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UMC Repository: Recent submissions

  • Social Defeat, Psychotic Symptoms, and Crime in Young Caribbean Immigrants to Rotterdam 
    Vinkers, David J; Van de Vorst, Micha; Hoek, Hans W; Van Os, Jim (Frontiers Research Foundation, 2021-04-07)
    Background: The negative experience of being excluded from the majority group (social defeat) may be associated with psychosis in immigrants. The social defeat hypothesis is supported by the high frequency of perceived ...
  • A rare cause of small bowel thickening 
    Hirdes, M; de Gier, S; Brosens, L A A (W.B. Saunders, 2021-12)
  • Baclofen and naltrexone, but not N-acetylcysteine, affect voluntary alcohol drinking in rats regardless of individual levels of alcohol intake 
    Minnaard, A Maryse; Ramakers, Geert M J; Vanderschuren, Louk J M J; Lesscher, Heidi M B (Lippincott Williams & Wilkins, 2021-04-01)
    In humans, there is profound individual variation in the risk of alcohol use disorder (AUD). Because GABA, opioid and glutamate neurotransmission have been implicated in AUD, functional differences in these neural systems ...
  • A Uremic Goat Model Created by Subtotal Renal Artery Embolization and Gentamicin 
    van Gelder, Maaike K; de Vries, Joost C; Ahmed, Sabbir; Monninkhof, Anneke S; de Kort, Gérard A P; Vonken, Evert-Jan P A; Hazenbrink, Diënty H M; Vaessen, Koen R D; Nguyen, Tri Q; Verhaar, Marianne C; Joles, Jaap A; Gerritsen, Karin G F (MDPI Multidisciplinary Digital Publishing Institute, 2021-04-03)
    A large animal model of (end-stage) kidney disease (ESKD) is needed for the preclinical testing of novel renal replacement therapies. This study aimed to create stable uremia via subtotal renal artery embolization in goats ...
  • International Forum on Transfusion Practices in Haematopoietic Stem-Cell Transplantation: Summary 
    Solves, Pilar; Lozano, Miquel; Zhiburt, Eugene; Anguita Velasco, Javier; Maria Pérez-Corral, Ana; Monsalvo-Saornil, Silvia; Yamazaki, Sho; Okazaki, Hitoshi; Selleng, Kathleen; Aurich, Konstanze; Krüger, William; Buser, Andreas; Holbro, Andreas; Infanti, Laura; Stehle, Gregor; Pierelli, Luca; Matteocci, Antonella; Rigacci, Luigi; De Vooght, Karen M.K.; Kuball, Jurgen H.E.; Fielding, Katherine L.; Westerman, David A.; Wood, Erica M.; Cohn, Claudia S.; Johnson, Andrew; Koh, Mickey B.C.; Qadir, Dara; Cserti-Gazdewich, Christine; Daguindau, Etienne; Angelot-Delettre, Fanny; Tiberghien, Pierre; Wendel-Neto, Silvano; Fachini, Roberta Maria; Morton, Suzy; Craddock, Charles; Lumley, Matthew; Antoniewicz-Papis, Jolanta; Hałaburda, Kazimierz; Łętowska, Magdalena; Dunbar, Nancy (Wiley-Blackwell, 2021-05)
  • Individual and Group Response of Treatment with Ivacaftor on Airway and Gut Microbiota in People with CF and a S1251N Mutation 
    Kristensen, Maartje I; de Winter-de Groot, Karin M; Berkers, Gitte; Chu, Mei Ling J N; Arp, Kayleigh; Ghijsen, Sophie; Heijerman, Harry G M; Arets, Hubertus G M; Majoor, Christof J; Janssens, Hettie M; van der Meer, Renske; Bogaert, Debby; van der Ent, Cornelis K (MDPI Multidisciplinary Digital Publishing Institute, 2021-05)
    Ivacaftor has been shown to restore the functionality of the S1251N (also known as c.3752G>A) mutated CFTR, which may cause alterations in both airway and gut physiology and micro-environment, resulting in a change of ...
  • Early life involvement in C9orf72 repeat expansion carriers 
    Gossink, Flora; Dols, Annemiek; Stek, Max L; Scheltens, Philip; Nijmeijer, Bas; Cohn Hokke, Petra; Dijkstra, Anke; Van Ruisssen, Fred; Aalfs, Cora; Pijnenburg, Yolande A L (BMJ Publishing Group, 2022-01)
    OBJECTIVES: The chromosome 9 open reading frame 72 gene (C9orf72) hexanucleotide repeat expansion (C9orf72RE) is the most common genetic cause of behavioural variant frontotemporal dementia (bvFTD). Since the onset of the ...
  • New Insights in Adherence and Survival in Myotonic Dystrophy Patients Using Home Mechanical Ventilation 
    Seijger, Charlotte; Raaphorst, Joost; Vonk, Judith; van Engelen, Baziel; Heijerman, Harry; Stigter, Nadine; Wijkstra, Peter (S. Karger AG, 2021-02)
    BACKGROUND: Non-invasive home mechanical ventilation (HMV) is a complex treatment in myotonic dystrophy type 1 (DM1) patients, due to a presumed poor adherence, variable symptom improvement, and uncertainty regarding ...
  • Mortality of Older Patients Admitted to an ICU: A Systematic Review 
    Vallet, Helene; Schwarz, Gabriele Leonie; Flaatten, Hans; de Lange, Dylan W; Guidet, Bertrand; Dechartres, Agnes (Lippincott Williams & Wilkins, 2021-02)
    OBJECTIVES: To conduct a systematic review of mortality and factors independently associated with mortality in older patients admitted to ICU. DATA SOURCES: MEDLINE via PubMed, EMBASE, the Cochrane Library, and references ...
  • Is secondary chemical exposure of hospital personnel of clinical importance? 
    De Groot, Ronald; Van Zoelen, Gerard A; Leenders, Marianne E C; Van Riel, Antoinette J H P; De Vries, Irma; De Lange, Dylan W (Informa Healthcare, 2021-04)
    INTRODUCTION: There is increasing concern among hospital personnel about potential secondary exposure when treating chemically contaminated patients. OBJECTIVE: To assess which circumstances and chemicals require the use ...
  • Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study 
    VIP2 study group (Springer-Verlag GmbH and Co. KG, 2021-02-03)
    PURPOSE: Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments developed ...
  • Biomarker-Guided Individualization of Antibiotic Therapy 
    Aulin, Linda B S; de Lange, Dylan W; Saleh, Mohammed A A; van der Graaf, Piet H; Völler, Swantje; van Hasselt, J G Coen (Wiley-Blackwell, 2021-08)
    Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a major clinical challenge, and is expected to become even more urgent with the global rise of antibiotic resistance. ...
  • Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients 
    Wernly, Bernhard; Bruno, Raphael Romano; Frutos-Vivar, Fernando; Peñuelas, Oscar; Rezar, Richard; Raymondos, Konstantinos; Muriel, Alfonso; Du, Bin; Thille, Arnaud W; Ríos, Fernando; González, Marco; Del-Sorbo, Lorenzo; Marín, Maria Del Carmen; Pinheiro, Bruno Valle; Soares, Marco Antonio; Nin, Nicolas; Maggiore, Salvatore M; Bersten, Andrew; Kelm, Malte; Amin, Pravin; Cakar, Nahit; Young Suh, Gee; Abroug, Fekri; Jibaja, Manuel; Matamis, Dimitros; Zeggwagh, Amine Ali; Sutherasan, Yuda; Guidet, Bertrand; De Lange, Dylan W; Beil, Michael; Svri, Sigal; van Heerden, Vernon; Flaatten, Hans; Anzueto, Antonio; Osmani, Venet; Esteban, Andrés; Jung, Christian (American Association for Respiratory Care, 2021-05-01)
    BACKGROUND: The growing proportion of elderly intensive care patients constitutes a public health challenge. The benefit of critical care in these patients remains unclear. We compared outcomes in elderly versus very elderly ...
  • Performance of Existing Definitions and Tests for the Diagnosis of Invasive Fungal Diseases other than Invasive Candidiasis and Invasive Aspergillosis in Critically Ill, Adult Patients: A Systematic Review with Qualitative Evidence Synthesis 
    The Fundicu Investigators (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-28)
    The Fungal Infections Definitions in Intensive Care Unit (ICU) patients (FUNDICU) project aims to provide standard sets of definitions for invasive fungal diseases (IFDs) in critically ill, adult patients, including invasive ...
  • The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study 
    COVIP study group (Springer Science + Business Media, 2021-04-19)
    Background: The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in ...
  • Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs 
    VIP2 study group (Oxford University Press, 2021-09-11)
    Background: Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function ...
  • An International Consensus List of Potentially Clinically Significant Drug-Drug Interactions in Older People 
    Anrys, P; Petit, A-E; Thevelin, S; Sallevelt, B; Drenth, C; Soiza, R L; Correa-Pérez, A; Dalleur, O; De Brauwer, I; Petrovic, M; Coleman, J J; Dalton, K; O'Mahony, D; Löwe, A; Thürig, S; Gudmundsson, A; Cherubini, A; Panos, A; Mavridis, D; Rodondi, N; Spinewine, Anne (Elsevier, 2021-10)
    OBJECTIVES: We aimed to establish an explicit list of potentially clinically significant drug-drug interactions (DDIs) in people aged ≥65 years. DESIGN: A preliminary list of potentially clinically significant DDIs was ...
  • Preschool Social Participation, the Impact of Early Life Stress and Parental Health 
    Doove, B. M.; Schiffelers, B. A.A.H.; Lukkien, C.; van Os, J.; Feron, F. J.M.; Drukker, M. (Taylor and Francis Ltd., 2022-10-02)
    In this article, the association between parental and professional caregivers’ perceptions of early life stress (ELS) and the level of preschool social participation was examined, as was the possible moderating effect of ...
  • The need for gentamicin adjunctive to cefuroxime as empirical sepsis therapy: a local protocol evaluation 
    de Vries Schultink, Aurelia H M; Sallevelt, Bastiaan T G M; Meinders, Arend Jan; van de Garde, Ewoudt M W; Roescher, Nienke (Elsevier, 2021-09)
  • Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation 
    van der Welle, Reini E N; Jobling, Rebekah; Burns, Christian; Sanza, Paolo; van der Beek, Jan A; Fasano, Alfonso; Chen, Lan; Zwartkruis, Fried J; Zwakenberg, Susan; Griffin, Edward F; Ten Brink, Corlinda; Veenendaal, Tineke; Liv, Nalan; van Ravenswaaij-Arts, Conny M A; Lemmink, Henny H; Pfundt, Rolph; Blaser, Susan; Sepulveda, Carolina; Lozano, Andres M; Yoon, Grace; Santiago-Sim, Teresa; Asensio, Cedric S; Caldwell, Guy A; Caldwell, Kim A; Chitayat, David; Klumperman, Judith (Springer Science and Business Media Deutschland GmbH, 2021-05-07)
    Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein Sorting (HOPS) complex required for lysosomal fusion events and, independent of HOPS, for regulated secretion. Here, we report three patients ...