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Now showing items 11361-11380 of 40729

Retrograde movements determine effective stem cell numbers in the intestine

Azkanaz, Maria; Corominas-Murtra, Bernat; Ellenbroek, Saskia I.J.; Bruens, Lotte; Webb, Anna T.; Laskaris, Dimitrios; Oost, Koen C.; Lafirenze, Simona J.A.; Annusver, Karl; Messal, Hendrik A.; Iqbal, Sharif; Flanagan, Dustin J.; Huels, David J.; Rojas-Rodríguez, Felipe; Vizoso, Miguel; Kasper, Maria; Sansom, Owen J.; Snippert, Hugo J.; Liberali, Prisca; Simons, Benjamin D.; Katajisto, Pekka; Hannezo, Edouard; van Rheenen, Jacco (Nature Research, 2022-07-21)

The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts1–3. Whether stem cell numbers and behaviour vary ...
Gregatins, a Group of Related Fungal Secondary Metabolites, Inhibit Aspects of Quorum Sensing in Gram-Negative Bacteria

Beenker, Wouter A.G.; Hoeksma, Jelmer; den Hertog, Jeroen (Frontiers Media S. A., 2022-07-05)

Quorum sensing (QS) is a process that regulates gene expression based on cell density. In bacteria, QS facilitates collaboration and controls a large number of pathways, including biofilm formation and virulence factor ...
Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo

van Leeuwen, Wessel; VanInsberghe, Michael; Battich, Nico; Salmén, Fredrik; van Oudenaarden, Alexander; Rabouille, Catherine (Cell Press, 2022-06-20)

Stress granules are phase-separated assemblies formed around RNAs. So far, the techniques available to identify these RNAs are not suitable for single cells and small tissues displaying cell heterogeneity. Here, we used ...
CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development

Klaus, Anna; Clapes, Thomas; Yvernogeau, Laurent; Basu, Sreya; Weijts, Bart; Maas, Joris; Smal, Ihor; Galjart, Niels; Robin, Catherine (Cell Press, 2022-06-14)

Hematopoietic stem cells (HSCs) express a large variety of cell surface receptors that are associated with acquisition of self-renewal and multipotent properties. Correct expression of these receptors depends on a delicate ...
Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells

Severino, Jacqueline; Bauer, Moritz; Mattimoe, Tom; Arecco, Niccolò; Cozzuto, Luca; Lorden, Patricia; Hamada, Norio; Nosaka, Yoshiaki; Nagaoka, So I.; Audergon, Pauline; Tarruell, Antonio; Heyn, Holger; Hayashi, Katsuhiko; Saitou, Mitinori; Payer, Bernhard (Springer Science and Business Media Deutschland GmbH, 2022-06-14)

The mammalian germline is characterized by extensive epigenetic reprogramming during its development into functional eggs and sperm. Specifically, the epigenome requires resetting before parental marks can be established ...
Patient-derived micro-organospheres enable clinical precision oncology

Ding, Shengli; Hsu, Carolyn; Wang, Zhaohui; Natesh, Naveen R.; Millen, Rosemary; Negrete, Marcos; Giroux, Nicholas; Rivera, Grecia O.; Dohlman, Anders; Bose, Shree; Rotstein, Tomer; Spiller, Kassandra; Yeung, Athena; Sun, Zhiguo; Jiang, Chongming; Xi, Rui; Wilkin, Benjamin; Randon, Peggy M.; Williamson, Ian; Nelson, Daniel A.; Delubac, Daniel; Oh, Sehwa; Rupprecht, Gabrielle; Isaacs, James; Jia, Jingquan; Chen, Chao; Shen, John Paul; Kopetz, Scott; McCall, Shannon; Smith, Amber; Gjorevski, Nikolche; Walz, Antje Christine; Antonia, Scott; Marrer-Berger, Estelle; Clevers, Hans; Hsu, David; Shen, Xiling (Cell Press, 2022-06-02)

Patient-derived xenografts (PDXs) and patient-derived organoids (PDOs) have been shown to model clinical response to cancer therapy. However, it remains challenging to use these models to guide timely clinical decisions ...
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

Allen, Jawara; Huber, Axel Rosendahl; Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; Wu, Shaoguang; Wu, Xinqun; Boot, Charelle; Saftien, Aurelia; O’Hagan, Heather M.; Wang, Hao; van Boxtel, Ruben; Clevers, Hans; Sears, Cynthia L. (American Society for Microbiology, 2022-05)

Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, ...
Evolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in Fungi

Mosunova, Olga V.; Navarro-Muñoz, Jorge C.; Haksar, Diksha; van Neer, Jacq; Hoeksma, Jelmer; Hertog, Jeroen den; Collemare, Jérôme (American Society for Microbiology, 2022-06)

Fungi produce a wide diversity of secondary metabolites with interesting biological activities for the health, industrial, and agricultural sectors. While fungal genomes have revealed an unexpectedly high number of ...
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes

Rinzema, Niels J.; Sofiadis, Konstantinos; Tjalsma, Sjoerd J.D.; Verstegen, Marjon J.A.M.; Oz, Yuva; Valdes-Quezada, Christian; Felder, Anna Karina; Filipovska, Teodora; van der Elst, Stefan; de Andrade dos Ramos, Zaria; Han, Ruiqi; Krijger, Peter H.L.; de Laat, Wouter (Nature Research, 2022-06)

Developmental gene expression is often controlled by distal regulatory DNA elements called enhancers. Distant enhancer action is restricted to structural chromosomal domains that are flanked by CTCF-associated boundaries ...
Single-cell profiling of transcriptome and histone modifications with EpiDamID

Rang, Franka J.; de Luca, Kim L.; de Vries, Sandra S.; Valdes-Quezada, Christian; Boele, Ellen; Nguyen, Phong D.; Guerreiro, Isabel; Sato, Yuko; Kimura, Hiroshi; Bakkers, Jeroen; Kind, Jop (Cell Press, 2022-05-19)

Recent advances in single-cell sequencing technologies have enabled simultaneous measurement of multiple cellular modalities, but the combined detection of histone post-translational modifications and transcription at ...
Patient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Lv, Tao; Shen, Lijun; Xu, Xiaoya; Yao, Ye; Mu, Peiyuan; Zhang, Hui; Wan, Juefeng; Wang, Yan; Guan, Ruoyu; Li, Xiaomeng; Fu, Guoxiang; Zhang, Long; Wang, Yaqi; Xia, Fan; Hu, Chen; Clevers, Hans; Zhang, Zhen; Hua, Guoqiang (John Wiley & Sons Inc., 2023-02-01)

Adding irinotecan to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) increases the pathologic complete response (pCR) rate but brings more toxicities. Robust biomarkers to predict response to ...
SOURCE beyond first-line: A survival prediction model for patients with metastatic esophagogastric adenocarcinoma after failure of first-line palliative systemic therapy

Kuijper, Steven C; Pape, Marieke; Haj Mohammad, Nadia; van Voorthuizen, Theo; Verhoeven, Rob H A; van Laarhoven, Hanneke W M (John Wiley & Sons Inc., 2023-03-15)

Prior models have been developed to predict survival for patients with esophagogastric cancer undergoing curative treatment or first-line chemotherapy (SOURCE models). Comprehensive clinical prediction models for patients ...
Adjusting for misclassification of an exposure in an individual participant data meta-analysis

de Jong, Valentijn M.T.; Campbell, Harlan; Maxwell, Lauren; Jaenisch, Thomas; Gustafson, Paul; Debray, Thomas P.A. (John Wiley & Sons Inc., 2023-03)

A common problem in the analysis of multiple data sources, including individual participant data meta-analysis (IPD-MA), is the misclassification of binary variables. Misclassification may lead to biased estimators of model ...
Reduction of GABA subunit theta-containing cortical neurons in schizophrenia

Dijkstra, Anke A; Gami-Patel, Priya; Rozemuller, Annemieke J M; Bugiani, Marianna; Pijnenburg, Yolande A L; Smit, Guus A B; Dols, Annemiek; Hoozemans, Jeroen J M (Elsevier, 2021-02)
The bvFTD phenocopy syndrome: a case study supported by repeated MRI, [18F]FDG-PET and pathological assessment

van Engelen, Marie-Paule E; Rozemuller, Annemieke J M; Ulugut Erkoyun, Hülya; Groot, Colin; Fieldhouse, Jay L P; Koene, Ted; Ossenkoppele, Rik; Gossink, Flora T; Krudop, Welmoed A; Vijverberg, Everard G B; Dols, Annemieke; Barkhof, Frederik; Berckel, Bart N M Van; Scheltens, Philip; Brain Bank, Netherlands; Pijnenburg, Yolande A L (Taylor and Francis Ltd., 2021-04)

A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental ...
European survey on the current surveillance practices, management guidelines, treatment pathways, and heterogeneity of testing of Clostridioides difficile, 2018-2019: results from The Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI)

COMBACTE-CDI consortium (W.B. Saunders Ltd, 2023-01)

Background: Awareness and compliance with international guidelines for diagnosis and clinical management of Clostridioides difficile infection (CDI) are unknown. Aim: To compare the awareness and compliance with the ...
Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project

Sajatovic, Martha; Dols, Annemiek; Rej, Soham; Almeida, Osvaldo P; Beunders, Alexandra J M; Blumberg, Hilary P; Briggs, Farren B S; Forester, Brent P; Patrick, Regan E; Forlenza, Orestes V; Gildengers, Ariel; Jimenez, Esther; Vieta, Eduard; Mulsant, Benoit; Schouws, Sigfried; Paans, Nadine; Strejilevich, Sergio; Sutherland, Ashley; Tsai, Shangying; Wilson, Betsy; Eyler, Lisa T (Blackwell Munksgaard, 2022-03)

Objective: Literature on older-age bipolar disorder (OABD) is limited. This first-ever analysis of the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) investigated associations among age, BD ...
Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment

International Society for Bipolar Disorders (ISBD) Older Adults with Bipolar Disorder (OABD) Task Force (Blackwell Munksgaard, 2022-03)

Objectives: We aim to characterize the cognitive performance in euthymic older adults with bipolar disorder (OABD) through a comprehensive neuropsychological assessment to obtain a detailed neuropsychological profile. ...
Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration

Almeida, Osvaldo P; Dols, Annemiek; Blanken, Machteld A J T; Rej, Soham; Blumberg, Hilary P; Villa, Luca; Forester, Brent P; Forlenza, Orestes V; Gildengers, Ariel; Vieta, Eduard; Jimenez, Esther; Mulsant, Benoit; Schouws, Sigfried; Tsai, Shangying; Korten, Nicole C M; Sutherland, Ashley; Briggs, Farren B S; Flicker, Leon; Eyler, Lisa T; Sajatovic, Martha (Lippincott Williams & Wilkins, 2022-06)

OBJECTIVES: To compare the prevalence of physical morbidities among men and women with older adult bipolar disorder (OABD), and men with and without OABD. METHODS: Cross-sectional analysis of the collaborative Global Aging ...
Is social functioning in older age patients with bipolar disorder associated with affective and/or non-affective cognition?

Paans, Nadine Pg; Korten, Nicole; Orhan, Melis; Ensing, Anne; Schouws, Sigfried Ntm; Kupka, Ralph; van Oppen, Patricia; Dols, Annemiek (John Wiley & Sons Inc., 2022-02)

OBJECTIVES: Previous research showed impairments in non-affective cognition, affective cognition, and social functioning in adult patients with bipolar disorder (BD). Only 37% of adult BD patients recovers in social ...

Now showing items 11361-11380 of 40729