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Now showing items 10881-10900 of 40729

Validation of the GetReal Trial Tool - Facilitating discussion and understanding more pragmatic design choices and their implications

Boateng , Daniel; Kumke, Thomas; Vernooij, Robin; Goetz, Iris; Meinecke, Anna Katharina; Steenhuis, Charlotte; Grobbee, Diederick; Zuidgeest, Mira GP (Elsevier, 2023-02)

Background: The GetReal Trial Tool is a decision support tool to assess the impact of design choices on generalizability of clinical trials to routine clinical practice, while taking into account the risk of bias, precision, ...
Imaging in neuroblastoma

Littooij, Annemieke S.; de Keizer, Bart (Springer-Verlag, 2023-04)

Neuroblastoma is the most common extracranial solid malignancy of childhood. The prognosis is highly variable ranging from spontaneous involution in infants to fatal outcome, despite aggressive treatment, in disseminated ...
Psychosocial factors and hippocampal subfields: The Medea-7T study

UCC-SMART Study Group (Wiley-Liss Inc., 2023-04-01)

Specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development ...
Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design

Doppenberg, D.; Besselink, M. G.; van Eijck, C. H.J.; Intven, M. P.W.; Koerkamp, B. Groot; Kazemier, G.; van Laarhoven, H. W.M.; Meijerink, M.; Molenaar, I. Q.; Nuyttens, J. J.M.E.; van Os, R.; van Santvoort, H. C.; van Tienhoven, G.; Verkooijen, H. M.; Versteijne, E.; Wilmink, J. W.; Lagerwaard, F. J.; Bruynzeel, A. M.E. (BioMed Central, 2022-12-29)

Background: Significant comorbidities, advanced age, and a poor performance status prevent surgery and systemic treatment for many patients with localized (non-metastatic) pancreatic ductal adenocarcinoma (PDAC). These ...
Computational modeling identifies the cellular electromechanical effects of disrupted intracellular calcium handling in arrhythmogenic cardiomyopathy patients

Lyon, Aurore; van Ham, WB; van der Voorn, Stephanie; Heijman, Jordi; Kirkels, Feddo; Vink, Aryan; te Riele, Anneline S.J.M.; Lumens, Joost; van Veen, TAB (Oxford University Press, 2022-05-19)
Determing the role of uremic toxins on cardiac electrophysiology and pro-arrhythmia during chronic kidney disease

van Ham, WB; Bossu, Alexandre; Houtman, Marien; Cornelissen, Carlijn M; Vos, MA; van Veen, TAB (Oxford University Press, 2022-05-19)
Accelerometer-measured physical activity, sedentary behavior, and sleep in children with cerebral palsy and their adherence to the 24-hour activity guidelines

Hulst, RY; Gorter, JW; Obeid, Joyce; Voorman, Jeanine; van Rijssen, Ilse; Gerritsen, Anke; Visser-Meilij, JM Anne; Pillen, Sigrid; Verschuren, Olaf (Wiley-Blackwell, 2023-03)

Aim: To measure and describe the 24-hour activities (i.e. physical activity, sedentary behavior, and sleep) and to examine adherence to the 24-hour activity guidelines among children with cerebral palsy (CP) using actigraphy. ...
The utility of the surprise question: A useful tool for identifying patients nearing the last phase of life? A systematic review and meta-analysis

van Lummel, Eline V.T.J.; Ietswaard, Larissa; Zuithoff, Nicolaas P.A.; Tjan, Dave H.T.; van Delden, Johannes J.M. (SAGE Publications Ltd, 2022-06-29)

Background: The surprise question is widely used to identify patients nearing the last phase of life. Potential differences in accuracy between timeframe, patient subgroups and type of healthcare professionals answering ...
Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28-week clinical and biomarker results from the BioDay registry

Kamphuis, Esmé; Boesjes, Celeste M.; Loman, Laura; Bakker, Daphne S.; Poelhekken, Mila; Zuithoff, Nicolaas P.A.; Kamsteeg, Marijke; Romeijn, Geertruida L.E.; van Wijk, Femke; de Bruin-Weller, Marjolein S.; de Graaf, Marlies; Schuttelaar, Marie L.A. (Blackwell Munksgaard, 2022-12-05)

Background: Dupilumab has proven to be an effective and safe treatment for atopic dermatitis (AD) in pediatric patients in clinical trials. However, few daily practice studies are available. The aim of this study is to ...
SARS-CoV-2 outbreaks in secondary school settings in the Netherlands during fall 2020; silent circulation

Jonker, Lotte; Linde, Kimberly J.; de Hoog, Marieke L.A.; Sprado, Robin; Huisman, Robin C.; Molenkamp, Richard; Oude Munnink, Bas B.; Dohmen, Wietske; Heederik, Dick J.J.; Eggink, Dirk; Welkers, Matthijs R.A.; Vennema, Harry; Fraaij, Pieter L.A.; Koopmans, Marion P.G.; Wouters, Inge M.; Bruijning-Verhagen, Patricia C.J.L. (BioMed Central, 2022-12-26)

Background: In fall 2020 when schools in the Netherlands operated under a limited set of COVID-19 measures, we conducted outbreaks studies in four secondary schools to gain insight in the level of school transmission and ...
Fetal MRI of the heart and brain in congenital heart disease

FUTURE 2.0 consortium (Elsevier, 2023-01)

Antenatal assessment of congenital heart disease and associated anomalies by ultrasound has improved perinatal care. Fetal cardiovascular MRI and fetal brain MRI are rapidly evolving for fetal diagnostic testing of congenital ...
The different clinical facets of SYN1-related neurodevelopmental disorders

SYN1 (Frontiers Media S. A., 2022-12-08)

Synapsin-I (SYN1) is a presynaptic phosphoprotein crucial for synaptogenesis and synaptic plasticity. Pathogenic SYN1 variants are associated with variable X-linked neurodevelopmental disorders mainly affecting males. In ...
The experienced positive and negative influence of HIV on quality of life of people with HIV and vulnerable to HIV in the Netherlands

Romijnders, Kim A.G.J.; de Groot, Laura; Vervoort, Sigrid C.J.M.; Basten, Maartje; van Welzen, Berend J.; Kretzschmar, Mirjam E.; Reiss, Peter; Davidovich, Udi; van der Loeff, Maarten F.Schim; Rozhnova, Ganna (Nature Publishing Group, 2022-12-19)

This qualitative study aimed to explore the experienced influence of HIV on the quality of life (QoL) of people with HIV (PHIV) and key populations without but are vulnerable to HIV in the Netherlands. We conducted and ...
QRS micro-fragmentation as a mortality predictor

Hnatkova, Katerina; Andršová, Irena; Novotný, Tomáš; Britton, Annie; Shipley, Martin; Vandenberk, Bert; Sprenkeler, David J; Junttila, Juhani; Reichlin, Tobias; Schlögl, Simon; Vos, Marc A; Friede, Tim; Bauer, Axel; Huikuri, Heikki V; Willems, Rik; Schmidt, Georg; Franz, Michael R; Sticherling, Christian; Zabel, Markus; Malik, Marek (Oxford University Press, 2022-10-21)

Aims Fragmented QRS complex with visible notching on standard 12-lead electrocardiogram (ECG) is understood to represent depolarization abnormalities and to signify risk of cardiac events. Depolarization abnormalities with ...
Exploring the Correlation Between Fibrosis Biomarkers and Clinical Disease Severity in PLN p.Arg14del Patients

van der Voorn, Stephanie M; Bourfiss, Mimount; Te Riele, Anneline S J M; Taha, Karim; Vos, Marc A; de Brouwer, Remco; Verstraelen, Tom E; de Boer, Rudolf A; Remme, Carol Ann; van Veen, Toon A B (Frontiers Media S. A., 2022-01-13)

Background: Pathogenic variants in phospholamban (PLN, like p. Arg14del), are found in patients diagnosed with arrhythmogenic (ACM) and dilated cardiomyopathy (DCM). Fibrosis formation in the heart is one of the hallmarks ...
Uremic toxins in chronic kidney disease highlight a fundamental gap in understanding their detrimental effects on cardiac electrophysiology and arrhythmogenesis

van Ham, Willem B; Cornelissen, Carlijn M; van Veen, Toon A B (Wiley, 2022-11)

Chronic kidney disease (CKD) and cardiovascular disease (CVD) have an estimated 700-800 and 523 million cases worldwide, respectively, with CVD being the leading cause of death in CKD patients. The pathophysiological ...
Quantitative Analysis of the Cytoskeleton's Role in Inward Rectifier K IR 2.1 Forward and Backward Trafficking

Li, Encan; Loen, Vera; van Ham, Willem B; Kool, Willy; van der Heyden, Marcel A G; Takanari, Hiroki (Frontiers Research Foundation, 2022-01-25)

Alteration of the inward rectifier current I K1, carried by K IR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired K IR2.1 ...
The HFA-PEFF score identifies 'early-HFpEF' phenogroups associated with distinct biomarker profiles

Henkens, Michiel T H M; van Ommen, Anne-Mar; Remmelzwaal, Sharon; Valstar, Gideon B; Wang, Ping; Verdonschot, Job A J; Hazebroek, Mark R; Hofstra, Leonard; van Empel, Vanessa P M; Beulens, Joline W J; den Ruijter, Hester M; Heymans, Stephane R B (John Wiley & Sons Inc., 2022-06)

Aims: The HFA-PEFF score was developed to optimize diagnosis and to aid in early recognition of heart failure (HF) with preserved ejection fraction (HFpEF) in patients who present with HF-like symptoms. Recognizing early-HFpEF ...
Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome

Houtman, Marien J C; Friesacher, Theres; Chen, Xingyu; Zangerl-Plessl, Eva-Maria; van der Heyden, Marcel A G; Stary-Weinzinger, Anna (Frontiers Media S. A., 2022-01-14)

Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit ...
Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions

van Ommen, A M L N; Canto, E Dal; Cramer, Maarten J; Rutten, F H; Onland-Moret, N C; Ruijter, H M den (BioMed Central Ltd., 2022-12-27)

Diastolic dysfunction of the left ventricle (LVDD) is equally common in elderly women and men. LVDD is a condition that can remain latent for a long time but is also held responsible for elevated left ventricular filling ...

Now showing items 10881-10900 of 40729