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UMC Repository: Recent submissions

  • Predictors of pregnancy outcomes in SLE - Authors' reply 
    Wind, Merlijn; Fierro, Juan J; Bloemenkamp, Kitty W M; de Leeuw, Karina; Lely, A Titia; Limper, Maarten; Sueters, Marieke; Teng, Y K Onno; Walter, Isabel J; Kooiman, Judith (Elsevier Limited, 2025-01)
  • A Systematic Review of Challenges and Opportunities in the Implementation of Managed Entry Agreements for Advanced Therapy Medicinal Products 
    Greco, Andrea; Frederix, Geert W J; Hooft, Lotty; Ten Ham, Renske M T (Excerpta Medica, 2025-02)
    PURPOSE: Managed Entry Agreements (MEAs) are agreements between firms and competent authorities for pricing and reimbursement, designed to enable coverage of new medicines while managing uncertainties around their financial ...
  • Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival 
    Schmidt, Marieke; Vernooij, Robin; van Nuland, Merel; Smeijsters, Erin; Devriese, Lot; Mohammad, Nadia Haj; Hermens, Thom; Stammers, Julian; Swart, Christina; Egberts, Toine; Haitjema, Saskia; Lammers, Laureen (BioMed Central, 2024-12-18)
    Background: The anticancer drug paclitaxel is primarily metabolized in the liver. Previous studies have indicated a correlation between impaired liver function and paclitaxel toxicity, which may indicate dose reduction. ...
  • The effect of SARS-CoV-2 infection and COVID-19 vaccination during pregnancy on neonatal outcomes 
    Huiberts, Anne J; Oosting, Ilse J; de Melker, Hester; van de Wijgert, Janneke H H M; Grobbee, Diederick E; van den Hof, Susan; Knol, Mirjam (Cambridge University Press, 2025)
    This study explored the effect of SARS-CoV-2 infection and COVID-19 vaccination during pregnancy on neonatal outcomes among women from the general Dutch population. VASCO is an ongoing prospective cohort study aimed at ...
  • Tralokinumab Treatment in Adult Atopic Dermatitis Patients: 28-Week Evaluation of Clinical Effectiveness, Safety, Serum Proteins and Total IgE Levels 
    Dekkers, Coco; Zuithoff, Nicolaas; Bakker, Daphne; Knol, Edward; Wevers, Anne; Touwslager, Wouter; Christoffers, Wianda; Prosje, Petra; van Lynden-van Nes, Anneke; van Lümig, Paula; Kamsteeg, Marijke; Oosting, Albert Jan; Schuttelaar, Marie L A; Haeck, Inge; de Graaf, Marlies; van Wijk, Femke; de Bruin-Weller, Marjolein (Wiley-Blackwell, 2025-04)
    INTRODUCTION AND OBJECTIVES: Tralokinumab-a biological that specifically targets interleukin-13-is one of the newer advanced systemic treatments for patients with moderate-to-severe atopic dermatitis (AD). Although safety ...
  • Pigmentvlekken bij kinderen als uiting van een syndroom Een klinische benadering 
    de Graaf, Marlies (DCHG Partners in Mediscne Communicatie, 2022)
    Hyperpigmented macules in children can be the first clinical sign of an underlying condition or syndrome. Café au lait maculae and lentigines are well-known examples. Café au lait maculae may be associated with syndromes ...
  • Missense MED12 variants in 22 males with intellectual disability: From nonspecific symptoms to complete syndromes 
    Maia, Nuno; Ibarluzea, Nekane; Misra-Isrie, Mala; Koboldt, Daniel C.; Marques, Isabel; Soares, Gabriela; Santos, Rosário; Marcelis, Carlo L.M.; Keski-Filppula, Riikka; Guitart, Miriam; Gabau Vila, Elisabeth; Lehman, April; Hickey, Scott; Mori, Mari; Terhal, Paulien; Valenzuela, Irene; Lasa-Aranzasti, Amaia; Cueto-González, Anna Maria; Chhouk, Brian H.; Yeh, Rebecca C.; Neil, Jennifer E.; Abu-Libde, Bassam; Kleefstra, Tjitske; Elting, Mariet W.; Császár, Andrea; Kárteszi, Judit; Bessenyei, Beáta; van Bokhoven, Hans; Jorge, Paula; van Hagen, Johanna M.; de Brouwer, Arjan P.M. (John Wiley & Sons Inc., 2023-01)
    We describe the phenotype of 22 male patients (20 probands) carrying a hemizygous missense variant in MED12. The phenotypic spectrum is very broad ranging from nonspecific intellectual disability (ID) to the three well-known ...
  • Exploring the "shared" in shared decision-making in the care for children with chronic diseases or disabilities: what are the roles of parents and professionals? 
    Alsem, M W; Bakkum, A; Ketelaar, M; Willemen, A M (Springer-Verlag, 2025-01)
    There is a growing body of literature that recognizes the importance of shared decision-making (SDM) in the care for children with chronic conditions and/or disabilities. Although participation in SDM can be more or less ...
  • Attrition and discontinuation in amyotrophic lateral sclerosis clinical trials: a meta-analysis 
    van Eijk, Ruben P.A.; van Loon, Floris T.; van Unnik, Jordi W.J.; Weemering, Daphne N.; Seitidis, Georgios; Mavridis, Dimitris; van den Berg, Leonard H.; Nikolakopoulos, Stavros (Springer Science and Business Media Deutschland GmbH, 2025-01)
    Objectives: Attrition due to adverse events and disease progression impacts the integrity and generalizability of clinical trials. The aim of this study is to provide evidence-based estimates of attrition for clinical ...
  • Prevalence of lower extremity edema following inguinal lymphadenectomy: A systematic review and meta-analysis 
    Hahn, Brett A.; Richir, Milan C.; Witkamp, Arjen J.; de Jong, Tim; Krijgh, David D. (Elsevier, 2025-03)
    Background: Lower extremity lymphedema (LEL) can develop because of inguinal lymph node dissection in the treatment of gynecologic, genitourinary, and dermatological malignancies. To optimize patient counseling and patient ...
  • Antenatal socioeconomic status of childhood family and the risk of pain spreading (ROPS) in early and mid-adulthood - a descriptive study from the northern Finland birth cohort 1966 
    Heikkala, Eveliina; Rissanen, Ina; Tanguay-Sabourin, Christophe; Vachon-Presseau, Etienne; Chang, Jeremy Rui; Wong, Arnold Yu Lok; Karppinen, Jaro; Oura, Petteri (Elsevier, 2025-02)
    Objective: The Risk of Pain Spreading (ROPS) is a six-item tool capturing key data-driven prognostic factors for chronic pain and its spreading. Higher values on the ROPS indicate a higher risk. Early factors potentially ...
  • Three studies, three steps forward in cardiovascular care 
    van der Harst, Pim (Bohn Stafleu van Loghum, 2025-01)
  • Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson´s disease within the EPIC4ND cohort 
    Gröninger, Mareike; Sabin, Jara; Kaaks, Rudolf; Amiano, Pilar; Aune, Dagfinn; Castro, Natalia Cabrera; Guevara, Marcela; Hansen, Johnni; Homann, Jan; Masala, Giovanna; Nicolas, Geneviève; Peters, Susan; Sacerdote, Carlotta; Sánchez, Maria Jose; De Magistris, Maria Santucci; Sieri, Sabina; Vermeulen, Roel; Zhao, Yujia; Lill, Christina M.; Katzke, Verena A. (Springer Netherlands, 2024-11)
    Literature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective ...
  • Publisher Correction: Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience (Nature Genetics, (2024), 10.1038/s41588-024-01975-5) 
    Jurgens, Sean J.; Rämö, Joel T.; Kramarenko, Daria R.; Wijdeveld, Leonoor F.J.M.; Haas, Jan; Chaffin, Mark D.; Garnier, Sophie; Gaziano, Liam; Weng, Lu Chen; Lipov, Alex; Zheng, Sean L.; Henry, Albert; Huffman, Jennifer E.; Challa, Saketh; Rühle, Frank; Verdugo, Carmen Diaz; Krijger Juárez, Christian; Kany, Shinwan; van Orsouw, Constance A.; Biddinger, Kiran; Poel, Edwin; Elliott, Amanda L.; Wang, Xin; Francis, Catherine; Ruan, Richard; Koyama, Satoshi; Beekman, Leander; Zimmerman, Dominic S.; Deleuze, Jean François; Villard, Eric; Trégouët, David Alexandre; Isnard, Richard; Boomsma, Dorret I.; de Geus, Eco J.C.; Tadros, Rafik; Pinto, Yigal M.; Wilde, Arthur A.M.; Hottenga, Jouke Jan; Sinisalo, Juha; Niiranen, Teemu; Walsh, Roddy; Schmidt, Amand F.; Choi, Seung Hoan; Chang, Kyong Mi; Tsao, Philip S.; Matthews, Paul M.; Ware, James S.; Lumbers, R. Thomas; van der Crabben, Saskia; Laukkanen, Jari; FinnGen; VA Million Veteran Program; HERMES Consortium (Nature Research, 2024-12-04)
    Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-024-01975-5, published online 21 November 2024. In the version of the article initially published, in the Methods, reference numbers were displayed one number ...
  • Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours 
    Melero, Ignacio; de Miguel Luken, Maria; de Velasco, Guillermo; Garralda, Elena; Martín-Liberal, Juan; Joerger, Markus; Alonso, Guzman; Goebeler, Maria Elisabeth; Schuler, Martin; König, David; Dummer, Reinhard; Reig, Maria; Rodriguez Ruiz, Maria Esperanza; Calvo, Emiliano; Esteban-Villarrubia, Jorge; Oberoi, Arjun; Sabat, Paula; Soto-Castillo, Juan José; Koster, Kira Lee; Saavedra, Omar; Sayehli, Cyrus; Gromke, Tanja; Läubli, Heinz; Ramelyte, Egle; Fortuny, Marta; Landa-Magdalena, Ana; Moreno, Irene; Torres-Jiménez, Javier; Hernando-Calvo, Alberto; Hess, Dagmar; Racca, Fabricio; Richly, Heike; Schmitt, Andreas M.; Eggenschwiler, Corinne; Sanduzzi-Zamparelli, Marco; Vilalta-Lacarra, Anna; Trojan, Jörg; Koch, Christine; Galle, Peter R.; Foerster, Friedrich; Trajanoski, Zlatko; Hackl, Hubert; Gogolla, Falk; Koll, Florestan J.; Wild, Peter; Chun, Felix Kyoung Hwan; Reis, Henning; Lloyd, Peter; Machacek, Matthias; Gajewski, Thomas F.; Fridman, Wolf H.; Eggermont, Alexander M.M.; Bargou, Ralf; Schöniger, Sandra; Rüschoff, Josef; Tereshchenko, Anastasiia; Zink, Carina; da Silva, Antonio; Lichtenegger, Felix S.; Akdemir, Julia; Rüdiger, Manfred; L’Huillier, Phil; Dutta, Aradhana; Haake, Markus; Auckenthaler, Alexandra; Gjorgjioska, Ana; Rössler, Bernhard; Hermann, Frank; Liebig, Mara; Reichhardt, Daniela; Schuberth-Wagner, Christine; Wischhusen, Jörg; Fettes, Petra; Auer, Marlene; Klar, Kathrin; Leo, Eugen (Nature Research, 2025-01)
    Cancer immunotherapies with antibodies blocking immune checkpoint molecules are clinically active across multiple cancer entities and have markedly improved cancer treatment1. Yet, response rates are still limited, and ...
  • Treatment of Pediatric, Adolescent, and Young Adult Patients With Fusion-Positive Alveolar Rhabdomyosarcoma Infiltrating Regional Lymph Nodes in the European CWS-2002P and RMS 2005 Studies and the Soft Tissue Sarcoma Registry 
    Heinz, Amadeus T.; Ciuffolotti, Melissa; Merks, Johannes H.M.; Schönstein, Anton; Minard-Colin, Véronique; Fuchs, Jörg; Guillen, Gabriela; Timmermann, Beate; Vokuhl, Christian; Koscielniak, Ewa; Chisholm, Julia C.; Sparber-Sauer, Monika; Bisogno, Gianni (Wiley-Liss Inc., 2025-03)
    Background: Patients with alveolar rhabdomyosarcoma (ARMS) with regional lymph node involvement (N1) are defined as “very-high-risk rhabdomyosarcoma” in Europe. Different chemotherapy regimens were used in European study ...
  • Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis 
    Ven, Luna van de; Félix, Ana Clara; Suarez, Joana; Dias, Jorge; Pinto, Fátima F.; Laranjo, Sérgio (Multidisciplinary Digital Publishing Institute (MDPI), 2024-11)
    Background and Objectives: Despite advances in the surgical management of patients with Fontan circulation, their exercise capacity and quality of life remain significantly impaired. Exercise-based cardiac rehabilitation ...
  • Large language models, updates, and evaluation of automation tools for systematic reviews: a summary of significant discussions at the eighth meeting of the International Collaboration for the Automation of Systematic Reviews (ICASR) 
    O’Connor, Annette M.; Clark, Justin; Thomas, James; Spijker, René; Kusa, Wojciech; Walker, Vickie R.; Bond, Melissa (BioMed Central, 2024-11-27)
    The eighth meeting of the International Collaboration for the Automation of Systematic Reviews (ICASR) was held on September 7 and 8, 2023, at the University College London, London, England. ICASR is an interdisciplinary ...
  • Diagnostic trajectories of patients with rare cancer in the Netherlands: results from a nationwide cross-sectional survey 
    Padilla, Catarina S.; de Heus, Eline; Reuvers, Milou J.P.; Schrieks, Marga; Engelen, Vivian; Grunhagen, Dirk; Tesselaar, Margot E.T.; van der Graaf, Winette T.A.; Duijts, Saskia F.A.; Husson, Olga (Springer-Verlag, 2024-12)
    Diagnosing rare cancers is challenging and often leads to prolonged diagnostic trajectories. This study investigated the diagnostic trajectory of patients with rare cancers in The Netherlands. Data from 1541 patients were ...
  • Computer-assisted screening in systematic evidence synthesis requires robust and well-evaluated stopping criteria 
    Callaghan, Max; Müller-Hansen, Finn; Bond, Melissa; Hamel, Candyce; Devane, Declan; Kusa, Wojciech; O’Mara-Eves, Alison; Spijker, Rene; Stevenson, Mark; Stansfield, Claire; Thomas, James; Minx, Jan C. (BioMed Central, 2024-12)