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UMC Repository: Recent submissions

  • Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies 
    van de Luitgaarden, Inge A.T.; van Oort, Sabine; Bouman, Emma J.; Schoonmade, Linda J.; Schrieks, Ilse C.; Grobbee, Diederick E.; van der Schouw, Yvonne T.; Larsson, Susanna C.; Burgess, Stephen; van Ballegooijen, Adriana J.; Onland-Moret, N. Charlotte; Beulens, Joline W.J. (Springer Netherlands, 2022-07)
    The causal effects of alcohol-in-moderation on cardiometabolic health are continuously debated. Mendelian randomization (MR) is an established method to address causal questions in observational studies. We performed a ...
  • Indices of callosal axonal density and radius from diffusion MRI relate to upper and lower limb motor performance 
    Gooijers, J.; De Luca, A.; Zivari Adab, H.; Leemans, A.; Roebroeck, A.; Swinnen, S. P. (Academic Press Inc., 2021-11-01)
    Understanding the relationship between human brain structure and functional outcome is of critical importance in systems neuroscience. Diffusion MRI (dMRI) studies show that fractional anisotropy (FA) is predictive of motor ...
  • Performance of knee image digital analysis of radiographs of patients with end-stage knee osteoarthritis 
    Jansen, M. P.; Welsing, P. M.J.; Vincken, K. L.; Mastbergen, S. C. (W.B. Saunders Ltd, 2021-11)
    Objective: Knee Image Digital Analysis (KIDA) is standardized radiographic analysis software for measuring osteoarthritis (OA) characteristics. It was validated in mild OA, but used for severe OA as well. The current goal ...
  • Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule 
    Hinrichs, Anneline C; Blokland, Sofie L M; Lopes, Ana P; Wichers, Catharina G K; Kruize, Aike A; Pandit, Aridaman; Radstake, Timothy R D J; van Roon, Joel A G (Frontiers Media S. A., 2021-07-27)
    Introduction: CCR9+ Tfh-like pathogenic T helper (Th) cells are elevated in patients with primary Sjögren's syndrome (pSS) and indicated to play a role in pSS immunopathology. Here we delineate the CCR9+ Th cell-specific ...
  • The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators 
    Lopes, Ana P; Bekker, Cornelis P J; Hillen, Maarten R; Blokland, Sofie L M; Hinrichs, Anneline C; Pandit, Aridaman; Kruize, Aike A; Radstake, Timothy R D J; van Roon, Joel A G (Frontiers Media S. A., 2021-08-03)
    Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by infiltration of the exocrine glands and prominent B cell hyperactivity. Considering the key role of monocytes in promoting B cell hyperactivity, ...
  • Predictive factors for vaccine failure to guide vaccination in allogeneic hematopoietic stem cell transplant recipients 
    Janssen, Michelle J.M.; Bruns, Anke H.W.; Verduyn Lunel, Frans M.; Raijmakers, Reinier A.P.; de Weijer, Roel J.; Nanlohy, Nening M.; Smits, Gaby P.; van Baarle, Debbie; Kuball, Jürgen (Springer Nature, 2021-12)
    Vaccination after hematopoietic stem cell transplantation (HSCT) is essential to protect high-risk patients against potentially lethal infections. Though multiple studies have evaluated vaccine specific responses, no ...
  • Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry 
    De Luca, Giuseppe; Debel, Niels; Cercek, Miha; Jensen, Lisette Okkels; Vavlukis, Marija; Calmac, Lucian; Johnson, Tom; Ferrer, Gerard Rourai; Ganyukov, Vladimir; Wojakowski, Wojtek; Kinnaird, Tim; von Birgelen, Clemens; Cottin, Yves; IJsselmuiden, Alexander; Tuccillo, Bernardo; Versaci, Francesco; Royaards, Kees Jan; Berg, Jurrien ten; Laine, Mika; Dirksen, Maurits; Siviglia, Massimo; Casella, Gianni; Kala, Petr; Díez Gil, José Luis; Banning, Adrian; Becerra, Victor; De Simone, Ciro; Santucci, Andrea; Carrillo, Xavier; Scoccia, Alessandra; Amoroso, Giovanni; van't Hof, Arnoud WJ; Kovarnik, Tomas; Tsigkas, Grigorios; Mehilli, Julinda; Gabrielli, Gabriele; Rios, Xacobe Flores; Bakraceski, Nikola; Levesque, Sébastien; Cirrincione, Giuseppe; Guiducci, Vincenzo; Kidawa, Michał; Spedicato, Leonardo; Marinucci, Lucia; Ludman, Peter; Zilio, Filippo; Galasso, Gennaro; Fabris, Enrico; Menichelli, Maurizio; Garcia-Touchard, Arturo; Manzo, Stephane; Caiazzo, Gianluca; Moreu, Jose; Forés, Juan Sanchis; Donazzan, Luca; Vignali, Luigi; Teles, Rui; Benit, Edouard; Agostoni, Pierfrancesco; Ojeda, Francisco Bosa; Lehtola, Heidi; Camacho-Freiere, Santiago; Kraaijeveld, Adriaan; Antti, Ylitalo; Boccalatte, Marco; Deharo, Pierre; Martínez-Luengas, Iñigo Lozano; Scheller, Bruno; Varytimiadi, Efthymia; Moreno, Raul; Uccello, Giuseppe; Faurie, Benjamin; Gutierrez Barrios, Alejandro; Milewski, Marek; Bruwiere, Ewout; Smits, Pieter; Wilbert, Bor; Di Uccio, Fortunato Scotto; Parodi, Guido; Kedhi, Elvin; Verdoia, Monica (Elsevier, 2021-09)
    Background and aims: SARS-Cov-2 predisposes patients to thrombotic complications, due to excessive inflammation, endothelial dysfunction, platelet activation, and coagulation/fibrinolysis disturbances. The aim of the present ...
  • Transformation of multicolour flow cytometry data with OTflow prevents misleading multivariate analysis results and incorrect immunological conclusions 
    Folcarelli, Rita; van Staveren, Selma; Tinnevelt, Gerjen; Cadot, Emily; Vrisekoop, Nienke; Buydens, Lutgarde; Koenderman, Leo; Jansen, Jeroen; van den Brink, Oscar F. (John Wiley & Sons Inc., 2022-01)
    The rapid evolution of the flow cytometry field, currently allowing the measurement of 30-50 parameters per cell, has led to a marked increase in deep multivariate information. Manual gating is insufficient to extract all ...
  • A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration 
    Daghrery, Arwa; Ferreira, Jessica A.; de Souza Araújo, Isaac J.; Clarkson, Brian H.; Eckert, George J.; Bhaduri, Sarit B.; Malda, Jos; Bottino, Marco C. (John Wiley & Sons Inc., 2021-11-03)
    Periodontitis is a chronic inflammatory, bacteria-triggered disorder affecting nearly half of American adults. Although some level of tissue regeneration is realized, its low success in complex cases demands superior ...
  • Impact of nationwide centralization of oesophageal, gastric, and pancreatic surgery on travel distance and experienced burden in the Netherlands 
    Luijten, J. C.H.B.M.; Nieuwenhuijzen, G. A.P.; Sosef, M. N.; de Hingh, I. H.J.T.; Rosman, C.; Ruurda, J. P.; van Duijvendijk, P.; Heisterkamp, J.; de Steur, W. O.; van Laarhoven, H. W.M.; Besselink, M. G.; Groot Koerkamp, B.; van Santvoort, H. C.; Lemmens, V. E.P.; Vissers, P. A.J. (W.B. Saunders Ltd, 2022-02)
    Background: This study aims to assess the impact of nationwide centralization of surgery on travel distance and travel burden among patients with oesophageal, gastric, and pancreatic cancer according to age in the Netherlands. ...
  • Early motor outcomes in infants with critical congenital heart disease are related to neonatal brain development and brain injury 
    Stegeman, Raymond; Sprong, Maaike C A; Breur, Johannes M P J; Groenendaal, Floris; de Vries, Linda S; Haas, Felix; van der Net, Janjaap; Jansen, Nicolaas J G; Benders, Manon J N L; Claessens, Nathalie H P; CHD LifeSpan Study Group Utrecht (Wiley-Blackwell, 2022-02)
    AIM: To assess the relationship between neonatal brain development and injury with early motor outcomes in infants with critical congenital heart disease (CCHD). METHOD: Neonatal brain magnetic resonance imaging was performed ...
  • Management of Individual Patient Expectations When Starting with Highly Effective CFTR Modulators 
    Aalbers, Bente L; Bronsveld, Inez; Hofland, Regina W; Heijerman, Harry G M (MDPI Multidisciplinary Digital Publishing Institute, 2021-08-19)
    Highly effective CFTR modulators such as elexacaftor/tezacaftor/ivacaftor (ELE/TEZ/IVA will become available for an increasing number of people with cystic fibrosis (pwCF) in the near future. Before the start of this ...
  • Innovating Clinical Trials for Amyotrophic Lateral Sclerosis: Challenging the Established Order 
    van Eijk, Ruben P A; Nikolakopoulos, Stavros; Roes, Kit C B; Kendall, Lindsay; Han, Steve S; Lavrov, Arseniy; Epstein, Noam; Kliest, Tessa; de Jongh, Adriaan D; Westeneng, Henk-Jan; Al-Chalabi, Ammar; Van Damme, Philip; Hardiman, Orla; Shaw, Pamela J; McDermott, Christopher J; Eijkemans, Marinus J C; van den Berg, Leonard H (Lippincott Williams & Wilkins, 2021-09-14)
    Development of effective treatments for amyotrophic lateral sclerosis (ALS) has been hampered by disease heterogeneity, a limited understanding of underlying pathophysiology, and methodologic design challenges. We have ...
  • De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus 
    Galosi, Serena; Edani, Ban H; Martinelli, Simone; Hansikova, Hana; Eklund, Erik A; Caputi, Caterina; Masuelli, Laura; Corsten-Janssen, Nicole; Srour, Myriam; Oegema, Renske; Bosch, Daniëlle G M; Ellis, Colin A; Amlie-Wolf, Louise; Accogli, Andrea; Atallah, Isis; Averdunk, Luisa; Barañano, Kristin W; Bei, Roberto; Bagnasco, Irene; Brusco, Alfredo; Demarest, Scott; Alaix, Anne-Sophie; Di Bonaventura, Carlo; Distelmaier, Felix; Elmslie, Frances; Gan-Or, Ziv; Good, Jean-Marc; Gripp, Karen; Kamsteeg, Erik-Jan; Macnamara, Ellen; Marcelis, Carlo; Mercier, Noëlle; Peeden, Joseph; Pizzi, Simone; Pannone, Luca; Shinawi, Marwan; Toro, Camilo; Verbeek, Nienke E; Venkateswaran, Sunita; Wheeler, Patricia G; Zdrazilova, Lucie; Zhang, Rong; Zorzi, Giovanna; Guerrini, Renzo; Sessa, William C; Lefeber, Dirk; Tartaglia, Marco; Hamdan, Fadi F; Grabińska, Kariona A; Leuzzi, Vincenzo (Oxford University Press, 2022-03-29)
    Subcellular membrane systems are highly enriched in dolichol, whose role in organelle homeostasis and endosomal-lysosomal pathway remains largely unclear besides being involved in protein glycosylation. DHDDS encodes for ...
  • The Impact of COVID-19 on the mental health of dialysis patients 
    Bonenkamp, Anna A.; Druiventak, Theresia A.; van Eck van der Sluijs, Anita; van Ittersum, Frans J.; van Jaarsveld, Brigit C.; Abrahams, Alferso C.; the DOMESTICO study group (Springer Science and Business Media Deutschland GmbH, 2021-04)
    Background: Studies have shown increased anxiety, depression, and stress levels among different populations during the coronavirus disease 2019 (COVID-19) pandemic. However, the impact of the pandemic on the mental health ...
  • The social licence for data-intensive health research: towards co-creation, public value and trust 
    Muller, Sam H A; Kalkman, Shona; van Thiel, Ghislaine J M W; Van Delden, Johannes; van Delden, Johannes J M (BioMed Central, 2021-08-10)
    BACKGROUND: The rise of Big Data-driven health research challenges the assumed contribution of medical research to the public good, raising questions about whether the status of such research as a common good should be ...
  • Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer 
    Guman, Noori A M; van Geffen, Roos J; Mulder, Frits I; van Haaps, Thijs F; Hovsepjan, Vahram; Labots, Mariette; Cirkel, Geert A; de Vos, Filip Y F L; Ten Tije, Albert J; Beerepoot, Laurens V; Tjan-Heijnen, Vivianne C G; van Laarhoven, Hanneke W M; Hamberg, Paul; Vulink, Annelie J E; Los, Maartje; Zwinderman, Aeilko H; Ferwerda, Bart; Lolkema, Martijn P J K; Steeghs, Neeltje; Büller, Harry R; Kamphuisen, Pieter W; van Es, Nick (Wiley-Blackwell, 2021-12)
    Background: The Khorana score is a validated tool to identify cancer patients at higher risk of venous thromboembolism (VTE). Objective: We compared its predictive performance to that of the clinical PROTECHT and the ...
  • Timing of Intraventricular Hemorrhage in Preterm Neonates Reply 
    Inder, Terrie E; de Vries, Linda S; Ment, Laura R (Mosby Inc., 2021-12)
  • A case series of hypothermic, sedated cats with sensory-induced CNS excitation: alphachloralose poisoning? 
    Dijkman, Marieke A.; Robben, Joris H.; de Lange, Dylan W. (Informa Healthcare, 2021-06-03)
    Objective: In the autumn of 2018, the Board for the Authorisation of Plant Protection Products and Biocides (Ctgb) announced that the registration of rodenticides based on anticoagulants will not be renewed for use by a ...
  • The successful treatment of thallium sulfate toxicity in a dog using Prussian blue 
    Kan, Anne; Robben, Joris H.; de Lange, Dylan W.; Dijkman, Marieke A. (Informa Healthcare, 2021-06-03)
    Objective: Thallium sulfate, once commonly used as a household rodenticide, is a poisonous heavy metal banned in most countries due to its high toxicity. We report a case of thallium poisoning in a dog which was successfully ...