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Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut

Beumer, Joep; Gehart, Helmuth; Clevers, Hans (The Endocrine Society, 2020-06-12)

The recent intersection of enteroendocrine cell biology with single-cell technologies and novel in vitro model systems has generated a tremendous amount of new data. Here we highlight these recent developments and explore ...
Heterogeneity in mRNA Translation

Sonneveld, Stijn; Verhagen, Bram M.P.; Tanenbaum, Marvin E. (Elsevier Limited, 2020-08)

During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental ...
The function of GORASPs in Golgi apparatus organization in vivo

Grond, Rianne; Veenendaal, Tineke; Duran, Juan M.; Raote, Ishier; van Es, Johan H.; Corstjens, Sebastiaan; Delfgou, Laura; El Haddouti, Benaissa; Malhotra, Vivek; Rabouille, Catherine (Rockefeller University Press, 2020-09-07)

In vitro experiments have shown that GRASP65 (GORASP1) and GRASP55 (GORASP2) proteins function in stacking Golgi cisternae. However, in vivo depletion of GORASPs in metazoans has given equivocal results. We have generated ...
Attributable mortality of antibiotic resistance in Gram-negative infections in the Netherlands: a parallel matched cohort study

Rottier, Wouter C; Deelen, J W Timotëus; Caruana, Giorgia; Buiting, Anton G M; Dorigo-Zetsma, J Wendelien; Kluytmans, Jan A J W; van der Linden, Paul D; Thijsen, Steven F T; Vlaminckx, Bart J M; Weersink, Annemarie J L; Ammerlaan, Heidi S M; Bonten, Marc J M (Elsevier, 2021-05)

Objectives: Antibiotic resistance in Gram-negative bacteria has been associated with increased mortality. This was demonstrated mostly for third-generation cephalosporin-resistant (3GC-R) Enterobacterales bacteraemia in ...
Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables

Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2020-10)

BACKGROUND: Individuals with a very high lifetime risk of developing pancreatic ductal adenocarcinoma; for example, hereditary pancreatitis and main-duct or mixed-type intraductal papillary mucinous neoplasm, may wish to ...
Microevolution of acquired colistin resistance in Enterobacteriaceae from ICU patients receiving selective decontamination of the digestive tract

Janssen, Axel B; van Hout, Denise; Bonten, Marc J M; Willems, Rob J L; van Schaik, Willem (Oxford University Press, 2020-11)

BACKGROUND: Colistin is an antibiotic that targets the LPS molecules present in the membranes of Gram-negative bacteria. It is used as a last-resort drug to treat infections with MDR strains. Colistin is also used in ...
Reply to Baird and Douglas

Bonten, Marc; Verstraeten, Thomas; Gravenstein, Stefan; Poolman, Jan (Oxford University Press, 2021-05-01)
How Viral Sequence Analysis May Guide Development of Respiratory Syncytial Virus Monoclonal Antibodies

Langedijk, Annefleur C; Bont, Louis J (Oxford University Press, 2021-12-01)
Infant respiratory syncytial virus prophylaxis and nasopharyngeal microbiota until 6 years of life: a subanalysis of the MAKI randomised controlled trial

Man, Wing Ho; Scheltema, Nienke M; Clerc, Melanie; van Houten, Marlies A; Nibbelke, Elisabeth E; Achten, Niek B; Arp, Kayleigh; Sanders, Elisabeth A M; Bont, Louis J; Bogaert, Debby (Elsevier Limited, 2020-10)

Background: Respiratory syncytial virus (RSV) infection during infancy is suggested to cause long-term wheeze. In turn, wheeze has been associated with bacterial dysbiosis of the respiratory tract. We investigated the ...
Low Sensitivity of BinaxNOW RSV in Infants

RESCEU Investigators (Oxford University Press, 2020-11-01)

BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen ...
Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants

Lin, Gu-Lung; Golubchik, Tanya; Drysdale, Simon; O'Connor, Daniel; Jefferies, Kimberley; Brown, Anthony; de Cesare, Mariateresa; Bonsall, David; Ansari, M Azim; Aerssens, Jeroen; Bont, Louis; Openshaw, Peter; Martinón-Torres, Federico; Bowden, Rory; Pollard, Andrew J (Oxford University Press, 2020-10-07)

Targeted metagenomics using strand-specific libraries with target enrichment is a sensitive, generalized approach to pathogen sequencing and transcriptome profiling. Using this method, we recovered 13 (76%) complete human ...
TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines

Rivero-Calle, Irene; Gómez-Rial, Jose; Bont, Louis; Gessner, Bradford D; Kohn, Melvin; Dagan, Ron; Payne, Daniel C; Bruni, Laia; Pollard, Andrew J; García-Sastre, Adolfo; Faustman, Denise L; Osterhaus, Albert; Butler, Robb; Giménez Sánchez, Francisco; Álvarez, Francisco; Kaforou, Myrsini; Bello, Xabier; Martinón-Torres, Federico (Landes Bioscience, 2021-03-04)

TIPICO is an expert meeting and workshop that aims to provide the most recent evidence in the field of infectious diseases and vaccination. The 10th Interactive Infectious Disease TIPICO workshop took place in Santiago de ...
Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis

Brunwasser, Steven M; Snyder, Brittney M; Driscoll, Amanda J; Fell, Deshayne B; Savitz, David A; Feikin, Daniel R; Skidmore, Becky; Bhat, Niranjan; Bont, Louis J; Dupont, William D; Wu, Pingsheng; Gebretsadik, Tebeb; Holt, Patrick G; Zar, Heather J; Ortiz, Justin R; Hartert, Tina V (Elsevier Limited, 2020-08)

BACKGROUND: Although a positive association has been established, it is unclear whether lower respiratory tract infections (LRTIs) with respiratory syncytial virus (RSV) cause chronic wheezing illnesses. If RSV-LRTI were ...
Respiratory Syncytial Virus-related Death in Children with down Syndrome: The RSV GOLD Study

Löwensteyn, Yvette N.; Phijffer, Emily W.E.M.; Simons, Juliette V.L.; Scheltema, Nienke M.; Mazur, Natalie I.; Nair, Harish; Bont, Louis J. (Lippincott Williams & Wilkins, 2020-08)

Background: Respiratory syncytial virus (RSV) is a major cause of mortality in children younger than 5 years worldwide. Systematic reviews have shown that Down syndrome (DS) is an independent risk factor for severe RSV ...
Life-threatening bronchiolitis in children: eight decades of critical care

Bem, Reinout A.; Bont, Louis J.; van Woensel, Job B.M. (Elsevier Limited, 2020-02)
Quantitative 166Ho-microspheres SPECT derived from a dual-isotope acquisition with 99mTc-colloid is clinically feasible

Stella, M; Braat, Arthur; Lam, Marnix; de Jong, Hugo; van Rooij, Rob (Springer International Publishing AG, 2020-07-14)

Purpose: Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 ( 166Ho)-microspheres, and ...
Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation

Kerr, Candace L.; Bol, Guus M.; Vesuna, Farhad; Raman, Venu (SAGE Publications Inc., 2019-02)

DDX3 is an RNA helicase that has antiapoptotic properties, and promotes proliferation and transformation. Besides the role of DDX3 in transformed cells, there is evidence to indicate that DDX3 expression is at its highest ...
User Experiences With and Recommendations for Mobile Health Technology for Hypertensive Disorders of Pregnancy: Mixed Methods Study

Jongsma, Karin Rolanda; van den Heuvel, Josephus F M; Rake, Jasmijn; Bredenoord, Annelien L; Bekker, Mireille N (JMIR Publications Inc., 2020-08)

BACKGROUND: Hypertensive disorders of pregnancy (HDP) are a primary cause of adverse maternal and neonatal outcomes worldwide. For women at risk of hypertensive complications, guidelines recommend frequent surveillance of ...
Value-sensitive design and global digital health

Jongsma, Karin; Jongepier, Fleur (World Health Organization, 2020-07-08)

In the field of digital ethics, value-sensitive design is one of the most influential normative methodologies. The basic aim of value-sensitive design is to integrate human values in technologies from the very start of the ...
SERIES: eHealth in primary care. Part 2: Exploring the ethical implications of its application in primary care practice

Boers, Sarah N.; Jongsma, Karin R.; Lucivero, Federica; Aardoom, Jiska; Büchner, Frederike L.; de Vries, Martine; Honkoop, Persijn; Houwink, Elisa J.F.; Kasteleyn, Marise J.; Meijer, Eline; Pinnock, Hilary; Teichert, Martina; van der Boog, Paul; van Luenen, Sanne; van der Kleij, Rianne M.J.J.; Chavannes, Niels H. (Informa Healthcare, 2020-12-16)

Background: eHealth promises to increase self-management and personalised medicine and improve cost-effectiveness in primary care. Paired with these promises are ethical implications, as eHealth will affect patients’ and ...

Now showing items 18881-18900 of 40729