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Now showing items 10301-10320 of 40729

Personal recovery suits us all: A study in patients with non-affective psychosis, unaffected siblings and healthy controls

Van Eck, Robin Michael; van Velden, Judith; Vellinga, Astrid; van der Krieke, Lian; Castelein, Stynke; de Haan, Lieuwe; Schirmbeck, Frederike; van Amelsvoort, Therese; Bartels-Velthuis, Agna A; Bruggeman, Richard; Cahn, Wiepke; Simons, Claudia J P; van Os, Jim (Elsevier, 2023-05)

Personal recovery transcends illness and is a unifying human experience. Core elements in personal recovery are hope, meaning, and rebuilding oneself. Here we aim to investigate whether factors associated with personal ...
Early-onset reduced bone mineral density in patients with pyruvate kinase deficiency

Al-Samkari, Hanny; Grace, Rachael F.; Glenthøj, Andreas; Andres, Oliver; Barcellini, Wilma; Galactéros, Frédéric; Kuo, Kevin H.M.; Layton, D. Mark; Morado Arias, Marta; Viprakasit, Vip; Dong, Yan; Tai, Feng; Hawkins, Peter; Gheuens, Sarah; Morales-Arias, Jaime; Gilroy, Keely S.; Porter, John B.; van Beers, Eduard J. (John Wiley & Sons Inc., 2023-03-01)
Challenges and Opportunities of Precision Medicine in Sickle Cell Disease: Novel European Approach by GenoMed4All Consortium and ERN-EuroBloodNet

Collado, Anna; Boaro, Maria Paola; Van Der Veen, Sigrid; Idrizovic, Amira; Biemond, Bart J.; Beneitez Pastor, David; Ortuño, Ana; Cela, Elena; Ruiz-Llobet, Anna; Bartolucci, Pablo; De Montalembert, Marianne; Castellani, Gastone; Biondi, Riccardo; Manara, Renzo; Sanavia, Tiziana; Fariselli, Piero; Kountouris, Petros; Kleanthous, Marina; Alvarez, Federico; Zazo, Santiago; Colombatti, Raffaella; Van Beers, Eduard J.; Mañú-Pereira, María Del Mar (Wolters Kluwer Health, 2023-03)
Op naar een gepersonaliseerde clozapinebehandeling

Okhuijsen-Pfeifer, C.; van der Horst, M. Z.; Luykx, J. J. (Uitgeverij Boom, 2023)

BACKGROUND: Clozapine is the most effective treatment for people with treatment-resistant schizophrenia. However, it is prescribed less often than guidelines indicate. AIM: To personalize clozapine treatment, we investigated ...
Clinical survival and performance of premolars restored with direct or indirect cusp-replacing resin composite restorations with a mean follow-up of 14 years

Hofsteenge, J W; Fennis, W M M; Kuijs, R H; Özcan, M; Cune, M S; Gresnigt, M M M; Kreulen, C M (Elsevier Science, 2023-04)

Objectives: The objective is to evaluate the long-term clinical survival and performance of direct and indirect resin composite restorations replacing cusps in vital upper premolars. Methods: Between 2001 and 2007, 176 ...
Do we need more clinical trials?

van Noesel, Max M (Wiley-Liss Inc., 2023-05)
MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma

Eleveld, Thomas F; Vernooij, Lindy; Schild, Linda; Koopmans, Bianca; Alles, Lindy K; Ebus, Marli E; Dandis, Rana; van Tinteren, Harm; Caron, Huib N; Koster, Jan; van Noesel, Max M; Tytgat, Godelieve A M; Eising, Selma; Versteeg, Rogier; Dolman, M Emmy M; Molenaar, Jan J (Frontiers Media S. A., 2023-02-21)

INTRODUCTION: Mutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor ...
Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency

the NAtural course and Prognosis of PFIC and Effect of biliary Diversion (NAPPED) Consortium (Elsevier, 2023-02)

BACKGROUND & AIMS: Bile salt export pump (BSEP) deficiency frequently necessitates liver transplantation in childhood. In contrast to two predicted protein truncating mutations (PPTMs), homozygous p.D482G or p.E297G mutations ...
Technical Note: Intensity-based quality assurance criteria for deformable image registration in image-guided radiotherapy

Bosma, L S; Zachiu, C; de Senneville, B Denis; Raaymakers, B W; Ries, M (John Wiley & Sons Inc., 2023-09)

BACKGROUND: Deformable image registration is increasingly used in radiotherapy to adapt the treatment plan and accumulate the delivered dose. Consequently, clinical workflows using deformable image registration require ...
In vitro 1H MT and CEST MRI mapping of gastro-intestinal milk protein breakdown

Mayar, Morwarid; Smeets, Paul; van Duynhoven, John; Terenzi, Camilla (Elsevier, 2023-04)

Protein digestion is commonly studied using in vitro models. Validating these models with more complex in vivo observations remains challenging, in particular due to the need for non-invasive techniques. Here, we explore ...
Dupilumab-associated ocular surface disease in atopic dermatitis patients: clinical characteristics, ophthalmic treatment response, and conjunctival goblet cell analysis

Achten, Roselie; Thijs, Judith; van der Wal, Marlot; van Luijk, Chantal; de Graaf, Marlies; Bakker, Daphne; de Boer, Joke; van Wijk, Femke; de Bruin-Weller, Marjolein (Wiley-Blackwell, 2023-08)

BACKGROUND: Dupilumab-associated ocular surface disease (DAOSD) is frequently reported as side effect in atopic dermatitis (AD) patients. Therefore, the aim of this study was to investigate the frequency and severity of ...
Organizational characteristics of European pediatric onco-critical care: An international cross-sectional survey

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care) (Frontiers Media S. A., 2022-12-01)

Background: Intensified treatment protocols have improved survival of pediatric oncology patients. However, these treatment protocols are associated with increased treatment-related morbidity requiring admission to pediatric ...
Increase in Invasive Group a Streptococcal Infections in Children in the Netherlands, A Survey Among 7 Hospitals in 2022

Van Kempen, Evelien B.; Bruijning-Verhagen, Patricia C.J.; Borensztajn, Dorine; Vermont, Clementien L.; Quaak, Marjolijn S.W.; Janson, Jo Anne; Maat, Ianthe; Stol, Kim; Vlaminckx, Bart J.M.; Wieringa, Jantien W.; Van Sorge, Nina M.; Boeddha, Navin P.; Van Veen, Mirjam (Lippincott Williams & Wilkins, 2023-04-01)

Following an increase in notifiable invasive group A streptococcal (iGAS) infections in the Netherlands, we conducted a survey among 7 hospitals. Pediatric iGAS case numbers were 2-fold higher between July 2021 and June ...
Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model

Steverink, Jasper G; van Tol, Floris R; Bruins, Suzanne; Smorenburg, Andre J; Tryfonidou, Marianna A; Oosterman, Bas J; van Dijk, Marijke R; Malda, Jos; Verlaan, Jorrit-Jan (Springer International Publishing AG, 2023-03-08)

PURPOSE: Various sustained-release formulations incorporate high bupivacaine concentrations but data on local toxicity is lacking. This study explores local toxic effects of highly concentrated (5%) bupivacaine compared ...
Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial

BCG-PRIME study group (Elsevier, 2023-06)

Objectives: To test whether Bacillus Calmette-Guérin (BCG) vaccination would reduce the incidence of COVID-19 and other respiratory tract infections (RTIs) in older adults with one or more comorbidities. Methods: ...
Feasibility and first results of the 'Trials-within-Cohorts' (TwiCs) design in patients undergoing radiotherapy for lung cancer

Tomassen, Mathijs L; Damen, Pim J J; Verkooijen, Helena M; Peters, Max; van der Stap, Janneke; van Lindert, Anne S R; Verhoeff, Joost J C; van Rossum, Peter S N (Informa Healthcare, 2023-03)

Background: 'Trials-within-Cohorts' (TwiCs), previously known as 'cohort multiple randomized controlled trials' is a pragmatic trial design, supporting an efficient and representative recruitment of patients for (future) ...
Management of systemic sclerosis: British Society for Rheumatology guideline scope

Denton, Christopher P.; De Lorenzis, Enrico; Roblin, Elen; Goldman, Nina; Alcacer-Pitarch, Begonya; Blamont, Emma; Buch, Maya; Carulli, Maresa; Cotton, Caroline; Del Galdo, Francesco; Derrett-Smith, Emma; Douglas, Karen; Farrington, Sue; Fligelstone, Kim; Gompels, Luke; Griffiths, Bridget; Herrick, Ariane; Hughes, Michael; Pain, Clare; Pantano, Georgina; Pauling, John; Prabu, Athiveeraramapandian; O'donoghue, Nuala; Renzoni, Elisabetta; Royle, Jeremy; Samaranayaka, Muditha; Spierings, Julia; Tynan, Aoife; Warburton, Louise; Ong, Voon (Oxford University Press, 2023-03-14)

This guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in evidence-based treatment and increased knowledge about assessment, ...
Prognostication of progressive pulmonary fibrosis in connective tissue disease-associated interstitial lung diseases: A cohort study

Chiu, Yu Hsiang; Koops, Maaike F.M.; Voortman, Mareye; van Es, H. Wouter; Langezaal, Lucianne C.M.; Welsing, Paco M.J.; Jamnitski, Anna; Wind, Anne E.; van Laar, Jacob M.; Grutters, Jan C.; Spierings, Julia (Frontiers Media S. A., 2023-02-27)

BACKGROUND: Connective tissue diseases-associated interstitial lung disease (CTD-ILD) is a heterogeneous condition that impairs quality of life and is associated with premature death. Progressive pulmonary fibrosis (PPF) ...
Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans.

Uglebjerg, Nicoline; Ahmadizar, Fariba; Aly, Dina M; Cañadas-Garre, Marisa; Hill, Claire; Naber, Annemieke; Oddsson, Asmundur; Singh, Sunny S; Smyth, Laura; Trégouët, David-Alexandre; Chaker, Layal; Ghanbari, Mohsen; Steinthorsdottir, Valgerdur; Ahlqvist, Emma; Hadjadj, Samy; Van Hoek, Mandy; Kavousi, Maryam; McKnight, Amy Jayne; Sijbrands, Eric J; Stefansson, Kari; Simons, Matias; Rossing, Peter; Ahluwalia, Tarunveer S (Frontiers Media S. A., 2023-02-28)

AIM: Rare genetic variants in the CUBN gene encoding the main albumin-transporter in the proximal tubule of the kidneys have previously been associated with microalbuminuria and higher urine albumin levels, also in diabetes. ...
C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: The UK Biobank and the Rotterdam study cohorts

Ochoa-Rosales, Carolina; van der Schaft, Niels; Braun, Kim V E; Ho, Frederick K; Petermann-Rocha, Fanny; Ahmadizar, Fariba; Kavousi, Maryam; Pell, Jill P; Ikram, M Arfan; Celis-Morales, Carlos A; Voortman, Trudy (Churchill Livingstone, 2023-05)

Background: Coffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes mellitus (T2D), but underlying mechanisms are not well understood. We aimed to ...

Now showing items 10301-10320 of 40729