de Dios Panal, Elena(Utrecht University, 2024-06-03)
This thesis investigates lymphocyte dynamics in a more natural mouse model (wildling mice) and translates these findings to the human situation. It re-evaluates known rates in standard mice and explores unaddressed questions. ...
With the transition from paper medical records to electronic medical records, data on the complete patient hospital journey became more accessible, reliable and detailed. These developments made data collected in routine ...
Childhood uveitis represents a rare group of ocular inflammatory entities with a varied spectrum of clinical presentation and treatment. Physicians face several challenges in the management of this potentially sight-threatening ...
van der Laan, Sabine(Utrecht University, 2024-05-21)
Nowadays, one in four individuals under the age of twenty-five is living with one or more chronic conditions. Youth living with a chronic condition experience disease-related challenges and more often develop depressive ...
Versluis, Judith M; Blankenstein, Stephanie A; Dimitriadis, Petros; Wilmott, James S; Elens, Robert; Blokx, Willeke A M; van Houdt, Winan; Menzies, Alexander Maxwell; Schrage, Yvonne M; Wouters, Michel W J M; Sanders, Joyce; Broeks, Annegien; Scolyer, Richard A; Suijkerbuijk, Karijn P M; Long, Georgina V; Akkooi, Alexander C J van; Blank, Christian U(BioMed Central Ltd., 2024-04-27)
BACKGROUND: A substantial proportion of patients with macroscopic stage III melanoma do not benefit sufficiently from adjuvant anti-PD-1 therapy, as they either recur despite therapy or would never have recurred. To better ...
MIE-CAT Netherlands Collaborative Group(American Medical Association, 2024-04-01)
IMPORTANCE: Suboptimal surgical performance is hypothesized to be associated with less favorable patient outcomes in minimally invasive esophagectomy (MIE). Establishing this association may lead to programs that promote ...
Van Not, Olivier J; van den Eertwegh, Alfons J M; Haanen, John B; van Rijn, Rozemarijn S; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; Blank, Christian U; Boers-Sonderen, Marye J; de Groot, Jan Willem W B; Hospers, Geke AP; Kapiteijn, Ellen; Bloem, Manja; Piersma, Djura; Stevense-den Boer, Marion; Verheijden, Rik J; van der Veldt, Astrid A M; Wouters, Michel W J M; Blokx, Willeke A M; Suijkerbuijk, Karijn P M(John Wiley and Sons Inc., 2024-05-01)
BACKGROUND: Effectivity of BRAF(/MEK) inhibitor rechallenge has been described in prior studies. However, structured data are largely lacking. METHODS: Data from all advanced melanoma patients treated with BRAFi(/MEKi) ...
Smits, Bas M; Boland, Sharisa L; Hol, Marjolein E; Dandis, Rana; Leavis, Helen; de Jong, Pim A; Prevaes, Sabine M P J; Mohamed Hoesein, Firdaus A A; van Montfrans, Joris M; Ellerbroek, Pauline M(Elsevier, 2024-04)
Background: Patients with primary antibody deficiency (PAD) frequently suffer from pulmonary complications, associated with severe morbidity and mortality. Hence, regular pulmonary screening by computed tomography (CT) ...
BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus ...
Versteeg, Edwin; Liu, Hongyan; van der Heide, Oscar; Fuderer, Miha; van den Berg, Cornelis A T; Sbrizzi, Alessandro(John Wiley and Sons Inc., 2024-07)
Purpose: To demonstrate the feasibility and robustness of the Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) framework for fast, high SNR relaxometry at 7T. Methods: To deploy MR-STAT on 7T-systems, we designed ...
Introduction: The aim of this study was to assess the possible extent of bias due to violation of a core assumption (event-dependent exposures) when using self-controlled designs to analyse the association between COVID-19 ...
BACKGROUND: There are great expectations for the potential role of gene therapy in the treatment of hemophilia. At the same time, developments in the field of hemophilia gene therapy have always raised ethical issues. It ...
The development of antibacterial coatings is a promising approach to preventing biofilm formation and reducing the overuse of systemic antibiotics. However, widespread antibiotic use has resulted in antibiotic-resistant ...
Rayegan, H.; Nguyen, H. C.; Weinans, H.; Gielis, W. P.; Ahmadi Brooghani, S. Y.; Custers, R. J.H.; van Egmond, N.; Lindner, C.; Arbabi, V.(SAGE Publications Inc., 2023-12)
Objective: Herewith, we report the development of Orthopedic Digital Image Analysis (ODIA) software that is developed to obtain quantitative measurements of knee osteoarthritis (OA) radiographs automatically. Manual ...
Nguyen, H. Chien; Rietbroek, Justin D.; van Egmond, Nienke; Weinans, Harrie; Emans, Pieter J.; Custers, Roel J.H.(Elsevier, 2023-03)
Background: Realignment osteotomies is gaining popularity amongst Dutch orthopaedic surgeons. Exact numbers and used standards in clinical practice concerning osteotomies are unknown due to the absence of a national registry. ...
for the GOALS Workgroup(Elsevier Ireland Ltd, 2023-05)
Background and Aims: Out-of-hospital cardiac arrest exerts a large disease burden, which may be mitigated by bystander cardiopulmonary resuscitation and automated external defibrillation. We aimed to estimate the global ...
Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is ...
Mekke, Joost M.; Verwer, Maarten C.; Stroes, Erik S.G.; Kroon, Jeffrey; Timmers, Leo; Pasterkamp, Gerard; de Borst, Gert J.; van der Laan, Sander W.; de Kleijn, Dominique P.V.(W.B. Saunders Ltd, 2023-05)
Introduction: Carotid plaque intraplaque haemorrhage (IPH) is associated with future cardiovascular events. It was hypothesised that plasma proteins associated with carotid plaque IPH are also likely to be associated with ...
van Erp, Joost H.J.; Gielis, Willem Paul; Arbabi, Vahid; de Gast, Arthur; Weinans, Harrie; Kaas, Laurens; Castelein, René M.; Schlösser, Tom P.C.(Wichtig Publishing, 2023-11)
Introduction: To date the aetiology of femoroacetabular impingement (FAI) is still not completely understood. There are mechanical theories that suggest symptomatic FAI is linked to sagittal pelvic morphology and ...