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Now showing items 11301-11320 of 40729

Survival in patients with neuroendocrine tumours of the small intestine: Nomogram validation and predictors of survival

Levy, Sonja; van Veenendaal, Linde M.; Korse, Catharina M.; Breekveldt, Emilie C.H.; Verbeek, Wieke H.M.; Vriens, Menno R.; Kuhlmann, Koert F.D.; van den Berg, José G.; Valk, Gerlof D.; Tesselaar, Margot E.T. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-08)

Neuroendocrine tumours of the small intestine (SI‐NETs) are rare and heterogeneous. There is an unmet need for prognostication of disease course and to aid treatment strategies. A previously developed nomogram based on ...
Robust high spatio-temporal line-scanning fMRI in humans at 7T using multi-echo readouts, denoising and prospective motion correction

Raimondo, Luisa; Priovoulos, Nikos; Passarinho, Catarina; Heij, Jurjen; Knapen, Tomas; Dumoulin, Serge O.; Siero, Jeroen C.W.; van der Zwaag, Wietske (Elsevier, 2023-01-15)

Background: Functional magnetic resonance imaging (fMRI), typically using blood oxygenation level-dependent (BOLD) contrast weighted imaging, allows the study of brain function with millimeter spatial resolution and temporal ...
Modeling gross motor developmental curves of extremely and very preterm infants using the AIMS home-video method

Suir, I; Boonzaaijer, M; Oudgenoeg-Paz, O; Westers, P; de Vries, L S; van der Net, J; Nuysink, J; Jongmans, M J (Elsevier Ireland Ltd, 2022-12)

BACKGROUND: Motor development is one of the first signals to identify whether an infant is developing well. For very preterm (VPT) infants without severe perinatal complications, little is known about their motor developmental ...
Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids

de Wit, Koos; Beuers, Ulrich; Mukha, Anna; Stigter, Edwin; Gulersonmez, M Can; Ramos Pittol, Jose M; Middendorp, Sabine; Takkenberg, R Bart; van Mil, Saskia W C (Wiley-Blackwell, 2023-03)

BACKGROUND AND AIMS: Recurrent hepatic encephalopathy (HE) is characterized by hyperammonaemia in combination with neuropsychiatric abnormalities and is treated with lactulose and rifaximin. Rifaximin is a pregnane X ...
Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

Lecour, Sandrine; Du PrCrossed D Sign©, Bastiaan C.; Bøtker, Hans Erik; Brundel, Bianca J.J.M.; Daiber, Andreas; Davidson, Sean M.; Ferdinandy, Peter; Girao, Henrique; Gollmann-Tepeköylü, Can; Gyöngyösi, Mariann; Hausenloy, Derek J.; Madonna, Rosalinda; Marber, Michael; Perrino, Cinzia; Pesce, Maurizio; Schulz, Rainer; Sluijter, Joost P.G.; Steffens, Sabine; Van Linthout, Sophie; Young, Martin E.; Van Laake, Linda W. (Oxford University Press, 2022-08-01)

Circadian rhythms are internal regulatory processes controlled by molecular clocks present in essentially every mammalian organ that temporally regulate major physiological functions. In the cardiovascular system, the ...
Gut microbiome mediates the protective effects of exercise after myocardial infarction

Zhou, Qiulian; Deng, Jiali; Pan, Xue; Meng, Danni; Zhu, Yujiao; Bai, Yuzheng; Shi, Chao; Duan, Yi; Wang, Tianhui; Li, Xinli; Sluijter, Joost Pg; Xiao, Junjie (BioMed Central Ltd., 2022-12)

Background: Gut microbiota plays important roles in health maintenance and diseases. Physical exercise has been demonstrated to be able to modulate gut microbiota. However, the potential role of gut microbiome in exercise ...
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling

Zhou, Qiulian; Meng, Danni; Li, Feng; Zhang, Xiao; Liu, Li; Zhu, Yujiao; Liu, Shuqin; Xu, Minjun; Deng, Jiali; Lei, Zhiyong; Sluijter, Joost P.G.; Xiao, Junjie (Elsevier, 2022-11)

Background: Homeodomain-Interacting Protein Kinase 2 (HIPK2) has been reported to maintain basal cardiac function, however, its role in pathological cardiac remodeling remains unclear. Methods: HIPK2 inhibitors (tBID and ...
Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes

Peters, Marijn C.; Maas, Renee G.C.; van Adrichem, Iris; Doevendans, Pieter A.M.; Mercola, Mark; Šarić, Tomo; Buikema, Jan W.; van Mil, Alain; Chamuleau, Steven A.J.; Sluijter, Joost P.G.; Hnatiuk, Anna P.; Neef, Klaus (Oxford University Press, 2022-10-21)

The development of new cardioprotective approaches using in vivo models of ischemic heart disease remains challenging as differences in cardiac physiology, phenotype, and disease progression between humans and animals ...
METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Wang, Lijun; Wang, Jiaqi; Yu, Pujiao; Feng, Jingyi; Xu, Gui e.; Zhao, Xuan; Wang, Tianhui; Lehmann, H. Immo; Li, Guoping; Sluijter, Joost P.G.; Xiao, Junjie (Nature Publishing Group, 2022-12)

RNA m6A modification is the most widely distributed RNA methylation and is closely related to various pathophysiological processes. Although the benefit of regular exercise on the heart has been well recognized, the role ...
Cardiac fibroblasts and mechanosensation in heart development, health and disease

Pesce, Maurizio; Duda, Georg N.; Forte, Giancarlo; Girao, Henrique; Raya, Angel; Roca-Cusachs, Pere; Sluijter, Joost P.G.; Tschöpe, Carsten; Van Linthout, Sophie (Nature Research, 2023-05)

The term ‘mechanosensation’ describes the capacity of cells to translate mechanical stimuli into the coordinated regulation of intracellular signals, cellular function, gene expression and epigenetic programming. This ...
Severe pulmonary toxicity associated with inhalation of pyrethroid-based domestic insecticides (Bop/Sapolio): a case series and literature review

Vorselaars, Adriane D M; van den Berg, Paulus M; Drent, Marjolein (Lippincott Williams & Wilkins, 2021-07-01)

PURPOSE OF REVIEW: The current review focuses on serious pulmonary toxicity after inhalation of over the counter available pyrethroid-based insecticides. Pyrethroid is a synthetic product of pyrethrin, which in turn is the ...
Hit-hard and early versus step-up treatment in severe sarcoidosis

Vorselaars, Adriane D. M.; Culver, Daniel A. (Lippincott Williams & Wilkins, 2022-09)

Purpose of reviewThe treatment of sarcoidosis remains uncertain, despite 70 years of study. The conventional approach is to initiate corticosteroids in individuals who require treatment. The position of more aggressive ...
Home-monitoring reduces hospital stay for COVID-19 patients

Grutters, Laura Agnes; Majoor, Kalle Iskander; Pol-Mattern, Eline Solange Kirsty; Hardeman, Johannes Anthonie; van Swol, Christiaan Franciscus Pieter; Vorselaars, Adriane Dore Marie (European Respiratory Society, 2021-11)

Home monitoring reduces hospital stay of patients with COVID-19, which increases regular healthcare capacity https://bit.ly/3CdFp1z
ULTrasound-guided TRAnsfemoral puncture in COmplex Large bORe PCI: study protocol of the UltraCOLOR trial

Meijers, Thomas A; Nap, Alexander; Aminian, Adel; Dens, Joseph; Teeuwen, Koen; van Kuijk, Jan-Peter; van Wely, Marleen; Schmitz, Thomas; Bataille, Yoann; Kraaijeveld, Adriaan O; Roolvink, Vincent; Hermanides, Renicus S; Braber, Thijs L; van Royen, Niels; van Leeuwen, Maarten A H (BMJ Publishing Group, 2022-12-01)

Introduction Although recently published evidence favours transradial access (TRA) when using large-bore guiding catheters for percutaneous coronary intervention (PCI) of complex coronary lesions, the femoral artery will ...
Optimal Timing of a Physical Exercise Intervention to Improve Cardiorespiratory Fitness: During or After Chemotherapy

van der Schoot, Gabriela G F; Ormel, Harm L; Westerink, Nico-Derk L; May, Anne M; Elias, Sjoerd G; Hummel, Yoran M; Lefrandt, Joop D; van der Meer, Peter; van Melle, Joost P; Poppema, Boelo J; Stel, Joyce M A; van der Velden, Annette W G; Vrieling, Aline H; Wempe, Johan B; Ten Wolde, Marcel G; Nijland, Marcel; de Vries, Elisabeth G E; Gietema, Jourik A; Walenkamp, Annemiek M E (Elsevier, 2022-11)

BACKGROUND: Despite the widely acknowledged benefit of exercise for patients with cancer, little evidence on the optimal timing of exercise on adverse effects of cancer treatment is available. OBJECTIVES: The aim of this ...
Quantifying cerebral blood arrival times using hypoxia-mediated arterial BOLD contrast

Bhogal, Alex A.; Sayin, Ece Su; Poublanc, Julien; Duffin, James; Fisher, Joseph A.; Sobcyzk, Olivia; Mikulis, David J. (Academic Press Inc., 2022-11-01)

Cerebral blood arrival and tissue transit times are sensitive measures of the efficiency of tissue perfusion and can provide clinically meaningful information on collateral blood flow status. We exploit the arterial blood ...
A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Petr, Jan; Hogeboom, Louise; Nikulin, Pavel; Wiegers, Evita; Schroyen, Gwen; Kallehauge, Jesper; Chmelík, Marek; Clement, Patricia; Nechifor, Ruben E.; Fodor, Liviu Andrei; De Witt Hamer, Philip C.; Barkhof, Frederik; Pernet, Cyril; Lequin, Maarten; Deprez, Sabine; Jančálek, Radim; Mutsaerts, Henk J.M.M.; Pizzini, Francesca B.; Emblem, Kyrre E.; Keil, Vera C. (Springer-Verlag, 2022-02)

Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage ...
Effect of lactate administration on cerebral blood flow during hypoglycemia in people with type 1 diabetes

Van Meijel, Lian A.; Van Asten, Jack J.A.; Grandjean, Joanes; Heerschap, Arend; Tack, Cornelis J.; Van Der Graaf, Marinette; Wiegers, Evita C.; De Galan, Bastiaan E. (BMJ Publishing Group, 2022-03-23)

Introduction Impaired awareness of hypoglycemia, clinically reflected by the inability to timely detect hypoglycemia, affects approximately 25% of the people with type 1 diabetes. Both altered brain lactate handling and ...
High-Grade Glioma Treatment Response Monitoring Biomarkers (2): A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 2: Spectroscopy, Chemical Exchange Saturation, Multiparametric Imaging, and Radiomics

the European Cooperation in Science Technology (COST) Glioma MR Imaging 2.0 (GliMR) initiative (Frontiers Media S. A., 2022-02-28)

Objective: To summarize evidence for use of advanced MRI techniques as monitoring biomarkers in the clinic, and to highlight the latest bench-to-bedside developments. Methods: The current evidence regarding the potential ...
High-Grade Glioma Treatment Response Monitoring Biomarkers (1): A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 1: Perfusion and Diffusion Techniques

the European Cooperation in Science and Technology (COST) Glioma MR Imaging 2.0 (GliMR) Initiative (Frontiers Media S. A., 2022-03-03)

Objective: Summarize evidence for use of advanced MRI techniques as monitoring biomarkers in the clinic, and highlight the latest bench-to-bedside developments. Methods: Experts in advanced MRI techniques applied to ...

Now showing items 11301-11320 of 40729