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UMC Repository: Recent submissions

  • Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation 
    Sikma, Maaike A.; Van Maarseveen, Erik M.; Hunault, Claudine C.; Moreno, Javier M.; Van de Graaf, Ed A.; Kirkels, Johannes H.; Verhaar, Marianne C.; Grutters, Jan C.; Kesecioglu, Jozef; De Lange, Dylan W.; Huitema, Alwin D. R. (Adis, 2020-06-01)
    Abstract: Therapeutic drug monitoring of tacrolimus whole-blood concentrations is standard care in thoracic organ transplantation. Nevertheless, toxicity may appear with alleged therapeutic concentrations possibly related ...
  • Prediction of human active mobility in rural areas: development and validity tests of three different approaches 
    Klous, Gijs; Kretzschmar, Mirjam E E; Coutinho, Roel A; Heederik, Dick J J; Huss, Anke (Springer Nature, 2020-11)
    BACKGROUND/AIM: Active mobility may play a relevant role in the assessment of environmental exposures (e.g. traffic-related air pollution, livestock emissions), but data about actual mobility patterns are work intensive ...
  • Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study 
    Chye, Yann; Mackey, Scott; Gutman, Boris A.; Ching, Christopher R.K.; Batalla, Albert; Blaine, Sara; Brooks, Samantha; Caparelli, Elisabeth C.; Cousijn, Janna; Dagher, Alain; Foxe, John J.; Goudriaan, Anna E.; Hester, Robert; Hutchison, Kent; Jahanshad, Neda; Kaag, Anne M.; Korucuoglu, Ozlem; Li, Chiang Shan R.; London, Edythe D.; Lorenzetti, Valentina; Luijten, Maartje; Martin-Santos, Rocio; Meda, Shashwath A.; Momenan, Reza; Morales, Angelica; Orr, Catherine; Paulus, Martin P.; Pearlson, Godfrey; Reneman, Liesbeth; Schmaal, Lianne; Sinha, Rajita; Solowij, Nadia; Stein, Dan J.; Stein, Elliot A.; Tang, Deborah; Uhlmann, Anne; van Holst, Ruth; Veltman, Dick J.; Verdejo-Garcia, Antonio; Wiers, Reinout W.; Yücel, Murat; Thompson, Paul M.; Conrod, Patricia; Garavan, Hugh (Wiley-Blackwell, 2020-11-01)
    While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies ...
  • Conserved NPPB plus Border Zone Switches From MEF2-to AP-1-Driven Gene Program 
    van Duijvenboden, Karel; de Bakker, Dennis E M; Man, Joyce C K; Janssen, Rob; Günthel, Marie; Hill, Matthew C; Hooijkaas, Ingeborg B; van der Made, Ingeborg; van der Kraak, Petra H; Vink, Aryan; Creemers, Esther E; Martin, James F; Barnett, Phil; Bakkers, Jeroen; Christoffels, Vincent M (Lippincott Williams & Wilkins, 2019-09-09)
    BACKGROUND: Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. ...
  • Childhood trauma and coping in patients with psychotic disorders and obsessive-compulsive symptoms and in un-affected siblings 
    GROUP Investigators (Elsevier Limited, 2020-01)
    BACKGROUND: Research on environmental and individual risk-factors in patients with a psychotic disorder and co-occurring obsessive-compulsive symptoms (OCS) is limited. OBJECTIVE: This study aimed to examine the role of ...
  • Who Are Hospice Patients and What Care Is Provided in Hospices?: A Pilot Study 
    Koorn, Remco M; van Klinken, Merel; de Graaf, Everlien; Bressers, Rick E G W; Jobse, Adri P; van der Baan, Frederieke; Teunissen, Saskia C C M (Sage Publications, 2020-06-01)
    Background: Hospices provide multidimensional care. In the Netherlands, patients with <3 months estimated life expectancy have access to hospice care. Insight into patients admitted to hospices and the care provided is ...
  • Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage 
    van der Knoop, Bloeme; Zonnenberg, Inge; Verbeke, Jonathan; de Vries, Linda; Pistorius, Lou; van Weissenbruch, Mirjam M; Vermeulen, R Jeroen; de Vries, Johanna (John Wiley & Sons Inc., 2020-09-01)
    Objective: To assess the additional value of fetal multiplanar (axial, coronal and sagittal) neurosonography and magnetic resonance imaging (MRI) to that of the standard axial ultrasound planes in diagnosing brain damage ...
  • HOspital care versus TELemonitoring in high-risk pregnancy (HOTEL): Study protocol for a multicentre non-inferiority randomised controlled trial 
    Van Den Heuvel, Josephus F.M.; Ganzevoort, Wessel; De Haan-Jebbink, Jiska M.; Van Der Ham, David P.; Deurloo, Koen L.; Seeber, Laura; Franx, Arie; Bekker, Mireille N. (BMJ Publishing Group, 2019-10-28)
    INTRODUCTION: Pregnant women faced with complications of pregnancy often require long-term hospital admission for maternal and/or fetal monitoring. Antenatal admissions cause a burden to patients as well as hospital resources ...
  • Prediction model of postnatal renal function in fetuses with lower urinary tract obstruction (LUTO)—Development and internal validation 
    Duin, Leonie K.; Fontanella, Federica; Groen, Henk; Adama van Scheltema, Phebe N.; Cohen-Overbeek, Titia E.; Pajkrt, Eva; Bekker, Mireille; Willekes, Christine; Bax, Caroline J.; Oepkes, Dick; Bilardo, Caterina M. (John Wiley & Sons Inc., 2019-12-01)
    Objective: To develop a prediction model of postnatal renal function in fetuses with lower urinary tract obstruction (LUTO) based on fetal ultrasound parameters and amniotic fluid volume. Methods: Retrospective nationwide ...
  • Is there still a role for nuchal translucency measurement in the changing paradigm of first trimester screening? 
    Bardi, Francesca; Bosschieter, Pien; Verheij, Joke; Go, Attie; Haak, Monique; Bekker, Mireille; Sikkel, Esther; Coumans, Audrey; Pajkrt, Eva; Bilardo, Caterina (John Wiley & Sons Inc., 2020-01)
    OBJECTIVES: To give an overview of the genetic and structural abnormalities occurring in fetuses with nuchal translucency (NT) measurement exceeding the 95th percentile at first-trimester screening and to investigate which ...
  • Retrospective evaluation of the Dutch pre-newborn screening cohort for propionic acidemia and isolated methylmalonic acidemia: what to aim, expect and evaluate from newborn screening? 
    Haijes, H A; Molema, F; Langeveld, M; Janssen, M C; Bosch, A M; van Spronsen, F J; Mulder, M F; Verhoeven-Duif, N M; Jans, J J M; van der Ploeg, A T; Wagenmakers, M A; Rubio-Gozalbo, M E; Brouwers, M C G J; de Vries, M C; Langendonk, J G; Williams, M; van Hasselt, P M (Springer Netherlands, 2020-05)
    Evidence for effectiveness of newborn screening (NBS) for propionic acidemia (PA) and isolated methylmalonic acidemia (MMA) is scarce. Prior to implementation in the Netherlands, we aim to estimate the expected health gain ...
  • Pancreatic cancer organoids recapitulate disease and allow personalized drug screening 
    Driehuis, Else; Van Hoeck, Arne; Moore, Kat; Kolders, Sigrid; Francies, Hayley E.; Gulersonmez, M. Can; Stigter, Edwin C.A.; Burgering, Boudewijn; Geurts, Veerle; Gracanin, Ana; Bounova, Gergana; Morsink, Folkert H.; Vries, Robert; Boj, Sylvia; Van Es, Johan; Offerhaus, G. Johan A.; Kranenburg, Onno; Garnett, Mathew J.; Wessels, Lodewyk; Cuppen, Edwin; Brosens, Lodewijk A.A.; Clevers, Hans (National Academy of Sciences, 2019-12-26)
    We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic alterations typical of pancreatic cancer. ...
  • Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) 
    Yakoub-Agha, Ibrahim; Chabannon, Christian; Bader, Peter; Basak, Grzegorz W; Bonig, Halvard; Ciceri, Fabio; Corbacioglu, Selim; Duarte, Rafael F; Einsele, Hermann; Hudecek, Michael; Kersten, Marie José; Köhl, Ulrike; Kuball, Jürgen; Mielke, Stephan; Mohty, Mohamad; Murray, John; Nagler, Arnon; Robinson, Stephen; Saccardi, Riccardo; Sanchez-Guijo, Fermin; Snowden, John A; Srour, Micha; Styczynski, Jan; Urbano-Ispizua, Alvaro; Hayden, Patrick J; Kröger, Nicolaus (Ferrata Storti Foundation, 2020-01-31)
    Chimeric antigen receptor (CAR) T cells are a novel class of anti-cancer therapy in which autologous or allogeneic T cells are engineered to express a CAR targeting a membrane antigen. In Europe, tisagenlecleucel (KymriahTM) ...
  • Individualized ovarian stimulation in IVF/ICSI treatment: It is time to stop using high FSH doses in predicted low responders 
    Leijdekkers, Jori A.; Torrance, Helen L.; Schouten, Nienke E.; van Tilborg, Theodora C.; Oudshoorn, Simone C.; Mol, Ben Willem J.; Eijkemans, Marinus J.C.; Broekmans, Frank J.M. (Oxford University Press, 2020-09-01)
    In IVF/ICSI treatment, the FSH starting dose is often increased in predicted low responders from the belief that it improves the chance of having a baby by maximizing the number of retrieved oocytes. This intervention has ...
  • A skew-based method for identifying intracranial EEG channels with epileptic activity without detecting spikes, ripples, or fast ripples 
    Mooij, Anne H.; Frauscher, Birgit; Gotman, Jean; Huiskamp, Geertjan J.M. (Elsevier Ireland Ltd, 2020-01-01)
    Objective: To develop a method for identifying intracranial EEG (iEEG) channels with epileptic activity without the need to detect spikes, ripples, or fast ripples. Methods: We compared the skew of the distribution of power ...
  • Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review 
    Wittekamp, Bastiaan H J; Oostdijk, Evelien A N; Cuthbertson, Brian H; Brun-Buisson, Christian; Bonten, Marc J M (Springer-Verlag, 2020-02)
    Selective decontamination of the digestive tract (SDD) is an infection prevention measure for intensive care unit (ICU) patients that was proposed more than 30 years ago, and that is currently considered standard of care ...
  • Exome-chip association analysis of intracranial aneurysms 
    van 't Hof, Femke N G; Lai, Dongbing; van Setten, Jessica; Bots, Michiel L; Vaartjes, Ilonca; Broderick, Joseph; Woo, Daniel; Foroud, Tatiana; Rinkel, Gabriel J E; de Bakker, Paul I W; Ruigrok, Ynte M (Lippincott Williams & Wilkins, 2020-02-04)
    OBJECTIVE: To investigate to what extent low-frequency genetic variants (with minor allele frequencies <5%) affect the risk of intracranial aneurysms (IAs). METHODS: One thousand fifty-six patients with IA and 2,097 ...
  • From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation 
    Goulay, Romain; Mena Romo, Luis; Hol, Elly M.; Dijkhuizen, Rick M. (Springer US, 2020-08-01)
    Stroke and Alzheimer’s disease (AD) are cerebral pathologies with high socioeconomic impact that can occur together and mutually interact. Vascular factors predisposing to cerebrovascular disease have also been specifically ...
  • Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group 
    Jia, Tianye; Chu, Congying; Liu, Yun; van Dongen, Jenny; Papastergios, Evangelos; Armstrong, Nicola J; Bastin, Mark E; Carrillo-Roa, Tania; den Braber, Anouk; Harris, Mathew; Jansen, Rick; Liu, Jingyu; Luciano, Michelle; Ori, Anil P S; Roiz Santiañez, Roberto; Ruggeri, Barbara; Sarkisyan, Daniil; Shin, Jean; Sungeun, Kim; Tordesillas Gutiérrez, Diana; Van't Ent, Dennis; Ames, David; Artiges, Eric; Bakalkin, Georgy; Banaschewski, Tobias; Bokde, Arun L W; Brodaty, Henry; Bromberg, Uli; Brouwer, Rachel; Büchel, Christian; Burke Quinlan, Erin; Cahn, Wiepke; de Zubicaray, Greig I; Ehrlich, Stefan; Ekström, Tomas J; Flor, Herta; Fröhner, Juliane H; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Hoare, Jacqueline; Ittermann, Bernd; Jahanshad, Neda; Jiang, Jiyang; Kwok, John B; Martin, Nicholas G; Martinot, Jean-Luc; Mather, Karen A; McMahon, Katie L; McRae, Allan F; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Sämann, Philipp G; Schofield, Peter R; Smolka, Michael N; Stein, Dan J; Strike, Lachlan T; Teeuw, Jalmar; Thalamuthu, Anbupalam; Trollor, Julian; Walter, Henrik; Wardlaw, Joanna M; Wen, Wei; Whelan, Robert; Apostolova, Liana G; Binder, Elisabeth B; Boomsma, Dorret I; Calhoun, Vince; Crespo-Facorro, Benedicto; Deary, Ian J; Hulshoff Pol, Hilleke; Ophoff, Roel A; Pausova, Zdenka; Sachdev, Perminder S; Saykin, Andrew; Wright, Margaret J; Thompson, Paul M; Schumann, Gunter; Desrivières, Sylvane (Springer Nature, 2021-08)
    DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues ...
  • Are current wireless monitoring systems capable of detecting adverse events in high-risk surgical patients?: A descriptive study 
    Breteler, Martine J M; KleinJan, Eline; Numan, Lieke; Ruurda, Jelle P; Van Hillegersberg, Richard; Leenen, Luke P H; Hermans, Mathilde; Kalkman, Cor J; Blokhuis, Taco J (Elsevier Limited, 2020-05)
    BACKGROUND: Adverse events are common in high-risk surgical patients, but early detection is difficult. Recent innovations have resulted in wireless and 'wearable' sensors, which may capture patient deterioration at an ...