Malignant cells are the result of mutations in genes controlling cell proliferation, invasion, and survival. Conventional chemotherapeutic drugs were designed to target vital cellular processes, such as DNA repair and ...
Improving functioning of children with disabilities is the main focus of paediatric rehabilitation services. This functioning is determined by a complex interaction between the health condition and contextual factors as ...
Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal disorder in the population. The effectiveness of hypnotherapy in treating IBS has been demonstrated but mainly for patients with refractory ...
Stroke is a major cause of death and adult disability world wide. Approximately 20-30% of all strokes occur in patients with a previous stroke. Secondary prevention is essential to reduce risk of recurrence after a first ...
Besides data that is primarily collected for research, in biomedical research, multiple additional sources of data, from e.g. electronic healthcare records, registries, and biobanks, are increasingly being combined into ...
Many people who survive a stroke, experience physical consequences such as reduced walking ability. Task-oriented Circuit Class Training (CCT) is an effective physical therapy intervention aimed at improving walking in the ...
The exact cause of severe disease in children during primary RSV infections is not completely clear. There is a link with viral load, but differences virus strains do not seem to be the major reason why in some children ...
Van Driel, Willemien J.; Koole, Simone N.; Sikorska, Karolina; Schagen Van Leeuwen, Jules H.; Schreuder, Henk W.R.; Hermans, Ralph H.M.; De Hingh, Ignace H.J.T.; Van Der Velden, Jacobus; Arts, Henriëtte J.; Massuger, Leon F.A.G.; Aalbers, Arend G.J.; Verwaal, Victor J.; Kieffer, Jacobien M.; Van De Vijver, Koen K.; Van Tinteren, Harm; Aaronson, Neil K.; Sonke, Gabe S.(2018-05-01)
The majority of patients with ovarian cancer (OC) receive an initial diagnosis of advanced disease that has spread from the ovaries to the peritoneal surface. The most effective treatment for patients with advanced disease ...
Otte, Willem M; Tijdink, Joeri K; Weerheim, Paul L; Lamberink, Herm J; Vinkers, Christiaan(2018-06-05)
Clinical trials have a vital role in ensuring the safety and efficacy of new treatments and interventions in medicine. A key characteristic of a clinical trial is its statistical power. Here we investigate whether the ...
Tirado-Conte, Gabriela; Rodés-Cabau, Josep; Rodríguez-Olivares, Ramón; Barbanti, Marco; Lhermusier, Thibault; Amat-Santos, Ignacio; Toggweiler, Stefan; Cheema, Asim N; Muñoz-García, Antonio J; Serra, Vicenc; Giordana, Francesca; Veiga, Gabriela; Jiménez-Quevedo, Pilar; Campelo-Parada, Francisco; Loretz, Lucca; Todaro, Denise; Del Trigo, María; Hernández-García, José M; García Del Blanco, Bruno; Bruno, Francesco; de la Torre Hernández, José M; Stella, Pieter; Tamburino, Corrado; Macaya, Carlos; Nombela-Franco, Luis(2018-03)
BACKGROUND: Chronic liver disease is a known risk factor for perioperative morbidity and mortality in patients undergoing cardiac surgery. Very little data exist about such patients treated with transcatheter aortic valve ...
van Hoeven, Loan R.; Kreuger, Aukje L.; Roes, Kit C.B.; Kemper, Peter F.; Koffijberg, Hendrik; Kranenburg, Floris J.; Rondeel, Jan M.M.; Janssen, Mart P.(2018-03-29)
Background: To enhance the utility of transfusion data for research, ideally every transfusion should be linked to a primary clinical indication. In electronic patient records, many diagnostic and procedural codes are ...
Verberne, Lisa M; Zwakman, Marieke; Kars, Marijke C; Hooft, Lotty; van Delden, Johannes J M; Spijker, René(2018-06-02)
BACKGROUND: In the rapidly developing specialty of palliative care, literature reviews have become increasingly important to inform and improve the field. When applying widely used methods for literature reviews developed ...
Andrejecsk, Jillian W.; Hosman, Anna E.; Botella, Luisa M.; Shovlin, Claire L.; Arthur, Helen M.; Dupuis-Girod, Sophie; Buscarini, Elisabetta; Hughes, Christopher C.W.; Lebrin, Franck; Mummery, Christine L.; Post, Marco C.; Mager, Johannes J.(2018-02-01)
Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. ...
Objective To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. Design Multicentre case-cohort study. Setting A study ...
van Melle, Marije A; van Stel, Henk F; Poldervaart, Judith M; de Wit, Niek J; Zwart, Dorien L M(2018)
BACKGROUND: Patients are at risk for harm when treated simultaneously by healthcare providers from different healthcare organisations. To assess current practice and improvements of transitional patient safety, valid ...
van Nunen, Daan P F; van den Boogaard, Marie-José H; Breugem, Corstiaan C(2018-06)
OBJECTIVE: Heterogeneity in both nomenclature and diagnostic criteria has hindered the interpretation of research into the congenital condition most widely known as (Pierre) Robin syndrome or sequence. In 2009, the discussion ...