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UMC Repository: Recent submissions

  • Defining the Traditional Mediterranean Lifestyle: Joint International Consensus Statement 
    Sidossis, Labros S.; Lawson, Rob; Aprilakis, Emmanuel; Barata, Bernardo C.; Baska, Alicja; Beneka, Anastasia; Bird, Robert; Birrell, Fraser; Chatzinikola, Charistoula; Chondronikola, Maria; Chrousos, George P.; Conduit, Russell; Constantinou, Constantina; de Courten, Barbora; Cvejic, Jelena Helene; Davis, Andrew M.; Demetriou, Christiana A.; Errington, Linda; Feehan, Jack; Figueroa, Catalina; Flynn, Mary M.; Frates, Beth; Kabthymer, Robel Hussen; Karagounis, Leonidas G.; Karimi, Leila; Kennedy, Gerard A.; Kolokotroni, Ourania; Korovljev, Darinka; Kouris-Blazos, Antigone; Kushkestani, Mehdi; Kyriakides, Tassos C.; Hutanu, Emanuela Mercore; Mosquera, Maria Cecilia; Nikiphorou, Elena; O'Brien, Nicola; Philippou, Elena; Piątek, Karolina; Poole, Simon; Popescu-Spineni, Dana; Radd-Vagenas, Sue; Sidossis, Amalia; Simonis, Magdalena; Soultanakis, Helen; Telinga, Aleksandra; Tierney, Audrey; Tkacz, Anna; Vlachopoulos, Dimitris; Yaman-Dent, Gulnur; Yap, Yang; Zervides, Zoe; Itsiopoulos, Catherine (2024-10)
    Introduction: The term “Mediterranean lifestyle” has gained increasing prominence in recent years, yet a specific definition remains elusive. In response, the Mediterranean Lifestyle Medicine Institute Board of Directors ...
  • Therapeutic Drug Monitoring of Oral Oncology Drugs: Finding the Right Nails 
    Guchelaar, Niels A D; Institute, Erasmus; Steeghs, Neeltje; Huitema, Alwin D R; Mathijssen, Ron H J; Koolen, Stijn L W (Nature Publishing Group, 2024-09)
  • Prioritizing family-centered developmental care: insights from parents of children with critical congenital heart disease: a qualitative study 
    Sprong, Maaike C A; Zwagerman, Iza R; Soeters, Lotte; Slieker, Martijn G; Takken, Tim; van den Hoogen, Agnes; van Brussel, Marco (Springer-Verlag, 2024-09)
    As survivors of early cardiac surgery are at high risk of neurodevelopmental impairments, systematic health observations of children with critical congenital heart disease (CCHD) throughout childhood are recommended to ...
  • Targeting persistent fatigue with tailored versus generic self-management strategies in adolescents and young adults with a fatigue syndrome or rheumatic condition: A randomized crossover trial 
    Vroegindeweij, Anouk; Wulffraat, Nico M.; Van De Putte, Elise M.; De Jong, Hanne B.T.; Lucassen, Desiree A.; Swart, Joost F.; Nijhof, Sanne L. (Wiley-Blackwell, 2024-09)
    Objectives: To evaluate the use of two self-management intervention strategies for persistent fatigue in adolescents and young adults with a fatigue syndrome or rheumatic condition. Design: A randomized crossover trial ...
  • A context-based approach to unravel Variants of (Uncertain) Significance 
    Muffels, Irena (Utrecht University, 2024-09-25)
    The Netherlands boasts one of the best healthcare systems globally, yet a subset of severely ill children remains overlooked. These children lack an official diagnosis despite extensive follow-up. Often, these children ...
  • Optimization of percutaneous coronary intervention using new stent designs and individualized antiplatelet therapy 
    van Hemert, Nicole (Utrecht University, 2024-09-13)
    Great improvement in the percutaneous treatment of obstructive coronary artery disease have been made over the past few decades. Recent developments have focused on alterations in stent design and the duration of dual ...
  • Targeted exome analysis in patients with rare bleeding disorders: data from the Rare Bleeding Disorders in the Netherlands study 
    Willems, Sterre P.E.; Simons, Annet; Saes, Joline L.; Weiss, Marjan; Rijpma, Sanna; Schoormans, Selene; Meijer, Karina; Cnossen, Marjon H.; Schutgens, Roger E.G.; van Es, Nick; Nieuwenhuizen, Laurens; den Exter, Paul L.; Kruis, Ilmar C.; Blijlevens, Nicole M.A.; van Heerde, Waander L.; Schols, Saskia E.M. (Wiley-Blackwell Publishing Ltd, 2024-05)
    Background: Rare coagulation factor deficiencies and disorders of fibrinolysis (defined as rare bleeding disorders [RBDs]) present with a heterogeneous bleeding phenotype, and bleeding severity is difficult to predict. ...
  • Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants 
    Vanderhasselt, Tim; Naeyaert, Maarten; Buls, Nico; Allemeersch, Gert Jan; Raeymaeckers, Steven; Raeymaekers, Hubert; Smeets, Nathalie; Cools, Filip; de Mey, Johan; Dudink, Jeroen (Springer-Verlag, 2024-08)
    Background: Early neurorehabilitation can enhance neurocognitive outcomes in very preterm infants (<32 weeks), and conventional magnetic resonance imaging (MRI) is commonly used to assess neonatal brain injury; however, ...
  • Bleeding phenotype according to factor level in 825 children with nonsevere hemophilia: data from the PedNet cohort 
    de Kovel, Marloes S.; Escuriola-Ettingshausen, C.; Königs, Christoph; Ranta, S.; Fischer, K.; PedNet Study Group (Wiley-Blackwell, 2024-09)
    Background: Information on bleeding phenotype in nonsevere hemophilia may be used to determine target factor levels for prophylaxis or gene therapy in severe hemophilia. Objectives: To assess the association between ...
  • Tutorial: dos and don'ts in clinical prediction research for venous thromboembolism 
    Nemeth, Banne; Smeets, Mark J.R.; Cannegieter, Suzanne C.; van Smeden, Maarten (Wiley-Blackwell Publishing Ltd, 2024-05)
    Clinical prediction modeling has become an increasingly popular domain of venous thromboembolism research in recent years. Prediction models can help healthcare providers make decisions regarding starting or withholding ...
  • Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction 
    Kahnert, Konstantin; Soattin, Luca; Mills, Robert W.; Wilson, Claire; Maurya, Svetlana; Sorrentino, Andrea; Al-Othman, Sami; Tikhomirov, Roman; van de Vegte, Yordi J.; Hansen, Finn B.; Achter, Jonathan; Hu, Wei; Zi, Min; Smith, Matthew; van der Harst, Pim; Olesen, Morten S.; Olsen, Kristine Boisen; Banner, Jytte; Jensen, Thomas H.L.; Zhang, Henggui; Boyett, Mark R.; D'Souza, Alicia; Lundby, Alicia (Oxford University Press, 2024-05)
    Aims: In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect ...
  • Left Ventricle Myocardial Work Correlated with Functional Capacity in Severe Rheumatic Mitral Stenosis with Preserved Left Ventricular Ejection Fraction 
    Rudiktyo, Estu; Cramer, Maarten J.; Yonas, Emir; Teske, Arco J.; Siswanto, Bambang Budi; Doevendans, Pieter A.; Soesanto, Amiliana M. (Wolters Kluwer Medknow Publications, 2024-04)
    Background and Aims: Functional capacity is reduced in mitral stenosis (MS) patients. Previous studies showed a correlation between left atrial strain and functional capacity in this population. However, currently, no left ...
  • Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours 
    Seiboldt, Till; Zeiser, Constantia; Nguyen, Duy; Celikyürekli, Simay; Herter, Sonja; Najafi, Sara; Stroh-Dege, Alexandra; Meulenbroeks, Chris; Mack, Norman; Salem-Altintas, Rabia; Westermann, Frank; Schlesner, Matthias; Milde, Till; Kool, Marcel; Holland-Letz, Tim; Vogler, Meike; Peterziel, Heike; Witt, Olaf; Oehme, Ina (2024)
    Background: Certain paediatric nervous system malignancies have dismal prognoses. Retinoic acid (RA) is used in neuroblastoma treatment, and preclinical data indicate potential benefit in selected paediatric brain tumour ...
  • Author Correction: Respiratory syncytial virus infection and novel interventions (Nature Reviews Microbiology, (2023), 21, 11, (734-749), 10.1038/s41579-023-00919-w) 
    Langedijk, Annefleur C.; Bont, Louis J. (Nature Publishing Group, 2024-09)
    In the version of this article initially published, there were typographical errors in the third paragraph of the “Preventive strategies” section, where in the text now reading “A single spontaneous mutation in the ...
  • The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes 
    Füllbrunn, Nadia; Nicastro, Raffaele; Mari, Muriel; Griffith, Janice; Herrmann, Eric; Rasche, René; Borchers, Ann Christin; Auffarth, Kathrin; Kümmel, Daniel; Reggiori, Fulvio; De Virgilio, Claudio; Langemeyer, Lars; Ungermann, Christian (Rockefeller University Press, 2024-06-03)
    Organelles of the endomembrane system contain Rab GTPases as identity markers. Their localization is determined by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). It remains largely unclear ...
  • Clinical effects of cannabis compared to synthetic cannabinoid receptor agonists (SCRAs): a retrospective cohort study of presentations with acute toxicity to European hospitals between 2013 and 2020 
    Waters, Mitchell L.; Dargan, Paul I.; Yates, Christopher; Dines, Alison M.; Eyer, Florian; Giraudon, Isabelle; Heyerdahl, Fridtjof; Hovda, Knut Erik; Liechti, Matthias E.; Miró, Òscar; Vallersnes, Odd Martin; Anseeuw, Kurt; Badaras, Robertas; Bitel, Marcin; Bonnici, Jeffrey; Brvar, Miran; Caganova, Blazena; Calýskan, Feriyde; Ceschi, Alessandro; Chamoun, Karam; Daveloose, Laurence; Galicia, Miguel; Gartner, Birgit; Gorozia, Ketevan; Grenc, Damjan; Gresnigt, Femke M.J.; Hondebrink, Laura; Jürgens, Gesche; Konstari, Jutta; Kutubidze, Soso; Laubner, Gabija; Liakoni, Evangelia; Liguts, Viesturs; Lyphout, Cathelijne; McKenna, Roy; Mégarbane, Bruno; Moughty, Adrian; Nitescu, Gabriela Viorela; Noseda, Roberta; O'Connor, Niall; Paasma, Raido; Ortega Perez, Juan; Perminas, Marius; Persett, Per Sverre; Põld, Kristiina; Puchon, Erik; Puiguriguer, Jordi; Radenkova-Saeva, Julia; Rulisek, Jan; Samer, Caroline; Schmid, Yasmin; Scholz, Irene; Stašinskis, Roberts; Surkus, Jonas; Van den Hengel-Koot, Irma; Vigorita, Federico; Vogt, Severin; Waldman, Wojciech; Waring, William Stephen; Zacharov, Sergej; Zellner, Tobias; Wood, David M. (Informa Healthcare, 2024)
    Introduction: Cannabis is the most common recreational drug worldwide and synthetic cannabinoid receptor agonists are currently the largest group of new psychoactive substances. The aim of this study was to compare the ...
  • Risk assessment tools for bleeding in patients with unprovoked venous thromboembolism: an analysis of the PLATO-VTE study 
    Guman, Noori A.M.; Becking, Anne Marie L.; Weijers, Suzanne S.; Kraaijpoel, Noémie; Mulder, Frits I.; Carrier, Marc; Jara-Palomares, Luis; Di Nisio, Marcello; Ageno, Walter; Beyer-Westendorf, Jan; Klok, Frederikus A.; Vanassche, Thomas; Otten, Johannes M.M.B.; Cosmi, Benilde; Peters, Mike J.L.; Wolde, Marije ten; Delluc, Aurélien; Sanchez-Lopez, Veronica; Porreca, Ettore; Bossuyt, Patrick M.M.; Gerdes, Victor E.A.; Büller, Harry R.; van Es, Nick; Kamphuisen, Pieter W. (Wiley-Blackwell, 2024-09)
    Background: Guidelines suggest indefinite anticoagulation after unprovoked venous thromboembolism (VTE) unless the bleeding risk is high, yet there is no consistent guidance on assessing bleeding risk. Objectives: This ...
  • Prevalence and 3-month follow-up of cerebrovascular MRI markers in hospitalized COVID-19 patients: the CORONIS study 
    van Lith, Theresa J.; Sluis, Wouter M.; Wijers, Naomi T.; Meijer, Frederick J.A.; Ulzen, Karin Kamphuis van; de Bresser, Jeroen; Dankbaar, Jan Willem; de Mast, Quirijn; Klok, Frederikus A.; Cannegieter, Suzanne C.; Wermer, Marieke J.H.; Huisman, Menno V.; Tuladhar, Anil M.; van der Worp, H. Bart; de Leeuw, Frank Erik (Springer-Verlag, 2024-09)
    Purpose: To investigate the prevalence of cerebrovascular MRI markers in unselected patients hospitalized for COVID-19 (Coronavirus disease 2019), we compared these with healthy controls without previous SARS-CoV-2 infection ...
  • Practical Management of the JAK1 Inhibitor Abrocitinib for Atopic Dermatitis in Clinical Practice: Special Safety Considerations 
    Gooderham, Melinda J.; de Bruin-Weller, Marjolein; Weidinger, Stephan; Cork, Michael J.; Eichenfield, Lawrence F.; Simpson, Eric L.; Tsianakas, Athanasios; Kerkmann, Urs; Feeney, Claire; Romero, William (Springer-Verlag, 2024)
    Abrocitinib, an oral, once-daily, Janus kinase (JAK) 1-selective inhibitor, is approved for the treatment of adults and adolescents with moderate-to-severe atopic dermatitis (AD). Abrocitinib has shown rapid and sustained ...
  • Object Tracking Based on Optical Flow Reconstruction of Motion-Group Parameters 
    Karpuzov, Simeon; Petkov, George; Ilieva, Sylvia; Petkov, Alexander; Kalitzin, Stiliyan (Multidisciplinary Digital Publishing Institute (MDPI), 2024-06)
    Rationale. Object tracking has significance in many applications ranging from control of unmanned vehicles to autonomous monitoring of specific situations and events, especially when providing safety for patients with ...