Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 1341-1360 of 40729

Sex and Common Germline Variants Affect the Toxicity Profile and Pharmacokinetics of Alectinib: A Nationwide Cohort Study in Patients With ALK-Positive NSCLC

Heersche, Niels; Lanser, Daan A C; Muntinghe-Wagenaar, M Benthe; Mohmaed Ali, Ma Ida; Ulas, Ezgi B; Trooster, Tessa M A; de Jonge, Evert; Oomen-de Hoop, Esther; Paats, Marthe S; Bahce, Idris; Croes, Sander; Hendriks, Lizza E L; van der Wekken, Anthonie J; Dingemans, Anne-Marie C; Huitema, Alwin D R; van Schaik, Ron H N; Mathijssen, Ron H J; Veerman, G D Marijn (Elsevier, 2025-04)

Introduction: Alectinib, a small-molecule kinase inhibitor, is used as first-line treatment for ALK-positive (ALK+) NSCLC. Albeit generally well-tolerated, a considerable subset of patients requires dose adjustments due ...
Comment on Burgos et al. Fusionless All-Pedicle Screws for Posterior Deformity Correction in AIS Immature Patients Permit the Restoration of Normal Vertebral Morphology and Removal of the Instrumentation Once Bone Maturity Is Reached. J. Clin. Med. 2023, 12, 2408

Lemans, Justin V.C.; Schlösser, Tom P.C.; Castelein, René M.; Kruyt, Moyo C. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-07)
Disease-Specific Differences in Pharmacokinetics of Paromomycin and Miltefosine Between Post-Kala-Azar Dermal Leishmaniasis and Visceral Leishmaniasis Patients in Eastern Africa

Chu, Wan-Yu; Verrest, Luka; Younis, Brima M; Musa, Ahmed M; Mbui, Jane; Mohammed, Rezika; Olobo, Joseph; Ritmeijer, Koert; Monnerat, Séverine; Wasunna, Monique; Roseboom, Ignace C; Solomos, Alexandra; Huitema, Alwin D R; Alves, Fabiana; Dorlo, Thomas P C (Oxford University Press, 2024-12-15)

Treatment regimens for post-kala-azar dermal leishmaniasis (PKDL) are usually extrapolated from those for visceral leishmaniasis (VL), but drug pharmacokinetics (PK) can differ due to disease-specific variations in absorption, ...
Seeking under threat of adversity: assessing control over reward pursuit in rats

van Koppen, Sofie; Minnaard, A. Maryse; Smeets, Johanna A.S.; Buzatouiu, Iulia; Ramakers, Geert M.J.; Adan, Roger A.H.; Vanderschuren, Louk J.M.J.; Lesscher, Heidi M.B. (Springer-Verlag, 2025)

Rationale: Substance use disorder (SUD) is a chronic relapsing brain disorder that is characterised by loss of control over substance use. A variety of rodent models employing punishment setups have been developed to assess ...
Evaluation and clinical applicability of angiography-derived assessment of coronary microcirculatory resistance: a [15O]H2O PET study

Jukema, Ruurt A.; Raijmakers, Pieter G.; Hoshino, Masahiro; Driessen, Roel S.; van Diemen, Pepijn A.; Knuuti, Juhani; Maaniitty, Teemu; Twisk, Jos; Kooistra, Rolf A.; Timmer, Janny; Reiber, Johan H.C.; van der Harst, Pim; Cramer, Maarten J.; van der Hoef, Tim; Knaapen, Paul; Danad, Ibrahim (Springer Netherlands, 2025)

The introduction of wire-free microcirculatory resistance index from functional angiography (angio-IMR) promises swift detection of coronary microvascular dysfunction, however it has not been properly validated. We sought ...
Defining and Predicting Early Recurrence for Optimal Treatment Strategies for Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Study

Habib, Joseph R.; Javed, Ammar A.; Rompen, Ingmar F.; Hidalgo Salinas, Camila; Sorrentino, Anthony; Campbell, Brady A.; Andel, Paul C.M.; Groot, Vincent P.; Lafaro, Kelly J.; Sacks, Greg D.; Billeter, Adrian T.; Molenaar, I. Quintus; Müller-Stich, Beat P.; Besselink, Marc G.; He, Jin; Wolfgang, Christopher L.; Daamen, Lois A. (Springer New York, 2025)

Background: Early recurrence in intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) is poorly defined. Predictors are lacking and needed for patient counseling, risk stratification, ...
Bi-allelic MYMX variants cause a syndromic congenital myopathy with recognizable facial palsy, growth restriction, and dysmorphism

Rahman, Fatima; Marsili, Luisa; Pasquetti, Domizia; Rad, Aboulfazl; Nadeem Anjum, Muhammad; Oprea, Gabriela; Cheema, Huma Arshad; Vona, Barbara; Augusto Alves, Cesar; Houlden, Henry; Maqbool, Shazia; Efthymiou, Stephanie; Smol, Thomas; Maroofian, Reza (Springer Nature, 2025)

Myogenic fusion, primarily regulated by the Myomaker and Myomixer proteins, is essential for skeletal muscle development, yet its mechanisms remain poorly understood. This study presents the clinical and molecular details ...
Pharmacist-led new medicine service: a real-world cohort study in the Netherlands on drug-related problems, satisfaction, and self-efficacy in cardiovascular patients transitioning to primary care

Ensing, Hendrik T.; Kurt, Nelly; Janssen, Ruby A.; Koster, Ellen S.; Heerdink, Eibert R. (Springer Netherlands, 2025-04)

Background: Patients transitioning from hospital to home while starting long-term cardiovascular medicines are likely to experience drug-related problems (DRPs). The New Medicine Service (NMS) may support readmission to ...
Performance of ARVC Risk Calculators in (Likely) Pathogenic Plakophilin-2 Variant Carriers Without Definite ARVC Diagnosis

Muller, Steven A.; Asatryan, Babken; Murray, Brittney; Tichnell, Crystal; Cox, Moniek G.P.J.; Amin, Ahmad S.; Yap, Sing Chien; Gasperetti, Alessio; Carrick, Richard T.; Cadrin-Tourigny, Julia; Oerlemans, Marish I.F.J.; Calkins, Hugh; Van Tintelen, J. Peter; James, Cynthia A.; Te Riele, Anneline S.J.M. (Lippincott Williams & Wilkins, 2025-01)
Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers

Sanati, Mehdi; Figueroa-Espada, Christian G.; Han, Emily L.; Mitchell, Michael J.; Yavari, Saber Amin (American Chemical Society, 2024-12-24)

Chemoresistance remains a long-standing challenge after cancer treatment. Over the last two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize cancer cells to chemotherapy. However, the ...
The respiratory microbiome is linked to the severity of RSV infections and the persistence of symptoms in children

Kristensen, Maartje; de Steenhuijsen Piters, Wouter A.A.; Wildenbeest, Joanne; van Houten, Marlies A.; Zuurbier, Roy P.; Hasrat, Raiza; Arp, Kayleigh; Chu, Mei Ling J.N.; Billard, Marie; Heikkinen, Terho; Cunningham, Steve; Snape, Matthew; Drysdale, Simon B.; Thwaites, Ryan S.; Martinon-Torres, Federico; Pollard, Andrew J.; Openshaw, Peter J.M.; Aerssen, Jeroen; Binkowska, Justyna; Bont, Louis; Bogaert, Debby; Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators (Cell Press, 2024-12-17)

Respiratory syncytial virus (RSV) is the leading cause of infant respiratory infections and hospitalizations. To investigate the relationship between the respiratory microbiome and RSV infection, we sequence nasopharyngeal ...
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between SLCO1B1 and statins and CYP2C9 and sulfonylureas

Wolthuis, David F.G.J.; Nijenhuis, Marga; Soree, Bianca; de Boer-Veger, Nienke J.; Buunk, Anne Marie; Guchelaar, Henk Jan; Risselada, Arne; Rongen, Gerard A.P.J.M.; van Schaik, Ron H.N.; Swen, Jesse J.; Touw, Daan J.; van Westrhenen, Roos; Deneer, Vera H.M.; Houwink, Elisa J.F. (Springer Nature, 2025)

Aligned with the mission of the Dutch Pharmacogenetics Working Group (DPWG) to promote the implementation of pharmacogenetics (PGx), this guideline is specifically designed to optimize pharmacotherapy of cholesterol lowering ...
Chances and challenges of questionnaires in heart failure care

Fiolet, Aernoud T.L.; Szymanski, Mariusz K. (Bohn Stafleu van Loghum, 2025-01)
Career perspectives of early-career cardiologists in the Netherlands

Kalkman, Deborah N.; Baggen, Vivan J.M.; Beusekamp, Joost C.; Kleinnibbelink, Geert; Meijers, Wouter C.; Peeters, Frederique E.C.M.; van der Wall, Sake J.; Yilmaz, Dilek; Minneboo, Madelon; Bosch, Lena (Bohn Stafleu van Loghum, 2025-01)
Sex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes and diabetic kidney disease: post hoc analyses of the RENAAL and IDNT trials

de Vries, Sieta T.; Pena, Michelle J.; Tye, Sok Cin; Peters, Sanne A.E.; van Raalte, Daniël H.; Arnott, Clare; Voors, Adriaan A.; Mol, Peter G.M.; Denig, Petra; Heerspink, Hiddo J.L. (Springer-Verlag, 2025-03)

Aims/hypothesis: Our aim was to assess sex differences in the efficacy of angiotensin receptor blockers (i.e. losartan and irbesartan) on kidney and cardiovascular outcomes in individuals with type 2 diabetes and diabetic ...
The neonatal gut microbiota: A role in the encephalopathy of prematurity

Vaher, Kadi; Cabez, Manuel Blesa; Parga, Paula Lusarreta; Binkowska, Justyna; van Beveren, Gina J.; Odendaal, Mari Lee; Sullivan, Gemma; Stoye, David Q.; Corrigan, Amy; Quigley, Alan J.; Thrippleton, Michael J.; Bastin, Mark E.; Bogaert, Debby; Boardman, James P. (Cell Press, 2024-12-17)

Preterm birth correlates with brain dysmaturation and neurocognitive impairment. The gut microbiome associates with behavioral outcomes in typical development, but its relationship with neurodevelopment in preterm infants ...
Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal †

Nabuurs, Cindy H.; Kievit, Wietske; Leemans, Charles (René) Reinier; Smit, Conrad F.G.M.; van den Brekel, Michiel W.M.; Pauw, Robert J.; van der Laan, Bernard F.A.M.; Jansen, Jeroen C.; Lacko, Martin; Braunius, Weibel W.; Dai, Chunfu; Shi, Xunbei; Danesi, Giovanni; Bouček, Jan; Borsetto, Daniele; Gowrishankar, Shavran; Kania, Romain; Jourdaine, Clément; Jansen, Thijs T.G.; Derks, Jolanda; Dijkema, Tim; Takes, Robert P.; Kunst, Henricus (Dirk) P.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2024-12)

Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical ...
The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment

Dadson, Prince; Ngum, Peter; Juarez-Orozco, Luis Eduardo; Ntodie, Michael; Loba, Piotr (Springer London, 2025-02)

The orbit is an important structure within the skull that houses the eye, optic nerve, and extraocular muscles. It also contains adipose/fat tissue, which provides a protective cushion for these components. Inflammatory ...
Definitions matter: Multicenter investigation of incidence and outcome of poor graft function after hematopoietic cell transplantation

Müskens, Konradin F.; Collot-d'Escury, Winny N.R.; Dandis, Rana; Haitjema, Saskia; Kuball, Jürgen; de Witte, Moniek A.; Bierings, Marc; Lindemans, Caroline A.; Nierkens, Stefan; Belderbos, Mirjam E. (Wolters Kluwer Health, 2024-12)

Despite advances in allogeneic hematopoietic cell transplantation (HCT), poor graft function (PGF) remains an important complication with substantial morbidity and mortality. The investigation of preventive and therapeutic ...
Brain-Computer Interfaces Using Flexible Electronics: An a-IGZO Front-End for Active ECoG Electrodes

van Oosterhout, Kyle; Chilundo, Ashley; Branco, Mariana P.; Aarnoutse, Erik J.; Timmermans, Martijn; Fattori, Marco; Ramsey, Nick F.; Cantatore, Eugenio (Wiley-VCH Verlag, 2025-02)

Brain-computer interfaces (BCIs) are evolving toward higher electrode count and fully implantable solutions, which require extremely low power densities (<15mW cm−2). To achieve this target, and allow for a large and ...

Now showing items 1341-1360 of 40729