Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 15841-15860 of 40729

Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial

van Moort, Iris; Preijers, Tim; Bukkems, Laura H.; Hazendonk, Hendrika C.A.M.; van der Bom, Johanna G.; Laros-van Gorkom, Britta A.P.; Beckers, Erik E.A.M.; Nieuwenhuizen, Laurens; van der Meer, Felix J.M.; Ypma, Paula; Coppens, Michiel; Fijnvandraat, Karin; Schutgens, Roger E.G.; Meijer, Karina; Leebeek, Frank W.G.; Mathôt, Ron A.A.; Cnossen, Marjon H.; “OPTI-CLOT” study group (Lancet Publishing Group, 2021-07)

Background: Dosing of replacement therapy with factor VIII concentrate in patients with haemophilia A in the perioperative setting is challenging. Underdosing and overdosing of factor VIII concentrate should be avoided to ...
Publisher Correction: Mutations and mechanisms of WNT pathway tumour suppressors in cancer

Bugter, Jeroen M.; Fenderico, Nicola; Maurice, Madelon M. (Nature Publishing Group, 2021-01)

Nature Reviews Cancer (2020) https://doi.org/10.1038/s41568-020-00307-z Published online 23 October 2020 Figure 3 of the article as originally published contained a graphic editing error, whereby the publisher’s redrawn ...
Organoid-based modeling of intestinal development, regeneration, and repair

Sprangers, Joep; Zaalberg, Irene C.; Maurice, Madelon M. (Springer Nature, 2021-01)

The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair. A key part of the regenerative response is the transient reprogramming of epithelial cells into a fetal-like state, which drives ...
Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group

van Houdt, Petra J.; Saeed, Hina; Thorwarth, Daniela; Fuller, Clifton D.; Hall, William A.; McDonald, Brigid A.; Shukla-Dave, Amita; Kooreman, Ernst S.; Philippens, Marielle E.P.; van Lier, Astrid L.H.M.W.; Keesman, Rick; Mahmood, Faisal; Coolens, Catherine; Stanescu, Teodor; Wang, Jihong; Tyagi, Neelam; Wetscherek, Andreas; van der Heide, Uulke A. (Elsevier Limited, 2021-08)

Quantitative imaging biomarkers (QIBs) derived from MRI techniques have the potential to be used for the personalised treatment of cancer patients. However, large-scale data are missing to validate their added value in ...
Geometrical imaging accuracy, image quality and plan quality for prostate cancer treatments on a 1.5 T MRLinac in patients with a unilateral hip implant

van Lier, Astrid L H M W; Meijers, Lieke T C; Philippens, Marielle E P; Hes, Jochem; Raaymakers, Bas W; van der Voort van Zyp, Jochem R N; de Boer, J C J (IOP Publishing Ltd., 2021-10-21)

Purpose. To assess the feasibility of prostate cancer radiotherapy for patients with a hip implant on an 1.5 T MRI-Linac (MRL) in terms of geometrical image accuracy, image quality, and plan quality. Methods. Pretreatment ...
Governing Gene Drive Technologies: A Qualitative Interview Study

de Graeff, N.; Jongsma, Karin R.; Lunshof, Jeantine E.; Bredenoord, Annelien L. (Taylor and Francis Ltd., 2022)

Background: Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to ...
Phase II study of definitive chemoradiation for locally advanced squamous cell cancer of the vulva: An efficacy study

van Triest, Baukelien; Rasing, Marnix; van der Velden, Jacobus; de Hullu, Joanne; Witteveen, Petronella O.; Beukema, Jannet C.; van der Steen-Banasik, Elsbieta; Westerveld, Henrike; Snyers, An; Peters, Max; Creutzberg, Carien L.; Nout, Remi A.; Lutgens, Ludy; Jürgenliemk-Schulz, Ina (Academic Press Inc., 2021-10)

Objective: To evaluate feasibility of chemoradiation as alternative for extensive surgery in patients with locally advanced vulvar cancer and to report on locoregional control, toxicity and survival. Methods: In a multicenter, ...
Reducing fatigue in pediatric rheumatic conditions: a systematic review

Kant-Smits, K.; Van Brussel, M.; Nijhof, S.; Van der Net, J. (BioMed Central Ltd., 2021-07-08)

Background: Although fatigue is a prevalent distressing symptom in children and adolescents with Pediatric Rheumatic Conditions (PRCs), intervention studies designed for reducing fatigue in PRCs are limited. Aim: To ...
MR-Guided Radiotherapy for Rectal Cancer: Current Perspective on Organ Preservation

Boldrini, Luca; Intven, Martijn; Bassetti, Michael; Valentini, Vincenzo; Gani, Cihan (Frontiers Media S. A., 2021-03-30)

Online MRI-guided radiotherapy (MRgRT) is one of the most recent technological advances in radiotherapy. MRgRT permits the visualization of tumorous and healthy tissue while the patient is on the treatment table and online ...
The evaluation of follow-up strategies of watch-and-wait patients with a complete response after neoadjuvant therapy in rectal cancer

the Dutch Watch-and-Wait Consortium (Wiley-Blackwell, 2021-07)

Aim: Many of the current follow-up schedules in a watch-and-wait approach include very frequent MRI and endoscopy examinations to ensure early detection of local regrowth (LR). The aim of this study was to analyse the ...
Exploring Associations between Oral Health and Frailty in Community-Dwelling Older People

Everaars, B.; Jerković-Ćosić, K.; Bleijenberg, N.; de Wit, N. J.; van der Heijden, G. J.M.G. (Elsevier Masson, 2021-01)

BACKGROUND: In frail older people with natural teeth factors like polypharmacy, reduced salivary flow, a decrease of oral self-care, general healthcare issues, and a decrease in dental care utilization contribute to an ...
Implementation of an interprofessional collaboration in practice program: a feasibility study using social network analysis

Smit, Linda C.; Dikken, Jeroen; Moolenaar, Nienke M.; Schuurmans, Marieke J.; de Wit, Niek J.; Bleijenberg, Nienke (BioMed Central Ltd., 2021-01-06)

Background: Due to multimorbidity and geriatric problems, older people often require both psychosocial and medical care. Collaboration between medical and social professionals is a prerequisite to deliver high-quality care ...
Cost-effectiveness of a stepwise cardiometabolic disease prevention program: results of a randomized controlled trial in primary care

Stol, Daphne M.; Over, Eelco A.B.; Badenbroek, Ilse F.; Hollander, Monika; Nielen, Mark M.J.; Kraaijenhagen, Roderik A.; Schellevis, François G.; de Wit, Niek J.; de Wit, G. Ardine (BioMed Central Ltd., 2021-03-11)

Background: Cardiometabolic diseases (CMD) are the major cause of death worldwide and are associated with a lower quality of life and high healthcare costs. To prevent a further rise in CMD and related healthcare costs, ...
Impact of the COVID-19 pandemic on diagnosis, stage, and initial treatment of breast cancer in the Netherlands: a population-based study

the NABON COVID-19 Consortium and the COVID and Cancer-NL Consortium (BioMed Central Ltd., 2021-04-17)

BACKGROUND: The onset of the COVID-19 pandemic forced the Dutch national screening program to a halt and increased the burden on health care services, necessitating the introduction of specific breast cancer treatment ...
Artificial intelligence techniques that may be applied to primary care data to facilitate earlier diagnosis of cancer: Systematic review

Jones, Owain T.; Calanzani, Natalia; Saji, Smiji; Duffy, Stephen W.; Emery, Jon; Hamilton, Willie; Singh, Hardeep; de Wit, Niek J.; Walter, Fiona M. (Journal of medical Internet Research, 2021-03-03)

Background: More than 17 million people worldwide, including 360,000 people in the United Kingdom, were diagnosed with cancer in 2018. Cancer prognosis and disease burden are highly dependent on the disease stage at ...
Unwillingness to participate in health checks for cardiometabolic diseases: A survey among primary health care patients in five European countries

SPIMEU Project Group (John Wiley & Sons Inc., 2021-06)

Background and aims: Since cardiometabolic diseases (CMD) are a frequent cause of death worldwide, preventive strategies are needed. Recruiting adults for a health check could facilitate the identification of individuals ...
Clinical pharmacists in Dutch general practice: an integrated care model to provide optimal pharmaceutical care

Hazen, Ankie; Sloeserwij, Vivianne; Pouls, Bart; Leendertse, Anne; de Gier, Han; Bouvy, Marcel; de Wit, Niek; Zwart, Dorien (Springer Netherlands, 2021-10)

Background Medication-related harm is a major problem in healthcare. New models of integrated care are required to guarantee safe and efficient use of medication. Aim To prevent medication-related harm by integrating a ...
Toekomst voor programmatische cardiometabole preventie?

Stol, Daphne; Badenbroek, Ilse; Hollander, Monika; Nielen, Marcus; de Wit, Niek; Schellevis, François (Bohn Stafleu van Loghum, 2021-08)
Alternatieven voor het screenen van kwetsbare ouderen

Numans, Mattijs; de Wit, Niek (Bohn Stafleu van Loghum, 2021-08)
Therapeutic implications of improved molecular diagnostics for rare CNS-embryonal tumor entities: results of an international, retrospective study

von Hoff, Katja; Haberler, Christine; Schmitt-Hoffner, Felix; Schepke, Elizabeth; de Rojas, Teresa; Jacobs, Sandra; Zapotocky, Michal; Sumerauer, David; Perek-Polnik, Marta; Dufour, Christelle; van Vuurden, Dannis; Slavc, Irene; Gojo, Johannes; Pickles, Jessica C; Gerber, Nicolas U; Massimino, Maura; Gil-da-Costa, Maria Joao; Garami, Miklos; Kumirova, Ella; Sehested, Astrid; Scheie, David; Cruz, Ofelia; Moreno, Lucas; Cho, Jaeho; Zeller, Bernward; Bovenschen, Niels; Grotzer, Michael; Alderete, Daniel; Snuderl, Matija; Zheludkova, Olga; Golanov, Andrey; Okonechnikov, Konstantin; Mynarek, Martin; Juhnke, B Ole; Rutkowski, Stefan; Schüller, Ulrich; Pizer, Barry; Zezschwitz, Barbara V; Kwiecien, Robert; Wechsung, Maximilian; Konietschke, Frank; Hwang, Eugene I; Sturm, Dominik; Pfister, Stefan M; von Deimling, Andreas; Rushing, Elisabeth J; Ryzhova, Marina; Hauser, Peter; Łastowska, Maria; Wesseling, Pieter; Giangaspero, Felice; Hawkins, Cynthia; Figarella-Branger, Dominique; Eberhart, Charles; Burger, Peter; Gessi, Marco; Korshunov, Andrey; Jacques, Tom S; Capper, David; Pietsch, Torsten; Kool, Marcel (Oxford University Press, 2021-09-01)

Background: Only few data are available on treatment-associated behavior of distinct rare CNS embryonal tumor entities previously treated as "CNS-primitive neuroectodermal tumors"(CNS-PNET). Respective data on specific ...

Now showing items 15841-15860 of 40729