Many cerebrovascular diseases are complex and treatment is often based on experience and relatively small studies. A mathematical blood flow model might aid in better treatment decisions and might lead to more personalised ...
In several countries, lung cancer screening programs are being implemented, in which heavy cigarette smokers are regularly invited for a CT scan of their lungs (chest CT). This scan can help detect lung cancer in an early ...
Large-scale data processing and analysis offers the promise of personalizing health and biomedicine. In order to realize this promise, growing numbers of patients and citizens are contributing data to health research. The ...
In conclusion, the studies presented in this thesis contributed to the field of cell fate dynamics in human CRC and its metastasis. We developed novel reporters and strategies to study functional intratumoral heterogeneity ...
Biomarkers are frequently used in the diagnosis of cardiovascular diseases. In this thesis, different cardiovascular biomarkers were studied in various clinical settings. The first part focuses on troponin elevation after ...
Acute respiratory tract infection (RTI) are common illnesses among children. RTI are mostly self-limiting, with low risk of complications. Only a fraction of the children with RTI present to their GP. This thesis evaluates ...
Gastroenteritis (GE) is an inflammation of the gastrointestinal tract that is often caused by infectious agents. GE is characterized by diarrhea and/or vomiting. In the Netherlands, GE is rarely life threatening, but it ...
Boers, Sarah Nelina(Utrecht University, 2019-05-16)
Recent advances in the stem cell field make it possible to culture three-dimensional human tissues in a dish called organoids. These organoids have promising scientific and clinical applications that range from disease ...
The aim of this thesis was to gain more insight into how clozapine influences processes in the body, with the hope that this would help us better understand and perhaps even predict its effects and adverse effects. The ...
This thesis focuses on neutrophils in cancer, acute and chronic inflammation. The first part of this thesis describes how intravital microscopy (IVM) can be used in biomedical research to study dynamic processes at cellular ...
Vliet, Q.M.J. van der(Utrecht University, 2019-05-24)
Dramatic improvements in injury prevention, prehospital and hospital care have led to decreased mortality rates from traumatic injury. Despite decreased mortality rates, trauma contributes significantly as well as increasingly ...
Vrisekoop, N; Drylewicz, J; van Gent, R.; Mugwagwa, T.; van Lelyveld, SFL; Veel, E.M.; Otto, S.A.; Ackermans, M.T.; Vermeulen, J.N.; Huidekoper, H.H.; Prins, J.M.; Miedema, F; de Boer, Rob J.; Tesselaar, NA; Borghans, JAM(2015-10)
Background: In HIV infection, the homeostasis of CD4+ and CD8+ T cells is dramatically disturbed, and several studies have pointed out that T-cell turnover rates are increased. To understand how the CD4+ and CD8+ T-cell ...
Objective: HLA-B*27 and B*57 are associated with relatively slow progression to AIDS. Mechanisms held responsible for this protective effect include the immunodominance and high magnitude, breadth, and affinity of the ...
We longitudinally evaluated HIV-specific T-cell immunity after discontinuation of highly active antiretroviral therapy (HAART). After treatment interruption (TI), some individuals could maintain a low plasma viral load ...
Miedema, F.; Hazenberg, M.; Tesselaar, K.; van Baarle, D.; de Boer, R.J.; Borghans, J.A.M.(2013-09)
In the past decade, evidence has accumulated that human immunodeficiency virus (HIV)-induced chronic immune activation drives progression to AIDS. Studies among different monkey species have shown that the difference between ...
Schellens, I.M.M.; Navis, M.; van Deutekom, H.W.M.; Boeser-Nunnink, B.; Berkhout, B.; Kootstra, N.; Miedema, F.; Kesmir, C.; Schuitemaker, H.; van Baarle, D.; Borghans, J.A.M.(2011)
Objective and design: HIV-1 is known to adapt to the human immune system, leading to accumulation of escape mutations during the course of infection within an individual. Cross-sectional studies have shown an inverse ...
Increasing knowledge about DosR regulon-encoded proteins has led us to produce novel Mycobacterium tuberculosis antigens for immunogenicity testing in human populations in three countries in Africa to which tuberculosis ...
Sutherland, Jayne S; Lalor, Maeve K; Black, Gillian F; Ambrose, Lyn R; Loxton, Andre G; Chegou, Novel N; Kassa, Desta; Mihret, Adane; Howe, Rawleigh; Mayanja-Kizza, Harriet; Gomez, Marie P; Donkor, Simon; Franken, Kees; Hanekom, Willem; Klein, Michel R; Parida, Shreemanta K; Boom, W Henry; Thiel, Bonnie A; Crampin, Amelia C; Ota, Martin; Walzl, Gerhard; Ottenhoff, Tom H M; Dockrell, Hazel M; Kaufmann, Stefan H E; Miedema, Frank; Ran, Leonie; Jacobi, Ronald; van Baarle, Debbie(2013)
BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium ...
Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an elderly human. By combining in vivo kinetic labeling using ...