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  • Harschnitz, Oliver (Utrecht University, 2017-09-15)
    The proper function of the motor circuit is essential for normal interaction as a human being with external cues. While the motor circuit consists of a variety of cell types, one of its core components is the motor neuron ...
  • Bouts, Mark. J. R. J.; Wu, O.; Dijkhuizen, R. M. (Elsevier Inc., 2017-03-07)
    Magnetic resonance imaging (MRI) provides a powerful (neuro)imaging modality for the diagnosis and outcome prediction after (acute) stroke. Since MRI allows noninvasive, longitudinal, and three-dimensional assessment of ...
  • van der Kaaij, Rosa T; Braam, Hidde Jw; Boot, Henk; Los, Maartje; Cats, Annemieke; Grootscholten, Cecile; Schellens, Jan Hm; Aalbers, Arend Gj; Huitema, Alwin Dr; Knibbe, Catherijne Aj; Boerma, Djamila; Wiezer, Marinus J; van Ramshorst, Bert; van Sandick, Johanna W. (2017-07-13)
    BACKGROUND: Patients with gastric cancer and peritoneal carcinomatosis have a very poor prognosis; median survival is 3 to 4 months. Palliative systemic chemotherapy is currently the only treatment available in the ...
  • Knuttel, Floortje M.; Huijsse, Sèvrin E.M.; Feenstra, Talitha L.; Moonen, Chrit T.W.; van den Bosch, Maurice A.A.J.; Buskens, Erik; Greuter, Marcel J W; de Bock, Geertruida H. (2017-08-01)
    Background: Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) ablation is in development for minimally invasive treatment of breast cancer. Cost-effectiveness has not been assessed yet. An early health ...
  • Guella, Ilaria; McKenzie, Marna B.; Evans, Daniel M.; Buerki, Sarah E.; Toyota, Eric B.; Van Allen, Margot I.; Adam, Shelin; Boelman, Cyrus; Bolbocean, Corneliu; Candido, Tara; Eydoux, Patrice; Horvath, Gabriella; Huh, Linda; Nelson, Tanya N.; Sinclair, Graham; van Karnebeek, Clara D M; Vercauteren, Suzanne; Suri, Mohnish; Elmslie, Frances; Simon, Marleen E.H.; van Gassen, Koen L.I.; Héron, Delphine; Keren, Boris; Nava, Caroline; Connolly, Mary B.; Demos, Michelle; Farrer, Matthew J.; Epilepsy Genomics Study; Deciphering Developmental Disorders Study; Deciphering Developmental Disorders Study (2017-08-03)
    Massively parallel sequencing has revealed many de novo mutations in the etiology of developmental and epileptic encephalopathies (EEs), highlighting their genetic heterogeneity. Additional candidate genes have been ...
  • Ylikallio, Emil; Woldegebriel, Rosa; Tumiati, Manuela; Isohanni, Pirjo; Ryan, Monique M.; Stark, Zornitza; Walsh, Maie; Sawyer, Sarah L.; Bell, Katrina M.; Oshlack, Alicia; Lockhart, Paul J.; Shcherbii, Mariia; Estrada-Cuzcano, Alejandro; Atkinson, Derek; Hartley, Taila; Tetreault, Martine; Cuppen, Inge; Van Der Pol, W. Ludo; Candayan, Ayse; Battaloglu, Esra; Parman, Yesim; Van Gassen, Koen L.I.; Van Den Boogaard, Marie José H.; Boycott, Kym M.; Kauppi, Liisa; Jordanova, Albena; Lönnqvist, Tuula; Tyynismaa, Henna (2017-08-01)
    Defects in mRNA export from the nucleus have been linked to various neurodegenerative disorders. We report mutations in the gene MCM3AP, encoding the germinal center associated nuclear protein (GANP), in nine affected ...
  • Zijlstra, Marieke; Hulsker, Caroline C.C.; Fanoy, Ewout B; Pijnacker, Roan; Kraaijeveld, Arie; Koene, Miriam G.J.; Wolfs, Tom F.W. (2017)
    Background Tularaemia is a rare disease. In Europe it mostly occurs in Scandinavia. Since 2011 more cases are being reported in the Netherlands. Tularaemia may manifest itself in various ways. It is important to take strict ...
  • De Koning, Coco; Admiraal, Rick; Nierkens, Stefan; Boelens, Jaap Jan (2017-05-01)
    Unrelated umbilical cord blood transplantation (UCBT) exhibits a low risk of graft-versus-hostdisease (GvHD) and has unique potent anti-virus and anti-leukemia effects. Anti-thymocyte globulin (ATG) in the conditioning ...
  • Kekre, Natasha; Zhang, Ying; Zhang, Mei Jie; Carreras, Jeanette; Ahmed, Parvez; Anderlini, Paolo; Atta, Elias Hallack; Ayas, Mouhab; Boelens, Jaap Jan; Bonfim, Carmem M.; Joachim Deeg, H.; Kapoor, Neena; Lee, Jong Wook; Nakamura, Ryotaro; Pulsipher, Michael A.; Eapen, Mary; Antin, Joseph H (2017-06-26)
    For treatment of severe aplastic anemia, immunosuppressive therapy with horse antithymocyte globulin results in superior response and survival compared with rabbit antithymocyte globulin. This relative benefit may be ...
  • Boelens, Jaap Jan (2017-08-01)
  • Shekhovtsova, Zhanna; Bonfim, Carmem M.; Ruggeri, Annalisa; Nichele, Samantha; Page, Kristin M.; Alseraihy, Amal; Barriga, Francisco; de Toledo Codina, José Sánchez; Veys, Paul; Boelens, Jaap Jan; Mellgren, Karin; Bittencourt, Henrique; O’Brien, Tracey; Shaw, Peter J.; Chybicka, Alicja; Volt, Fernanda; Giannotti, Federica; Gluckman, Eliane; Kurtzberg, Joanne; Gennery, Andrew R.; Rocha, Vanderson; Eurocord, Cord Blood Committee of Cellular Therapy and Immunobiology Working Party of the EBMT, Federal University of Parana, Duke University Medical Center and Inborn Errors Working Party of the EBMT (2017)
    Wiskott-Aldrich syndrome is a severe X-linked recessive immune deficiency disorder. A scoring system of Wiskott-Aldrich syndrome severity (0.5-5) distinguishes two phenotypes: X-linked thrombocytopenia and classic ...
  • van Tuijn, Charlotte F. J.; Schimmel, Marein; van Beers, Eduard J; Nur, Erfan; Biemond, Bart J. (2017)
    Organ damage in sickle cell disease (SCD) is a crucial determinant for disease severity and prognosis. In a previous study, we analyzed the prevalence of SCD-related organ damage and complications in adult sickle cell ...
  • Evers, Dorothea; van der Bom, Johanna G; Tijmensen, Janneke; de Haas, Masja; Middelburg, Rutger A.; de Vooght, Karen M K; van de Kerkhof, Daan; Visser, Otto J; Péquériaux, Nathalie C V; Hudig, Francisca; Zwaginga, Jaap Jan (2017-08)
  • Kreuger, Aukje L; Middelburg, Rutger A.; Bank, Cock M C; Beckers, Erik A M; van Gammeren, Adriaan J; Leyte, Anja; Rondeel, Jan M.M.; de Vooght, Karen M K; Weerkamp, Floor; Zwaginga, Jaap Jan; Kerkhoffs, Jean Louis H; van der Bom, Johanna G (2017-09)
    BACKGROUND: Extension of storage time of platelet (PLT) concentrates may result in an increased risk of bacteremia, directly via transfusion of contaminated products or indirectly via transfusion-related immunomodulation. ...
  • Visscher, Simeon J A; van Stel, Henk F (2017-06-19)
    Child maltreatment (CM) is a common condition with a large impact on the victim and society. In the Netherlands, the preventive child healthcare (CHC) aims to protect children against such threats. However, several studies ...
  • Zijlmans, Maeike; Worrell, Gregory A.; Dümpelmann, Matthias; Stieglitz, Thomas; Barborica, Andrei; Heers, Marcel; Ikeda, Akio; Usui, Naotaka; Le Van Quyen, Michel (2017-08-01)
    Objective: Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high-frequency oscillations (HFOs) ...
  • Pasanen, Anu; Karjalainen, Minna K.; Bont, Louis; Piippo-Savolainen, Eija; Ruotsalainen, Marja; Goksör, Emma; Kumawat, Kuldeep; Hodemaekers, Hennie M; Nuolivirta, Kirsi; Jartti, Tuomas; Wennergren, Göran; Hallman, Mikko; Rämet, Mika; Korppi, Matti (2017-01-31)
    Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. ...
  • Fauroux, Brigitte; Simões, Eric A F; Checchia, Paul A; Paes, Bosco; Figueras-Aloy, Josep; Manzoni, Paolo; Bont, Louis; Carbonell-Estrany, Xavier (2017-06-01)
    Introduction: The REGAL (RSV Evidence—a Geographical Archive of the Literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over ...
  • Salimi, Vahid; Ramezani, Ali; Mirzaei, Habibollah; Tahamtan, Alireza; Faghihloo, Ebrahim; Rezaei, Farhad; Naseri, Maryam; Bont, Louis; Mokhtari-Azad, Talat; Tavakoli-Yaraki, Masoumeh (2017-08-01)
    Human respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection during early childhood and imposes a great burden on patients, parents, and society. Disease is thought to be caused, at least ...
  • Morren, Marie Anne; Jaeken, Jaak; Visser, Gepke; Salles, Isabelle; Van Geet, Chris; Simeoni, Ilenia; Turro, Ernest; Freson, Kathleen (2017-05-25)
    Background: Several genetic defects have been identified in the glycosylphosphatidylinositol (GPI) anchor synthesis, including mutations in PIGO encoding phosphatidylinositol glycan anchor biosynthesis class O protein. ...

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