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UMC Repository: Recent submissions

  • Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant 
    Dandoy, Christopher E.; Kim, Soyoung; Chen, Min; Ahn, Kwang Woo; Ardura, Monica I.; Brown, Valerie; Chhabra, Saurabh; Diaz, Miguel Angel; Dvorak, Christopher; Farhadfar, Nosha; Flagg, Aron; Ganguly, Siddartha; Hale, Gregory A.; Hashmi, Shahrukh K.; Hematti, Peiman; Martino, Rodrigo; Nishihori, Taiga; Nusrat, Roomi; Olsson, Richard F.; Rotz, Seth J.; Sung, Anthony D.; Perales, Miguel Angel; Lindemans, Caroline A.; Komanduri, Krishna V.; Riches, Marcie L. (American Medical Association, 2020-01-03)
    Importance: Patients undergoing hematopoietic stem cell transplant (HSCT) are at risk for bloodstream infection (BSI) secondary to translocation of bacteria through the injured mucosa, termed mucosal barrier injury-laboratory ...
  • Cross-cutting view of current challenges in paediatric solid organ and haematopoietic stem cell transplantation in Europe: The European Reference Network TransplantChild 
    Jara, P.; Baker, A.; Baumann, U.; Borobia, A. M.; Branchereu, S.; Candusso, M.; Carcas, A. J.; Chardot, C.; Cobas, J.; D'Antiga, L.; Ferreras, C.; Fitzpatrick, E.; Frauca, E.; Hernández-Oliveros, F.; Kaliciński, P.; Lindemans, C.; Lopes, M. F.; López-Granados, E.; De Magnée, C.; Mota, C.; Muñoz, J. M.; Ojeda, J. J.; Pérez-Martínez, A.; Perilongo, G.; Rascon, J.; Sciveres, M.; Stone, R.; Tarutis, V.; Toporski, J.; Torres, J. M.; Wennberg, L. (BioMed Central, 2020-01-15)
    The low prevalence of European paediatric transplanted patients and scarcity of resources and expertise led to the need for a multidisciplinary network able to improve the quality of life of paediatric patients and families ...
  • T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage 
    Takashima, S.; Martin, M. L.; Jansen, S. A.; Fu, Y.; Bos, J.; Chandra, D.; O'Connor, M. H.; Mertelsmann, A. M.; Vinci, P.; Kuttiyara, J.; Devlin, S. M.; Middendorp, S.; Calafiore, M.; Egorova, A.; Kleppe, M.; Lo, Y.; Shroyer, N. F.; Cheng, E. H.; Levine, R. L.; Liu, C.; Kolesnick, R.; Lindemans, C. A.; Hanash, A. M. (American Association for the Advancement of Science, 2019-12-06)
    Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance, there is limited understanding of how immune-mediated damage affects ISCs and their niche. We found that stem cell compartment injury is a ...
  • Loss of microbial topography between oral and nasopharyngeal microbiota and development of respiratory infections early in life 
    Man, Wing Ho; Clerc, Melanie; de Steenhuijsen Piters, Wouter A.A.; van Houten, Marlies A.; Chu, Mei Ling J.N.; Kool, Jolanda; Keijser, Bart J.F.; Sanders, Elisabeth A.M.; Bogaert, Debby (American Thoracic Society, 2019-09-15)
    Rationale: The respiratory microbiota is increasingly being appreciated as an important mediator in the susceptibility to childhood respiratory tract infections (RTIs). Pathogens are presumed to originate from the ...
  • In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis 
    Sun, Xingshen; Yi, Yaling; Yan, Ziying; Rosen, Bradley H.; Liang, Bo; Winter, Michael C.; Evans, T. Idil Apak; Rotti, Pavana G.; Yang, Yu; Gray, Jaimie S.; Park, Soo Yeun; Zhou, Weihong; Zhang, Yulong; Moll, Shashanna R.; Woody, Lisa; Tran, Dao M.; Jiang, Licong; Vonk, Annelotte M.; Beekman, Jeffrey M.; Negulescu, Paul; Van Goor, Fred; Fiorino, Dennis F.; Gibson-Corley, Katherine N.; Engelhardt, John F. (American Association for the Advancement of Science, 2019-03-27)
    Cystic fibrosis (CF) is a multiorgan disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). In patients with CF, abnormalities initiate in several organs before birth. However, the ...
  • High-resolution 3D imaging of fixed and cleared organoids 
    Dekkers, Johanna F.; Alieva, Maria; Wellens, Lianne M.; Ariese, Hendrikus C.R.; Jamieson, Paul R.; Vonk, Annelotte M.; Amatngalim, Gimano D.; Hu, Huili; Oost, Koen C.; Snippert, Hugo J.G.; Beekman, Jeffrey M.; Wehrens, Ellen J.; Visvader, Jane E.; Clevers, Hans; Rios, Anne C. (Springer Nature, 2019-06-01)
    In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the characterization of the cellular composition of organoids and ...
  • Activating alternative chloride channels to treat CF: Friends or Foes?: Report on the Meeting of the Basic Science Working Group in Dubrovnik, Croatia 
    Amaral, Margarida D.; Beekman, Jeffrey M. (Elsevier, 2020-01-01)
    The European Cystic Fibrosis Society (ECFS) Basic Science Working Group (BSWG) organized a session on the topic “Activating Alternative Chloride Channels to Treat CF: Friends or Foes?”, within the 16th ECFS Basic Science ...
  • Exome sequencing in routine diagnostics: A generic test for 254 patients with primary immunodeficiencies 
    Arts, Peer; Simons, Annet; Alzahrani, Mofareh S.; Yilmaz, Elanur; Alidrissi, Eman; Van Aerde, Koen J.; Alenezi, Njood; Alghamdi, Hamza A.; Aljubab, Hadeel A.; Al-Hussaini, Abdulrahman A.; Almanjomi, Fahad; Alsaad, Alaa B.; Alsaleem, Badr; Andijani, Abdulrahman A.; Asery, Ali; Ballourah, Walid; Bleeker-Rovers, Chantal P.; Van Deuren, Marcel; Van Der Flier, Michiel; Gerkes, Erica H.; Gilissen, Christian; Habazi, Murad K.; Hehir-Kwa, Jayne Y.; Henriet, Stefanie S.; Hoppenreijs, Esther P.; Hortillosa, Sarah; Kerkhofs, Chantal H.; Keski-Filppula, Riikka; Lelieveld, Stefan H.; Lone, Khurram; MacKenzie, Marius A.; Mensenkamp, Arjen R.; Moilanen, Jukka; Nelen, Marcel; Ten Oever, Jaap; Potjewijd, Judith; Van Paassen, Pieter; Schuurs-Hoeijmakers, Janneke H.M.; Simon, Anna; Stokowy, Tomasz; Van De Vorst, Maartje; Vreeburg, Maaike; Wagner, Anja; Van Well, Gijs T.J.; Zafeiropoulou, Dimitra; Zonneveld-Huijssoon, Evelien; Veltman, Joris A.; Van Zelst-Stams, Wendy A.G.; Faqeih, Eissa A.; Van De Veerdonk, Frank L.; Netea, Mihai G.; Hoischen, Alexander (BioMed Central, 2019-06-17)
    Background: Diagnosis of primary immunodeficiencies (PIDs) is complex and cumbersome yet important for the clinical management of the disease. Exome sequencing may provide a genetic diagnosis in a significant number of ...
  • Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis 
    Lees, John A.; Ferwerda, Bart; Kremer, Philip H.C.; Wheeler, Nicole E.; Serón, Mercedes Valls; Croucher, Nicholas J.; Gladstone, Rebecca A.; Bootsma, Hester J.; Rots, Nynke Y.; Wijmega-Monsuur, Alienke J.; Sanders, Elisabeth A.M.; Trzciński, Krzysztof; Wyllie, Anne L.; Zwinderman, Aeilko H.; van den Berg, Leonard H.; van Rheenen, Wouter; Veldink, Jan H.; Harboe, Zitta B.; Lundbo, Lene F.; de Groot, Lisette C.P.G.M.; van Schoor, Natasja M.; van der Velde, Nathalie; Ängquist, Lars H.; Sørensen, Thorkild I.A.; Nohr, Ellen A.; Mentzer, Alexander J.; Mills, Tara C.; Knight, Julian C.; du Plessis, Mignon; Nzenze, Susan; Weiser, Jeffrey N.; Parkhill, Julian; Madhi, Shabir; Benfield, Thomas; von Gottberg, Anne; van der Ende, Arie; Brouwer, Matthijs C.; Barrett, Jeffrey C.; Bentley, Stephen D.; van de Beek, Diederik (Nature Publishing Group, 2019-05-15)
    Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a ...
  • Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants 
    Van Willigen, Marcel; Vonk, Annelotte M.; Yeoh, Hui Ying; Kruisselbrink, Evelien; Kleizen, Bertrand; Van Der Ent, Cornelis K.; Egmond, Maarten R.; De Jonge, Hugo R.; Braakman, Ineke; Beekman, Jeffrey M.; Van Der Sluijs, Peter (Life Science Alliance, LLC, 2019-01-01)
    Cystic fibrosis is caused by mutations in the CFTR gene, which are subdivided into six classes. Mutants of classes III and IV reach the cell surface but have limited function. Most class-III and class-IV mutants respond ...
  • Association Between Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection in Early Life and Recurrent Wheeze and Asthma in Later Childhood 
    RESCEU Investigators (Oxford University Press, 2020-10-07)
    BACKGROUND: Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and ...
  • Sustained Cellular and Humoral Immune Responses From an Adenoviral Vector-based Respiratory Syncytial Virus Vaccine 
    Korsten, Koos; Bont, Louis J (Oxford University Press, 2020-05-15)
  • Clinical Development of Respiratory Syncytial Virus Antivirals-What We Can Learn From Oseltamivir 
    Löwensteyn, Yvette N; Bont, Louis J (Oxford University Press, 2020-12-01)
  • Correction to: Cost-effectiveness of rule-based immunoprophylaxis against respiratory syncytial virus infections in preterm infants (vol 177, pg 133, 2018) 
    on behalf of the Dutch RSV Neonatal Network (Springer-Verlag, 2020-02-01)
    The name of the co-author Wendy J. Ungar was inadvertently omitted on the original published article. Her name and affiliation have now been added to the author list.
  • Measles seroprevalence in pregnant women in Soweto, South Africa: a nested cohort study 
    Gieles, N. C.; Mutsaerts, E. A.M.L.; Kwatra, G.; Bont, L.; Cutland, C. L.; Jones, S.; Moultrie, A.; Madhi, S. A.; Nunes, M. C. (Elsevier, 2020-04-01)
    OBJECTIVES: Measles infection causes particularly severe disease in young children who, prior to vaccination, are dependent on maternal antibodies for protection against infection. Measles vaccination was introduced into ...
  • Rubella seroprevalence in pregnant women living with and without HIV in Soweto, South Africa 
    Gieles, Noor C.; Mutsaerts, Eleonora A.M.L.; Kwatra, Gaurav; Bont, Louis; Cutland, Clare L.; Jones, Stephanie; Moultrie, Andrew; Madhi, Shabir A.; Nunes, Marta C. (Elsevier, 2020-02-01)
    OBJECTIVES: Rubella infection during pregnancy may cause foetal death or congenital rubella syndrome. In South Africa, the national public immunization programme does not include rubella vaccination. The aim of this study ...
  • Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: Multicenter, retrospective data collection 
    PReS working party of Vaccination Study Group (Elsevier, 2020-02-24)
    PURPOSE: To collect retrospective data of patients with Juvenile Idiopathic Arthritis (JIA) and other rheumatic diseases who received live attenuated booster measles-mumps-rubella (MMR) or measles-mumps-rubella-varicella ...
  • Towards European harmonisation of healthcare for patients with rare immune disorders: outcome from the ERN RITA registries survey 
    ERN RITA Council (BioMed Central, 2020-01-30)
    The Rare Immunodeficiency, AutoInflammatory and AutoImmune Disease (RITA) network is a European Research Network (ERN) that brings together the leading centres for rare immune disorders. On April 2018 an online survey was ...
  • Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial 
    Male, Christoph; Lensing, Anthonie W. A.; Palumbo, Joseph S.; Kumar, Riten; Nurmeev, Ildar; Hege, Kerry; Bonnet, Damien; Connor, Philip; Hooimeijer, Helene L.; Torres, Marcela; Chan, Anthony K. C.; Kenet, Gili; Holzhauer, Susanne; Santamaria, Amparo; Amedro, Pascal; Chalmers, Elizabeth; Simioni, Paolo; Bhat, Rukhmi V.; Yee, Donald L.; Lvova, Olga; Beyer-Westendorf, Jan; Biss, Tina T.; Martinelli, Ida; Saracco, Paola; Peters, Marjolein; Kallay, Krisztian; Gauger, Cynthia A.; Massicotte, M. Patricia; Young, Guy; Pap, Akos F.; Majumder, Madhurima; Smith, William T.; Heubach, Jurgen F.; Berkowitz, Scott D.; Thelen, Kirstin; Kubitza, Dagmar; Crowther, Mark; Prins, Martin H.; Monagle, Paul; EINSTEIN-Jr Phase 3 Investigators (Lancet Publishing Group, 2020-01)
    Background: Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. The aim of our study was to compare the efficacy and ...
  • Demographic and clinical features as predictors of clozapine response in patients with schizophrenia spectrum disorders: A systematic review and meta-analysis 
    Okhuijsen-Pfeifer, C; Sterk, A Y; Horn, I M; Terstappen, J; Kahn, R S; Luykx, J J (Elsevier Limited, 2020-04)
    OBJECTIVES: Clozapine (CLZ) is prescribed to (relatively) treatment-resistant patients with schizophrenia spectrum disorders. Currently, it is unknown what factors predict response to CLZ. Therefore, we performed meta-analyses ...