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Now showing items 17481-17500 of 40729

Long-term follow-up and treatment outcomes of conjunctivitis during dupilumab treatment in patients with moderate-to-severe atopic dermatitis

Achten, Roselie; Bakker, Daphne; Ariens, Lieneke; Lans, Amanda; Thijs, Judith; van der Schaft, Jorien; de Boer, Joke; Balak, Deepak; de Graaf, Marlies; van Luijk, Chantal; de Bruin-Weller, Marjolein (2021-03)
Long-Term Survival After Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Nationwide Propensity-Score Matched Analysis

Dutch Upper Gastrointestinal Cancer Audit group (Lippincott Williams & Wilkins, 2022-12-01)

Objectives: This study aimed to compare long-term survival following MIE versus OE for esophageal cancer using a nationwide propensity-score matched cohort. Summary of Background Data: MIE provides lower postoperative ...
State of the art in esophagectomy: robotic assistance in the abdominal phase

de Groot, Eline M; Goense, Lucas; Ruurda, Jelle P; van Hillegersberg, Richard (Springer Verlag Italia, 2021-06)

Over the years, robot-assisted esophagectomy gained popularity. The current literature focused mainly on robotic assistance in the thoracic phase, whereas the implementation of robotic assistance in the abdominal phase is ...
Survival outcomes of patients with advanced melanoma from 2013 to 2017: Results of a nationwide population-based registry

van Zeijl, M. C.T.; de Wreede, L. C.; van den Eertwegh, A. J.M.; Wouters, M. W.J.M.; Jochems, A.; Schouwenburg, M. G.; Aarts, M. J.B.; van Akkooi, A. C.J.; van den Berkmortel, F. W.P.J.; de Groot, J. W.B.; Hospers, G. A.P.; Kapiteijn, E.; Piersma, D.; van Rijn, R. S.; Suijkerbuijk, K. P.M.; ten Tije, A. J.; van der Veldt, A. A.M.; Vreugdenhil, G.; van der Hoeven, J. J.M.; Haanen, J. B.A.G. (Elsevier Limited, 2021-02)

Background: The treatment landscape has completely changed for advanced melanoma. We report survival outcomes and the differential impact of prognostic factors over time in daily clinical practice. Methods: From a Dutch ...
Cardiac complications in patients hospitalised with COVID-19

Linschoten, Marijke; CAPACITY-COVID collaborative consortium (24150509, 2020-12)

AIMS: To determine the frequency and pattern of cardiac complications in patients hospitalised with coronavirus disease (COVID-19). METHODS AND RESULTS: CAPACITY-COVID is an international patient registry established to ...
Clinical Features and Natural History of PRKAG2 Variant Cardiac Glycogenosis

Lopez-Sainz, Angela; Dominguez, Fernando; Lopes, Luis Rocha; Ochoa, Juan Pablo; Barriales-Villa, Roberto; Climent, Vicente; Linschoten, Marijke; Tiron, Coloma; Chiriatti, Chiara; Marques, Nuno; Rasmussen, Torsten B; Espinosa, María Ángeles; Beinart, Roy; Quarta, Giovanni; Cesar, Sergi; Field, Ella; Garcia-Pinilla, Jose M; Bilinska, Zofia; Muir, Alison R; Roberts, Angharad M; Santas, Enrique; Zorio, Esther; Peña-Peña, Maria Luisa; Navarro, Marina; Fernandez, Adrian; Palomino-Doza, Julian; Azevedo, Olga; Lorenzini, Massimiliano; García-Álvarez, Maria I; Bento, Dina; Jensen, Morten K; Méndez, Irene; Pezzoli, Laura; Sarquella-Brugada, Georgia; Campuzano, Oscar; Gonzalez-Lopez, Esther; Mogensen, Jens; Kaski, Juan Pablo; Arad, Michael; Brugada, Ramon; Asselbergs, Folkert W; Monserrat, Lorenzo; Olivotto, Iacopo; Elliott, Perry M; Garcia-Pavia, Pablo; European Genetic Cardiomyopathies Initiative Investigators (Elsevier, 2020-07-14)

BACKGROUND: PRKAG2 gene variants cause a syndrome characterized by cardiomyopathy, conduction disease, and ventricular pre-excitation. Only a small number of cases have been reported to date, and the natural history of the ...
Hermes

Nievelstein, Rutger A.J. (Springer-Verlag, 2020-11-01)
Classification of end-of-life decisions by Dutch physicians: findings from a cross-sectional survey

Overbeek, Anouk; van de Wetering, Veerle E; van Delden, Johannes J M; Mevis, Paul A M; Onwuteaka-Philipsen, Bregje D; Postma, Liselotte; Rietjens, Judith A C; van der Heide, Agnes (AME Publishing Company, 2021-03)

BACKGROUND: At the end of patients' lives, physicians sometimes provide medication with the explicit intention to hasten death. Physicians' assessment of such acts varies. We studied which characteristics are associated ...
Ethics and the marketing authorization of pharmaceuticals: what happens to ethical issues discovered post-trial and pre-marketing authorization?

Bernabe, Rosemarie D L C; van Thiel, Ghislaine J M W; Breekveldt, Nancy S; Gispen, Christine C; van Delden, Johannes J M (BioMed Central, 2020-12-01)

BACKGROUND: In the EU, clinical assessors, rapporteurs and the Committee for Medicinal Products for Human Use are obliged to assess the ethical aspects of a clinical development program and include major ethical flaws in ...
Health-related quality of life and symptoms of conservative care versus dialysis in patients with end-stage kidney disease: a systematic review

Verberne, Wouter R; van den Wittenboer, Iris D; Voorend, Carlijn G N; Abrahams, Alferso C; van Buren, Marjolijn; Dekker, Friedo W; van Jaarsveld, Brigit C; van Loon, Ismay N; Mooijaart, Simon P; Ocak, Gurbey; van Delden, Johannes J M; Bos, Willem Jan W (Oxford University Press, 2021-08-01)

BACKGROUND: Non-dialytic conservative care (CC) has been proposed as a viable alternative to maintenance dialysis for selected older patients to treat end-stage kidney disease (ESKD). This systematic review compares both ...
Integrating public health programs and research after the malaria vaccine implementation program (MVIP): Recommendations for next steps

van der Graaf, Rieke; Macklin, Ruth; Rid, Annette; Bhan, Anant; Gefenas, Eugenijus; Greco, Dirceu; Haerry, David; Hurst, Samia; London, Alex John; Saracci, Rodolfo; Sprumont, Dominique; van Delden, Johannes J.M. (Elsevier, 2020-10-21)

Background: In February 2020, international controversy arose about the ethical acceptability of the WHO Malaria Vaccine Implementation Program (MVIP). Whereas some have argued that this program must be seen as research ...
Physicians' and Public Attitudes Toward Euthanasia in People with Advanced Dementia

Brinkman-Stoppelenburg, Arianne; Evenblij, Kirsten; Pasman, H Roeline W; van Delden, Johannes J M; Onwuteaka-Philipsen, Bregje D; van der Heide, Agnes (Wiley-Blackwell, 2020-10)

BACKGROUND/OBJECTIVES: To explore the opinion of the Dutch general public and of physicians regarding euthanasia in patients with advanced dementia. DESIGN: A cross-sectional survey. SETTING: The Netherlands. PARTICIPANTS: ...
Framework to Support the Process of Decision-Making on Life-Sustaining Treatments in the ICU: Results of a Delphi Study

Kerckhoffs, Monika C.; Senekal, Jannien; Van Dijk, Diederik; Artigas, Antonio; Butler, Jenie; Michalsen, Andrej; Van Mol, Margo M.C.; Moreno, Rui; Pais Da Silva, Filipa; Picetti, Edoardo; Póvoa, Pedro; Robertsen, Annette; Van Delden, Johannes J.M. (Lippincott Williams & Wilkins, 2020-05)

Objectives: To develop a consensus framework that can guide the process of decision-making on continuing or limiting life-sustaining treatments in ICU patients, using evidence-based items, supported by caregivers, patients, ...
Ethical and research governance approval across Europe: Experiences from three European palliative care studies

Preston, Nancy; van Delden, Johannes J.M.; Ingravallo, Francesca; Hughes, Sean; Hasselaar, Jeroen; van der Heide, Agnes; Van den Block, Lieve; Dunleavy, Lesley; Groot, Marieke; Csikos, Agnes; Payne, Sheila (SAGE Publications Ltd, 2020-06-01)

Background: Research requires high-quality ethical and governance scrutiny and approval. However, when research is conducted across different countries, this can cause challenges due to the differing ethico-legal framework ...
Some Unresolved Ethical Challenges in Healthcare Decision-Making: Navigating Family Involvement

Menon, Sumytra; Entwistle, Vikki A.; Campbell, Alastair V.; van Delden, Johannes J.M. (National University of Singapore, Department of Biological Sciences, Centre for Biomedical Ethics, 2020-03-01)

Family involvement in healthcare decision-making for competent patients occurs to varying degrees in many communities around the world. There are different attitudes about who should make treatment decisions, how and why. ...
Real-Time Access to Electronic Health Record via a Patient Portal in a Tertiary Hospital: Is it Harmful? A Retrospective Mixed Methods Observational Study: Is it harmful? A retrospective observational study

van Kuppenveld, Savannah I. R.; van Os-Medendorp, Harmieke; Tiemessen, Nicole A. M.; van Delden, Johannes J. M. (Journal of medical Internet Research, 2020-02-11)

Background: The rapid implementation of patient portals, through which patients can view their electronic health record, creates possibilities for information exchange and communication between patients and health care ...
Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation

Berkers, Gitte; van der Meer, Renske; van Mourik, Peter; Vonk, Annelotte M; Kruisselbrink, Evelien; Suen, Sylvia Wf; Heijerman, Harry Gm; Majoor, Christof J; Koppelman, Gerard H; Roukema, Jolt; Janssens, Hettie M; de Rijke, Yolanda B; Kemper, E Marleen; Beekman, Jeffrey M; van der Ent, Cornelis K; de Jonge, Hugo R (Elsevier, 2020-11)

BACKGROUND: The natural food supplements curcumin and genistein, and the drug ivacaftor were found effective as CFTR potentiators in the organoids of individuals carrying a S1251N gating mutation, possibly in a synergistic ...
How should the 'privilege' in therapeutic privilege be conceived when considering the decision-making process for patients with borderline capacity?

Menon, Sumytra; Entwistle, Vikki; Campbell, Alastair Vincent; Van Delden, Johannes J.M. (BMJ Publishing Group, 2021-01-01)

Therapeutic privilege (TP) is a defence that may be available to doctors who fail to disclose to the patient relevant information when seeking informed consent for treatment if they have a reasonable belief that providing ...
Effectiveness of pulmonary rehabilitation at high-altitude compared to sea-level in adults with severe refractory asthma

de Nijs, S B; Krop, E J M; Portengen, L; Rijssenbeek-Nouwens, L H; de Vries, D; Weersink, E J M; Heijerman, H G M; Heederik, D J J; Lammers, J W J (W.B. Saunders Ltd, 2020-09)

Background: Beneficial effects of pulmonary rehabilitation at high-altitude (HAPR) in patients with severe refractory asthma have been reported earlier, but evidence for the effectiveness is limited. Aim: To investigate ...
Lumacaftor/ivacaftor in people with cystic fibrosis with an A455E-CFTR mutation

Berkers, Gitte; van der Meer, Renske; Heijerman, Harry; Beekman, Jeffrey M; Boj, Sylvia F; Vries, Robert G J; van Mourik, Peter; Doyle, Jamie R; Audhya, Paul; Yuan, Zheng Jason; Kinnman, Nils; van der Ent, C Kors (Elsevier, 2021-09)

BACKGROUND: Previous in vitro organoid data showed A455E-CFTR, a rare CFTR mutation with 4.1% prevalence in the Netherlands, responds to lumacaftor/ivacaftor (LUM/IVA). We explored LUM/IVA's clinical efficacy in people ...

Now showing items 17481-17500 of 40729