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Now showing items 18861-18880 of 40729

Monte Carlo-based scatter correction for the SMARTZOOM collimator

Dietze, Martijn M A; Kunnen, Britt; Stella, Martina; de Jong, Hugo W A M (Springer International Publishing AG, 2020-07-22)

BACKGROUND: Myocardial perfusion imaging is a commonly performed SPECT protocol and hence it would be beneficial if its scan duration could be shortened. For traditional gamma cameras, two developments have separately shown ...
Fasciola hepatica Serine Protease Inhibitor Family (Serpins): Purposely crafted for regulating host proteases

De Marco Verissimo, Carolina; Jewhurst, Heather L; Tikhonova, Irina G; Urbanus, Rolf T; Maule, Aaron G; Dalton, John P; Cwiklinski, Krystyna (Public Library of Science, 2020-08)

Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica ...
Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia

Waissi, Farahnaz; Dekker, Mirthe; Bank, Ingrid E M; Korporaal, Suzanne J A; Urbanus, Rolf T; de Borst, Gert J; Pasterkamp, Gerard; Scholtens, Asbjorn M; Grobbee, Diederick E; Mosterd, Arend; de Kleijn, Dominique P V; Timmers, Leo (Elsevier, 2020-07)

Background: Antiplatelet therapy is the mainstay of secondary prevention of cardiovascular events. Studies suggest that women do not obtain equal therapeutic benefit from antiplatelet therapy compared with men. The link ...
Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data

Widera, Paweł; Welsing, Paco M.J.; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.F.J.; Petit Dop, Florence; Larkin, Jonathan; Weinans, Harrie; Mobasheri, Ali; Bacardit, Jaume (Nature Publishing Group, 2020-05-21)

Conventional inclusion criteria used in osteoarthritis clinical trials are not very effective in selecting patients who would benefit from a therapy being tested. Typically majority of selected patients show no or limited ...
Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers

van Helvoort, Eefje M.; van Spil, Willem E.; Jansen, Mylène P.; Welsing, Paco M.J.; Kloppenburg, Margreet; Loef, Marieke; Blanco, Francisco J.; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Ladel, Christoph H.; Loughlin, John; Bay-Jensen, Anne C.; Mobasheri, Ali; Larkin, Jonathan; Boere, Janneke; Weinans, Harrie H.; Lalande, Agnes; Marijnissen, Anne C.A.; Lafeber, Floris P.J.G. (BMJ Publishing Group, 2020-07-28)

PURPOSE: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using conventional ...
Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands: A Nationwide Analysis

Dutch Pancreatic Cancer Group (Lippincott Williams & Wilkins, 2022-04-01)

OBJECTIVE: To evaluate whether detection of recurrent pancreatic ductal adenocarcinoma (PDAC) in an early, asymptomatic stage increases the number of patients receiving additional treatment, subsequently improving survival. ...
Practice-level association between antibiotic prescribing and resistance: an observational study in primary care

Batenburg, Dylan; Verheij, Theo; van ’t Veen, Annemarie; van der Velden, Alike (Multidisciplinary Digital Publishing Institute (MDPI), 2020-08-01)

A direct relation between antibiotic use and resistance has been shown at country level. We aim to investigate the association between antibiotic prescribing for patients from individual Dutch primary care practices and ...
Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs

Janssen, Julie M.; Dorlo, Thomas P.C.; Beijnen, Jos H.; Huitema, Alwin D.R. (Lippincott Williams & Wilkins, 2020-08-01)

BACKGROUND: For oral anticancer drugs, trough concentration (Cmin) is usually used as a target in therapeutic drug monitoring (TDM). Recording of Cmin is highly challenging in outpatients, in whom there is typically a ...
Exposure-response analyses of anaplastic lymphoma kinase inhibitors crizotinib and alectinib in non-small-cell lung cancer patients

Groenland, Stefanie L; Geel, Dieuwertje R; Janssen, Julie M; de Vries, Niels; Rosing, Hilde; Beijnen, Jos H; Burgers, Jacobus A; Smit, Egbert F; Huitema, Alwin D R; Steeghs, Neeltje (Wiley-Blackwell, 2021-02)

Crizotinib and alectinib are anaplastic lymphoma kinase (ALK)-inhibitors indicated for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC). At the currently used fixed doses, interindividual variability ...
Tapering with Pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-Dependent Patients: A Matched-Subject Observational Study of Treatment-as-Usual in Belgium and The Netherlands

Beurmanjer, Harmen; Luykx, J J; De Wilde, B; van Rompaey, K; Buwalda, V J A; De Jong, C A J; Dijkstra, B A G; Schellekens, A F A (Adis, 2020-06-01)

BACKGROUND: The gamma-hydroxybutyric acid (GHB) withdrawal syndrome often has a fulminant course, with a rapid onset and swift progression of severe complications. In clinical practice, two pharmacological regimens are ...
Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice

IJzerman, Nikki S; Groenland, Stefanie L; Koenen, Anne Miek; Kerst, Martijn; van der Graaf, Winette T A; Rosing, Hilde; Beijnen, Jos H; Huitema, Alwin D R; Steeghs, Neeltje (Elsevier Limited, 2020-09)

AIM: Higher imatinib exposure is correlated with longer time to progression, while the variability in exposure is high. This provides a strong rationale for therapeutic drug monitoring, which has therefore been implemented ...
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

UMC Utrecht, Julius Center (Wiley-Blackwell, 2021-01)

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of ...
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Eating Disorders Working Group of the Psychiatric Genomics Consortium; International Headache Genetics Consortium; 23andMe Research Team (Nature Research, 2020-05-01)

Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study ...
Persistence of Antipsychotic Use After Clozapine Discontinuation: A Real-World Study Across Antipsychotics

Stam, Noraly; Taipale, Heidi; Tanskanen, Antti; Isphording, Luka; Okhuijsen-Pfeifer, Cynthia; Schuiling-Veninga, Catharina C.M.; Bos, Jens H.J.; Bijker, Bert J.; Tiihonen, Jari; Luykx, Jurjen J. (John Wiley & Sons Inc., 2020-11)

Although clozapine treatment is often discontinued due to limited efficacy or low tolerability, there is a lack of guidelines and evidence on treatment options after discontinuation of clozapine in patients with schizophrenia. ...
Psychiatry in Times of the Coronavirus Disease 2019 (COVID-19) Pandemic: An Imperative for Psychiatrists to Act Now

Luykx, Jurjen J.; Vinkers, Christiaan H.; Tijdink, Joeri K. (American Medical Association, 2020-11)
Prednisolone versus placebo addition in the treatment of patients with recent-onset psychotic disorder: A trial design

Nasib, Lyliana G.; Sommer, Iris E.; Winter - Van Rossum, Inge; De Vries, Jacqueline; Gangadin, Shiral S.; Oomen, Priscilla P.; Judge, Gurmeet; Blom, Renske E.; Luykx, Jurjen J.; Van Beveren, Nico J.M.; Veen, Natalie D.; Kroken, Rune A.; Johnsen, Erik L. (BioMed Central, 2020-06-08)

Background: The symptom severity of a substantial group of schizophrenia patients (30-40%) does not improve through pharmacotherapy with antipsychotic medication, indicating a clear need for new treatment options to improve ...
The role of rare compound heterozygous events in autism spectrum disorder

Lin, Bochao Danae; Colas, Fabrice; Nijman, Isaac J.; Medic, Jelena; Brands, William; Parr, Jeremy R.; van Eijk, Kristel R.; Klauck, Sabine M.; Chiocchetti, Andreas G.; Freitag, Christine M.; Maestrini, Elena; Bacchelli, Elena; Coon, Hilary; Vicente, Astrid; Oliveira, Guiomar; Pagnamenta, Alistair T.; Gallagher, Louise; Ennis, Sean; Anney, Richard; Bourgeron, Thomas; Luykx, Jurjen J.; Vorstman, Jacob (Nature Publishing Group, 2020-06-22)

The identification of genetic variants underlying autism spectrum disorders (ASDs) may contribute to a better understanding of their underlying biology. To examine the possible role of a specific type of compound heterozygosity ...
Eeg als methode voor precisiepsychiatrie bij depressiebehandeling

Luykx, Jurjen (Uitgeverij Boom, 2020-01-01)
Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis

Hederih, Jure; Nuninga, Jasper O.; van Eijk, Kristel; van Dellen, Edwin; Smit, Dirk J.A.; Oranje, Bob; Luykx, Jurjen J. (Elsevier, 2021-01-10)

Although substantial research into genetics of psychotic disorders has been conducted, a large proportion of their genetic architecture has remained unresolved. Electroencephalographical intermediate phenotypes (EIP) have ...
Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

Whittle, James R.; Vaillant, François; Surgenor, Elliot; Policheni, Antonia N.; Giner, Göknur; Capaldo, Bianca D.; Chen, Huei Rong; Liu, He K.; Dekkers, Johanna F.; Sachs, Norman; Clevers, Hans; Fellowes, Andrew; Green, Thomas; Xu, Huiling; Fox, Stephen B.; Herold, Marco J.; Smyth, Gordon K.; Gray, Daniel H.D.; Visvader, Jane E.; Lindeman, Geoffrey J. (American Association for Cancer Research Inc., 2020-08-01)

Purpose: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metastatic estrogen receptor–positive (ER þ) breast cancer, relapse is almost inevitable. This may, ...

Now showing items 18861-18880 of 40729