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UMC Repository: Recent submissions

  • PLASMACYTOID DCS FROM PATIENTS WITH SJOGREN'S SYNDROME ARE TRANSCRIPTIONALLY PRIMED FOR ENHANCED PRO-INFLAMMATORY CYTOKINE PRODUCTION 
    Hillen, Maarten; Pandit, Aridaman; Blokland, Sofie; Hartgring, Sarita Ay; Bekker, Cornelis; van der Heijden, Eefje; Servaas, Nila; Rossato, Marzia; Kruize, Aike A.; van Roon, Joel; Radstake, Timothy R. (Elsevier, 2019-06)
  • The role of innate immune cells in systemic sclerosis in the context of autologous hematopoietic stem cell transplantation 
    Servaas, N. H.; Spierings, J.; Pandit, A.; van Laar, J. M. (Wiley-Blackwell, 2020-07-01)
    Systemic sclerosis (SSc) is a complex, heterogeneous autoimmune connective tissue disease. Autologous hematopoietic stem-cell transplantation (AHSCT) has emerged as a valuable treatment option for rapidly progressive diffuse ...
  • CLINICAL EFFICACY OF LEFLUNOMIDE/HYDROXYCHLOROQUINE COMBINATION THERAPY IN PRIMARY SJOGREN'S SYNDROME IS PREDICTED BY SERUM PROTEOME BIOMARKERS - RESULTS FROM REPURPSS-I 
    Van Roon, Joel; van der Heijden, Eefje; Blokland, Sofie; Lopes, Ana; Moret, Frederique; Welsing, Paco; Janssen, Nard; Rosenberg, Toine; Pandit, Aridaman; Tao, Weiyang; Hillen, Maarten; Kruize, Aike A.; Radstake, Timothy R. (Elsevier, 2019-06)
  • Leflunomide–hydroxychloroquine combination therapy in patients with primary Sjögren's syndrome (RepurpSS-I): a placebo-controlled, double-blinded, randomised clinical trial 
    van der Heijden, Eefje Hanna Martine; Blokland, Sofie Liny Marie; Hillen, Maarten Reinier; Lopes, Ana Paula Pinheiro; van Vliet-Moret, Fréderique Marie; Rosenberg, Antoine Johan Wilhelm Peter; Janssen, Nard Gabriëlle; Welsing, Paco Mattheus Jacobus; Iannizzotto, Valentina; Tao, Weiyang; Pandit, Aridaman; Barone, Francesca; Kruize, Aike Albert; Radstake, Timothy Ruben Dirk Jan; van Roon, Joel Adrianus Gijsbert (Elsevier Limited, 2020-05)
    Background: Primary Sjögren's syndrome is a systemic autoimmune disease characterised by secretory gland dysfunction, for which no effective therapy is available. Based on the complementary properties of leflunomide and ...
  • Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives - a report of the European Academy of Allergy and Clinical Immunology (EAACI) 
    Sokolowska, M; Lukasik, Z; Agache, I; Akdis, C A; Akdis, D; Akdis, M; Barcik, W; Brough, H; Eiwegger, T; Eliaszewicz, A; Eyerich, S; Feleszko, W; Gomez Casado, C; Hoffmann-Sommergruber, K; Janda, J; Jiménez-Saiz, R; Jutel, M; Knol, E; Kortekaas Krohn, I; Kothari, A; Makowska, J; Moniuszko, M; Morita, H; O'Mahony, L; Nadeau, K; Ozdemir, C; Pali-Schöll, I; Palomares, O; Papaleo, F; Prunicki, M; Schmidt-Weber, C B; Sediva, A; Schwarze, J; Shamji, M H; Tramper-Stranders, G; van, W; de Veen, R.; Untersmayr, E (Wiley-Blackwell, 2020-10)
    With the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS-CoV-2-induced ...
  • COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper 
    Pfaar, O; Klimek, L; Jutel, M; Akdis, C A; Bousquet, J; Breiteneder, H; Chinthrajah, S; Diamant, Z; Eiwegger, T; Fokkens, W J; Fritsch, H W; Nadeau, K C; O'Hehir, R E; O'Mahony, L; Rief, W; Sampath, V; Schedlowski, M; Torres, M; Traidl-Hoffmann, C; Wang, D Y; Zhang, L; Bonini, M; Brehler, R; Brough, H A; Chivato, T; Del Giacco, S; Dramburg, S; Gawlik, R; Gelincik, A; Hoffmann-Sommergruber, K; Hox, V; Knol, E; Lauerma, A; Matricardi, P M; Mortz, C G; Ollert, M; Palomares, O; Riggioni, C; Schwarze, J; Skypala, I; Untersmayr, S; Walusiak-Skorupa, J; Ansotegui, I; Bachert, C; Bedbrook, A; Bosnic-Anticevich, S; Brussino, L; Canonica, G W; Cardona, V; Carreiro-Martins, P; Cruz, A A; Czarlewski, W; Fonseca, J A; Gotua, M; Haatela, T; Ivancevich, J C; Kuna, P; Kvedariene, V; Larenas-Linnemann, D; Latiff, A; Morais-Almeida, M; Mullol, J; Naclerio, R; Ohta, K; Okamoto, Y; Onorato, G L; Papadopoulos, N G; Patella, V; Regateiro, F S; Samolinski, B; Suppli Ulrik, C; Toppila-Salmi, S; Valiulis, A; Ventura, M T; Yorgancioglu, A; Zuberbier, T; Agache, I (Wiley-Blackwell, 2021-03)
    BACKGROUND: The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers ...
  • ARIA-EAACI statement on Asthma and COVID-19 (June 2, 2020) 
    Bousquet, Jean; Jutel, Marek; Akdis, Cezmi A; Klimek, Ludger; Pfaar, Oliver; Nadeau, Kari C; Eiwegger, Thomas; Bedbrook, Anna; Ansotegui, Ignacio J; Anto, Josep M; Bachert, Claus; Bateman, Eric D; Bennoor, Kazi S; Berghea, Emilia Camelia; Bergmann, Karl-Christian; Blain, Hubert; Bonini, Mateo; Bosnic-Anticevich, Sinthia; Boulet, Louis-Philippe; Brussino, Luisa; Buhl, Roland; Camargos, Paulo; Canonica, G Walter; Cardona, Victoria; Casale, Thomas; Chinthrajah, Sharon; Akdis, Mübeccel; Chivato, Tomas; Christoff, George; Cruz, Alvaro A; Czarlewski, Wienczyslawa; Del Giacco, Stefano; Du, Hui; El-Gamal, Yehia; Fokkens, Wytske J; Fonseca, Joao A; Gao, Yadong; Gaga, Mina; Gemicioglu, Bilun; Gotua, Maia; Haahtela, Tari; Halpin, David; Hamelmann, Eckard; Hoffmann-Sommergruber, Karin; Humbert, Marc; Ilina, Nataliya; Ivancevich, Juan-Carlos; Joos, Guy; Khaitov, Musa; Kirenga, Bruce; Knol, Edward F; Ko, Fanny W; Koskinen, Seppo; Kowalski, Marek L; Kraxner, Helga; Kudlay, Dmitri; Kuna, Piotr; Kupczyk, Maciej; Kvedariene, Violeta; Abdul Latiff, Amir H; Le, Lan T; Levin, Michael; Larenas-Linnemann, Desiree; Louis, Renaud; Masjedi, Mohammad R; Melén, Erik; Mihaltan, Florin; Milenkovic, Branislava; Mohammad, Yousser; Morais-Almeida, Mario; Mullol, Joaquim; Namazova, Leyla; Neffen, Hugo; Nunes, Elisabete; O'Byrne, Paul; O'Hehir, Robyn; O'Mahony, Liam; Ohta, Ken; Okamoto, Yoshitaka; Onorato, Gabrielle L; Panzner, Petr; Papadopoulos, Nikos G; Passalacqua, Gianni; Patella, Vincenzo; Pawankar, Ruby; Pham-Thi, Nhân; Pigearias, Bernard; Popov, Todor A; Puggioni, Francesca; Regateiro, Frederico S; Rolla, Giovanni; Rottem, Menachem; Samolinski, Boleslaw; Sastre, Joaquin; Schwarze, Jurgen; Sheikh, Aziz; Scichilone, Nicola; Soto-Quiros, Manuel; Sova, Milan; Nicola, Stefania; Stelmach, Rafael; Suppli-Ulrik, Charlotte; Taborda-Barata, Luis; To, Teresa; Tomazic, Peter-Valentin; Toppila-Salmi, Sanna; Tsiligianni, Ioanna; Usmani, Omar; Valiulis, Arunas; Ventura, Maria Teresa; Viegi, Giovanni; Vontetsianos, Theodor; Wang, De Yun; Williams, Sian; Wong, Gary Wk; Yorgancioglu, Arzu; Zernotti, Mario; Zidarn, Mihaela; Zuberbier, Torsten; Agache, Ioana (Wiley-Blackwell, 2021-03)
  • Immune modulation via T regulatory cell enhancement: disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases - An EAACI position paper of the Task Force on Immunopharmacology (TIPCO) 
    Roth-Walter, F; Adcock, I M; Benito-Villalvilla, C; Bianchini, R; Bjermer, L; Boyman, O; Caramori, G; Cari, L; Chung, K F; Diamant, Z; Eguiluz-Gracia, I; Knol, E F; Kolios, Aga; Levi-Schaffer, F; Nocentini, G; Palomares, O; Redegeld, F; Van Esch, B; Stellato, C (Wiley-Blackwell, 2021-01)
    Therapeutic advances using targeted biologicals and small molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune and inflammatory diseases particularly for some patients with ...
  • Clinical rule-guided pharmacists' intervention in hospitalized patients with hypokalaemia: A time series analysis 
    Wasylewicz, Arthur T.M.; Korsten, Erik H.M.; Egberts, Toine C.G.; Grouls, Rene J.E. (Wiley-Blackwell, 2020-06)
    WHAT IS KNOWN AND OBJECTIVE: Physicians' response to moderate and severe hypokalaemia in hospitalized patients is frequently suboptimal, leading to increased risk of cardiac arrhythmias and sudden death. While actively ...
  • Reporting Patterns of Sialorrhea Comparing Users of Clozapine to Users of Other Antipsychotics: A Disproportionality Analysis Using VigiBase 
    Man, Wai Hong; Wilting, Ingeborg; Souverein, Patrick; Meyboom, Ronald; Egberts, Toine; Heerdink, Eibert R. (Lippincott Williams & Wilkins, 2020-05)
    BACKGROUND: Sialorrhea is a non-life-threatening, but potentially invalidating adverse drug reaction (ADR) in patients using clozapine. In light of the very serious ADRs (agranulocytosis and myocarditis), sialorrhea is at ...
  • Adverse events related to biologicals used for patients with multiple sclerosis: a comparison between information originating from regulators and information originating from the scientific community 
    Minnema, L. A.; Giezen, T. J.; Egberts, T. C.G.; Leufkens, H. G.M.; Gardarsdottir, H. (Wiley-Blackwell, 2020-07)
    Background and purpose: Clinical decision making is facilitated by healthcare professionals’ and patients’ adequate knowledge of the adverse events. This is especially important for biologicals used for treating multiple ...
  • The association between receptor binding affinity and metabolic side effect profile of antipsychotics and major cardio- and cerebrovascular events: A case/non-case study using VigiBase 
    Aguiar, João Pedro; Alves da Costa, Filipa; Egberts, Toine; Leufkens, Hubert; Souverein, Patrick (Elsevier, 2020-06)
    Antipsychotics (APs) have been associated with major adverse cardio- and cerebrovascular events (MACCE), but the underlying mechanisms are unclear. Our aim was to elucidate the association between APs, stratified for ...
  • Corrigendum to INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma 
    van den Bent, Martin; Eoli, Marica; Sepulveda, Juan Manuel; Smits, Marion; Walenkamp, Annemiek; Frenel, Jean-Sebastian; Franceschi, Enrico; Clement, Paul M; Chinot, Olivier; de Vos, Filip; Whenham, Nicolas; Sanghera, Paul; Weller, Michael; Dubbink, H J; French, Pim; Looman, Jim; Dey, Jyotirmoy; Krause, Scott; Ansell, Pete; Nuyens, Sarah; Spruyt, Maarten; Brilhante, Joana; Coens, Corneel; Gorlia, Thierry; Golfinopoulos, Vassilis (Oxford University Press, 2021-08-01)
    Corrigendum to Bent et al. INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma. Neuro Oncol (doi: 10.1093/neuonc/noz222) ...
  • Methylation Profile of X-Chromosome-Related Genes in Male Breast Cancer 
    Foschini, Maria P; Morandi, Luca; Sanchez, Alejandro M; Santoro, Angela; Mulè, Antonino; Zannoni, Gian Franco; Varga, Zsuzsanna; Moskovszky, Linda; Cucchi, Maria C; Moelans, Cathy B; Giove, Gianluca; van Diest, Paul J; Masetti, Riccardo (Frontiers Media S. A., 2020-06-17)
    Background: Androgen receptor (AR) has been described to play a prominent role in male breast cancer (MBC). It maps on chromosome X, and recent reports indicate that X-chromosome polysomy is frequent in MBC. Since the ...
  • In Children and Adolescents From Brugada Syndrome-Families, Only SCN5A Mutation Carriers Develop a Type-1 ECG Pattern Induced By Fever 
    Peltenburg, Puck J; Blom, Nico A; Vink, Arja S; Kammeraad, Janneke A E; Breur, Hans J M P J; Rammeloo, Lukas A J; Wilde, Arthur A M; Clur, Sally-Ann B (Lippincott Williams & Wilkins, 2020-07-07)
  • A Noninterventional, Observational, European Post-Authorization Safety Study of Patients With Relapsed/Refractory Multiple Myeloma Treated With Lenalidomide 
    Gamberi, Barbara; Berthou, Christian; Hernandez, Miguel; Semenzato, Gianpietro; Tholouli, Eleni; Hájek, Roman; Caers, Jo; Dimopoulos, Meletios; Minnema, Monique C; Andreasson, Bjorn; Parreira, Joana; Crotty, Gerard; Remes, Kari; Kueenburg, Elisabeth; Rosettani, Barbara; Di Micco, Antonia; Peters, Sarah; Bacon, Pamela; Blau, Igor Wolfgang (Elsevier, 2020-10)
    INTRODUCTION: Lenalidomide plus dexamethasone is effective and well tolerated in relapsed/refractory multiple myeloma (RRMM). In this observational, noninterventional European post-authorization safety study, the safety ...
  • Prediction of psychological distress among persons with spinal cord injury or acquired brain injury and their significant others 
    Scholten, Eline W M; Ketelaar, Marjolijn; Visser-Meily, Johanna M A; Roels, Ellen H; Kouwenhoven, Mirjam; Post, Marcel W M (W.B. Saunders, 2020-12)
    Objectives: To identify intra- and interpersonal sociodemographic, injury-related, and psychological variables measured at admission of inpatient rehabilitation that predict psychological distress among dyads of individuals ...
  • Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain 
    van Helvoort, Eefje M; Eijkelkamp, Niels; Lafeber, Floris P J G; Mastbergen, Simon C (Oxford University Press, 2020-11-01)
    Objectives. The crosstalk between the immune and nervous system in the regulation of OA pain is increasingly becoming evident. GM-CSF signals in both systems and might be a new treatment target to control OA pain. Anti ...
  • Amyloid Proteins and Peripheral Neuropathy 
    Asiri, Mohammed M H; Engelsman, Sjoukje; Eijkelkamp, Niels; Höppener, Jo W M (Multidisciplinary Digital Publishing Institute (MDPI), 2020-06-26)
    Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common ...
  • Clinical management of woman with bleeding disorders: A survey among European haemophilia treatment centres 
    van Galen, Karin P M; Lavin, Michelle; Skouw-Rasmussen, Naja; Ivanova, Eva; Mauser-Bunschoten, Eveline; Punt, Marieke; Romana, Gerychová; Elfvinge, Petra; D'Oiron, Roseline; Abdul-Kadir, Rezan (Wiley-Blackwell, 2020-07)
    Introduction: The impact of bleeding for women with bleeding disorders (WBD) is of increasing focus and importance. Despite this, optimal management strategies are unclear and knowledge gaps persist. Aim: To examine practices ...