Psychosocial factors and hippocampal subfields: The Medea-7T study
UCC-SMART Study Group
(2023) Human Brain Mapping, volume 44, issue 5, pp. 1964 - 1984
(Article)
Abstract
Specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development of neurodegenerative diseases. A systematic review on psychosocial factors and hippocampal subfield volumes was performed and showed inconsistent results, highlighting
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the need for future studies to explore this relationship. The current study aimed to explore the association of psychosocial factors with hippocampal (subfield) volumes, using high-field 7T MRI. Data were from the Memory Depression and Aging (Medea)-7T study, which included 333 participants without dementia. Hippocampal subfields were automatically segmented from T2-weighted images using ASHS software. Generalized linear models accounting for correlated outcomes were used to assess the association between subfields (i.e., entorhinal cortex, subiculum, Cornu Ammonis [CA]1, CA2, CA3, dentate gyrus, and tail) and each psychosocial factor (i.e., depressive symptoms, anxiety symptoms, childhood maltreatment, recent stressful life events, and social support), adjusted for age, sex, and intracranial volume. Neither depression nor anxiety was associated with specific hippocampal (subfield) volumes. A trend for lower total hippocampal volume was found in those reporting childhood maltreatment, and a trend for higher total hippocampal volume was found in those who experienced a recent stressful life event. Among subfields, low social support was associated with lower volume in the CA3 (B = −0.43, 95% CI: −0.72; −0.15). This study suggests possible differential effects among hippocampal (subfield) volumes and psychosocial factors.
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Keywords: anxiety, depression, early life adversity, hippocampus, MRI, psychosocial, Humans, Organ Size, Entorhinal Cortex, Magnetic Resonance Imaging, Hippocampus/diagnostic imaging, Aging, CA1 Region, Hippocampal, Clinical Neurology, Neurology, Radiological and Ultrasound Technology, Radiology Nuclear Medicine and imaging, Anatomy, Journal Article
ISSN: 1065-9471
Publisher: Wiley-Liss Inc.
Note: Funding Information: We would like to gratefully acknowledge the SMART participants, as well as all general practitioners from the general practice “Huisartsenpraktijk Bosboomstraat” for their time in inclusion of participants. We would also like to thank those in the memory clinics who assisted in data acquisition, as well as those involved in the PREDICT‐MR study. Members of the Utrecht Vascular Cognitive Impairment (VCI) Study group involved in the present study (in alphabetical order by department): University Medical Center Utrecht, the Netherlands, Department of Neurology: E. van den Berg, J. M. Biesbroek, G. J. Biessels, L.G. Exalto, S. M. Heringa, L. J. Kappelle, J. Verwer; Department of Radiology/Image Sciences Institute: J. de Bresser, H. J. Kuijf, P. R. Luijten, J. J. M. Zwanenburg; Department of Geriatrics: H. L. Koek; Hospital Diakonessenhuis Zeist, the Netherlands: M. Hamaker, R. Faaij, M. Pleizier, E. Vriens. We would like to acknowledge the following SMART research nurses: R. van Petersen (data manager), B. G. F. Dinther (vascular manager), and the members of the Utrecht Cardiovascular Cohort‐Second Manifestations of ARTerial disease‐Study Group (UCC‐SMART‐Study Group) F. W. Asselbergs and H. M. Nathoe, Department of Cardiology; G. J. de Borst, Department of Vascular Surgery; M. L. Bots and M. I. Geerlings, Julius Center for Health Sciences and Primary Care; M. H. Emmelot, Department of Geriatrics; P. A. de Jong and T. Leiner, Department of Radiology; A. T. Lely, Department of Obstetrics and Gynecology; N. P. van der Kaaij, Department of Cardiothoracic Surgery; L. J. Kappelle and Y. M. Ruigrok, Department of Neurology; M. C. Verhaar, Department of Nephrology; F. L. J. Visseren (chair) and J. Vesterink, Department of Vascular Medicine, University Medical Center and Utrecht University. We would like to thank NP. A. Zuithoff, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, for his assistance with validating our analyses in R with previous mixed models of correlated outcomes in SAS. This study was funded by a grant from Alzheimer Nederland (Grant number 12504) and was conducted as part of the Netherlands Consortium of Dementia Cohorts (NCDC). NCDC receives funding in the Deltaplan Dementie from ZonMw (Project number 73305095005) and Alzheimer Nederland. Funding Information: We would like to gratefully acknowledge the SMART participants, as well as all general practitioners from the general practice “Huisartsenpraktijk Bosboomstraat” for their time in inclusion of participants. We would also like to thank those in the memory clinics who assisted in data acquisition, as well as those involved in the PREDICT-MR study. Members of the Utrecht Vascular Cognitive Impairment (VCI) Study group involved in the present study (in alphabetical order by department): University Medical Center Utrecht, the Netherlands, Department of Neurology: E. van den Berg, J. M. Biesbroek, G. J. Biessels, L.G. Exalto, S. M. Heringa, L. J. Kappelle, J. Verwer; Department of Radiology/Image Sciences Institute: J. de Bresser, H. J. Kuijf, P. R. Luijten, J. J. M. Zwanenburg; Department of Geriatrics: H. L. Koek; Hospital Diakonessenhuis Zeist, the Netherlands: M. Hamaker, R. Faaij, M. Pleizier, E. Vriens. We would like to acknowledge the following SMART research nurses: R. van Petersen (data manager), B. G. F. Dinther (vascular manager), and the members of the Utrecht Cardiovascular Cohort-Second Manifestations of ARTerial disease-Study Group (UCC-SMART-Study Group) F. W. Asselbergs and H. M. Nathoe, Department of Cardiology; G. J. de Borst, Department of Vascular Surgery; M. L. Bots and M. I. Geerlings, Julius Center for Health Sciences and Primary Care; M. H. Emmelot, Department of Geriatrics; P. A. de Jong and T. Leiner, Department of Radiology; A. T. Lely, Department of Obstetrics and Gynecology; N. P. van der Kaaij, Department of Cardiothoracic Surgery; L. J. Kappelle and Y. M. Ruigrok, Department of Neurology; M. C. Verhaar, Department of Nephrology; F. L. J. Visseren (chair) and J. Vesterink, Department of Vascular Medicine, University Medical Center and Utrecht University. We would like to thank NP. A. Zuithoff, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, for his assistance with validating our analyses in R with previous mixed models of correlated outcomes in SAS. This study was funded by a grant from Alzheimer Nederland (Grant number 12504) and was conducted as part of the Netherlands Consortium of Dementia Cohorts (NCDC). NCDC receives funding in the Deltaplan Dementie from ZonMw (Project number 73305095005) and Alzheimer Nederland. Publisher Copyright: © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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