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UMC Repository: Recent submissions

  • A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs 
    Sanrattana, Wariya; Sefiane, Thibaud; Smits, Simone; van Kleef, Nadine D; Fens, Marcel H; Lenting, Peter J; Maas, Coen; de Maat, Steven (National Academy of Sciences, 2021-11-09)
    Serine proteases are essential for many physiological processes and require tight regulation by serine protease inhibitors (SERPINs). A disturbed SERPIN-protease balance may result in disease. The reactive center loop (RCL) ...
  • Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin 
    Arenas, Jesús; Szabo, Zalan; van der Wal, Jelle; Maas, Coen; Riaz, Tahira; Tønjum, Tone; Tommassen, Jan (Landes Bioscience, 2021-12)
    Biofilm formation is a general strategy for bacterial pathogens to withstand host defense mechanisms. In this study, we found that serum proteases inhibit biofilm formation by Neisseria meningitidis, Neisseria gonorrhoeae, ...
  • Disturbed lipid and amino acid metabolisms in COVID-19 patients 
    Masoodi, Mojgan; Peschka, Manuela; Schmiedel, Stefan; Haddad, Munif; Frye, Maike; Maas, Coen; Lohse, Ansgar; Huber, Samuel; Kirchhof, Paulus; Nofer, Jerzy-Roch; Renné, Thomas (Springer-Verlag, 2022-04)
    The Coronavirus disease 2019 (COVID-19) pandemic is overwhelming the healthcare systems. Identification of systemic reactions underlying COVID-19 will lead to new biomarkers and therapeutic targets for monitoring and early ...
  • Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes 
    Maas, Renee G.C.; Lee, Soah; Harakalova, Magdalena; Snijders Blok, Christian J.B.; Goodyer, William R.; Hjortnaes, Jesper; Doevendans, Pieter A.F.M.; Van Laake, Linda W.; van der Velden, Jolanda; Asselbergs, Folkert W.; Wu, Joseph C.; Sluijter, Joost P.G.; Wu, Sean M.; Buikema, Jan W. (Cell Press, 2021-03-19)
    Since the discovery of human induced pluripotent stem cells (hiPSCs), numerous strategies have been established to efficiently derive cardiomyocytes from hiPSCs (hiPSC-CMs). Here, we describe a cost-effective strategy for ...
  • Novel CineECG enables anatomical 3D localization and classification of bundle branch blocks 
    Boonstra, MacHteld J.; Hilderink, Bashar N.; Locati, Emanuela T.; Asselbergs, Folkert W.; Loh, Peter; Van Dam, Peter M. (Oxford University Press, 2021-03-01)
    Aims: Ventricular conduction disorders can induce arrhythmias and impair cardiac function. Bundle branch blocks (BBBs) are diagnosed by 12-lead electrocardiogram (ECG), but discrimination between BBBs and normal tracings ...
  • Diagnosis and risk prediction of dilated cardiomyopathy in the era of big data and genomics 
    Sammani, Arjan; Baas, Annette F.; Asselbergs, Folkert W.; Te Riele, Anneline S.J.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-03-01)
    Dilated cardiomyopathy (DCM) is a leading cause of heart failure and life-threatening ventricular arrhythmias (LTVA). Work-up and risk stratification of DCM is clinically challenging, as there is great heterogeneity in ...
  • A novel risk model for predicting potentially life-threatening arrhythmias in non-ischemic dilated cardiomyopathy (DCM-SVA risk) 
    Kayvanpour, Elham; Sammani, Arjan; Sedaghat-Hamedani, Farbod; Lehmann, David H.; Broezel, Alicia; Koelemenoglu, Jan; Chmielewski, Przemysław; Curjol, Angelique; Socie, Pierre; Miersch, Tobias; Haas, Jan; Gi, Weng Tein; Richard, Pascale; Płoski, Rafał; Truszkowska, Grażyna; Baas, Annette F.; Foss-Nieradko, Bogna; Michalak, Ewa; Stępień-Wojno, Małgorzata; Zakrzewska-Koperska, Joanna; Śpiewak, Mateusz; Zieliński, Tomasz; Villard, Eric; te Riele, Anneline S.J.M.; Katus, Hugo A.; Frey, Norbert; Bilińska, Zofia T.; Charron, Philippe; Asselbergs, Folkert W.; Meder, Benjamin (Elsevier Ireland Ltd, 2021-09-15)
    Background: Non-ischemic dilated cardiomyopathy (DCM) can be complicated by sustained ventricular arrhythmias (SVA) and sudden cardiac death (SCD). By now, left-ventricular ejection fraction (LV-EF) is the main guideline ...
  • Impact of cardiovascular disease and cardiovascular risk factors in hospitalised COVID-19 patients 
    Jewbali, L. S.D.; Hoogervorst-Schilp, J.; Belfroid, E.; Jansen, C. W.; Asselbergs, F. W.; Siebelink, H. J. (Bohn Stafleu van Loghum, 2021-05)
    Background: Hospitalised COVID-19 patients with underlying cardiovascular disease (CVD) and cardiovascular risk factors appear to be at risk of poor outcome. It is unknown if these patients should be considered a vulnerable ...
  • Heritability estimates for 361 blood metabolites across 40 genome-wide association studies 
    BBMRI Metabolomics Consortium (Nature Publishing Group, 2020-01-07)
    Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite ...
  • Bedside testing of CYP2C19 vs. conventional clopidogrel treatment to guide antiplatelet therapy in ST-segment elevation myocardial infarction patients 
    Al-Rubaish, Abdullah M; Al-Muhanna, Fahad A; Alshehri, Abdullah M; Al-Mansori, Mohammed A; Alali, Rudaynah A; Khalil, Rania M; Al-Faraidy, Khalid A; Cyrus, Cyril; Sulieman, Mohammed M; Vatte, Chittibabu; Loza, Bao-Li; Claassens, Daniel M F; Asselbergs, Folkert W; Al-Ali, Amein K (Elsevier Ireland Ltd, 2021-11-15)
    BACKGROUND: ST-segment elevation myocardial infarction (STEMI) patients are treated with dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor. Clopidogrel is widely used in these patients in several areas ...
  • Less loop diuretic use in patients on sacubitril/valsartan undergoing remote pulmonary artery pressure monitoring 
    Böhm, Michael; Assmus, Birgit; Anker, Stefan D; Asselbergs, Folkert W; Brachmann, Johannes; Brett, Marie-Elena; Brugts, Jasper J; Ertl, Georg; Wang, AiJia; Hilker, Lutz; Koehler, Friedrich; Rosenkranz, Stephan; Leistner, David M; Abdin, Amr; Wintrich, Jan; Zhou, Qian; Adamson, Philip B; Angermann, Christiane E (John Wiley & Sons Inc., 2022-02)
    AIMS: Control of pulmonary pressures monitored remotely reduced heart failure hospitalizations mainly by lowering filling pressures through the use of loop diuretics. Sacubitril/valsartan improves heart failure outcomes ...
  • Factor V Leiden and the Risk of Bleeding in Patients With Acute Coronary Syndromes Treated With Antiplatelet Therapy: Pooled Analysis of 3 Randomized Clinical Trials 
    Mahmoodi, Bakhtawar K; Eriksson, Niclas; Ross, Stephanie; Claassens, Daniel M F; Asselbergs, Folkert W; Meijer, Karina; Siegbahn, Agneta; James, Stefan; Pare, Guillaume; Wallentin, Lars; Ten Berg, Jurriën M (Wiley-Blackwell, 2021-09-07)
    Background Whether factor V Leiden is associated with lower bleeding risk in patients with acute coronary syndromes using (dual) antiplatelet therapy has yet to be investigated. Methods and Results We pooled data from 3 ...
  • Identification and mapping real-world data sources for heart failure, acute coronary syndrome, and atrial fibrillation 
    Studer, Rachel; Sartini, Claudio; Suzart-Woischnik, Kiliana; Agrawal, Rumjhum; Natani, Harshul; Gill, Simrat; Wirta, Sara Bruce; Asselbergs, Folkert W; Dobson, Richard; Denaxas, Spiros; Kotecha, Dipak (S. Karger AG, 2022-01)
    BACKGROUND: Transparent and robust real-world evidence sources are increasingly important for global health, including cardiovascular (CV) diseases. We aimed to identify global real-world data (RWD) sources for heart failure ...
  • Transforming and evaluating electronic health record disease phenotyping algorithms using the OMOP common data model: a case study in heart failure 
    Papez, Vaclav; Moinat, Maxim; Payralbe, Stefan; Asselbergs, Folkert W; Lumbers, R Thomas; Hemingway, Harry; Dobson, Richard; Denaxas, Spiros (Oxford University Press, 2021-07)
    Objective: The aim of the study was to transform a resource of linked electronic health records (EHR) to the OMOP common data model (CDM) and evaluate the process in terms of syntactic and semantic consistency and quality ...
  • An informatics consult approach for generating clinical evidence for treatment decisions 
    Lai, Alvina G; Chang, Wai Hoong; Parisinos, Constantinos A; Katsoulis, Michail; Blackburn, Ruth M; Shah, Anoop D; Nguyen, Vincent; Denaxas, Spiros; Davey Smith, George; Gaunt, Tom R; Nirantharakumar, Krishnarajah; Cox, Murray P; Forde, Donall; Asselbergs, Folkert W; Harris, Steve; Richardson, Sylvia; Sofat, Reecha; Dobson, Richard J B; Hingorani, Aroon; Patel, Riyaz; Sterne, Jonathan; Banerjee, Amitava; Denniston, Alastair K; Ball, Simon; Sebire, Neil J; Shah, Nigam H; Foster, Graham R; Williams, Bryan; Hemingway, Harry (BioMed Central, 2021-12)
    BACKGROUND: An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient. However, the availability of such ...
  • Comparing Non-invasive Inverse Electrocardiography With Invasive Endocardial and Epicardial Electroanatomical Mapping During Sinus Rhythm 
    Roudijk, Robert W; Boonstra, Machteld J; Brummel, Rolf; Kassenberg, Wil; Blom, Lennart J; Oostendorp, Thom F; Te Riele, Anneline S J M; van der Heijden, Jeroen F; Asselbergs, Folkert W; van Dam, Peter M; Loh, Peter (Frontiers Research Foundation, 2021)
    This study presents a novel non-invasive equivalent dipole layer (EDL) based inverse electrocardiography (iECG) technique which estimates both endocardial and epicardial ventricular activation sequences. We aimed to ...
  • Methodological issues in meta-analyses of real-world clinical data to infer causality 
    Uijl, Alicia; Lund, Lars H; Asselbergs, Folkert W; Savarese, Gianluigi (Elsevier Ireland Ltd, 2021-12-15)
  • A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential 
    Banerjee, Amitava; Pasea, Laura; Chung, Sheng-Chia; Direk, Kenan; Asselbergs, Folkert; Grobbee, Diederick E; Kotecha, Dipak; Anker, Stefan D; Dyszynski, Tomasz; Tyl, Benoît; Denaxas, Spiros; Lumbers, R Thomas; Hemingway, Harry (Oxford University Press, 2022-03)
    Aims: Primary prevention strategies for heart failure (HF) have had limited success, possibly due to a wide range of underlying risk factors (RFs). Systematic evaluations of the prognostic burden and preventive potential ...
  • Reliability and validity of multicentre surveillance of surgical site infections after colorectal surgery 
    Verberk, Janneke D.M.; van Rooden, Stephanie M.; Hetem, David J.; Wunderink, Herman F.; Vlek, Anne L.M.; Meijer, Corianne; van Ravensbergen, Eva A.H.; Huijskens, Elisabeth G.W.; Vainio, Saara J.; Bonten, Marc J.M.; van Mourik, Maaike S.M. (BioMed Central Ltd., 2022-01-21)
    BACKGROUND: Surveillance is the cornerstone of surgical site infection prevention programs. The validity of the data collection and awareness of vulnerability to inter-rater variation is crucial for correct interpretation ...
  • Surgical margins in the resection of oral squamous cell carcinoma under local versus general anesthesia 
    van Munster, Meeke H; de Bree, Remco; Breimer, Gerben E; Van Cann, Ellen M (Elsevier Limited, 2022-02)
    OBJECTIVES: This study analyzes the influence of the surgical setting, i.e. resection under local anesthesia versus resection under general anesthesia, on surgical margins in tumor resection of stage I and II oral squamous ...