Veen, Arjen van der(Utrecht University, 2022-09-22)
General introduction and thesis outline
Gastric and esophageal cancer are the third and sixth more common causes of cancer-related death worldwide. In addition, the incidence of adenocarcinoma of the proximal stomach, ...
Although advances have been made toward elucidating the molecular mechanisms of stroke pathology, there are still no clinically effective strategies for poststroke brain repair. A potential therapeutic target, the peri-infarct ...
Ven, Koen Cornelis Gerardus Petrus van de(Utrecht University, 2022-09-20)
Influenza viruses are still a major problem. Vaccines are available, but current influenza vaccines only protect against specific virus strains. This protection is insufficient when the virus mutates or when new flu viruses ...
Pancreatic surgery is complex and remains associated with a high risk of complications. A single complication may provoke a potentially lethal cascade of associated complications. Early recognition and management of ...
Hortensius, Lisa Marije(Utrecht University, 2022-09-06)
This thesis focuses on the effect of nutrition on brain development and neurodevelopmental outcome in very (gestational age 28-32 weeks) and extremely (gestational age <28 weeks) preterm born infants. These infants are at ...
Antibiotic resistant bacteria (ARB) and COVID-19 are both important infectious diseases of the 21st century. During my PhD I firstly summarized the available knowledge on ARB transmission pathways, I studied whether ARB ...
Mouthaan, Brian Edward(Utrecht University, 2022-09-08)
Success of epilepsy surgery depends on adequate identification of the epileptogenic zone, the brain area responsible for generating seizures. The presurgical workup involves the use of numerous diagnostic methods to allow ...
Delivering high-quality healthcare requires interprofessional collaboration and shared
understanding of patient care goals. However, few health professions education programs are designed with consideration of the interactive ...
Muijzer, Marc Bastiaan(Utrecht University, 2022-09-01)
The aim of this research was to study the utility of intraoperative OCT and investigate predictive factors of graft detachment in DMEK surgery. The first part of this dissertation focuses on the applications of intraoperative ...
Our genomes are 99.5% identical, and yet we are different. Part of this variation can be explained by genetic variation. The genomic locations where a certain nucleotide (a different 'letter' in the DNA sequence) is ...
Hollestelle, Marieke J.; Graaf, Rieke van der; Hartman, Sarah Dewi; Sturkenboom, Miriam C. J. M.; Delden, Johannes J. M. van(2022-04-18)
Background: Most medications lack evidence-based information about its safety and efficacy during pregnancy and breastfeeding, because pregnant women are often not included in clinical research. Another way to generate ...
Dijk, Lukas Alexander van(Utrecht University, 2022-07-06)
The overall aim of this thesis was to determine if and how topography of calcium phosphates can be improved for increased efficacy as bone graft materials for maxillofacial and orthopedic surgery.
To achieve this objective, ...
Professionals’ ability and willingness to work and continue working until their retirement age are challenged in today's demanding and dynamic work environment. Medical specialists are typical examples of professionals who ...
Mevalonate Kinase Deficiency (MKD)is a inflammatory disease, characterized by fever and inflammation in different organ systems. The disease is rare with approximately 300 known cases worldwide. This complicates the diagnosis ...
Dijk, Wobke Else Maria van(Utrecht University, 2022-09-20)
This thesis aimed to address several “gaps” in the care for patients with immune thrombocytopenia (ITP).
FATIGUE
In the “PICI”-study, a cross-sectional study with 60 chronic ITP patients, we validated the Checklist ...
Pediatric oncologic surgery can be improved by bringing novel imaging strategies
from the scientific bench to the operation room. This thesis focusses on 3D imaging
innovation in surgery for children with neuroblastoma ...
To improve patient selection for surgery of bone metastases, one must first have an accurate understanding of the incidence and consequences of surgery before weighing adverse event risks in comparison to benefits. Therefore, ...
Technology has been growing exponentially since the first introduction of the planar silicon transistor in 1959. These technologies have led to a rapid change in how we perceive our world. Now, computers, the internet, ...
In attempts to contain increasing health care costs while maintaining high quality, the concept of low-value care has gained widespread attention over recent years. This thesis specifically addresses low-value laboratory ...
The killing potential and relative contribution of all granzymes in tumor elimination during immunotherapy as well as the extracellular roles of tumor microenvironment-associated granzymes in tumorigenesis and cancer ...