Cardiac complications in patients hospitalised with COVID-19
Linschoten, Marijke; CAPACITY-COVID collaborative consortium
(2020) European Heart Journal. Acute Cardiovascular Care, volume 9, issue 8, pp. 817 - 823
(Article)
Abstract
AIMS: To determine the frequency and pattern of cardiac complications in patients hospitalised with coronavirus disease (COVID-19). METHODS AND RESULTS: CAPACITY-COVID is an international patient registry established to determine the role of cardiovascular disease in the COVID-19 pandemic. In this registry, data generated during routine clinical practice are collected in
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a standardised manner for patients with a (highly suspected) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requiring hospitalisation. For the current analysis, consecutive patients with laboratory confirmed COVID-19 registered between 28 March and 3 July 2020 were included. Patients were followed for the occurrence of cardiac complications and pulmonary embolism from admission to discharge. In total, 3011 patients were included, of which 1890 (62.8%) were men. The median age was 67 years (interquartile range 56-76); 937 (31.0%) patients had a history of cardiac disease, with pre-existent coronary artery disease being most common (n=463, 15.4%). During hospitalisation, 595 (19.8%) patients died, including 16 patients (2.7%) with cardiac causes. Cardiac complications were diagnosed in 349 (11.6%) patients, with atrial fibrillation (n=142, 4.7%) being most common. The incidence of other cardiac complications was 1.8% for heart failure (n=55), 0.5% for acute coronary syndrome (n=15), 0.5% for ventricular arrhythmia (n=14), 0.1% for bacterial endocarditis (n=4) and myocarditis (n=3), respectively, and 0.03% for pericarditis (n=1). Pulmonary embolism was diagnosed in 198 (6.6%) patients. CONCLUSION: This large study among 3011 hospitalised patients with COVID-19 shows that the incidence of cardiac complications during hospital admission is low, despite a frequent history of cardiovascular disease. Long-term cardiac outcomes and the role of pre-existing cardiovascular disease in COVID-19 outcome warrants further investigation.
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Keywords: Acute Coronary Syndrome/epidemiology, Aged, Atrial Fibrillation/epidemiology, COVID-19, COVID-19/complications, Coronary Artery Disease/epidemiology, Endocarditis, Bacterial/epidemiology, Female, Heart Diseases/epidemiology, Heart Failure/epidemiology, Hospitalization/trends, Humans, Incidence, Male, Middle Aged, Myocarditis/epidemiology, Outcome Assessment, Health Care, Pericarditis/epidemiology, Pulmonary Embolism/epidemiology, Registries, SARS-CoV-2/genetics, cardiac complications, cohorts, coronavirus, patient registry, pulmonary embolism, Journal Article
ISSN: 2048-8726
Publisher: SAGE Publications Ltd
Note: Publisher Copyright: © The European Society of Cardiology 2020.
(Peer reviewed)