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UMC Repository: Recent submissions

  • Colorectal cancer screening in patients with inherited bleeding disorders: high cancer detection rate in hemophilia patients 
    Kempers, Eva K; van Kwawegen, Calvin B; de Meris, Joke; Spaander, Manon C W; Schols, Saskia E M; Ypma, Paula F; Heubel-Moenen, Floor C J I; van Vulpen, Lize F D; Coppens, Michiel; van der Bom, Johanna G; Fijnvandraat, Karin; Meijer, Karina; Eikenboom, Jeroen; Gouw, Samantha C; Leebeek, Frank W G; Kruip, Marieke J H A (Wiley-Blackwell, 2023-05)
    Background: The population-based colorectal cancer (CRC) screening program in individuals aged 55 to 75 years in the Netherlands uses fecal immunochemical testing (FIT), to detect hemoglobin in feces, followed by colonoscopy ...
  • 90Y Radioembolization in the Treatment of Neuroendocrine Neoplasms: Results of an International Multicenter Retrospective Study 
    Schaarschmidt, Benedikt M.; Wildgruber, Moritz; Kloeckner, Roman; Nie, James; Steinle, Verena; Braat, Arthur J.A.T.; Lohoefer, Fabian; Kim, Hyun S.; Lahner, Harald; Weber, Manuel; Theysohn, Jens (Society of Nuclear Medicine Inc., 2022-05-01)
    In neuroendocrine neoplasms (NENs), the presence of distant metastases has a severe impact on survival leading to a relevant decrease in the 5-y survival rate. Here, 90Y radioembolization (90Y RE) might be an important ...
  • Systematic assessment of coronary calcium detectability and quantification on four generations of CT reconstruction techniques: a patient and phantom study 
    Dobrolinska, M. M.; van Praagh, G. D.; Oostveen, L. J.; Poelhekken, K.; Greuter, M. J.W.; Fleischmann, D.; Willemink, M. J.; de Lange, F.; Slart, R. H.J.A.; Leiner, T.; van der Werf, N. R. (Springer Netherlands, 2023-01)
    In computed tomography, coronary artery calcium (CAC) scores are influenced by image reconstruction. The effect of a newly introduced deep learning-based reconstruction (DLR) on CAC scoring in relation to other algorithms ...
  • Cardiovascular magnetic resonance-derived left ventricular intraventricular pressure gradients among patients with precapillary pulmonary hypertension 
    Vos, Jacqueline L.; Leiner, Tim; van Dijk, Arie P.J.; Pedrizzetti, Gianni; Alenezi, Fawaz; Rodwell, Laura; van der Wegen, Constantijn T.P.M.; Post, Marco C.; Driessen, Mieke M.P.; Nijveldt, Robin (Oxford University Press, 2023-01-01)
    AIMS: Precapillary pulmonary hypertension (pPH) affects left ventricular (LV) function by ventricular interdependence. Since LV ejection fraction (EF) is commonly preserved, LV dysfunction should be assessed with more ...
  • Overview of the 2022 WHO Classification of Adrenal Cortical Tumors 
    Mete, Ozgur; Erickson, Lori A.; Juhlin, C. Christofer; de Krijger, Ronald R.; Sasano, Hironobu; Volante, Marco; Papotti, Mauro G. (Humana Press, 2022-03)
    The new WHO classification of adrenal cortical proliferations reflects translational advances in the fields of endocrine pathology, oncology and molecular biology. By adopting a question–answer framework, this review ...
  • Molecular Characterization Reveals Subclasses of 1q Gain in Intermediate Risk Wilms Tumors 
    van Belzen, Ianthe A.E.M.; van Tuil, Marc; Badloe, Shashi; Strengman, Eric; Janse, Alex; Verwiel, Eugène T.P.; van der Leest, Douwe F.M.; de Vos, Sam; Baker-Hernandez, John; Groenendijk, Alissa; de Krijger, Ronald; Kerstens, Hindrik H.D.; Drost, Jarno; van den Heuvel-Eibrink, Marry M.; Tops, Bastiaan B.J.; Holstege, Frank C.P.; Kemmeren, Patrick; Hehir-Kwa, Jayne Y. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-10)
    Chromosomal alterations have recurrently been identified in Wilms tumors (WTs) and some are associated with poor prognosis. Gain of 1q (1q+) is of special interest given its high prevalence and is currently actively studied ...
  • Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors 
    Schmutzler, Rita K.; Schmitz-Luhn, Björn; Borisch, Bettina; Devilee, Peter; Eccles, Diana; Hall, Per; Balmaña, Judith; Boccia, Stefania; Dabrock, Peter; Emons, Günter; Gaissmaier, Wolfgang; Gronwald, Jacek; Houwaart, Stefanie; Huster, Stefan; Kast, Karin; Katalinic, Alexander; Linn, Sabine C.; Moorthie, Sowmiya; Pharoah, Paul; Rhiem, Kerstin; Spranger, Tade; Stoppa-Lyonnet, Dominique; Van Delden, Johannes Jozef Marten; Van Den Bulcke, Marc; Woopen, Christiane (S. Karger AG, 2022-04-01)
    Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine ...
  • Recipient of the 2022 Endocrine Pathology Society Lifetime Achievement Award: Dr. Virginia Anne LiVolsi, M.D 
    Baloch, Zubair W.; Barletta, Justine A.; Mete, Ozgur; de Krijger, Ronald R.; Ghossein, Ronald A.; Montone, Kathleen (Humana Press, 2022-12-01)
  • 100 jaar Peutz-Jeghers-syndroom 
    de Jong, Myrthe A.; van Leerdam, Monique E.; Offerhaus, G. J.A.Johan; Keller, Josbert J. (Bohn Stafleu van Loghum, 2022-05-04)
    In 2021 it was 100 years since drPeutz published his case report titled: 'a very remarkable case of familial polyposis of mucous membranes of intestinal tract and nasopharynx accompanied by peculiar pigmentations of skin ...
  • Outcome of SIOP patients with low- or intermediate-risk Wilms tumour relapsing after initial vincristine and actinomycin-D therapy only - the SIOP 93-01 and 2001 protocols 
    Groenendijk, Alissa; van Tinteren, Harm; Jiang, Yilin; de Krijger, Ronald R; Vujanic, Gordan M; Godzinski, Jan; Rübe, Christian; Schenk, Jens-Peter; Morosi, Carlo; Pritchard-Jones, Kathy; Al-Saadi, Reem; Vaidya, Sucheta J; Verschuur, Arnauld C; Ramírez-Villar, Gema L; Graf, Norbert; de Camargo, Beatriz; Drost, Jarno; Perotti, Daniela; van den Heuvel-Eibrink, Marry M; Brok, Jesper; Spreafico, Filippo; Mavinkurve-Groothuis, Annelies M C (Elsevier Limited, 2022-03)
    PURPOSE: Society of International Pediatric Oncology - Renal Tumor Study Group (SIOP-RTSG) treatment recommendations for relapsed Wilms tumour (WT) are stratified by the intensity of first-line treatment. To explore the ...
  • Artificial Intelligence in Pediatric Pathology: The Extinction of a Medical Profession or the Key to a Bright Future? 
    van der Kamp, Ananda; Waterlander, Tomas J; de Bel, Thomas; van der Laak, Jeroen; van den Heuvel-Eibrink, Marry M; Mavinkurve-Groothuis, Annelies M C; de Krijger, Ronald R (SAGE Publications Inc., 2022-07)
    Artificial Intelligence (AI) has become of increasing interest over the past decade. While digital image analysis (DIA) is already being used in radiology, it is still in its infancy in pathology. One of the reasons is ...
  • Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas 
    Mete, Ozgur; Asa, Sylvia L; Gill, Anthony J; Kimura, Noriko; de Krijger, Ronald R; Tischler, Arthur (Humana Press, 2022-03)
    This review summarizes the classification of tumors of the adrenal medulla and extra-adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and Neuroendocrine Tumors. The non-epithelial ...
  • Outcomes of Patients Treated for Hepatoblastoma with Low Alpha-Fetoprotein and/or Small Cell Undifferentiated Histology: A Report from the Children's Hepatic Tumors International Collaboration (CHIC) 
    Trobaugh-Lotrario, Angela D; Maibach, Rudolf; Aronson, Daniel C; Rangaswami, Arun; Häberle, Beate; O'Neill, Allison F; Schmid, Irene; Ansari, Marc; Hishiki, Tomoro; Ranganathan, Sarangarajan; Alaggio, Rita; de Krijger, Ronald R; Tanaka, Yukichi; Cho, Soo-Jin; Vokuhl, Christian; Maxwell, Rebecca; Krailo, Mark; Hiyama, Eiso; Czauderna, Piotr; Finegold, Milton; Feusner, James H; Malogolowkin, Marcio H; Meyers, Rebecka L; Lopez-Terrada, Dolores (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01-11)
    Small cell undifferentiated (SCU) histology and alpha-fetoprotein (AFP) levels below 100 ng/mL have been reported as poor prognostic factors in hepatoblastoma (HB); subsequent studies reported SMARCB1 mutations in some SCU ...
  • Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics 
    Schipper, L. J.; Samsom, K. G.; Snaebjornsson, P.; Battaglia, T.; Bosch, L. J.W.; Lalezari, F.; Priestley, P.; Shale, C.; van den Broek, A. J.; Jacobs, N.; Roepman, P.; van der Hoeven, J. J.M.; Steeghs, N.; Vollebergh, M. A.; Marchetti, S.; Cuppen, E.; Meijer, G. A.; Voest, E. E.; Monkhorst, K. (Elsevier, 2022-12)
    Background: In ∼3%-5% of patients with metastatic disease, tumor origin remains unknown despite modern imaging techniques and extensive pathology work-up. With long diagnostic delays and limited and ineffective therapy ...
  • Paracoccidioidomycosis: Current Status and Future Trends 
    Hahn, Rosane Christine; Hagen, Ferry; Mendes, Rinaldo Poncio; Burger, Eva; Nery, Andreia Ferreira; Siqueira, Nathan Pereira; Guevara, Armando; Rodrigues, Anderson Messias; de Camargo, Zoilo Pires (American Society for Microbiology, 2022-12-21)
    Paracoccidioidomycosis (PCM), initially reported in 1908 in the city of São Paulo, Brazil, by Adolpho Lutz, is primarily a systemic and neglected tropical mycosis that may affect individuals with certain risk factors around ...
  • The effect of competition between health opinions on epidemic dynamics 
    Teslya, Alexandra; Nunner, Hendrik; Buskens, Vincent; Kretzschmar, Mirjam E (National Academy of Sciences, 2022-11-01)
    Past major epidemic events showed that when an infectious disease is perceived to cause severe health outcomes, individuals modify health behavior affecting epidemic dynamics. To investigate the effect of this feedback ...
  • Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S 
    Harryvan, Tom J.; Visser, Marten; De Bruin, Linda; Plug, Léonie; Griffioen, Lisa; Mulder, Arend; Van Veelen, Peter A.; Van Der Heden Van Noort, Gerbrand J.; Jongsma, Marlieke L.M.; Meeuwsen, Miranda H.; Wiertz, Emmanuel J.H.J.; Santegoets, Saskia J.; Hardwick, James C.H.; Van Hall, Thorbald; Neefjes, Jacques; Van Der Burg, Sjoerd H.; Hawinkels, Lukas J.A.C.; Verdegaal, Els M.E. (BioMed Central Ltd., 2022-03-09)
    Background Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional ...
  • Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumours in dogs and identifies CYP26B1 as a potential new therapeutic target 
    Sanders, Karin; Kooistra, Hans S.; van den Heuvel, Marieke; Mokry, Michal; Grinwis, Guy C.M.; van den Dungen, Noortje A.M.; van Steenbeek, Frank G.; Galac, Sara (Wiley-Blackwell, 2023-03)
    Cushing's syndrome (CS) is a serious endocrine disorder that is relatively common in dogs, but rare in humans. In ~15%-20% of cases, CS is caused by a cortisol-secreting adrenocortical tumour (csACT). To identify differentially ...
  • The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis 
    Spekhorst, Lotte S; de Graaf, Marlies; van der Rijst, Lisa P; Zuithoff, Nicolaas P A; Schweizer, René C; Kamsteeg, Marijke; Haeck, Inge; van Lynden-van Nes, Anneke M T; van Lumig, Paula; Romeijn, Geertruida L E; Schuttelaar, Marie-Louise; de Bruin-Weller, Marjolein S (BioMed Central, 2023-01)
  • Spontaneous Complete Regression of Colon Cancer Liver Metastases in a Lung Transplant Patient: A Case Report 
    Zwart, Koen; Ruigrok, Dieuwertje; de Graaf-Bos, Magda; Goldschmeding, Roel; Koopman, Miriam; Bol, Guus M (2023)
    BACKGROUND: Cancer has become an important cause of death in solid organ transplant patients. The cause of malignancies in patients with solid organ transplants is multifactorial, but the use of intensive immunosuppression ...