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UMC Repository: Recent submissions

  • Feasibility and first results of the trials-within-cohorts design in patients with lung cancer. 
    Tomassen, M.; Damen, P.; Verkooijen, H.; Peters, M.; van der Stap, J.; van Lindert, A.; Verhoeff, J.; van Rossum, P. (Elsevier Ireland Ltd, 2022-05)
    Purpose or Objective ‘Trials-within-Cohorts’ (TwiCs), previously referred to as ‘cohort multiple RCT’ is a modern trial design that supports a quick and representative recruitment of patients for future trials. To our ...
  • Patient Experience of MR-guided Radiotherapy using a 1.5T MR-Linac 
    Westerhoff, J.; van Otterloo, S. de Mol; Leer, T.; Daamen, L.; Rutgers, R.; Meijers, L.; Intven, M.; Verkooijen, H. (Elsevier Ireland Ltd, 2022-05)
    Purpose or Objective The 1.5 Tesla MR-linac device (Elekta Stockholm, Sweden) is a combination of a diagnostic 1.5 T MRI scanner and 7MV linear accelerator and enables MR-guided radiotherapy (MRgRT) through daily adjustment ...
  • Factors Associated with Late Local Radiation Toxicity after Post-Operative Breast Irradiation 
    Batenburg, M. C. T.; Bartels, M.; Maarse, W.; Witkamp, A.; Verkooijen, H. M.; van den Bongard, H. J. G. D. (Wiley-Blackwell, 2022-04-16)
    Purpose. To assess determinants associated with late local radiation toxicity in patients treated for breast cancer. Methods. A systematic review was performed. All studies reporting ≥2 variables associated with late local ...
  • Cost-effectiveness analysis of 1.5T MRI-guided radiotherapy: A survey in the MR-Linac Consortium 
    Hehakaya, C.; van Zijp, J. R. van der Voort; Grobbee, D. E.; Verkooijen, H. M.; Frederix, G. F. (Elsevier Ireland Ltd, 2022-05)
    Purpose or Objective Cost-effectiveness analysis prior to technology implementation is important, but often not performed. The international MR-Linac Consortium works towards evidence-based introduction of the 1.5 Tesla ...
  • Implementation of Magnetic Resonance Imaging-Guided Radiation Therapy in Routine Care: Opportunities and Challenges in the United States 
    Hehakaya, Charisma; Sharma, Ankur M.; Zijp, Jochem R. N. van der Voort Van; Grobbee, Diederick E.; Verkooijen, Helena M.; Sharma, Ankur M; Moors, Ellen H. M. (Elsevier, 2022-05-25)
    Purpose Magnetic resonance image (MRI)-guided radiation therapy with the 1.5 Tesla magnetic resonance linear accelerator (MR-Linac) is a rapidly evolving and emerging treatment. The MR-Linac literature mainly focused on ...
  • Predicting Response to Neoadjuvant Therapy in Oesophageal Adenocarcinoma 
    Jiang, William; de Jong, Jelske M.; van Hillegersberg, Richard; Read, Matthew (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-16)
    (1) Background: Oesophageal cancers are often late-presenting and have a poor 5-year survival rate. The standard treatment of oesophageal adenocarcinomas involves neoadjuvant chemotherapy with or without radiotherapy ...
  • Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: Results from the International Esodata Study Group 
    Van Der Wilk, Berend J.; Hagens, Eliza R.C.; Eyck, Ben M.; Gisbertz, Suzanne S.; Van Hillegersberg, Richard; Nafteux, Philippe; Schröder, Wolfgang; Wijnhoven, Bas P.L.; Lagarde, Sjoerd M.; Van Berge Henegouwen, Mark I. (John Wiley & Sons Inc., 2022-03-01)
    Background: Large studies comparing totally minimally invasive oesophagectomy (TMIE) with laparoscopically assisted (hybrid) oesophagectomy are lacking. Although randomized trials have compared TMIE invasive with open ...
  • Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed: The Study Protocol for the Randomized Controlled NEEDS Trial 
    Nilsson, Magnus; Olafsdottir, Halla; Alexandersson von Döbeln, Gabriella; Villegas, Fernanda; Gagliardi, Giovanna; Hellström, Mats; Wang, Qiao-Li; Johansson, Hemming; Gebski, Val; Hedberg, Jakob; Klevebro, Fredrik; Markar, Sheraz; Smyth, Elizabeth; Lagergren, Pernilla; Al-Haidari, Ghazwan; Rekstad, Lars Cato; Aahlin, Eirik Kjus; Wallner, Bengt; Edholm, David; Johansson, Jan; Szabo, Eva; Reynolds, John V; Pramesh, C S; Mummudi, Naveen; Joshi, Amit; Ferri, Lorenzo; Wong, Rebecca Ks; O'Callaghan, Chris; Lukovic, Jelena; Chan, Kelvin Kw; Leong, Trevor; Barbour, Andrew; Smithers, Mark; Li, Yin; Kang, Xiaozheng; Kong, Feng-Ming; Chao, Yin-Kai; Crosby, Tom; Bruns, Christiane; van Laarhoven, Hanneke; van Berge Henegouwen, Mark; van Hillegersberg, Richard; Rosati, Riccardo; Piessen, Guillaume; de Manzoni, Giovanni; Lordick, Florian (Frontiers Media S. A., 2022-07-13)
    BACKGROUND: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment ...
  • The surgical anatomy of a (robot-assisted) minimally invasive transcervical esophagectomy 
    Filz von Reiterdank, I C L J; Defize, I L; de Groot, E M; Wedel, T; Grimminger, P P; Egberts, J H; Stein, H; Ruurda, J P; van Hillegersberg, R; Bleys, R L A W (Wiley-Blackwell, 2023-04-01)
    BACKGROUND: Transcervical esophagectomy allows for esophagectomy through transcervical access and bypasses the thoracic cavity, thereby eliminating single lung ventilation. A challenging surgical approach demands thorough ...
  • Team dynamics and clinician's experience influence decision-making during Upper-GI multidisciplinary team meetings: A multiple case study 
    Luijten, J C H B M; Westerman, M J; Nieuwenhuijzen, G A P; Walraven, J E W; Sosef, M N; Beerepoot, L V; van Hillegersberg, R; Muller, K; Hoekstra, R; Bergman, J J G H M; Siersema, P D; van Laarhoven, H W M; Rosman, C; Brom, L; Vissers, P A J; Verhoeven, R H A (Frontiers Media S. A., 2022-10)
    BACKGROUND: The probability of undergoing treatment with curative intent for esophagogastric cancer has been shown to vary considerately between hospitals of diagnosis. Little is known about the factors that attribute to ...
  • Physical functioning and physical activity after gastrointestinal or bladder oncological surgery: An observational cohort study 
    Bor, Petra; de Leeuwerk, Marijke Elizabeth; Valkenet, Karin; van Hillegersberg, Richard; Veenhof, Cindy (Wiley-Blackwell, 2022-11)
    OBJECTIVE: The aim of this study was to investigate the recovery of physical functioning and objective physical activity levels up to 3 months after oncological surgery and to determine the association between physical ...
  • Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts 
    van der Kemp, W J M; Grinde, M T; Malvik, J O; van Laarhoven, H W M; Prompers, J J; Klomp, D W J; Burgering, B M T; Bathen, T F; Moestue, S A (John Wiley & Sons Inc., 2023-04)
    Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ...
  • Neurological soft signs in adolescents are associated with brain structure 
    Bonke, Elena M; Bonfert, Michaela V; Hillmann, Stefan M; Seitz-Holland, Johanna; Gaubert, Malo; Wiegand, Tim L T; De Luca, Alberto; Cho, Kang Ik K; Sandmo, Stian B; Yhang, Eukyung; Tripodis, Yorghos; Seer, Caroline; Kaufmann, David; Kaufmann, Elisabeth; Muehlmann, Marc; Gooijers, Jolien; Lin, Alexander P; Leemans, Alexander; Swinnen, Stephan P; Bahr, Roald; Shenton, Martha E; Pasternak, Ofer; Tacke, Uta; Heinen, Florian; Koerte, Inga K (Oxford University Press, 2023-05-01)
    Neurological soft signs (NSS) are minor deviations in motor performance. During childhood and adolescence, NSS are examined for functional motor phenotyping to describe development, to screen for comorbidities, and to ...
  • Causality in transcription and genome folding: Insights from X inactivation 
    Bauer, Moritz; Payer, Bernhard; Filion, Guillaume J. (John Wiley & Sons Inc., 2022-10)
    The spatial organization of genomes is becoming increasingly understood. In mammals, where it is most investigated, this organization ties in with transcription, so an important research objective is to understand whether ...
  • A dualistic approach to heart repair through FGF10 
    Koopmans, Tim; van Rooij, Eva (Oxford University Press, 2022-09-20)
  • Rapid tissue prototyping with micro-organospheres 
    Wang, Zhaohui; Boretto, Matteo; Millen, Rosemary; Natesh, Naveen; Reckzeh, Elena S.; Hsu, Carolyn; Negrete, Marcos; Yao, Haipei; Quayle, William; Heaton, Brook E.; Harding, Alfred T.; Bose, Shree; Driehuis, Else; Beumer, Joep; Rivera, Grecia O.; van Ineveld, Ravian L.; Gex, Donald; DeVilla, Jessica; Wang, Daisong; Puschhof, Jens; Geurts, Maarten H.; Yeung, Athena; Hamele, Cait; Smith, Amber; Bankaitis, Eric; Xiang, Kun; Ding, Shengli; Nelson, Daniel; Delubac, Daniel; Rios, Anne; Abi-Hachem, Ralph; Jang, David; Goldstein, Bradley J.; Glass, Carolyn; Heaton, Nicholas S.; Hsu, David; Clevers, Hans; Shen, Xiling (Cell Press, 2022-09-13)
    In vitro tissue models hold great promise for modeling diseases and drug responses. Here, we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-encapsulated miniature three-dimensional (3D) ...
  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation 
    He, Gui Wei; Lin, Lin; DeMartino, Jeff; Zheng, Xuan; Staliarova, Nadzeya; Dayton, Talya; Begthel, Harry; van de Wetering, Willine J.; Bodewes, Eduard; van Zon, Jeroen; Tans, Sander; Lopez-Iglesias, Carmen; Peters, Peter J.; Wu, Wei; Kotlarz, Daniel; Klein, Christoph; Margaritis, Thanasis; Holstege, Frank; Clevers, Hans (Cell Press, 2022-09-01)
    Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have optimized human small intestinal organoid (hSIO) culturing, constitutively generating all differentiated cell types while maintaining an ...
  • Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome 
    Motta, Marialetizia; Solman, Maja; Bonnard, Adeline A.; Kuechler, Alma; Pantaleoni, Francesca; Priolo, Manuela; Chandramouli, Balasubramanian; Coppola, Simona; Pizzi, Simone; Zara, Erika; Ferilli, Marco; Kayserili, Hülya; Onesimo, Roberta; Leoni, Chiara; Brinkmann, Julia; Vial, Yoann; Kamphausen, Susanne B.; Thomas-Teinturier, Cécile; Guimier, Anne; Cordeddu, Viviana; Mazzanti, Laura; Zampino, Giuseppe; Chillemi, Giovanni; Zenker, Martin; Cavé, Hélène; den Hertog, Jeroen; Tartaglia, Marco (Oxford University Press, 2022-08-23)
    We previously molecularly and clinically characterized Mazzanti syndrome, a RASopathy related to Noonan syndrome that is mostly caused by a single recurrent missense variant (c.4A > G, p.Ser2Gly) in SHOC2, which encodes a ...
  • Digging for treasures in the tumour interactome 
    Giladi, Amir (Nature Publishing Group, 2022-08)
  • Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF 
    Corbeski, Ivan; Guo, Xiaohu; Eckhardt, Bruna V.; Fasci, Domenico; Wiegant, Wouter; Graewert, Melissa A.; Vreeken, Kees; Wienk, Hans; Svergun, Dmitri I.; Heck, Albert J.R.; van Attikum, Haico; Boelens, Rolf; Sixma, Titia K.; Mattiroli, Francesca; van Ingen, Hugo (American Association for the Advancement of Science, 2022-07-29)
    Nucleosome assembly requires the coordinated deposition of histone complexes H3-H4 and H2A-H2B to form a histone octamer on DNA. In the current paradigm, specific histone chaperones guide the deposition of first H3-H4 and ...