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UMC Repository: Recent submissions

  • Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion 
    Sork, Helena; Conceicao, Mariana; Corso, Giulia; Nordin, Joel; Lee, Yi Xin Fiona; Krjutskov, Kaarel; Orzechowski Westholm, Jakub; Vader, Pieter; Pauwels, Marie; Vandenbroucke, Roosmarijn E.; Wood, Matthew Ja; El Andaloussi, Samir; Mäger, Imre (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-18)
    The extracellular environment consists of a plethora of molecules, including extracellular miRNA that can be secreted in association with extracellular vesicles (EVs) or soluble protein complexes (non-EVs). Yet, interest ...
  • Functional siRNA Delivery by Extracellular Vesicle–Liposome Hybrid Nanoparticles 
    Evers, Martijn J.W.; van de Wakker, Simonides I.; de Groot, Ellis M.; de Jong, Olivier G.; Gitz-François, Jerney J.J.; Seinen, Cor S.; Sluijter, Joost P.G.; Schiffelers, Raymond M.; Vader, Pieter (John Wiley & Sons Inc., 2022-03-02)
    The therapeutic use of RNA interference is limited by the inability of siRNA molecules to reach their site of action, the cytosol of target cells. Lipid nanoparticles, including liposomes, are commonly employed as siRNA ...
  • Protocol for tissue clearing and 3D analysis of dopamine neurons in the developing mouse midbrain 
    Adolfs, Youri; Raj, Divya D.A.; Brignani, Sara; Pasterkamp, R. Jeroen (Cell Press, 2021-09-17)
    Advances in tissue clearing enable analysis of complex migratory patterns of developing neurons in whole intact tissue. Here, we implemented a modified version of 3DISCO to study migration of midbrain dopamine (DA) neurons. ...
  • Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: A prospective 6-year cohort study 
    De Boer, N.; Vermeulen, J.; Lin, B.; Van Os, J.; Ten Have, M.; De Graaf, R.; Van Dorsselaer, S.; Bak, M.; Rutten, B.; Batalla, A.; Guloksuz, S.; Luykx, J. J. (Cambridge University Press, 2023-03-11)
    BACKGROUND: Alcohol consumption, smoking and mood disorders are leading contributors to the global burden of disease and are highly comorbid. Yet, their interrelationships have remained elusive. The aim of this study was ...
  • Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications 
    Johannesen, Katrine M; Liu, Yuanyuan; Koko, Mahmoud; Gjerulfsen, Cathrine E; Sonnenberg, Lukas; Schubert, Julian; Fenger, Christina D; Eltokhi, Ahmed; Rannap, Maert; Koch, Nils A; Lauxmann, Stephan; Krüger, Johanna; Kegele, Josua; Canafoglia, Laura; Franceschetti, Silvana; Mayer, Thomas; Rebstock, Johannes; Zacher, Pia; Ruf, Susanne; Alber, Michael; Sterbova, Katalin; Lassuthová, Petra; Vlckova, Marketa; Lemke, Johannes R; Platzer, Konrad; Krey, Ilona; Heine, Constanze; Wieczorek, Dagmar; Kroell-Seger, Judith; Lund, Caroline; Klein, Karl Martin; Billie Au, P Y; Rho, Jong M; Ho, Alice W; Masnada, Silvia; Veggiotti, Pierangelo; Giordano, Lucio; Accorsi, Patrizia; Hoei-Hansen, Christina E; Striano, Pasquale; Zara, Federico; Verhelst, Helene; Verhoeven, Judith S; van der Zwaag, Bert; Harder, Aster V E; Brilstra, Eva; Pendziwiat, Manuela; Lebon, Sebastian; Vaccarezza, Maria; Minh Le, Ngoc; Christensen, Jakob; Grønborg, Sabine; Scherer, Stephen W; Howe, Jennifer; Fazeli, Walid; Howell, Katherine B; Leventer, Richard; Stutterd, Chloe; Walsh, Sonja; Gerard, Marion; Gerard, Bénédicte; Matricardi, Sara; Bonardi, Claudia M; Sartori, Stefano; Berger, Andrea; Hoffman-Zacharska, Dorota; Mastrangelo, Massimo; Darra, Francesca; Vøllo, Arve; Motazacker, M Mahdi; Lakeman, Phillis; Nizon, Mathilde; Betzler, Cornelia; Altuzarra, Cecilia; Caume, Roseline; Roubertie, Agathe; Gélisse, Philippe; Marini, Carla; Guerrini, Renzo; Bilan, Frederic; Tibussek, Daniel; Koch-Hogrebe, Margarete; Perry, M Scott; Ichikawa, Shoji; Dadali, Elena; Sharkov, Artem; Mishina, Irina; Abramov, Mikhail; Kanivets, Ilya; Korostelev, Sergey; Kutsev, Sergey; Wain, Karen E; Eisenhauer, Nancy; Wagner, Monisa; Savatt, Juliann M; Müller-Schlüter, Karen; Bassan, Haim; Borovikov, Artem; Nassogne, Marie-Cecile; Destrée, Anne; Schoonjans, An-Sofie; Meuwissen, Marije; Buzatu, Marga; Jansen, Anna; Scalais, Emmanuel; Srivastava, Siddharth; Tan, Wen-Hann; Olson, Heather E; Loddenkemper, Tobias; Poduri, Annapurna; Helbig, Katherine L; Helbig, Ingo; Fitzgerald, Mark P; Goldberg, Ethan M; Roser, Timo; Borggraefe, Ingo; Brünger, Tobias; May, Patrick; Lal, Dennis; Lederer, Damien; Rubboli, Guido; Heyne, Henrike O; Lesca, Gaetan; Hedrich, Ulrike B S; Benda, Jan; Gardella, Elena; Lerche, Holger; Møller, Rikke S (Oxford University Press, 2022-09-01)
    We report detailed functional analyses and genotype-phenotype correlations in 392 individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ channel Nav1.6, with the aim of describing clinical ...
  • Combining Ixazomib With Subcutaneous Rituximab and Dexamethasone in Relapsed or Refractory Waldenström's Macroglobulinemia: Final Analysis of the Phase I/II HOVON124/ECWM-R2 Study 
    Kersten, Marie José; Amaador, Karima; Minnema, Monique C; Vos, Josephine M I; Nasserinejad, Kazem; Kap, Marcel; Kastritis, Efstathios; Gavriatopoulou, Maria; Kraan, Willem; Chamuleau, Martine E D; Deeren, Dries; Tick, Lidwine W; Doorduijn, Jeanette K; Offner, Fritz; Böhmer, Lara H; Liu, Roberto D; Pals, Steven T; Dimopoulos, Meletios A (Lippincott Williams & Wilkins, 2022-01-01)
    PURPOSE: Proteasome inhibitors are effective in Waldenström's macroglobulinemia (WM) but require parenteral administration and are associated with polyneuropathy. We investigated efficacy and toxicity of the less neurotoxic ...
  • Interventions to control nosocomial transmission of SARS-CoV-2: a modelling study 
    Pham, Thi Mui; Tahir, Hannan; van de Wijgert, Janneke H H M; Van der Roest, Bastiaan R; Ellerbroek, Pauline; Bonten, Marc J M; Bootsma, Martin C J; Kretzschmar, Mirjam E (BioMed Central Ltd., 2021-12)
    BACKGROUND: Emergence of more transmissible SARS-CoV-2 variants requires more efficient control measures to limit nosocomial transmission and maintain healthcare capacities during pandemic waves. Yet the relative importance ...
  • Impact of curative treatment on the physical fitness of patients with esophageal cancer: A systematic review and meta-analysis 
    Reijneveld, Elja A E; Bor, Petra; Dronkers, Jaap J; Argudo, Núria; Ruurda, Jelle P; Veenhof, Cindy (W.B. Saunders Ltd, 2022-02)
    BACKGROUND: Esophageal cancer and curative treatment have a significant impact on the physical fitness of patients. Knowledge about the course of physical fitness during neoadjuvant therapy and esophagectomy is helpful to ...
  • Severe lymphopenia acquired during chemoradiotherapy for esophageal cancer: Incidence and external validation of a prediction model 
    Kroese, Tiuri E.; Jairam, Jasvir; Ruurda, Jelle P.; Lin, Steven H.; Mohan, Radhe; Mook, Stella; Haitjema, Saskia; Hoefer, Imo; Haj Mohammad, Nadia; Peters, Max; van Hillegersberg, Richard; van Rossum, Peter S.N. (Elsevier Ireland Ltd, 2021-10)
    Background: The incidence of grade 4 lymphopenia in patients treated with chemoradiotherapy (CRT) according to Chemoradiotherapy for Oesophageal cancer followed by Surgery Study (CROSS) regimen is unclear. The primary aim ...
  • Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing 
    Schumacher, A.; Rookmaaker, M. B.; Joles, J. A.; Kramann, R.; Nguyen, T. Q.; van Griensven, M.; LaPointe, V. L.S. (Nature Publishing Group, 2021-08-11)
    The kidney is among the most complex organs in terms of the variety of cell types. The cellular complexity of human kidneys is not fully unraveled and this challenge is further complicated by the existence of multiple ...
  • Lobular breast cancer: Histomorphology and different concepts of a special spectrum of tumors 
    Christgen, Matthias; Cserni, Gábor; Floris, Giuseppe; Marchio, Caterina; Djerroudi, Lounes; Kreipe, Hans; Derksen, Patrick W.B.; Vincent-Salomon, Anne (Multidisciplinary Digital Publishing Institute (MDPI), 2021-08-01)
    Invasive lobular breast cancer (ILC) is the most common special histological type of breast cancer (BC). This review recapitulates developments in the histomorphologic assessment of ILC from its beginnings with the seminal ...
  • Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors 
    van de Wouw, Jens; Sorop, Oana; van Drie, Ruben W.A.; Joles, Jaap A.; Danser, A. H.Jan; Verhaar, Marianne C.; Merkus, Daphne; Duncker, Dirk J. (Springer Science and Business Media Deutschland GmbH, 2021-08-26)
    In the present study, we tested the hypothesis that multiple risk factors, including diabetes mellitus (DM), dyslipidaemia and chronic kidney disease (CKD) result in a loss of nitric oxide (NO) signalling, thereby contributing ...
  • Increasing the Efficiency of a National Laboratory Response to COVID-19: a Nationwide Multicenter Evaluation of 47 Commercial SARS-CoV-2 Immunoassays by 41 Laboratories 
    Van den Beld, Maaike J.C.; Murk, Jean Luc; Kluytmans, Jan; Koopmans, Marion P.G.; Reimerink, Johan; van Loo, Inge H.M.; Wegdam-Blans, Marjolijn C.A.; Zaaijer, Hans; GeurtsvanKessel, Corine; Reusken, Chantal (American Society for Microbiology, 2021-09)
    In response to the worldwide pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the subsequent antibody tests that flooded the market, a nationwide collaborative approach in the Netherlands was ...
  • Populations of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae are different in human-polluted environment and food items: a multicentre European study 
    MODERN WP3 study group (Elsevier, 2022-03)
    Objectives: To assess the extent to which food items are a source of extended-spectrum β-lactamase (ESBL) -producing Escherichia coli (ESBL-Ec) and ESBL-producing Klebsiella pneumoniae (ESBL-Kp) for humans in five European ...
  • The correlation between ATP measurement and microbial contamination of inanimate surfaces 
    van Arkel, Andreas; Willemsen, Ina; Kluytmans, Jan (BioMed Central Ltd., 2021-08-06)
    Background: The objective of this study was to determine the correlation between adenosine triphosphate (ATP) measurements and microbial contamination using a standardized method. Secondarily, analyzing reproducibility of ...
  • Modeling a gross motor curve of typically developing Dutch infants from 3.5 to 15.5 months based on the Alberta Infant Motor Scale 
    Boonzaaijer, Marike; Oudgenoeg-Paz, Ora; Suir, Imke; Westers, Paul; Nuysink, Jacqueline; Volman, Michiel; Jongmans, Marian (Elsevier Ireland Ltd, 2021-06)
    Background: Interindividual variability in gross motor development of infants is substantial and challenges the interpretation of motor assessments. Longitudinal research can provide insight into variability in individual ...
  • Gender-Specific Changes in Life Satisfaction After the COVID-19–Related Lockdown in Dutch Adolescents: A Longitudinal Study 
    van der Laan, Sabine E.I.; Finkenauer, Catrin; Lenters, Virissa C.; van Harmelen, Anne Laura; van der Ent, Cornelis K.; Nijhof, Sanne L. (Elsevier, 2021-11)
    Purpose: The purposes of this study were to assess whether mental well-being has changed after introduction of the lockdown measures compared with that before, whether this change differs between boys and girls, and whether ...
  • Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial 
    Groen, Veerle H.; Zuithoff, Nicolaas P.A.; van Schie, Marcel; Monninkhof, Evelyn M.; Kunze-Busch, Martina; de Boer, Hans C.J.; van der Voort van Zyp, Jochem; Pos, Floris J.; Smeenk, Robert Jan; Haustermans, Karin; Isebaert, Sofie; Draulans, Cédric; Depuydt, Tom; Verkooijen, Helena M.; van der Heide, Uulke A.; Kerkmeijer, Linda G.W. (Elsevier Ireland Ltd, 2021-09)
    BACKGROUND AND PURPOSE: The phase III FLAME trial (NCT01168479) showed an increase in five-year biochemical disease-free survival, with no significant increase in toxicity when adding a focal boost to external beam ...
  • On-line daily plan optimization combined with a virtual couch shift procedure to address intrafraction motion in prostate magnetic resonance guided radiotherapy 
    de Muinck Keizer, Daan M.; van der Voort van Zyp, Jochem R.N.; de Groot-van Breugel, Eline N.; Raaymakers, Bas W.; Lagendijk, Jan J.W.; de Boer, Hans C.J. (Elsevier, 2021-07)
    Background and purpose: In daily adaptive magnetic resonance (MR)-guided radiotherapy, plans are adapted based on the patient's daily anatomy. During this adaptation phase, prostate intrafraction motion (IM) can occur. The ...
  • Impact of DNA damage repair defects on response to PSMA radioligand therapy in metastatic castration-resistant prostate cancer 
    Privé, Bastiaan M.; Slootbeek, Peter H.J.; Laarhuis, Babette I.; Naga, Samhita Pamidimarri; van der Doelen, Maarten J.; van Kalmthout, Ludwike W.M.; de Keizer, Bart; Ezziddin, Samer; Kratochwil, Clemens; Morgenstern, Alfred; Bruchertseifer, Frank; Ligtenberg, Marjolijn J.L.; Witjes, J. Alfred; van Oort, Inge M.; Gotthardt, Martin; Heskamp, Sandra; Janssen, Marcel J.R.; Gerritsen, Winald R.; Nagarajah, James; Mehra, Niven (Springer Nature, 2022-03)
    Purpose: Prostate-specific membrane antigen radioligand therapy (PSMA-RLT) is a novel treatment for castration-resistant prostate cancer (mCRPC). While the majority of patients responds to PSMA-RLT, with 10–15% having an ...