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Now showing items 19941-19960 of 40729

Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants

Besteman, Sjanna B.; Callaghan, Amie; Hennus, Marije P.; Westerlaken, Geertje H.A.; Meyaard, Linde; Bont, Louis L. (Academic Press Inc., 2020-02-01)

During severe respiratory syncytial virus (RSV) bronchiolitis there is a massive influx of activated neutrophils to the lungs. An exaggerated immune response contributes to lung damage and disease severity during RSV ...
RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

Hauer, Allard J; Kleinloog, Rachel; Giuliani, Fabrizio; Rinkel, Gabriël J E; de Kort, Gerard A; Berkelbach van der Sprenkel, Jan Willem; van der Zwan, Albert; Gosselaar, Peter H; van Rijen, Peter C; de Boer-Bergsma, Jelkje J; Deelen, Patrick; Swertz, Morris A; De Muynck, Louis; Van Damme, Philip; Veldink, Jan H; Ruigrok, Ynte M; Klijn, Catharina J M (Lippincott Williams & Wilkins, 2020-01-01)

Background and Purpose- Interventional treatment of unruptured brain arteriovenous malformations (BAVMs) has become increasingly controversial. Because medical therapy is still lacking, we aimed to obtain insight into the ...
Final Results of the Prospective Multicenter Excimer Laser-Assisted High-Flow Bypass Study on the Treatment of Giant Anterior Circulation Aneurysms

van der Zwan, Albert; Vajkoczy, Peter; Amin-Hanjani, Sepideh; Charbel, Fady T; Welch, Babu; Tymianski, Michael; Kivipelto, Leena; van Thoor, Sander; Chakraborty, Shamik; O'Donnell, Devon; Langer, David J (Lippincott Williams & Wilkins, 2020-10-01)

BACKGROUND: Both conventional bypass utilizing temporary recipient vessel occlusion and the excimer laser-assisted nonocclusive anastomosis (ELANA) bypass technique are possible strategies in the treatment of giant aneurysms. ...
Hypothyroidism (HT) after Radiotherapy (RT) in Children: Initial Results of Thyroid Gland Dose-Response Relationship from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Initiative

Vogelius, Ivan; Vargo, John Austin; Ronckers, C. M.; Yorke, E.D.; Kremer, L.C.; Chafe, S.M.J.M.J.; van Santen, HM; Bentzen, S.M.; Constine, Louis S; Milano, M.T. (Elsevier, 2019-09-01)
Simulated driving: The added value of dynamic testing in the assessment of visuo-spatial neglect after stroke

Spreij, Lauriane A; Ten Brink, Antonia F; Visser-Meily, Johanna M A; Nijboer, Tanja C W (Wiley-Blackwell, 2020-03-01)

BACKGROUND: Visuo-spatial neglect (VSN) is generally assessed with neuropsychological paper-and-pencil tasks, which are often not sensitive enough to detect mild and/or well-compensated VSN. It is of utmost importance to ...
CoCo - participation: The development and clinical use of a novel inventory measuring cognitive complaints in daily life

Spreij, Lauriane A; Sluiter, David; Gosselt, Isabel K; Visser-Meily, Johanna M A; Nijboer, Tanja C W (Taylor and Francis Ltd., 2021-03)

Cognitive difficulties can be subtle and only come to light when patients return home from inpatient care and start to participate in society. Subjective cognitive complaints often interfere with participation, hence ...
The current use of telehealth in ALS care and the barriers to and facilitators of implementation: a systematic review

Helleman, Jochem; Kruitwagen, Esther T; van den Berg, Leonard H; Visser-Meily, Johanna M A; Beelen, Anita (Informa Healthcare, 2020-05)

Objective: We aimed to provide an overview of telehealth used in the care for patients with amyotrophic lateral sclerosis (ALS), and identify the barriers to and facilitators of its implementation. Methods: We searched ...
Fast contour propagation for MR-guided prostate radiotherapy using convolutional neural networks

Eppenhof, K A J; Maspero, M; Savenije, M H F; de Boer, J C J; van der Voort van Zyp, J R N; Raaymakers, B W; Raaijmakers, A J E; Veta, M; van den Berg, C A T; Pluim, J P W (John Wiley & Sons Inc., 2020-03-01)

PURPOSE: To quickly and automatically propagate organ contours from pretreatment to fraction images in magnetic resonance (MR)-guided prostate external-beam radiotherapy. METHODS: Five prostate cancer patients underwent ...
Spectrum of K(V)2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders

Kang, Seok Kyu; Vanoye, Carlos G.; Misra, Sunita N.; Echevarria, Dennis M.; Calhoun, Jeffrey D.; O'Connor, John B.; Fabre, Katarina L.; McKnight, Dianalee; Demmer, Laurie; Goldenberg, Paula; Grote, Lauren E.; Thiffault, Isabelle; Saunders, Carol; Strauss, Kevin A.; Torkamani, Ali; van der Smagt, Jasper; van Gassen, Koen; Carson, Robert P.; Diaz, Jullianne; Leon, Eyby; Jacher, Joseph E.; Hannibal, Mark C.; Litwin, Jessica; Friedman, Neil R.; Schreiber, Allison; Lynch, Bryan; Poduri, Annapurna; Marsh, Eric D.; Goldberg, Ethan M.; Millichap, John J.; George, Alfred L., Jr.; Kearney, Jennifer A. (John Wiley & Sons Inc., 2019-12-01)

Objective: Pathogenic variants in KCNB1, encoding the voltage-gated potassium channel K V2.1, are associated with developmental and epileptic encephalopathy (DEE). Previous functional studies on a limited number of KCNB1 ...
A scoping review on Chronic Venous Disease and the development of a Venous Leg Ulcer: The role of obesity and mobility

Meulendijks, A. M.; Franssen, W. M.A.; Schoonhoven, L.; Neumann, H. A.M. (Tissue Viability Society, 2020-08)

Objective: The risk factors obesity and reduced mobility are not well known in the development of a Venous Leg Ulcer (VLU). The aim of this scoping review is to explore the mechanisms by which obesity and reduced mobility ...
A qualitative study on the patient's narrative in the progression of chronic venous disease into a first venous leg ulcer: a series of events

Meulendijks, A. M.; Welbie, M.; Tjin, E. P.M.; Schoonhoven, L.; Neumann, H. A.M. (Wiley-Blackwell, 2020-08-01)

Background: A venous leg ulcer (VLU) has a significant negative impact on quality of life. Prevention of a VLU is not yet imbedded in clinical practice because risk factors for developing a first VLU are not well known. ...
Comparability of PD-L1 immunohistochemistry assays for non-small cell lung cancer: a systematic review

Koomen, Bregje M; Badrising, Sushil K; van den Heuvel, Michel M; Willems, Stefan M (Wiley-Blackwell, 2020-05)

Programmed cell death ligand 1 (PD-L1) immunohistochemistry is used to determine which patients with advanced non-small-cell lung cancer (NSCLC) respond best to treatment with PD-L1 inhibitors. For each inhibitor, a unique ...
Skeletal muscle mass is an imaging biomarker for decreased survival in patients with oropharyngeal squamous cell carcinoma

Chargi, N; Bril, S I; Swartz, J E; Wegner, I; Willems, S W; de Bree, R (Elsevier Limited, 2020-02-01)

Objectives: Low skeletal muscle mass (SMM) and sarcopenic obesity (co-presence of low SMM and obesity) are emerging prognosticators in oncology, but the prevalence and prognostic value in oropharyngeal squamous cell carcinoma ...
MET ectodomain shedding is associated with poor disease-free survival of patients diagnosed with oral squamous cell carcinoma

De Herdt, Maria J; Koljenović, Senada; van der Steen, Berdine; Willems, Stefan M; Noorlag, Rob; Nieboer, Daan; Hardillo, Jose A; Gruver, Aaron M; Zeng, Wei; Liu, Ling; de Jong, Robert J Baatenburg; Looijenga, Leendert H (Elsevier, 2020-06)

Ectodomain shedding unleashes the aggressive nature of the MET oncogene product. Using specific C- and N-terminal MET antibodies (D1C2 and A2H2-3), MET protein status (i.e., no MET, decoy MET, transmembranous C-terminal ...
Inflammatory pseudotumour of the alveolar process of the maxilla as clinical manifestation of IgG4-related disease: a case report and literature review

Kouwenberg, W L; Dieleman, F J; Willems, S M; Rosenberg, A J W P (Churchill Livingstone, 2020-06)

IgG4-related disease (IgG4-RD) is an uncommon immune-mediated condition considered to be a systemic disease, described in multiple organ systems. IgG4-RD that involves the maxillary and sinonasal region is rare. This report ...
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Cross-Disorder Working Group of the Psychiatric Genomics Consortium (Elsevier, 2019-12-12)

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed ...
Diet as connecting factor: Functional brain connectivity in relation to food intake and sucrose tasting, assessed with resting-state functional MRI in rats

Roelofs, Theresia J.M.; Straathof, Milou; van der Toorn, Annette; Otte, Willem M.; Adan, Roger A.H.; Dijkhuizen, Rick M. (Wiley-Liss Inc., 2022-05)

Eating disorders and obesity form a major health problem in Western Society. To be able to provide adequate treatment and prevention, it is necessary to understand the neural mechanisms underlying the development of eating ...
An ecological momentary intervention incorporating personalised feedback to improve symptoms and social functioning in schizophrenia spectrum disorders

Hanssen, Esther; Balvert, Sanne; Oorschot, Margreet; Borkelmans, Karel; van Os, Jim; Delespaul, Philippe; Fett, Anne-Kathrin (Elsevier Ireland Ltd, 2020-02)

This study examined the feasibility and effectiveness of an interactive smartphone application that aimed to improve daily-life social functioning and symptoms in schizophrenia spectrum disorders (SZ) with Experience ...
Cardiovascular disease risk and its determinants in people living with HIV across different settings in South Africa

Roozen, Gvt; Vos, A G; Tempelman, H A; Venter, Wdf; Grobbee, D E; Scheuermaier, K; Klipstein-Grobusch, K (Wiley-Blackwell, 2020-07)

OBJECTIVES: Socio-economic factors and lifestyle are known to differ across geographies and populations, which may result in distinct risk profiles for cardiovascular disease (CVD). This study assessed carotid intima-media ...
Endoscopic ultrasound and fine-needle aspiration for the detection of residual nodal disease after neoadjuvant chemoradiotherapy for esophageal cancer

van der Bogt, Ruben D; van der Wilk, Berend J; Poley, Jan-Werner; Krishnadath, Kausilia K; Schoon, Erik J; Oostenbrug, Liekele E; Siersema, Peter D; Vleggaar, Frank P; Bruno, Marco J; Biermann, Katharina; van Lanschot, J Jan B; Spaander, Manon C W (Georg Thieme Verlag, 2020-03)

BACKGROUND: Endoscopic ultrasound (EUS) and fine-needle aspiration (FNA) are potential tools for the detection of residual disease after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer. This study investigated ...

Now showing items 19941-19960 of 40729