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UMC Repository: Recent submissions

  • Interventional respiratory motion compensation by simultaneous fluoroscopic and nuclear imaging: a phantom study 
    Dietze, Martijn M A; Kunnen, Britt; Lam, Marnix G E H; de Jong, Hugo W A M (IOP Publishing Ltd., 2021-03-21)
    Purpose A compact and mobile hybrid c-arm scanner, capable of simultaneously acquiring nuclear and fluoroscopic projections and SPECT/CBCT, was developed to aid fluoroscopy-guided interventional procedures involving the ...
  • Exploring label dynamics of velocity-selective arterial spin labeling in the kidney 
    Bones, Isabell K; Franklin, Suzanne L; Harteveld, Anita A; van Osch, Matthias J P; Schmid, Sophie; Hendrikse, Jeroen; Moonen, Chrit; van Stralen, Marijn; Bos, Clemens (John Wiley & Sons Inc., 2021-07)
    PURPOSE: Velocity-selective arterial spin labeling (VSASL) has been proposed for renal perfusion imaging to mitigate planning challenges and effects of arterial transit time (ATT) uncertainties. In VSASL, label generation ...
  • CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [Ga-68]Ga-Pentixafor/[Lu-177]Lu-Pentixather 
    Jacobs, Sarah M; Wesseling, Pieter; de Keizer, Bart; Tolboom, Nelleke; Ververs, F F Tessa; Krijger, Gerard C; Westerman, Bart A; Snijders, Tom J; Robe, Pierre A; van der Kolk, Anja G (Springer-Verlag, 2022-01)
    PURPOSE: CXCR4 (over)expression is found in multiple human cancer types, while expression is low or absent in healthy tissue. In glioblastoma it is associated with a poor prognosis and more extensive infiltrative phenotype. ...
  • Isoprostanes as Biomarker for White Matter Injury in Extremely Preterm Infants 
    Coviello, Caterina; Perrone, Serafina; Buonocore, Giuseppe; Negro, Simona; Longini, Mariangela; Dani, Carlo; de Vries, Linda S; Groenendaal, Floris; Vijlbrief, Daniel C; Benders, Manon J N L; Tataranno, Maria Luisa (Frontiers Media S. A., 2021-01-15)
    Background and Aim: Preterm white matter is vulnerable to lipid peroxidation-mediated injury. F2-isoprostanes (IPs), are a useful biomarker for lipid peroxidation. Aim was to assess the association between early peri-postnatal ...
  • A roadmap for optimizing chronic kidney disease patient care and patient-oriented research in the Eastern European nephrology community 
    Sever, Mehmet Şükrü; Jager, Kitty J; Vanholder, Raymond; Stengel, Benedicte; Harambat, Jerome; Finne, Patrik; Tesař, Vladimir; Barbullushi, Myftar; Bumblytė, Inga A; Zakharova, Elena; Spasovski, Goce; Resic, Halima; Wiecek, Andrzej; Blankestijn, Peter J; Bruchfeld, Annette; Cozzolino, Mario; Goumenos, Dimitris; Soler, Maria Jose; Rychlík, Ivan; Stevens, Kate I; Wanner, Christoph; Zoccali, Carmine; Massy, Ziad A (Oxford University Press, 2021-01)
    Chronic kidney disease (CKD) is a major health problem because of its high prevalence, associated complications and high treatment costs. Several aspects of CKD differ significantly in the Eastern European nephrology ...
  • Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death 
    Verstraelen, Tom E; van Barreveld, Marit; van Dessel, Pascal H F M; Boersma, Lucas V A; Delnoy, Peter-Paul P H M; Tuinenburg, Anton E; Theuns, Dominic A M J; van der Voort, Pepijn H; Kimman, Gerardus P; Buskens, Erik; Hulleman, Michiel; Allaart, Cornelis P; Strikwerda, Sipke; Scholten, Marcoen F; Meine, Mathias; Abels, René; Maass, Alexander H; Firouzi, Mehran; Widdershoven, Jos W M G; Elders, Jan; van Gent, Marco W F; Khan, Muchtiar; Vernooy, Kevin; Grauss, Robert W; Tukkie, Raymond; van Erven, Lieselot; Spierenburg, Han A M; Brouwer, Marc A; Bartels, Gerard L; Bijsterveld, Nick R; Borger van der Burg, Alida E; Vet, Mattheus W; Derksen, Richard; Knops, Reinoud E; Bracke, Frank A L E; Harden, Markus; Sticherling, Christian; Willems, Rik; Friede, Tim; Zabel, Markus; Dijkgraaf, Marcel G W; Zwinderman, Aeilko H; Wilde, Arthur A M (Oxford University Press, 2021-06-07)
    AIMS: This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock and mortality to identify subgroups with insufficient benefit from ICD ...
  • Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic 
    van den Berg, Annette I S; Yun, Chae-Ok; Schiffelers, Raymond M; Hennink, Wim E (Elsevier, 2021-03-10)
    Gene therapy using nucleic acids has many clinical applications for the treatment of diseases with a genetic origin as well as for the development of innovative vaccine formulations. Since nucleic acids in their free form ...
  • Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles 
    Murphy, Daniel E; de Jong, Olivier G; Evers, Martijn J W; Nurazizah, Maratussholikhah; Schiffelers, Raymond M; Vader, Pieter (American Chemical Society, 2021-02-24)
    RNA therapeutics have high potential that is yet to be fully realized, largely due to challenges involved in the appropriate delivery to target cells. Extracellular vesicles (EVs) are lipid bound nanoparticles released by ...
  • Reactie op ‘Methylfenidaat en het risico op een psychose’ 
    Lancee, M; Maat, A; van Veelen, N; Roder, C H; Schellekens, A F A; Batalla, A (Uitgeverij Boom, 2021)
  • The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes 
    Davydova, Erna; Shimazu, Tadahiro; Schuhmacher, Maren Kirstin; Jakobsson, Magnus E; Willemen, Hanneke L D M; Liu, Tongri; Moen, Anders; Ho, Angela Y Y; Małecki, Jędrzej; Schroer, Lisa; Pinto, Rita; Suzuki, Takehiro; Grønsberg, Ida A; Sohtome, Yoshihiro; Akakabe, Mai; Weirich, Sara; Kikuchi, Masaki; Olsen, Jesper V; Dohmae, Naoshi; Umehara, Takashi; Sodeoka, Mikiko; Siino, Valentina; McDonough, Michael A; Eijkelkamp, Niels; Schofield, Christopher J; Jeltsch, Albert; Shinkai, Yoichi; Falnes, Pål Ø (Nature Publishing Group, 2021-02-09)
    Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five ...
  • Within-family influences on dimensional neurobehavioral traits in a high-risk genetic model 
    Fiksinski, Ania M; Heung, Tracy; Corral, Maria; Breetvelt, Elemi J; Costain, Gregory; Marshall, Christian R; Kahn, Rene S; Vorstman, Jacob A S; Bassett, Anne S (Cambridge University Press, 2022-10-14)
    Background Genotype-first and within-family studies can elucidate factors that contribute to psychiatric illness. Combining these approaches, we investigated the patterns of influence of parental scores, a high-impact ...
  • Prognostic and Predictive Value of Integrated Qualitative and Quantitative Magnetic Resonance Imaging Analysis in Glioblastoma 
    Verduin, Maikel; Primakov, Sergey; Compter, Inge; Woodruff, Henry C; van Kuijk, Sander M J; Ramaekers, Bram L T; Te Dorsthorst, Maarten Te; Revenich, Elles G M; Ter Laan, Mark Ter; Pegge, Sjoert A H; Meijer, Frederick J A; Beckervordersandforth, Jan; Speel, Ernst Jan; Kusters, Benno; de Leng, Wendy W J; Anten, Monique M; Broen, Martijn P G; Ackermans, Linda; Schijns, Olaf E M G; Teernstra, Onno; Hovinga, Koos; Vooijs, Marc A; Tjan-Heijnen, Vivianne C G; Eekers, Danielle B P; Postma, Alida A; Lambin, Philippe; Hoeben, Ann (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-02)
    Glioblastoma (GBM) is the most malignant primary brain tumor for which no curative treatment options exist. Non-invasive qualitative (Visually Accessible Rembrandt Images (VASARI)) and quantitative (radiomics) imaging ...
  • Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder 
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Springer Nature, 2021-09)
    Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic) sequences ...
  • Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years 
    Karolinska Schizophrenia Project (KaSP) (Wiley-Liss Inc., 2022-01)
    Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce ...
  • Focal therapy compared to radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched study 
    Shah, Taimur T; Reddy, Deepika; Peters, Max; Ball, Daniel; Kim, Na Hyun; Gomez, Enrique Gomez; Miah, Saiful; Evans, David Eldred; Guillaumier, Stephanie; van Rossum, Peter S N; Van Son, Marieke J; Hosking-Jervis, Feargus; Dudderidge, Tim; Hindley, Richard; Emara, Amr; McCracken, Stuart; Greene, Damian; Nigam, Raj; McCartan, Neil; Valerio, Massimo; Minhas, Suks; Afzal, Naveed; Lewi, Henry; Ogden, Chris; Persad, Raj; Virdi, Jaspal; Moore, Caroline M; Arya, Manit; Emberton, Mark; Ahmed, Hashim U; Winkler, Mathias (Springer Nature, 2021-06)
    Introduction: Focal therapy (FT) ablates areas of prostate cancer rather than treating the whole gland. We compared oncological outcomes of FT to radical prostatectomy (RP). Methods: Using prospective multicentre databases ...
  • Stauffer's syndrome: A true entity? 
    van Roekel, C; Slot, A S Bruins; Viddeleer, A C; van Erpecum, K J; Lock, M T W T (Elsevier Masson, 2021-01)
  • Inferior Outcome of Addition of the Aminopeptidase Inhibitor Tosedostat to Standard Intensive Treatment for Elderly Patients with AML and High Risk MDS 
    Janssen, Jeroen; Löwenberg, Bob; Manz, Markus; Bargetzi, Mario; Biemond, Bart; Borne, Peter von dem; Breems, Dimitri; Brouwer, Rolf; Chalandon, Yves; Deeren, Dries; Efthymiou, Anna; Gjertsen, Bjørn-Tore; Graux, Carlos; Gregor, Michael; Heim, Dominik; Hess, Urs; Hoogendoorn, Mels; Jaspers, Aurelie; Jie, Asiong; Jongen-Lavrencic, Mojca; Klein, Saskia; Klift, Marjolein van der; Kuball, Jürgen; Lammeren-Venema, Danielle van; Legdeur, Marie-Cecile; Loosdrecht, Arjan van de; Maertens, Johan; Kooy, Marinus van Marwijk; Moors, Ine; Nijziel, Marten; Obbergh, Florence van; Oosterveld, Margriet; Pabst, Thomas; Poel, Marjolein van der; Sinnige, Harm; Spertini, Olivier; Terpstra, Wim; Tick, Lidwine; Velden, Walter van der; Vekemans, Marie-Christiane; Vellenga, Edo; Weerdt, Okke de; Westerweel, Peter; Stüssi, Georg; Norden, Yvette van; Ossenkoppele, Gert (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-02)
    Treatment results of AML in elderly patients are unsatisfactory. We hypothesized that addition of tosedostat, an aminopeptidase inhibitor, to intensive chemotherapy may improve outcome in this population. After establishing ...
  • A directional 3D neurite outgrowth model for studying motor axon biology and disease 
    Spijkers, Xandor M.; Pasteuning-Vuhman, Svetlana; Dorleijn, Jennifa C.; Vulto, Paul; Wevers, Nienke R.; Pasterkamp, R. Jeroen (Nature Publishing Group, 2021-01-22)
    We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their ...
  • Therapeutic inertia in the management of hypertension in primary care 
    Ali, Dalia H; Kiliç, Birsen; Hart, Huberta E; Bots, Michiel L; Biermans, Marion C J; Spiering, Wilko; Rutten, Frans H; Hollander, Monika (Lippincott Williams & Wilkins, 2021-06-01)
    BACKGROUND: Therapeutic inertia is considered to be an obstacle to effective blood pressure (BP) control. AIMS: To identify patient characteristics associated with therapeutic inertia in patients with hypertension managed ...
  • SENS-U: continuous home monitoring of natural nocturnal bladder filling in children with nocturnal enuresis - a feasibility study 
    Kwinten, W M J; van Leuteren, P G; van Duren-van Iersel, M; Dik, P; Jira, P E (Elsevier, 2020-04)
    Introduction: Enuresis is a common problem in children. One treatment option is a wetting alarm that provides an alarm when incontinence occurs. A drawback of this approach is that the child is still awakened by wet sheets. ...