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Now showing items 20001-20020 of 40729

Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis

Kucukgoncu, Suat; Guloksuz, Sinan; Celik, Kubra; Bahtiyar, Mert Ozan; Luykx, Jurjen J; Rutten, Bart P F; Tek, Cenk (Oxford University Press, 2020-03)

BACKGROUND: We have limited knowledge about the effects of antipsychotic exposure on the development of gestational diabetes mellitus (GDM). Aim of this study is to perform a systematic review and meta-analysis to assess ...
Treatment decision-making in diffuse cutaneous systemic sclerosis: a patient's perspective

Spierings, Julia; van Rhijn-Brouwer, Femke C C; de Bresser, Carolijn J M; Mosterman, Petra T M; Pieterse, Arwen H; Vonk, Madelon C; Voskuyl, Alexandre E; de Vries-Bouwstra, Jeska K; Kars, Marijke C; van Laar, Jacob M (Oxford University Press, 2020-08-01)

OBJECTIVES: To examine the treatment decision-making process of patients with dcSSc in the context of haematopoietic stem cell transplantation (HSCT). METHODS: A qualitative semi-structured interview study was done in ...
Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells

Schneeberger, Kerstin; Sánchez-Romero, Natalia; Ye, Shicheng; van Steenbeek, Frank G; Oosterhoff, Loes A; Pla Palacin, Iris; Chen, Chen; van Wolferen, Monique E; van Tienderen, Gilles; Lieshout, Ruby; Colemonts-Vroninks, Haaike; Schene, Imre; Hoekstra, Ruurdtje; Verstegen, Monique M A; van der Laan, Luc J W; Penning, Louis C; Fuchs, Sabine A; Clevers, Hans; De Kock, Joery; Baptista, Pedro M; Spee, Bart (John Wiley & Sons Inc., 2020-07)

Background and Aims: The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from leucine-rich repeat-containing G protein-coupled receptor 5 ...
Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy

Driehuis, Else; Spelier, Sacha; Beltrán Hernández, Irati; de Bree, Remco; M Willems, Stefan; Clevers, Hans; Oliveira, Sabrina (Multidisciplinary Digital Publishing Institute (MDPI), 2019-11-05)

Patients diagnosed with head and neck squamous cell carcinoma (HNSCC) are currently treated with surgery and/or radio- and chemotherapy. Despite these therapeutic interventions, 40% of patients relapse, urging the need for ...
'We don't know for sure': discussion of uncertainty concerning multigene panel testing during initial cancer genetic consultations

Medendorp, Niki M; Hillen, Marij A; van Maarschalkerweerd, Pomme E A; Aalfs, Cora M; Ausems, Margreet G E M; Verhoef, Senno; van der Kolk, Lizet E; Berger, Lieke P V; Wevers, Marijke R; Wagner, Anja; Caanen, Barbara A H; Stiggelbout, Anne M; Smets, Ellen M A (Springer Netherlands, 2020-01-01)

Pre-test counseling about multigene panel testing involves many uncertainties. Ideally, counselees are informed about uncertainties in a way that enables them to make an informed decision about panel testing. It is presently ...
Advanced Neuroimaging to Unravel Mechanisms of Cerebral Small Vessel Diseases

Gurol, M Edip; Biessels, Geert J; Polimeni, Jonathan R (Lippincott Williams & Wilkins, 2020-01)
No association between anti-thyroidperoxidase antibodies and bipolar disorder: A study in the Dutch Bipolar Cohort and a meta-analysis

Snijders, G J L J; de Witte, L D; van den Berk, D; van der Laan, C; Regeer, E; Begemann, M J H; Berdenis van Berlekom, A; Litjens, M; Boks, M P; Ophoff, R A; Kahn, R S; Hillegers, M H J (Elsevier Limited, 2020-02)

BACKGROUND: Thyroid autoimmunity has been associated with bipolar disorder (BD). However, results from previous studies on the seroprevalence of anti-thyroid peroxidase antibodies (TPO-abs) in BD are inconsistent. OBJECTIVES: ...
Impact of baseline cigarette smoking status on clinical outcome after transcatheter aortic valve replacement

Abawi, Masieh; van Gils, Lennart; Agostoni, Pierfrancesco; van Mieghem, Nicolas M.; Kooistra, Nynke H. M.; van Dongen, Charlotte S.; van Jaarsveld, Romy C.; de Jaegere, Peter P. T.; Doevendans, Pieter A. F. M.; Stella, Pieter R. (John Wiley & Sons Inc., 2019-11-15)

OBJECTIVES: To explore the prevalence of smoking, and its association with clinical and mortality outcome among patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Less data exist regarding the ...
Safety and efficacy of stenting for aortic arch hypoplasia in patients with coarctation of the aorta

Warmerdam, Evangeline; Krings, Gregor; Meijs, Timion; Franken, Anouk; Driesen, Bart; Sieswerda, Gertjan Tj; Meijboom, Folkert; Doevendans, PA; Molenschot, Mirella; Voskuil, Michiel (Bohn Stafleu van Loghum, 2020-03-01)

BACKGROUND: Despite a successful repair procedure for coarctation of the aorta (CoA), up to two-thirds of patients remain hypertensive. CoA is often seen in combination with abnormal aortic arch anatomy and morphology. ...
In training for a marathon: Runners and running-related injury prevention

Hofstede, H; Franke, T P C; van Eijk, R P A; Backx, F J G; Kemler, E; Huisstede, B M A (Elsevier, 2020-01)

Objective: To investigate which preventive measures runners use when preparing for a half- or full-marathon and whether the use of these measures at baseline and during the preparation-period differs between runners who ...
Liver segmentation and metastases detection in MR images using convolutional neural networks

Jansen, Mariëlle J A; Kuijf, Hugo J; Niekel, Maarten; Veldhuis, Wouter B; Wessels, Frank J; Viergever, Max A; Pluim, Josien P W (SPIE, 2019-10-15)

Primary tumors have a high likelihood of developing metastases in the liver, and early detection of these metastases is crucial for patient outcome. We propose a method based on convolutional neural networks to detect liver ...
Comparative genetic architectures of schizophrenia in East Asian and European populations

Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature Research, 2019-12)

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important ...
Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

EU-GEI High Risk Study Group (American Medical Association, 2020-02)

Importance: The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations ...
Psychotic experiences from preadolescence to adolescence: when should we be worried about adolescent risk behaviors?

Rimvall, Martin K; van Os, Jim; Rask, Charlotte Ulrikka; Olsen, Else Marie; Skovgaard, Anne Mette; Clemmensen, Lars; Larsen, Janne Tidselbak; Verhulst, Frank; Jeppesen, Pia (Springer Science and Business Media Deutschland GmbH, 2020-09-01)

Psychotic experiences (PE), below the threshold of psychotic disorder, are common in the general population. PE are associated with risk behaviors such as suicidality, non-suicidal self-injury (NSSI) and substance use. ...
Cognition and violent behavior in psychotic disorders: A nationwide case-control study

Genetic Risk and Outcome of Psychosis (GROUP) Investigators (Elsevier, 2020-03)

Background: The excess risk of violence in psychotic disorders may partly be explained by impairments in executive functions (EFs) and theory of mind (ToM). However, previous studies have been limited by composite measures ...
An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Cambridge University Press, 2020-09)

BackgroundPositive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation ...
Tenascin C Plasma Levels in Critically Ill Patients with or Without Sepsis: A Multicenter Observational Study

MARS Consortium (Lippincott Williams & Wilkins, 2020-07)

Tenascin C (TNC) is an extracellular matrix protein able to modulate the immune response. Knowledge regarding its role during sepsis and general critical illness is still limited. We here assessed the temporal dynamics of ...
Adapted cabling of an EEG cap improves simultaneous measurement of EEG and fMRI at 7T

Meyer, Matthias C; Scheeringa, René; Webb, Andrew G; Petridou, Natalia; Kraff, Oliver; Norris, David G (Elsevier, 2020-02-01)

BACKGROUND: The combination of EEG and ultra-high-field (7 T and above) fMRI holds the promise to relate electrophysiology and hemodynamics with greater signal to noise level and at higher spatial resolutions than conventional ...
Utility of emergency call centre, dispatch and ambulance data for syndromic surveillance of infectious diseases: a scoping review

Duijster, Janneke W; Doreleijers, Simone DA; Pilot, Eva; van der Hoek, Wim; Kommer, Geert Jan; van der Sande, Marianne Ab; Krafft, Thomas; van Asten, Liselotte Chi (Oxford University Press, 2020-08-01)

BACKGROUND: Syndromic surveillance can supplement conventional health surveillance by analyzing less-specific, near-real-time data for an indication of disease occurrence. Emergency medical call centre dispatch and ambulance ...
Daily life participation in childhood chronic disease: a qualitative study

Nap-van der Vlist, Merel M; Kars, Marijke C; Berkelbach van der Sprenkel, Emma E; Nijhof, Linde N; Grootenhuis, Martha A; van Geelen, Stefan M; van der Ent, Cornelis K; Swart, Joost F; van Royen-Kerkhof, Annet; van Grotel, Martine; van de Putte, Elise M; Nijhof, Sanne L (BMJ Publishing Group, 2020-05-01)

OBJECTIVE: Opportunities to participate in daily life have improved considerably for children with chronic disease. Nevertheless, they still face challenges associated with their ever-present illness affecting every aspect ...

Now showing items 20001-20020 of 40729