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UMC Repository: Recent submissions

  • A novel undergraduate biomedical laboratory course concept in synergy with ongoing faculty research 
    Schot, Willemijn D.; Hegeman, Maria A.; ten Broeke, Toine; Valentijn, Floris A.; Meijerman, Irma; Prins, Frans J.; Dictus, Wim J. A. G.; Bovenschen, Niels (Wiley-Blackwell, 2021-09-01)
    Optimal integration of education and ongoing faculty research in many undergraduate science programs is limited to the capstone project. Here, we aimed to develop a novel course-based undergraduate research experience ...
  • Direct and Indirect Costs of Influenza-Like Illness Treated with and Without Oseltamivir in 15 European Countries: A Descriptive Analysis Alongside the Randomised Controlled ALIC4E Trial 
    Li, Xiao; Bilcke, Joke; van der Velden, Alike W.; Bongard, Emily; Bruyndonckx, Robin; Sundvall, Pär Daniel; Harbin, Nicolay J.; Coenen, Samuel; Francis, Nick; Bruno, Pascale; Garcia-Sangenis, Ana; Glinz, Dominik; Kosiek, Katarzyna; Mikó-Pauer, Réka; Radzeviciene Jurgute, Ruta; Seifert, Bohumil; Tsakountakis, Nikolaos; Aabenhus, Rune; Butler, Christopher C.; Beutels, Philippe (Adis International Ltd, 2021-08)
    Background and Objective: Influenza-like illness (ILI) leads to a substantial disease burden every winter in Europe; however, oseltamivir is not frequently prescribed to ILI patients in the primary-care setting. An open-label, ...
  • Parents' experiences of VOICE: A novel support programme in the NICU 
    van den Hoogen, Agnes; Eijsermans, Rian; Ockhuijsen, Henriette D.L.; Jenken, Floor; Oude Maatman, Sabine M.; Jongmans, Marian J.; Verhage, Lianne; van der Net, Janjaap; Latour, Jos M. (Wiley-Blackwell, 2021-05)
    BACKGROUND: Admission of an infant to a neonatal intensive care unit (NICU) is often a stressful experience for parents and can be associated with feelings of inadequacy to fulfil the desirable parental role. The values, ...
  • Metabolic fingerprint in hereditary spherocytosis correlates with red blood cell characteristics and clinical severity 
    Van Dooijeweert, Birgit; Broeks, Melissa H.; Verhoeven-Duif, Nanda M.; Van Solinge, Wouter W.; Van Beers, Eduard J.; Rab, Minke A.E.; Nieuwenhuis, Edward E.S.; Jans, Judith J.M.; Bartels, Marije; Van Wijk, Richard (Wolters Kluwer Health, 2021-07)
  • First-time fathers’ experiences and needs during childbirth: A systematic review 
    van Vulpen, Maartje; Heideveld-Gerritsen, Mariëlle; van Dillen, Jeroen; Oude Maatman, Sabine; Ockhuijsen, Henrietta; van den Hoogen, Agnes (Churchill Livingstone, 2021-03)
    Objective: Fathers have been increasingly involved in childbirth since 1990. Attendance at childbirth is considered to benefit fathers’ health as well as that of their partner and children. However, childbirth is a life ...
  • Maternity care experiences of women with physical disabilities: A systematic review 
    Heideveld-Gerritsen, Mariëlle; van Vulpen, Maartje; Hollander, Martine; Oude Maatman, Sabine; Ockhuijsen, Henrietta; van den Hoogen, Agnes (Churchill Livingstone, 2021-05)
    Objective: Fifteen percent of the world's population has some form of disability, the most common form being a physical disability. Ten percent of women with disabilities are of childbearing age; however, because women ...
  • Age at Menopause and Risk of Ischemic and Hemorrhagic Stroke 
    Welten, Sabrina J. G. C.; Onland-Moret, N. Charlotte; Boer, Jolanda M. A.; Verschuren, W. M. Monique; van der Schouw, Yvonne T. (Lippincott Williams & Wilkins, 2021-08)
    Background and Purpose: The few epidemiological studies that addressed the association between age at menopause and ischemic and hemorrhagic stroke risk in women had conflicting findings. We aimed to investigate whether ...
  • The Needs of Dutch Women During Decision-Making About Treatment for Miscarriage 
    Bussink-Legters, Anja G.; den Hoogen, Agnes van; Veersema, Sebastiaan; Meijer, Wouter J.; Ockhuijsen, Henrietta D.L. (Elsevier, 2021-07)
    Objective: To explore the needs of women during decision-making about treatment for miscarriage. Design: Descriptive qualitative design. Settings: University and teaching hospitals in the Netherlands. Participants: We ...
  • Primary care for patients with respiratory tract infection before and early on in the COVID-19 pandemic: an observational study in 16 European countries 
    van der Velden, Alike W; Bax, Eva A; Bongard, Emily; Munck Aabenhus, Rune; Anastasaki, Marilena; Anthierens, Sibyl; Balan, Anca; Böhmer, Femke; Bruno, Pascale; Chlabicz, Slawomir; Coenen, Samuel; Colliers, Annelies; Emmerich, Susanne; Garcia-Sangenis, Ana; Ghazaryan, Hrachuhi; van der Linde, Sanne R; Malania, Lile; Pauer, József; Tomacinschii, Angela; Tonkin-Crine, Sarah; Vellinga, Akke; Zastavnyy, Ihor; Verheij, Theo; Goossens, Herman; Butler, Christopher C (BMJ Publishing Group, 2021-07-29)
    OBJECTIVE: To describe primary health care (consultation characteristics and management) for patients contacting their general practitioner (GP) with a respiratory tract infection (RTI) early on in the COVID-19 pandemic ...
  • Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes-1 negatively regulates human neutrophils 
    Rumpret, Matevž; von Richthofen, Helen J.; van der Linden, Maarten; Westerlaken, Geertje H.A.; Talavera Ormeño, Cami; Low, Teck Y.; Ovaa, Huib; Meyaard, Linde (Wiley-VCH Verlag, 2021-09)
    Signal inhibitory receptor on leukocytes-1 (SIRL-1) is an inhibitory receptor with a hitherto unknown ligand, and is expressed on human monocytes and neutrophils. SIRL-1 inhibits myeloid effector functions such as reactive ...
  • Diagnostic accuracy of rapid antigen tests in asymptomatic and presymptomatic close contacts of individuals with confirmed SARS-CoV-2 infection: cross sectional study 
    Schuit, Ewoud; Veldhuijzen, Irene K; Venekamp, Roderick P; van den Bijllaardt, Wouter; Pas, Suzan D; Lodder, Esther B; Molenkamp, Richard; GeurtsvanKessel, Corine H; Velzing, Jans; Huisman, Robin C; Brouwer, Lieke; Boelsums, Timo L; Sips, Gregorius J; Benschop, Kimberly S M; Hooft, Lotty; van de Wijgert, Janneke H H M; van den Hof, Susan; Moons, Karel G M (BMJ Publishing Group, 2021-07-27)
    AbstractObjective To assess the diagnostic test accuracy of two rapid antigen tests in asymptomatic and presymptomatic close contacts of people with SARS-CoV-2 infection on day 5 after exposure. Design Prospective cross ...
  • Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study 
    van Dijk, Wobke E M; Nijdam, Jelle S; Haitjema, Saskia; de Groot, Mark C H; Huisman, Albert; Punt, Marieke C; Evers, Annemiek C C; Schutgens, Roger E G; Lely, A Titia; van Galen, Karin P M (Wiley-Blackwell, 2021-11)
    Background: Severe postpartum hemorrhage (SPPH) is the leading cause of maternal mortality and morbidity worldwide. Platelet anomalies frequently occur during pregnancy. However, their role in the etiology of SPPH is largely ...
  • Patterns of Care, Tolerability, and Safety of the First Cohort of Patients Treated on a Novel High-Field MR-Linac Within the MOMENTUM Study: Initial Results From a Prospective Multi-Institutional Registry 
    MR-linac Consortium (Elsevier, 2021-11-15)
    Purpose: High-field magnetic resonance-linear accelerators (MR-Linacs), linear accelerators combined with a diagnostic magnetic resonance imaging (MRI) scanner and online adaptive workflow, potentially give rise to novel ...
  • Planning target volume margin assessment for online adaptive MR-guided dose-escalation in rectal cancer on a 1.5 T MR-Linac 
    Eijkelenkamp, Hidde; Boekhoff, Mick R; Verweij, Maaike E; Peters, Femke P; Meijer, Gert J; Intven, Martijn P W (Elsevier Ireland Ltd, 2021-09)
    PURPOSE: This study assessed the margins needed to cover tumor intrafraction motion during an MR-guided radiotherapy (MRgRT) dose-escalation strategy in intermediate risk rectal cancer. METHODS: Fifteen patients with rectal ...
  • Progression-free survival in patients with Ga-68-PSMA-PET-directed SBRT for lymph node oligometastases 
    Werensteijn-Honingh, Anita M; Wevers, Anne F J; Peters, Max; Kroon, Petra S; Intven, Martijn; Eppinga, Wietse S C; Jürgenliemk-Schulz, Ina M (Informa Healthcare, 2021-10)
    BACKGROUND: Prostate cancer oligometastatic disease can be treated using stereotactic body radiotherapy (SBRT) in order to postpone start of systemic treatments such as androgen deprivation therapy (ADT). 68Ga-PSMA-PET/CT ...
  • Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1 
    Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L.N.; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B.; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D.; Chotard, Guillaume; Bjergvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N.; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M.; Reuss, David E.; Wick, Wolfgang; von Deimling, Andreas; Jones, David T.W.; Sahm, Felix (Springer, 2021-07-01)
    Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ...
  • Physical therapy in patients with systemic sclerosis: physical therapists’ perspectives on current delivery and educational needs 
    Liem, S. I.E.; van Leeuwen, N. M.; Vliet Vlieland, T. P.M.; Boerrigter, G. M.W.; van den Ende, C. H.M.; de Pundert, L. A.J.; Schriemer, M. R.; Spierings, J.; Vonk, M. C.; de Vries-Bouwstra, J. K. (Informa Healthcare, 2022-09-03)
    Objective: To assess the perspectives of physical therapists treating patients with systemic sclerosis (SSc) on their current practice and educational needs. Method: In July 2019, 405 SSc patients attending a multidisciplinary ...
  • Initiating Pancreatic Neuroendocrine Tumor (pNET) Screening in Young MEN1 Patients: results from the DutchMEN Study Group 
    Klein Haneveld, Mirthe J; van Treijen, Mark J C; Pieterman, Carolina R C; Dekkers, Olaf M; van de Ven, Annenienke; de Herder, Wouter W; Zandee, Wouter T; Drent, Madeleine L; Bisschop, Peter H; Havekes, Bas; Vriens, Menno R; Verrijn Stuart, Annemarie A; Valk, Gerlof D; van Leeuwaarde, Rachel S (Endocrine Society, 2021-12-01)
    CONTEXT: Nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) are highly prevalent and constitute an important cause of mortality in patients with multiple endocrine neoplasia type 1 (MEN1). Still, the optimal age ...
  • A blood-based polyamine signature associated with MEN1 duodenopancreatic neuroendocrine tumor progression 
    Fahrmann, Johannes F; Wasylishen, Amanda R; Pieterman, Carolina R C; Irajizad, Ehsan; Vykoukal, Jody; Murage, Eunice; Wu, Ranran; Dennison, Jennifer B; Krishna, Hansini; Peterson, Christine B; Lozano, Guillermina; Zhao, Hua; Do, Kim-Anh; Halperin, Daniel M; Agarwal, Sunita K; Blau, Jenny E; Del Rivero, Jaydira; Nilubol, Naris; Walter, Mary F; Welch, James M; Weinstein, Lee S; Vriens, Menno R; van Leeuwaarde, Rachel S; van Treijen, Mark J C; Valk, Gerlof D; Perrier, Nancy D; Hanash, Samir M (Endocrine Society, 2021-12-01)
    Context: Duodenopancreatic neuroendocrine tumors (dpNETs) frequently occur in patients with multiple endocrine neoplasia type 1 (MEN1), and metastatic dpNET is the primary cause of disease-related mortality. There is a ...
  • Retrospective analyses of 18FDG-PET/CT thyroid incidentaloma in adults: incidence, treatment and outcome in a tertiary cancer referral center 
    Piek, Marceline W; de Boer, Jan Paul; Vriens, Menno R; van Leeuwaarde, Rachel S; Stokkel, Marcel; Hartemink, Koen J; van Duijnhoven, Frederieke; Kessels, Rob; van der Ploeg, Iris M C (Mary Ann Liebert Inc., 2021-11-10)
    Background: A thyroid incidentaloma (TI) is an unexpected, asymptomatic thyroid lesion discovered during the investigation of an unrelated condition. The aim of the present study is to examine the incidence of 18Fluorodeoxyglucose ...