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Impact of expert center endoscopic assessment of confirmed low grade dysplasia in Barrett's esophagus diagnosed in community hospitals

Nieuwenhuis, Esther; van Munster, Sanne; Curvers, Wouter L; Weusten, Bas L A M; Alvarez Herrero, Lorenza; Bogte, Auke; Alkhalaf, Alaa; Schenk, B E; Koch, Arjun Dave; Spaander, Manon C W; Tang, Thjon J; Nagengast, Wouter B; Westerhof, Jessie; Houben, Martin H M G; Bergman, Jacques Jghm; Schoon, Erik J; Pouw, Roos E (Georg Thieme Verlag, 2022-10-01)

BACKGROUND : The optimal management for patients with low grade dysplasia (LGD) in Barrett's esophagus (BE) is unclear. According to the Dutch national guideline, all patients with LGD with histological confirmation of the ...
Response to "Head and neck cancer diagnoses and faster treatment initiation during COVID-19 Correspondence"

Dutch Head and Neck Society and the COVID and Cancer-NL consortium (Elsevier Ireland Ltd, 2022-04-01)
A Comprehensive Grading System for a Magnetic Sentinel Lymph Node Biopsy Procedure in Head and Neck Cancer Patients

Nieuwenhuis, Eliane R.; Kolenaar, Barry; Hof, Jurrit J.; Baarlen, Joop van; van Bemmel, Alexander J.M.; Christenhusz, Anke; Scheenen, Tom W.J.; Ten Haken, Bernard; de Bree, Remco; Alic, Lejla (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)

A magnetic sentinel lymph node biopsy ((SLN)B) procedure has recently been shown feasible in oral cancer patients. However, a grading system is absent for proper identification and classification, and thus for clinical ...
Application of Artificial Intelligence for Nasopharyngeal Carcinoma Management - A Systematic Review

Ng, Wai Tong; But, Barton; Choi, Horace C W; de Bree, Remco; Lee, Anne W M; Lee, Victor H F; López, Fernando; Mäkitie, Antti A; Rodrigo, Juan P; Saba, Nabil F; Tsang, Raymond K Y; Ferlito, Alfio (Dove Medical Press Ltd., 2022-01-26)

Introduction: Nasopharyngeal carcinoma (NPC) is endemic to Eastern and South-Eastern Asia, and, in 2020, 77% of global cases were diagnosed in these regions. Apart from its distinct epidemiology, the natural behavior, ...
Immunomodulator withdrawal from anti-TNF therapy is not associated with loss of response in inflammatory bowel disease

Mahmoud, Remi; Schultheiss, Hans-Paul; Louwers, Jonas; van der Kaaij, M T; van Hellemondt, B P; Mahmmod, N; van Boeckel, P G; Jharap, B; Fidder, Herma; Oldenburg, Bas (W.B. Saunders, 2022-11)

BACKGROUND AND AIMS: The benefit of concomitant immunomodulators (thiopurines or methotrexate) in patients with inflammatory bowel disease (IBD) on anti-tumor necrosis factor α (anti-TNF) (infliximab or adalimumab) maintenance ...
Maternal and fetal characteristics for predicting risk of Cesarean section following induction of labor: pooled analysis of PROBAAT trials

Quach, D.; ten Eikelder, M.; Jozwiak, M.; Davies-Tuck, M.; Bloemenkamp, K. W.M.; Mol, B. W.; Li, W. (John Wiley & Sons Inc., 2022-01)

OBJECTIVE: Induction of labor (IOL) is one of the most widely used obstetric interventions. However, one-fifth of IOLs result in Cesarean section (CS). We aimed to assess maternal and fetal characteristics that influence ...
Severe COVID-19 in pregnancy is almost exclusively limited to unvaccinated women – time for policies to change

Engjom, Hilde; van den Akker, Thomas; Aabakke, Anna; Ayras, Outi; Bloemenkamp, Kitty; Donati, Serena; Cereda, Danilo; Overtoom, Evelien; Knight, Marian (Elsevier, 2022-02)
Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group

Van Bockstal, Mieke R.; Cooks, Maxine; Nederlof, Iris; Brinkhuis, Mariel; Dutman, Annemiek; Koopmans, Monique; Kooreman, Loes; van der Vegt, Bert; Verhoog, Leon; Vreuls, Celine; Westenend, Pieter; Kok, Marleen; van Diest, Paul J.; Nauwelaers, Inne; Laudus, Nele; Denkert, Carsten; Rimm, David; Siziopikou, Kalliopi P.; Ely, Scott; Zardavas, Dimitrios; Roberts, Mustimbo; Floris, Giuseppe; Hartman, Johan; Acs, Balazs; Peeters, Dieter; Bartlett, John M. S.; Dequeker, Els; Salgado, Roberto; Giudici, Fabiola; Michiels, Stefan; Horlings, Hugo; van Deurzen, Carolien H. M. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-10)

Patients with advanced triple‐negative breast cancer (TNBC) benefit from treatment with atezolizumab, provided that the tumor contains ≥1% of PD‐L1/SP142‐positive immune cells. Numbers of tumor‐infiltrating lymphocytes ...
Middle cerebral arterial flow redistribution is an indicator for intrauterine fetal compromise in late pregnancy in low-resource settings: a prospective cohort study

Ali, Sam; Kawooya, Michael G; Byamugisha, Josaphat; Kakibogo, Isaac M; Biira, Esther A; Kagimu, Adia N; Grobbee, Diederick E; Zakus, David; Papageorghiou, Aris T; Klipstein-Grobusch, Kerstin; Rijken, Marcus J (Wiley-Blackwell, 2022-09)

Objective: We aimed to determine the prevalence of abnormal umbilical artery (UA), uterine artery (UtA), middle cerebral artery (MCA) and cerebroplacental ratio (CPR) Doppler, and their relationship with adverse perinatal ...
Hypoglycemia in infants with hypoxic-ischemic encephalopathy is associated with additional brain injury and worse neurodevelopmental outcome

Parmentier, Corline E J; de Vries, Linda S; van der Aa, Niek E; Eijsermans, Rian M J C; Harteman, Johanneke C; Lequin, Maarten H; Swanenburg de Veye, Henriette F N; Koopman, Corine; Groenendaal, Floris (Mosby Inc., 2022-06)

Objective: To determine the incidence of hypoglycemia among infants with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia, and to assess whether infants with hypoglycemia had more brain injury on ...
The progressive relationship between increasing Breslow thickness and decreasing survival is lost in patients with ultra-thick melanomas (≥15mm in thickness)

El Sharouni, Mary-Ann; Rawson, Robert V; Sigurdsson, Vigfús; Witkamp, Arjen J; van Gils, Carla H; Scolyer, Richard A; Thompson, John F; van Diest, Paul J; Lo, Serigne N (Mosby Inc., 2022-08)

Background: Survival tends to decrease as the Breslow thickness of a primary melanoma increases. However, little is known about the prognostic value of Breslow thickness in patients with very thick melanomas. Objective: ...
Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann, Tassilo L A; Wouters, Anne K; Remst, Dennis F G; Hagedoorn, Renate S; Meeuwsen, Miranda H; van Diest, Eline; Leusen, Jeanette; Kuball, Jürgen; Falkenburg, J H Frederik; Heemskerk, Mirjam H M (Landes Bioscience, 2022)

Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but a significant proportion of patients do not respond or relapse ...
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits

Rodriguez, Ernesto; Boelaars, Kelly; Brown, Kari; Madunić, Katarina; van Ee, Thomas; Dijk, Frederike; Verheij, Joanne; Li, R. J.Eveline; Schetters, Sjoerd T.T.; Meijer, Laura L.; Le Large, Tessa Y.S.; Driehuis, Else; Clevers, Hans; Bruijns, Sven C.M.; O’Toole, Tom; van Vliet, Sandra J.; Bijlsma, Maarten F.; Wuhrer, Manfred; Kazemier, Geert; Giovannetti, Elisa; Garcia-Vallejo, Juan J.; van Kooyk, Yvette (Springer Nature, 2022-01-11)

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a 5-year survival rate of only 9%. Despite the fact that changes in glycosylation patterns during tumour progression have been ...
Author Correction: Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist (Nature Communications, (2021), 12, 1, (6003), 10.1038/s41467-021-26077-2)

Salas-Leiva, Dayana E.; Tromer, Eelco C.; Curtis, Bruce A.; Jerlström-Hultqvist, Jon; Kolisko, Martin; Yi, Zhenzhen; Salas-Leiva, Joan S.; Gallot-Lavallée, Lucie; Williams, Shelby K.; Kops, Geert J.P.L.; Archibald, John M.; Simpson, Alastair G.B.; Roger, Andrew J. (Nature Publishing Group, 2021-12)

The original version of this Article contained an error in Fig. 1 panel b, which presented a left-handed helix instead of a right-handed helix conformation. Furthermore the labels for the 5' and 3' DNA ends and arrows to ...
Signalling dynamics in embryonic development

Sonnen, Katharina F.; Janda, Claudia Y. (Portland Press Ltd., 2021-12)

In multicellular organisms, cellular behaviour is tightly regulated to allow proper embryonic development and maintenance of adult tissue. A critical component in this control is the communication between cells via signalling ...
A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium

van der Linden, Franka H.; Mahlandt, Eike K.; Arts, Janine J.G.; Beumer, Joep; Puschhof, Jens; de Man, Saskia M.A.; Chertkova, Anna O.; Ponsioen, Bas; Clevers, Hans; van Buul, Jaap D.; Postma, Marten; Gadella, Theodorus W.J.; Goedhart, Joachim (Nature Publishing Group, 2021-12)

The most successful genetically encoded calcium indicators (GECIs) employ an intensity or ratiometric readout. Despite a large calcium-dependent change in fluorescence intensity, the quantification of calcium concentrations ...
Single-cell transcriptomics links loss of human pancreatic β-cell identity to er stress

Groen, Nathalie; Leenders, Floris; Mahfouz, Ahmed; Munoz-Garcia, Amadeo; Muraro, Mauro J.; de Graaf, Natascha; Rabelink, Ton J.; Hoeben, Rob; van Oudenaarden, Alexander; Zaldumbide, Arnaud; Reinders, Marcel J.T.; de Koning, Eelco J.P.; Carlotti, Françoise (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12)

The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage ...
Ewsr1-wt1 target genes and therapeutic options identified in a novel dsrct in vitro model

Bleijs, Margit; Pleijte, Corine; Engels, Sem; Ringnalda, Femke; Meyer-Wentrup, Friederike; van de Wetering, Marc; Clevers, Hans (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma with a lack of effective treatment options and a poor prognosis. DSRCT is characterized by a chromosomal translocation, resulting in ...
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

Koopmans, Tim; van Beijnum, Henriette; Roovers, Elke F.; Tomasso, Antonio; Malhotra, Divyanshu; Boeter, Jochem; Psathaki, Olympia E.; Versteeg, Danielle; van Rooij, Eva; Bartscherer, Kerstin (Nature Publishing Group, 2021-12)

Ischemic heart disease and by extension myocardial infarction is the primary cause of death worldwide, warranting regenerative therapies to restore heart function. Current models of natural heart regeneration are restricted ...
SARS-CoV-2 infection and replication in human gastric organoids

Giobbe, Giovanni Giuseppe; Bonfante, Francesco; Jones, Brendan C.; Gagliano, Onelia; Luni, Camilla; Zambaiti, Elisa; Perin, Silvia; Laterza, Cecilia; Busslinger, Georg; Stuart, Hannah; Pagliari, Matteo; Bortolami, Alessio; Mazzetto, Eva; Manfredi, Anna; Colantuono, Chiara; Di Filippo, Lucio; Pellegata, Alessandro Filippo; Panzarin, Valentina; Thapar, Nikhil; Li, Vivian Sze Wing; Eaton, Simon; Cacchiarelli, Davide; Clevers, Hans; Elvassore, Nicola; De Coppi, Paolo (Nature Publishing Group, 2021-12)

COVID-19 typically manifests as a respiratory illness, but several clinical reports have described gastrointestinal symptoms. This is particularly true in children in whom gastrointestinal symptoms are frequent and viral ...

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