No association between anti-thyroidperoxidase antibodies and bipolar disorder: A study in the Dutch Bipolar Cohort and a meta-analysis
Snijders, G J L J; de Witte, L D; van den Berk, D; van der Laan, C; Regeer, E; Begemann, M J H; Berdenis van Berlekom, A; Litjens, M; Boks, M P; Ophoff, R A; Kahn, R S; Hillegers, M H J
(2020) Psychoneuroendocrinology, volume 112, pp. 1 - 8
(Article)
Abstract
BACKGROUND: Thyroid autoimmunity has been associated with bipolar disorder (BD). However, results from previous studies on the seroprevalence of anti-thyroid peroxidase antibodies (TPO-abs) in BD are inconsistent. OBJECTIVES: The aim of the present study is to investigate whether the seroprevalence and titer levels of TPO-abs are related to BD. METHOD:
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TPO-abs were measured in plasma samples of 760 patients with bipolar disorder, 261 first-degree relatives and 363 controls by enzyme-linked immunosorbent assay (ELISA). To address methodological limitations of previous studies, we assessed clinical characteristics with several (self-reported) questionnaires to investigate whether TPO-abs positivity is related to particular clinical subgroups of BD patients. We performed an additional meta-analysis of seroprevalences of TPO-abs in BD patients including data from present and previous studies. RESULTS: Seroprevalence or titer levels of TPO-abs did not significantly differ between patients with BD, their first-degree relatives, and controls. In BD patients, the prevalence of TPO-abs was unrelated to specific clinical factors, including lithium use. Our meta-analysis of twelve studies showed an overall odds ratio of 1.3 (CI 95 %: 0.7-2.3; p = 0.30), reaffirming the absence of an association of BD with TPO-abs. CONCLUSIONS: In the largest study of TPO-abs in BD to date, our findings indicate that TPO-abs are not associated with (the risk for) bipolar disorder.
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Keywords: Antithyroid microsomal antibody, Bipolar disorder, Thyroid diseases, Endocrine and Autonomic Systems, Psychiatry and Mental health, Biological Psychiatry, Endocrinology, Endocrinology, Diabetes and Metabolism, Journal Article
ISSN: 0306-4530
Publisher: Elsevier Limited
Note: Funding Information: This research is funded by the National Institute of Mental Health , Grant number: R01 MH090553 (to Prof. R.A. Ophoff). The funding source had no further role in study design, collection, analysis and interpretation and writing of data, and in the decision to submit this paper for publication. Appendix A Publisher Copyright: © 2019 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
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