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UMC Repository: Recent submissions

  • Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial 
    Gerss, Joachim; Tedy, Monika; Klein, Ariane; Horneff, Gerd; Miranda-Garcia, Maria; Kessel, Christoph; Holzinger, Dirk; Stanevica, Valda; Swart, Joost F.; Cabral, David A.; Brunner, Hermine I.; Foell, Dirk (Elsevier, 2022-07-01)
    Objectives To investigate the ability of high-sensitivity C-reactive protein (hsCRP) and S100A12 to serve as predictive biomarkers of successful drug withdrawal in children with clinical remission of juvenile idiopathic ...
  • Anakinra in Patients With Systemic Juvenile Idiopathic Arthritis: Long-term Safety From the Pharmachild Registry 
    Paediatric Rheumatology International Trials Organisation (PRINTO) (Journal of Rheumatology, 2022-04-01)
    Objective. To evaluate the long-term safety profile of anakinra in patients with systemic juvenile idiopathic arthritis (sJIA). Methods. Data from patients with sJIA enrolled in the Pharmachild registry (ClinicalTrials.gov: ...
  • Mogelijke toepassingen van organoïden in de geneeskunde 
    Mijnders, Marjolein; Fuchs, Sabine A; Nieuwenhuis, Edward E S (Bohn Stafleu van Loghum, 2022-01-12)
    With the development of organoids as three-dimensional model organs it is now possible to mimic the growth of human organs in a culture dish. As these model organs can be generated from patients' (diseased) tissue and ...
  • Mutation-specific reporter for optimization and enrichment of prime editing 
    Schene, I F; Joore, I P; Baijens, J H L; Stevelink, R; Kok, G; Shehata, S; Ilcken, E F; Nieuwenhuis, E E S; Bolhuis, D P; van Rees, R C M; Spelier, S A; van der Doef, H P J; Beekman, J M; Houwen, R H J; Nieuwenhuis, E E S; Fuchs, S A (Nature Publishing Group, 2022-03-01)
    Prime editing is a versatile genome-editing technique that shows great promise for the generation and repair of patient mutations. However, some genomic sites are difficult to edit and optimal design of prime-editing tools ...
  • Improved neonatal brain MRI segmentation by interpolation of motion corrupted slices 
    Verschuur, Anouk S; Boswinkel, Vivian; Tax, Chantal M W; van Osch, Jochen A C; Nijholt, Ingrid M; Slump, Cornelis H; de Vries, Linda S; van Wezel-Meijler, Gerda; Leemans, Alexander; Boomsma, Martijn F (Wiley-Blackwell, 2022-05-01)
    BACKGROUND AND PURPOSE: To apply and evaluate an intensity-based interpolation technique, enabling segmentation of motion-affected neonatal brain MRI. METHODS: Moderate-late preterm infants were enrolled in a prospective ...
  • Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology 
    Piepoli, Massimo F; Adamo, Marianna; Barison, Andrea; Bestetti, Reinaldo B; Biegus, Jan; Böhm, Michael; Butler, Javed; Carapetis, Jonathan; Ceconi, Claudio; Chioncel, Ovidiu; Coats, Andrew; Crespo-Leiro, Maria G; de Simone, Giovanni; Drexel, Heinz; Emdin, Michele; Farmakis, Dimitros; Halle, Martin; Heymans, Stephane; Jaarsma, Tiny; Jankowska, Ewa; Lainscak, Mitja; Lam, Carolyn S P; Løchen, Maja-Lisa; Lopatin, Yuri; Maggioni, Aldo; Matrone, Benedetta; Metra, Marco; Noonan, Katharine; Pina, Ileana; Prescott, Eva; Rosano, Giuseppe; Seferovic, Petar M; Sliwa, Karen; Stewart, Simon; Uijl, Alicia; Vaartjes, Ilonca; Vermeulen, Roel; Verschuren, W M; Volterrani, Maurizio; Von Haehling, Stephan; Hoes, Arno (Oxford University Press, 2022-01-01)
    The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present consensus ...
  • Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology 
    Piepoli, Massimo F; Adamo, Marianna; Barison, Andrea; Bestetti, Reinaldo B; Biegus, Jan; Böhm, Michael; Butler, Javed; Carapetis, Jonathan; Ceconi, Claudio; Chioncel, Ovidiu; Coats, Andrew; Crespo-Leiro, Maria G; de Simone, Giovanni; Drexel, Heinz; Emdin, Michele; Farmakis, Dimitros; Halle, Martin; Heymans, Stephane; Jaarsma, Tiny; Jankowska, Ewa; Lainscak, Mitja; Lam, Carolyn S P; Løchen, Maja-Lisa; Lopatin, Yuri; Maggioni, Aldo; Matrone, Benedetta; Metra, Marco; Noonan, Katharine; Pina, Ileana; Prescott, Eva; Rosano, Giuseppe; Seferovic, Petar M; Sliwa, Karen; Stewart, Simon; Uijl, Alicia; Vaartjes, Ilonca; Vermeulen, Roel; Monique Verschuren, W M; Volterrani, Maurizio; von Heahling, Stephan; Hoes, Arno (Oxford University Press, 2022-01)
    The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present position ...
  • Plasma concentration guided dosing of drugs used for the treatment of childhood leukaemias: protocol for a systematic review 
    van Dyk, Madelé; Boylan, Chelsea; Michelet, Robin; Mc Laughlin, Anna M; Kichenadasse, Ganessan; May, Nikki; Ziesenitz, Victoria; Van Den Anker, Johannes N; Groenland, Stefanie L; Huitema, Alwin D R; Steeghs, Neeltje; Mikus, Gerd; Kloft, Charlotte; Tapp, Heather (BMJ Publishing Group, 2022-01-03)
    Introduction Childhood leukaemia is the most common type of cancer in children and represents among 25% of the diagnoses in children <15 years old. Childhood survival rates have significantly improved within the last 40 ...
  • Developing a Nationwide Infrastructure for Therapeutic Drug Monitoring of Targeted Oral Anticancer Drugs: The ON-TARGET Study Protocol 
    Mc Laughlin, Anna M; Schmulenson, Eduard; Teplytska, Olga; Zimmermann, Sebastian; Opitz, Patrick; Groenland, Stefanie L; Huitema, Alwin D R; Steeghs, Neeltje; Müller, Lothar; Fuxius, Stefan; Illerhaus, Gerald; Joerger, Markus; Mayer, Frank; Fuhr, Uwe; Holdenrieder, Stefan; Hempel, Georg; Scherf-Clavel, Oliver; Jaehde, Ulrich; Kloft, Charlotte; For The On-Target Study Consortium (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)
    Exposure-efficacy and/or exposure-toxicity relationships have been identified for up to 80% of oral anticancer drugs (OADs). Usually, OADs are administered at fixed doses despite their high interindividual pharmacokinetic ...
  • The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials 
    van Eijk, Maarten; Vermunt, Marit A C; van Werkhoven, Erik; Wilthagen, Erica A; Huitema, Alwin D R; Beijnen, Jos H (BioMed Central, 2022-01-25)
    BACKGROUND: Administration of single-agent docetaxel in a weekly schedule may offer similar efficacy, with a more favorable toxicity profile, compared to a three-weekly schedule in patients with metastatic breast cancer. ...
  • Carboplatin-Cyclophosphamide or Paclitaxel without or with Bevacizumab as First-Line Treatment for Metastatic Triple-Negative Breast Cancer (BOOG 2013-01) 
    van Rossum, Annelot G J; Mandjes, Ingrid A M; van Werkhoven, Erik; van Tinteren, Harm; van Leeuwen-Stok, A Elise; Nederlof, Petra; Portielje, Johanna E A; van Alphen, Robbert J; Platte, Els; van den Broek, Daan; Huitema, Alwin; Kok, Marleen; Linn, Sabine C; Oosterkamp, Hendrika M (S. Karger AG, 2021-12-01)
    The addition of bevacizumab to chemotherapy conferred a modest progression-free survival (PFS) benefit in metastatic triple-negative breast cancer (mTNBC). However, no overall survival (OS) benefit has been reported. Also, ...
  • Everolimus Concentration in Saliva to Predict Stomatitis: A Feasibility Study in Patients with Cancer 
    Laura, Molenaar-Kuijsten; Verheijen, Remy B; Jacobs, Bart A W; Bas, Thijssen; Hilde, Rosing; Dorlo, Thomas P C; Beijnen, Jos H; Neeltje, Steeghs; Huitema, Alwin D R (Lippincott Williams & Wilkins, 2022-08)
    BACKGROUND: Most patients with cancer treated with everolimus experience stomatitis, which seriously affects the quality of life. The salivary concentrations of everolimus may predict the incidence and severity of stomatitis. ...
  • Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy in Children with Cancer: A Systematic Review and Meta-Analysis 
    Uittenboogaard, Aniek; Neutel, Céline L G; Ket, Johannes C F; Njuguna, Festus; Huitema, Alwin D R; Kaspers, Gertjan J L; van de Velde, Mirjam E (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)
    Vincristine-induced peripheral neuropathy (VIPN) is a debilitating side-effect of vincristine. It remains a challenge to predict which patients will suffer from VIPN. Pharmacogenomics may explain an individuals' susceptibility ...
  • Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity 
    Laoukili, Jamila; Constantinides, Alexander; Wassenaar, Emma C E; Elias, Sjoerd G; Raats, Danielle A E; van Schelven, Susanne J; van Wettum, Jonathan; Volckmann, Richard; Koster, Jan; Huitema, Alwin D R; Nienhuijs, Simon W; de Hingh, Ignace H J T; Wiezer, René J; van Grevenstein, Helma M U; Rinkes, Inne H M Borel; Boerma, Djamila; Kranenburg, Onno (Springer Nature, 2022-06-01)
    BACKGROUND: Peritoneal metastases (PM) in colorectal cancer (CRC) are associated with therapy resistance and poor survival. Oxaliplatin monotherapy is widely applied in the intraperitoneal treatment of PM, but fails to ...
  • VhH anti-thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow 
    van Moorsel, Marc V A; Poolen, Geke; Koekman, Cornelis A; Verhoef, Sandra; de Maat, Steven; Barendrecht, Arjan; van Kleef, Nadine D; Meijers, Joost C M; Schiffelers, Raymond; Maas, Coen; Urbanus, Rolf T (Wiley-Blackwell, 2022-05)
    Background: Thrombomodulin on endothelial cells can form a complex with thrombin. This complex has both anticoagulant properties, by activating protein C, and clot-protective properties, by activating thrombin-activatable ...
  • False Utopia of One Unifying Description of the Vulnerable Atherosclerotic Plaque: A Call for Recalibration That Appreciates the Diversity of Mechanisms Leading to Atherosclerotic Disease 
    Pasterkamp, Gerard; den Ruijter, Hester M; Giannarelli, Chiara (Lippincott Williams & Wilkins, 2022-04-01)
    Atherosclerosis is a complex disease characterized by the formation of arterial plaques with a broad diversity of morphological phenotypic presentations. Researchers often apply one description of the vulnerable plaque as ...
  • The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease 
    Slenders, Lotte; Tessels, Daniëlle E; van der Laan, Sander W; Pasterkamp, Gerard; Mokry, Michal (Frontiers Media S. A., 2022-02-08)
    Atherosclerosis still is the primary cause of death worldwide. Our characterization of the atherosclerotic lesion is mainly rooted in definitions based on pathological descriptions. We often speak in absolutes regarding ...
  • Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia 
    Noordermeer, Tessa; van Asten, Ivar; Schutgens, Roger E.G.; Lakerveld, Anke J.; Koekman, Cornelis A.; Hage, Kay Y.; Sebastian, Silvie A.E.; Huisman, Albert; van den Heuvel, Dave J.; Gerritsen, Hans C.; Korporaal, Suzanne J.A.; Bierings, Marc; van der Smagt, Jasper J.; van Gijn, Marielle E.; Urbanus, Rolf T. (The American Society of Hematology, 2022-06-14)
  • Non-invasive monitoring of in vitro gastric milk protein digestion kinetics by 1H NMR magnetization transfer 
    Mayar, Morwarid; Miltenburg, Julie L; Hettinga, Kasper; Smeets, Paul A M; van Duynhoven, John P M; Terenzi, Camilla (Elsevier Limited, 2022-07-30)
    Processing of milk involves heating, which can modify the structure and digestibility of its proteins. In vitro models are useful for studying protein digestion. However, validating these models with in vivo data is ...
  • Relevance of polyp size for primary endoscopic full-thickness resection of suspected T1 colorectal cancers 
    Didden, Paul; van Eijck van Heslinga, Rixta; Schwartz, M P; Arensman, L.R.; Vleggaar, Frank P; de Graaf, Wilmar; Koch, Arjun Dave; Doukas, Michael; Lacle, M M; Moons, Leon Mg (Georg Thieme Verlag, 2022-11)
    BACKGROUND: En bloc local excision of suspected T1 colorectal cancer (CRC) provides optimal tumor risk assessment with curative intent. Endoscopic full-thickness resection (eFTR) with an over-the-scope device has emerged ...