Fatigue is a common and disabling symptom in patients with cancer. Meta-analyses have shown that exercise has significant beneficial effects on cancer-related fatigue, both during and post-treatment. However, the majority ...
Geijselaers, Stefan LC; Sep, Simone JS; Schram, Miranda T.; van Boxtel, Martin PJ; van Sloten, Thomas T.; op het Roodt, Jos; Henry, Ronald MA; Reesink, Koen D.; Schaper, Nicolaas C.; Dagnelie, Pieter C.; van der Kallen, Carla JH; Biessels, Geert Jan; Stehouwer, Coen DA(2018-09-01)
Background and aims: Arterial remodelling aims at normalising circumferential wall stress (CWS). Greater CWS in the carotid artery has previously been associated with the prevalence and severity of cerebral small vessel ...
Arranja, A. G.; Hennink, W. E.; Denkova, A. G.; Hendrikx, R. W.A.; Nijsen, J. F.W.(2018-09-05)
The aim of this study was the development of radioactive holmium phosphate microspheres (HoPO4-MS) with a high holmium content and that are stable in human serum for selective internal radiation therapy (SIRT) of liver ...
Sun, Feilong; Ye, Chengpei; Thanki, Kaushik; Leng, Donglei; van Hasselt, Peter M.; Hennink, Wim E.; van Nostrum, Cornelus F.(2018-10-01)
Poorly soluble vitamin K cannot be absorbed by patients suffering from cholestasis due to extremely low level of bile salts in the intestine. A formulation of vitamin K including glycocholic acid (i.e. Konakion® MM), does ...
Tse, Chun Yu; Yip, Long Yin; Lui, Troby Ka Yan; Xiao, Xue Zhen; Wang, Yang; Chu, Winnie Chiu Wing; Parks, Nathan Allen; Chan, Sandra Sau Man; Neggers, Sebastiaan Franciscus Wijnandus(2018-10-01)
Current theories of pre-attentive deviant detection postulate that before the Superior Temporal Cortex (STC) detects a change, the Inferior Frontal Cortex (IFC) engages in stimulus analysis, which is particularly critical ...
Filius, Renée M.; de Kleijn, Renske A.M.; Uijl, Sabine G.; Prins, Frans J.; van Rijen, Harold V.M.; Grobbee, Diederick E.(2018-10-01)
This study is focused on how peer feedback in SPOCs (Small Private Online Courses) can effectively lead to deep learning. Promoting deep learning in online courses, such as SPOCs, is often a challenge. We aimed for deep ...
Precise localization of electrodes is essential in the field of high-density (HD) electrocorticography (ECoG) brain signal analysis in order to accurately interpret the recorded activity in relation to functional anatomy. ...
Nonterah, Engelbert Adamwaba; Debpuur, Cornelius; Agongo, Godfred; Amenga-Etego, Lucas; Crowther, Nigel J.; Ramsay, Michèle; Rexford Oduro, Abraham; as members of AWI-Gen and the H3Africa Consortium(2018-11-16)
Background: Obesity and associated cardiometabolic diseases are increasing in urban sub-Saharan Africa due to a complex epidemiological and nutritional transition. Related data on rural communities is scarce. Objectives: ...
Background: Psychosocial research has shown that perceived exposure can influence symptom reporting, regardless of actual exposure. The impact of this phenomenon on the interpretation of results from epidemiological research ...
We demonstrate the fabrication of fully printed microfluidic CD4 counting chips with complete on-chip sample preparation and their applicability as a CD4 counting assay using samples from healthy donors and HIV-infected ...
Food fraud is receiving considerable attention with the growing body of literature that recognises its importance. No system exists that collects media reports on food fraud. In this study, we used the infrastructure ...
Klein, Alison P.; Wolpin, Brian M.; Risch, Harvey A.; Stolzenberg-Solomon, Rachael Z.; Mocci, Evelina; Zhang, Mingfeng; Canzian, Federico; Childs, Erica J.; Hoskins, Jason W.; Jermusyk, Ashley; Zhong, Jun; Chen, Fei; Albanes, Demetrius; Andreotti, Gabriella; Arslan, Alan A.; Babic, Ana; Bamlet, William R.; Beane-Freeman, Laura; Berndt, Sonja I.; Blackford, Amanda; Borges, Michael; Borgida, Ayelet; Bracci, Paige M.; Brais, Lauren; Brennan, Paul; Brenner, Hermann; Bueno-De-Mesquita, Bas; Buring, Julie; Campa, Daniele; Capurso, Gabriele; Cavestro, Giulia Martina; Chaffee, Kari G.; Chung, Charles C.; Cleary, Sean; Cotterchio, Michelle; Dijk, Frederike; Duell, Eric J.; Foretova, Lenka; Fuchs, Charles; Funel, Niccola; Gallinger, Steven; Gaziano, J. Michael M.; Gazouli, Maria; Giles, Graham G.; Giovannucci, Edward; Goggins, Michael; Goodman, Gary E.; Goodman, Phyllis J.; Hackert, Thilo; Haiman, Christopher; Hartge, Patricia; Hasan, Manal; Hegyi, Peter; Helzlsouer, Kathy J.; Herman, Joseph; Holcatova, Ivana; Holly, Elizabeth A.; Hoover, Robert; Hung, Rayjean J.; Jacobs, Eric J.; Jamroziak, Krzysztof; Janout, Vladimir; Kaaks, Rudolf; Khaw, Kay Tee; Klein, Eric A.; Kogevinas, Manolis; Kooperberg, Charles; Kulke, Matthew H.; Kupcinskas, Juozas; Kurtz, Robert J.; Laheru, Daniel; Landi, Stefano; Lawlor, Rita T.; Lee, I. Min; Lemarchand, Loic; Lu, Lingeng; Malats, Núria; Mambrini, Andrea; Mannisto, Satu; Milne, Roger L.; Mohelníková-Duchoňová, Beatrice; Neale, Rachel E.; Neoptolemos, John P.; Oberg, Ann L.; Olson, Sara H.; Orlow, Irene; Pasquali, Claudio; Patel, Alpa V.; Peters, Ulrike; Pezzilli, Raffaele; Porta, Miquel; Real, Francisco X.; Rothman, Nathaniel; Scelo, Ghislaine; Sesso, Howard D.; Severi, Gianluca; Shu, Xiao Ou; Silverman, Debra; Smith, Jill P.; Soucek, Pavel; Sund, Malin; Talar-Wojnarowska, Renata; Tavano, Francesca; Thornquist, Mark D.; Tobias, Geoffrey S.; Van Den Eeden, Stephen K.; Vashist, Yogesh; Visvanathan, Kala; Vodicka, Pavel; Wactawski-Wende, Jean; Wang, Zhaoming; Wentzensen, Nicolas; White, Emily; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Kraft, Peter; Li, Donghui; Chanock, Stephen; Obazee, Ofure; Petersen, Gloria M.; Amundadottir, Laufey T.(2018-12-01)
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including ...
Coebergh Van Den Braak, Robert R.J.; Sieuwerts, Anieta M.; Lalmahomed, Zarina S.; Smid, Marcel; Wilting, Saskia M.; Bril, Sandra I.; Xiang, Shanshan; Van Der Vlugt-Daane, Michelle; De Weerd, Vanja; Van Galen, Anne; Biermann, Katharina; Van Krieken, J. Han J.M.; Kloosterman, Wigard P.; Foekens, John A.; Martens, John W.M.; Ijzermans, Jan N.M.; Coene, Peter Paul L.O.; Dekker, Jan Willem T.; Zimmerman, David D.E.; Tetteroo, Geert W.M.; Vles, Wouter J.; Vrijland, Wietske W.; MATCH study group(2018-12-01)
The identification of patients with high-risk stage II colon cancer who may benefit from adjuvant therapy may allow the clinical approach to be tailored for these patients based on an understanding of tumour biology. ...
Sharma, Arun; Zhang, Yuan; Buikema, Jan W.; Serpooshan, Vahid; Chirikian, Orlando; Kosaric, Nina; Churko, Jared M.; Dzilic, Elda; Shieh, Alice; Burridge, Paul W.; Wu, Joseph C.; Wu, Sean M.(2018-12-01)
Bioactive lipids such as sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) regulate diverse processes including cell proliferation, differentiation, and migration. However, their roles in cardiac differentiation ...
Boersma, Liesbeth J.; Van Vulpen, Marco; Rasch, Coen R.N.; Langendijk, Johannes L.A.; DUPROTON (Dutch Proton Therapy Centres)(2018-01-01)
Na een langdurige maatschappelijke discussie, is in 2018 protonentherapie beschikbaar gekomen in Nederland. Deze therapie is in Nederland op een unieke wijze geïntroduceerd. De protonencentra hebben vergunning om jaarlijks ...
Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The molecular events controlling endothelial ...
Hollingshead, S.; Jongerius, I.; Exley, R. M.; Johnson, S.; Lea, S. M.; Tang, C. M.(2018-12-01)
There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to use ...
Li, Hong Hua; Shan, Ling; Wang, Bing; Du, Lin; Xu, Zhi Da; Jia, Fei Yong(2018-09-01)
The aim of this study is to evaluate serum 25-hydroxyvitamin D[25(OH)D] levels in children with tic disorders and to explore the relationship between serum 25(OH)D level and tic severity. Children (n = 179, 31 females, 148 ...
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging ...
De Vries, S. A.H.; Van Doeselaar, M.; Kaper, H. J.; Sharma, P. K.; Ito, K.(2018-12-01)
Notochordal cell derived matrix (NCM) can induce regenerative effects on nucleus pulposus cells and may exert such effects on chondrocytes as well. Furthermore, when dissolved at low concentrations, NCM forms a viscous ...