomized, double-blind, placebo-controlled, ...
  • Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge 
    Nath, Vishwesh; Schilling, Kurt G.; Parvathaneni, Prasanna; Huo, Yuankai; Blaber, Justin A.; Hainline, Allison E.; Barakovic, Muhamed; Romascano, David; Rafael-Patino, Jonathan; Frigo, Matteo; Girard, Gabriel; Thiran, Jean Philippe; Daducci, Alessandro; Rowe, Matt; Rodrigues, Paulo; Prčkovska, Vesna; Aydogan, Dogu B.; Sun, Wei; Shi, Yonggang; Parker, William A.; Ould Ismail, Abdol A.; Verma, Ragini; Cabeen, Ryan P.; Toga, Arthur W.; Newton, Allen T.; Wasserthal, Jakob; Neher, Peter; Maier-Hein, Klaus; Savini, Giovanni; Palesi, Fulvia; Kaden, Enrico; Wu, Ye; He, Jianzhong; Feng, Yuanjing; Paquette, Michael; Rheault, Francois; Sidhu, Jasmeen; Lebel, Catherine; Leemans, Alexander; Descoteaux, Maxime; Dyrby, Tim B.; Kang, Hakmook; Landman, Bennett A. (John Wiley & Sons Inc., 2020-01-01)
    Background: Fiber tracking with diffusion-weighted MRI has become an essential tool for estimating in vivo brain white matter architecture. Fiber tracking results are sensitive to the choice of processing method and tracking ...
  • Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification 
    Association for European Cardiovascular Pathology (AECVP) (Springer-Verlag, 2020-02)
    Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially ...
  • Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion 
    Ferro, DA; Mutsaerts, Henk-Jan; Hilal, Saima; Kuijf, Hugo J; Petersen, Esben T; Petr, Jan; van Veluw, Susanne J; Venketasubramanian, Narayanaswamy; Yeow, Tan Boon; Biessels, Geert Jan; Chen, Christopher (SAGE Publications Inc., 2020-09-01)
    Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to ...
  • The nephrology crystal ball: the medium-term future 
    Zoccali, Carmine; Blankestijn, Peter J; Bruchfeld, Annette; Capasso, Giovambattista; Fliser, Danilo; Fouque, Denis; Goumenos, Dimitrios; Massy, Ziad; Rychlık, Ivan; Soler, Maria J; Stevens, Kate; Spasovski, Goce; Wanner, Christoph (Oxford University Press, 2020-02-01)
    In January 2019, the ERA-EDTA surveyed nephrologists with questions on kidney care and kidney research designed to explore comprehension of the impact of alterations to organization of renal care and of advancements in ...
  • The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies 
    Angus, Lindsay; Smid, Marcel; Wilting, Saskia M; van Riet, Job; Van Hoeck, Arne; Nguyen, Luan; Nik-Zainal, Serena; Steenbruggen, Tessa G; Tjan-Heijnen, Vivianne C G; Labots, Mariette; van Riel, Johanna M G H; Bloemendal, Haiko J; Steeghs, Neeltje; Lolkema, Martijn P; Voest, Emile E; van de Werken, Harmen J G; Jager, Agnes; Cuppen, Edwin; Sleijfer, Stefan; Martens, John W M (Nature Research, 2019-10)
    The whole-genome sequencing of prospectively collected tissue biopsies from 442 patients with metastatic breast cancer reveals that, compared to primary breast cancer, tumor mutational burden doubles, the relative contributions ...
  • Development and assessment of the inter-rater and intra-rater reproducibility of a self-administration version of the ALSFRS-R 
    Bakker, Leonhard; Schröder, Carin; Tan, Harold H G; Vugts, Simone; van Eijk, Ruben; van Es, MA; Visser-Meily, J M Anne; van den Berg, Leonard (BMJ Publishing Group, 2020-01)
    OBJECTIVE: The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is widely applied to assess disease severity and progression in patients with motor neuron disease (MND). The objective of the study ...
  • Age-related difference in health care use and costs of patients with chronic kidney disease and matched controls: analysis of Dutch health care claims data 
    van Oosten, Manon J M; Logtenberg, Susan J J; Leegte, Martijn J H; Bilo, Henk J G; Mohnen, Sigrid M; Hakkaart-van Roijen, Leona; Hemmelder, Marc H; de Wit, G Ardine; Jager, Kitty J; Stel, Vianda S (Oxford University Press, 2020-12-04)
    BACKGROUND: The financial burden of chronic kidney disease (CKD) is increasing due to the ageing population and increased prevalence of comorbid diseases. Our aim was to evaluate age-related differences in health care use ...
  • The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs 
    Goversen, Birgit; Jonsson, Malin KB; van den Heuvel, Nikki HL; Rijken, Rianne; Vos, Marc A.; van Veen, Toon AB; de Boer, Teun P. (Elsevier Limited, 2019-12-01)
    The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current I Kr . I Kr drives repolarization in the heart and when I Kr is ...
  • DamC reveals principles of chromatin folding in vivo without crosslinking and ligation 
    Redolfi, Josef; Zhan, Yinxiu; Valdes-Quezada, Christian; Kryzhanovska, Mariya; Guerreiro, Isabel; Iesmantavicius, Vytautas; Pollex, Tim; Grand, Ralph S; Mulugeta, Eskeatnaf; Kind, Jop; Tiana, Guido; Smallwood, Sebastien A; de Laat, Wouter; Giorgetti, Luca (Nature Research, 2019-06)
    Current understanding of chromosome folding is largely reliant on chromosome conformation capture (3C)-based experiments, where chromosomal interactions are detected as ligation products after chromatin crosslinking. To ...
  • The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo 
    Kiers, Dorien; Tunjungputri, Rahajeng N; Borkus, Rowie; Scheffer, Gert-Jan; de Groot, Philip G; Urbanus, Rolf T; van der Ven, Andre J; Pickkers, Peter; de Mast, Quirijn; Kox, Matthijs (Informa Healthcare, 2019)
    Systemic inflammation and hypoxia frequently occur simultaneously in critically ill patients, and are both associated with platelet activation and coagulopathy. However, human in vivo data on the effects of hypoxia on ...
  • Noncoding deletions reveal a gene that is critical for intestinal function 
    Oz-Levi, Danit; Olender, Tsviya; Bar-Joseph, Ifat; Zhu, Yiwen; Marek-Yagel, Dina; Barozzi, Iros; Osterwalder, Marco; Alkelai, Anna; Ruzzo, Elizabeth K; Han, Yujun; Vos, Erica S M; Reznik-Wolf, Haike; Hartman, Corina; Shamir, Raanan; Weiss, Batia; Shapiro, Rivka; Pode-Shakked, Ben; Tatarskyy, Pavlo; Milgrom, Roni; Schvimer, Michael; Barshack, Iris; Imai, Denise M; Coleman-Derr, Devin; Dickel, Diane E; Nord, Alex S; Afzal, Veena; van Bueren, Kelly Lammerts; Barnes, Ralston M; Black, Brian L; Mayhew, Christopher N; Kuhar, Matthew F; Pitstick, Amy; Tekman, Mehmet; Stanescu, Horia C; Wells, James M; Kleta, Robert; de Laat, Wouter; Goldstein, David B; Pras, Elon; Visel, Axel; Lancet, Doron; Anikster, Yair; Pennacchio, Len A (Nature Research, 2019-07)
    Large-scale genome sequencing is poised to provide a substantial increase in the rate of discovery of disease-associated mutations, but the functional interpretation of such mutations remains challenging. Here we show that ...
  • Autonomy in participation in cerebral palsy from childhood to adulthood 
    Perrin-Decade Pip Study Groups (Wiley-Blackwell, 2020-03)
    Aim: To determine the long-term development of autonomy in participation of individuals with cerebral palsy (CP) without intellectual disability. Method: Individuals with CP (n=189, 117 males, 72 females; mean age [SD] 21y ...
  • The performance of dual-energy CT in the classification criteria of gout: a prospective study in subjects with unclassified arthritis 
    Gamala, Mihaela; Jacobs, Johannes W G; Linn-Rasker, Suzanne F; Nix, Maarten; Heggelman, Ben G F; Pasker-de Jong, Pieternel C M; van Laar, Jaap M; Klaasen, Ruth (Oxford University Press, 2020-04-01)
    OBJECTIVE: To establish the performance of (subsets of) the 2015 ACR/EULAR gout classification criteria in patients with unclassified arthritis, and to determine the value of dual-energy CT (DECT) herein. Reference was the ...
  • How do patients with systemic sclerosis experience currently provided healthcare and how should we measure its quality? 
    Spierings, Julia; van den Ende, Cornelia H M; Schriemer, Rita M; Moens, Hein J Bernelot; van der Bijl, Egon A; Bonte-Mineur, Femke; de Buck, Marieke P D; de Kanter, Meeke A E; Knaapen-Hans, Hanneke K A; van Laar, Jacob M; Mulder, Udo D J; Potjewijd, Judith; de Pundert, Lian A J; Schoonbrood, Thea H M; Schouffoer, Anne A; Stel, Alja J; Vercoutere, Ward; Voskuyl, Alexandre E; de Vries-Bouwstra, Jeska K; Vonk, Madelon C (Oxford University Press, 2020-06-01)
    OBJECTIVES: To gain insight into SSc patients' perspective on quality of care and to survey their preferred quality indicators. METHODS: An online questionnaire about healthcare setting, perceived quality of care (CQ index) ...
  • In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine 
    Xu, Meng; Deng, Jingwen; Xu, Kaikun; Zhu, Tiansheng; Han, Ling; Yan, Yuhong; Yao, Danni; Deng, Hao; Wang, Dan; Sun, Yaoting; Chang, Cheng; Zhang, Xiaomei; Dai, Jiayu; Yue, Liang; Zhang, Qiushi; Cai, Xue; Zhu, Yi; Duan, Hu; Liu, Yuan; Li, Dong; Zhu, Yunping; Radstake, Timothy R.D.J.; Balak, Deepak M.W.; Xu, Danke; Guo, Tiannan; Lu, Chuanjian; Yu, Xiaobo (Ivyspring International Publisher, 2019-01-01)
    Serum and plasma contain abundant biological information that reflect the body’s physiological and pathological conditions and are therefore a valuable sample type for disease biomarkers. However, comprehensive profiling ...
  • Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis 
    Affandi, Alsya J.; Carvalheiro, Tiago; Ottria, Andrea; Broen, Jasper C.A.; Bossini-Castillo, Lara; Tieland, Ralph G.; Bon, Lenny Van; Chouri, Eleni; Rossato, Marzia; Mertens, Jorre S.; Garcia, Samuel; Pandit, Aridaman; De Kroon, Laurie M.G.; Christmann, Romy B.; Martin, Javier; Van Roon, Joel A.G.; Radstake, Timothy R.D.J.; Marut, Wioleta (Elsevier, 2019-09-01)
    Objectives Systemic sclerosis (SSc) is an autoimmune disease with unknown pathogenesis manifested by inflammation, vasculopathy and fibrosis in skin and internal organs. Type I interferon signature found in SSc propelled ...