Antiretroviral therapy (ART) has substantially improved treatment outcomes for people with HIV (PWH) by effectively suppressing viral replication. However, HIV hides in resting cells and achievement of HIV cure therefore ...
Approximately 35% of older adults with care needs are malnourished and this has negative consequences for their health. Nutritional care for older adults is of utmost importance to fight malnutrition. The focus of this PhD ...
Around 1,700 men and boys in the Netherlands suffer from haemophilia, which is characterized by prolonged bleeding after trauma or surgery and an increased risk of (spontaneous) muscle and joint bleeds. People with haemophilia ...
Setting the context
Still waters run deep. Type 2 diabetes, the commonest form of diabetes, is largely an
asymptomatic disease. The pathophysiologic defects often continue irrespective of
attainment of euglycaemia.1,2
Globally ...
DNA can be damaged by a variety of mutagenic processes, like smoking and UV-radiation. Cells can repair the damage to their DNA, but when this does not happen or happens incorrectly, mutations can occur. Different combinations ...
In this thesis research on CCR9-expressing T cell subsets in primary Sjögren’s syndrome (pSS) is described. pSS is a chronic autoimmune disease in which most patients have complaints of dryness of eyes and mouth, fatigue, ...
Atteveld, Jenneke Elizabeth van(Utrecht University, 2023-02-09)
Due to the increased survival of children with cancer, research on acute and long-term side effects has become increasingly important to also improve the quality of life for survivors. Bone toxicity and frailty are side ...
This thesis aims to describe the surgical treatment and the long-term sequelae of patients with long-gap esophageal atresia (LGEA) in the Netherlands. Until recently, surgical correction for LGEA in the Netherlands was ...
This thesis presents image analysis techniques for the detection and characterisation of unruptured intracranial aneurysms (UIAs). Using such methods, robust and reliable growth and rupture assessment of UIAs can be made ...
Cardiovascular diseases (CVDs) are diseases that affect the heart and blood vessels and to date, there is no cure. The only available clinical practices to manage CVDs are suggesting lifestyle changes, exercise-based cardiac ...
Diagnosing venous thromboembolism (VTE) is often difficult for general practitioners (GPs) because symptoms can mimic other less life-threatening diseases. GPs can use clinical decision rules to determine whom has a high ...
Teuben, Michel Paul Johan(Global Academic Press, 2023-01-16)
Neutrophils are the most abundant type of circulatory white blood cells. Neutrophil activation can be triggered by stimuli such as bacterial invasion, obstruction of vessels, fractures or organ injuries. Upon severe trauma, ...
Primary carnitine deficiency (PCD) is an inherited error of metabolism which results in severely decreased blood carnitine levels caused by a poorly functioning carnitine transport protein (OCTN2). Low blood carnitine ...
The complex balance between scientific evidence, clinical expertise and the patient’s experience makes healthcare systems prone to inefficiency and fragmentation. This sparks the interest into a care system that aligns the ...
Bergen, Eline Dorothea Petronella van(Utrecht University, 2023-02-02)
The inherited coagulation disorder haemophilia is characterized by spontaneous and trauma-related bleeding. Recurrent joint bleeds leading to synovial inflammation and osteochondral damage cause major morbidity amongst ...
In the recent years much progress has been made in cancer treatment. Besides the traditional therapies such as chemotherapy, surgery and radiotherapy, targeted therapy and immunotherapy are increasingly being used and have ...
Evers, Martijn Johannes Wilhelmus(Utrecht University, 2023-01-19)
RNA therapeutics can potentially revolutionize the way in which we are able to treat a disease, namely directly at its biological origin. RNA therapeutics can modulate the expression of almost any gene. However, clinical ...
Thrombosis, the disruption of blood flow in the circulation by a blood clot (thrombus), can cause serious and life-threatening disease and still forms an important healthcare challenge. Thrombosis resulting from cardiovascular ...
Tuberculosis (TB) and infection with human immuno-deficiency virus (HIV) are leading infectious causes of morbidity particularly in sub-Saharan Africa, which is disproportionately affected by the two epidemics. Kenya is ...
Chapter 1 provides the general background for the thesis, providing an overview of the global burden and trends of stillbirths. While most stillbirths result from preventable causes, the possible reasons behind the lack ...