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Now showing items 16501-16520 of 40729

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Hackeng, Wenzel M; Brosens, Lodewijk A A; Kim, Joo Young; O'Sullivan, Roderick; Sung, You-Na; Liu, Ta-Chiang; Cao, Dengfeng; Heayn, Michelle; Brosnan-Cashman, Jacqueline; An, Soyeon; Morsink, Folkert H M; Heidsma, Charlotte M; Valk, Gerlof D; Vriens, Menno R; Nieveen van Dijkum, Els; Offerhaus, G Johan A; Dreijerink, Koen M A; Zeh, Herbert; Zureikat, Amer H; Hogg, Melissa; Lee, Kenneth; Geller, David; Marsh, J Wallis; Paniccia, Alessandro; Ongchin, Melanie; Pingpank, James F; Bahary, Nathan; Aijazi, Muaz; Brand, Randall; Chennat, Jennifer; Das, Rohit; Fasanella, Kenneth E; Khalid, Asif; McGrath, Kevin; Sarkaria, Savreet; Singh, Harkirat; Slivka, Adam; Nalesnik, Michael; Han, Xiaoli; Nikiforova, Marina N; Lawlor, Rita Teresa; Mafficini, Andrea; Rusev, Boris; Corbo, Vincenzo; Luchini, Claudio; Bersani, Samantha; Pea, Antonio; Cingarlini, Sara; Landoni, Luca; Salvia, Roberto; Milione, Massimo; Milella, Michele; Scarpa, Aldo; Hong, Seung-Mo; Heaphy, Christopher M; Singhi, Aatur D (BMJ Publishing Group, 2022-05)

Objective: Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative ...
Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled Trials: A Pooled Analysis of Randomised Controlled Trials

Carotid Stenosis Trialists’ Collaboration (W.B. Saunders Ltd, 2021-06)

OBJECTIVE: Current guidelines recommending rapid revascularisation of symptomatic carotid stenosis are largely based on data from clinical trials performed at a time when best medical therapy was potentially less effective ...
ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

Venema, Wouter J; Hiddingh, Sanne; de Boer, Joke H; Claas, Frans H J; Mulder, Arend; den Hollander, Anneke I; Stratikos, Efstratios; Sarkizova, Siranush; van der Veken, Lars T; Janssen, George M C; van Veelen, Peter A; Kuiper, Jonas J W (Frontiers Media S. A., 2021-02-25)

Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation ...
Systematic analysis of short tandem repeats in 38,095 exomes provides an additional diagnostic yield

van der Sanden, Bart P G H; Corominas, Jordi; de Groot, Michelle; Pennings, Maartje; Meijer, Rowdy P P; Verbeek, Nienke; van de Warrenburg, Bart; Schouten, Meyke; Yntema, Helger G; Vissers, Lisenka E L M; Kamsteeg, Erik-Jan; Gilissen, Christian (Lippincott Williams & Wilkins, 2021-08)

PURPOSE: Expansions of a subset of short tandem repeats (STRs) have been implicated in approximately 30 different human genetic disorders. Despite extensive application of exome sequencing (ES) in routine diagnostic genetic ...
Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

Wensink, G Emerens; Elias, Sjoerd G; Mullenders, Jasper; Koopman, Miriam; Boj, Sylvia F; Kranenburg, Onno W; Roodhart, Jeanine M L (Springer Nature, 2021-04-12)

Effective predictive biomarkers are needed to enable personalized medicine and increase treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and treatment costs. Patient-derived organoids ...
Temporal trends in heart failure medication prescription in a population-based cohort study

Uijl, Alicia; Vaartjes, Ilonca; Denaxas, S; Hemingway, Harry; Shah, Anoop; Cleland, J; Grobbee, Diederick; Hoes, Arno; Asselbergs, Folkert W; Koudstaal, Stefan (BMJ Publishing Group, 2021-03-02)

OBJECTIVE: We examined temporal heart failure (HF) prescription patterns in a large representative sample of real-world patients in the UK, using electronic health records (EHR). METHODS: From primary and secondary care ...
Identification of Distinct Phenotypic Clusters in Heart Failure with Preserved Ejection Fraction

Uijl, Alicia; Savarese, Gianluigi; Vaartjes, Ilonca; Dahlström, Ulf; Brugts, Jasper J; Linssen, Gerard Cm; van Empel, Vanessa; Rocca, Hans-Peter Brunner-La; Asselbergs, Folkert W; Lund, Lars H; Hoes, Arno W; Koudstaal, Stefan (Oxford University Press, 2021-06)

Aims: We aimed to derive and validate clinically useful clusters of patients with heart failure with preserved ejection fraction (HFpEF; left ventricular ejection fraction ≥50%). Methods and results: We derived a cluster ...
Internal-external cross-validation helped to evaluate the generalizability of prediction models in large clustered datasets

Takada, Toshihiko; Nijman, Steven; Denaxas, Spiros; Snell, Kym I E; Uijl, Alicia; Nguyen, Tri-Long; Asselbergs, Folkert W; Debray, Thomas P A (Elsevier, 2021-09)

OBJECTIVE: To illustrate how to evaluate the need of complex strategies for developing generalizable prediction models in large clustered datasets. STUDY DESIGN AND SETTING: We developed eight Cox regression models to ...
Treatment patterns and primary reasons for adjusted treatment in older and younger patients with stage II or III colorectal cancer

Scheepers, E. R.M.; Schiphorst, A. H.; van Huis-Tanja, L. H.; Emmelot-Vonk, M. H.; Hamaker, M. E. (W.B. Saunders Ltd, 2021-07)

Objective: This study aims to assess age-related treatment patterns and primary reasons for adjusted treatment in patients with colorectal cancer. Methods: Patients with colorectal cancer stage II or III diagnosed between ...
Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications

Lo Presti, Vania; Cornel, Annelisa M.; Plantinga, Maud; Dünnebach, Ester; Kuball, Jurgen; Boelens, Jaap Jan; Nierkens, Stefan; van Til, Niek P. (Cell Press, 2021-06-11)

Adoptive T cell therapy utilizing tumor-specific autologous T cells has shown promising results for cancer treatment. However, the limited numbers of autologous tumor-associated antigen (TAA)-specific T cells and the ...
High discordance rate in assessing sentinel node positivity in cutaneous melanoma: Expert review may reduce unjustified adjuvant treatment

El Sharouni, Mary Ann; Laeijendecker, Annelien E.; Suijkerbuijk, Karijn PM; Witkamp, Arjen J.; Sigurdsson, Vigfús; van Diest, Paul J.; van Gils, Carla H.; Blokx, Willeke AM (Elsevier Limited, 2021-05)

Introduction: Identification of sentinel node (SN) metastases can set the adjuvant systemic therapy indication for patients with stage III melanoma. Studies re-evaluating the diagnosis of initially positive SN biopsies are ...
Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Turan, Ayla S; Moons, Leon M G; Schreuder, Ramon-Michel; Schoon, Erik J; Terhaar Sive Droste, Jochim S; Schrauwen, Ruud W M; Straathof, Jan Willem; Bastiaansen, Barbara A J; Schwartz, Matthijs P; Hazen, Wouter L; Alkhalaf, Alaa; Allajar, Daud; Hadithi, Muhammed; van der Spek, Bas W; Heine, Dimitri G D N; Tan, Adriaan C I T L; de Graaf, Wilmar; Boonstra, Jurjen J; Voogd, Fia J; Roomer, Robert; de Ridder, Rogier J J; Kievit, Wietske; Siersema, Peter D; Didden, Paul; van Geenen, Erwin J M; Dutch EMR Study Group (BioMed Central, 2021-01-18)

Background: Endoscopic mucosal resection (EMR) for large colorectal polyps is in most cases the preferred treatment to prevent progression to colorectal carcinoma. The most common complication after EMR is delayed bleeding, ...
Diagnostic yield of colonoscopy surveillance in testicular cancer survivors treated with platinum-based chemotherapy: study protocol of a prospective cross-sectional cohort study

Ykema, Berbel L.M.; Bisseling, Tanya M.; Spaander, Manon C.W.; Moons, Leon M.G.; van der Biessen-van Beek, Dorien; Saveur, Lisette; Kerst, Martijn; Mulder, Sasja F.; de Wit, Ronald; Zweers, Danielle; Meijer, Gerrit A.; Beijnen, Jos H.; Lansdorp-Vogelaar, Iris; van Leeuwen, Flora E.; Snaebjornsson, Petur; van Leerdam, Monique E. (BioMed Central, 2021-02-12)

BACKGROUND: Testicular cancer (TC) survivors have an increased risk of various second primary malignancies. A recent cohort study detected an increased risk of colorectal cancer (CRC) in TC survivors treated with platinum-based ...
Compliance with mismatch repair testing in pT1 colorectal cancer diagnosed before the age of 70 years

Ykema, Berbel L M; Nagtegaal, Iris D; Kuhlmann, Koert; van Berkel, Annemarie M; van Leerdam, Monique E; Dutch T1 CRC Working Group (Springer-Verlag, 2021-09)

Mismatch repair (MMR) testing is recommended in the Netherlands for all patients under 70 years of age with newly diagnosed colorectal cancer (CRC) in order to identify Lynch syndrome. T1 CRC can be removed by local excision ...
A Simplified Decision Rule to Rule Out Deep Vein Thrombosis Using Clinical Assessment And D-dimer

Xu, Keying; de Wit, Kerstin; Geersing, Geert-Jan; Takada, Toshihiko; Schutgens, Roger; Elf, Johan; Kearon, Clive; Parpia, Sameer (Wiley-Blackwell, 2021-07)

Background: Current clinical decision rules to exclude deep vein thrombosis (DVT) are underused partly because of their complexity. A simplified rule that can be easily applied would be more appealing to use in clinical ...
Challenges in biomarker research in haemophilic arthropathy

van Bergen, Eline D.P.; Mastbergen, Simon C.; Lafeber, Floris P.J.G.; Schutgens, Roger E.G.; van Vulpen, Lize F.D. (Wiley-Blackwell, 2021-07)
ESTRO-ACROP recommendations on the clinical implementation of hybrid MR-linac systems in radiation oncology

Corradini, Stefanie; Alongi, Filippo; Andratschke, Nicolaus; Azria, David; Bohoudi, Omar; Boldrini, Luca; Bruynzeel, Anna; Hörner-Rieber, Juliane; Jürgenliemk-Schulz, Ina; Lagerwaard, Frank; McNair, Helen; Raaymakers, Bas; Schytte, Tine; Tree, Alison; Valentini, Vincenzo; Wilke, Lotte; Zips, Daniel; Belka, Claus (Elsevier Ireland Ltd, 2021-06)

Online magnetic resonance-guided radiotherapy (oMRgRT) represents one of the most innovative applications of current image-guided radiation therapy (IGRT). The revolutionary concept of oMRgRT systems is the ability to ...
Comparison of different diagnostic approaches in the management of the clinically negative neck in early oral cancer patients

de Bree, Remco; de Keizer, Bart (John Wiley & Sons Inc., 2021-06-15)
Advances in radiotherapy technology for pediatric cancer patients and roles of medical physicists: COG and SIOP Europe perspectives

Hua, Chia-Ho; Mascia, Anthony E; Seravalli, Enrica; Lomax, Antony J; Seiersen, Klaus; Ulin, Kenneth (Wiley-Liss Inc., 2021-05)

Over the last two decades, rapid technological advances have dramatically changed radiation delivery to children with cancer, enabling improved normal-tissue sparing. This article describes recent advances in photon and ...
Circular Modelling of Circumplex Measurements for Interpersonal Behavior

Cremers, Jolien; Pennings, Helena J.M.; Mainhard, Tim; Klugkist, Irene (SAGE Publications Inc., 2021-03)

This article describes a new way to analyze data from the interpersonal circumplex (IPC) for interpersonal behavior. Instead of analyzing Agency and Communion separately or analyzing the IPC’s octants, we propose using a ...

Now showing items 16501-16520 of 40729