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  • Janssen, W.J.M. (Universiteit Utrecht, 2017-04-20)
    Common Variable Immunodeficiency (CVID) disorder is the most prevalent symptomatic primary immunodeficiency in children and adults. Typically, a patient presents with recurrent pulmonary and/or gastrointestinal infections ...
  • Hoed, M.A.H. den (Utrecht University, 2017-05-17)
    In the Netherlands, there are approximately 8000 childhood cancer survivors, and this population of survivors is expanding due to improved therapy. However, therapy has a consequent flip side, namely their inherent side ...
  • Baranova, E V; Verhoef, T I; Ragia, G; le Cessie, S; Asselbergs, F W; de Boer, A; Manolopoulos, V G; Maitland-van der Zee, A H; EU-PACT group (2017)
    Essentials Prospective studies of pharmacogenetic-guided (PG) coumarin dosing produced varying results. EU-PACT acenocoumarol and phenprocoumon trials compared PG and non-PG dosing algorithms. Sub-analysis of EU-PACT ...
  • van der Kooy, Jacoba; de Graaf, Johanna P.; Birnie, Doctor Erwin; Denktas, Semiha; Steegers, Eric A P; Bonsel, Gouke J. (2016-12-01)
    Objectives: The claimed advantages of home deliveries, including fewer medical interventions, are potentially counter balanced by the small additional risk on perinatal adverse outcome compared to hospital deliveries in ...
  • Ter Brugge, Petra; Kristel, Petra; Van Der Burg, Eline; Boon, Ute; De Maaker, Michiel; Lips, Esther; Mulder, Lennart; De Ruiter, Julian; Moutinho, Catia; Gevensleben, Heidrun; Marangoni, Elisabetta; Majewski, Ian; Jozwiak, Katarzyna; Kloosterman, Wigard; Van Roosmalen, Markus; Duran, Karen; Hogervorst, Frans; Turner, Nick; Esteller, Manel; Cuppen, Edwin; Wesseling, Jelle; Jonkers, Jos (2016-11)
    Background: Although BRCA1-deficient tumors are extremely sensitive to DNA-damaging drugs and poly(ADP-ribose) polymerase (PARP) inhibitors, recurrences do occur and, consequently, resistance to therapy remains a serious ...
  • Santuari, Luca; Sanchez-Perez, Gabino F.; Luijten, Marijn; Rutjens, Bas; Terpstra, Inez; Berke, Lidija; Gorte, Maartje; Prasad, Kalika; Bao, Dongping; Timmermans-Hereijgers, Johanna L P M; Maeo, Kenichiro; Nakamura, Kenzo; Shimotohno, Akie; Pencik, Ales; Novak, Ondrej; Ljung, Karin; van Heesch, Sebastiaan; de Bruijn, Ewart; Cuppen, Edwin; Willemsen, Viola; Mähönen, Ari Pekka; Lukowitz, Wolfgang; Berend, Snel; de Ridder, Dick; Scheres, Ben; Heidstra, Renze (2016-12-01)
    Organ formation in animals and plants relies on precise control of cell state transitions to turn stem cell daughters into fully differentiated cells. In plants, cells cannot rearrange due to shared cell walls. Thus, ...
  • Haitjema, Saskia; Meddens, Claartje A; van der Laan, Sander W; Kofink, Daniel; Harakalova, Magdalena; Tragante, Vinicius; Foroughi Asl, Hassan; van Setten, Jessica; Brandt, Maarten M; Bis, Joshua C; O'Donnell, Christopher; Cheng, Caroline; Hoefer, Imo E; Waltenberger, Johannes; Biessen, Erik; Jukema, J Wouter; Doevendans, Pieter A F M; Nieuwenhuis, Edward E S; Erdmann, Jeanette; Björkegren, Johan L M; Pasterkamp, Gerard; Asselbergs, Folkert W; den Ruijter, Hester M; Mokry, Michal (2017-04)
    BACKGROUND: As genome-wide association efforts, such as CARDIoGRAM and METASTROKE, are ongoing to reveal susceptibility loci for their underlying disease-atherosclerotic disease-identification of candidate genes explaining ...
  • van de Wall, Bryan J M; Stam, Marguerite A W; Draaisma, Werner A.; Stellato, R.; Bemelman, Willem A.; Boermeester, Marja A.; Broeders, Ivo A M J; Belgers, Eric J.; Toorenvliet, Boudewijn R.; Prins, Hubert A.; Consten, Esther C J (2017-01)
    Background Patients with recurrent or persisting complaints after an episode of left-sided diverticulitis are managed with either conservative measures or elective sigmoidectomy. To date, there are no data from randomised ...
  • Güder, G. (Utrecht University, 2017-04-11)
    Introduction: Chronic obstructive pulmonary disease (COPD), heart failure (HF) or both syndromes are the most common reasons for dyspnea in the elderly. Currently there is no standard to diagnose COPD and multiple definitions ...
  • Petrelli, Alessandra (Utrecht University, 2017-04-20)
    Chronic inflammatory diseases (CID) are characterized by a chronic and recurrent state of local inflammation mediated by the immune system. T cells are essential component of the immune system, whose imbalanced actions ...
  • Wijers, S.C. (Utrecht University, 2017-04-11)
    In this thesis an effort was made to translate basic research into clinical practice to improve cardiac device therapy. We showed the electrocardiogram (ECG) is everything but obsolete or outdated and is of great value as ...
  • Lange, Rogier; Ter Heine, Rob; Van Der Gronde, Toon; Selles, Suzanne; De Klerk, John; Bloemendal, Haiko; Hendrikse, Harry (2016-07-30)
    Introduction Rhenium-188-HEDP (188Re-HEDP) is a therapeutic radiopharmaceutical for treatment of osteoblastic bone metastases. No standard procedure for the preparation of this radiopharmaceutical is available. Preparation ...
  • Rydkjær, J.; Møllegaard Jepsen, J. R.; Pagsberg, A. K.; Fagerlund, B.; Glenthøj, B. Y.; Oranje, B. (2017-01-01)
    Background Deficient mismatch negativity (MMN) has been proposed as a candidate biomarker in schizophrenia and may therefore be potentially useful in early identification and intervention in early onset psychosis. In this ...
  • El Idrissi, Ayman; van Berkel, Lisanne; Bonekamp, Nadia E; Dalemans, Diana J Z; van der Heyden, Marcel A G (2017-03)
    CONTEXT: Zinc chloride (ZnCl2)-based smoke bombs and screens are in use since the Second World War (1939-1945). Many case descriptions on ZnCl2 smoke inhalation incidents appeared since 1945. OBJECTIVE: We provide a ...
  • de Graaf, Ireen; Schappin, R (Trimbos Instituut, 2015)
  • Faber, T.E. (Utrecht University, 2017-04-13)
    Since its discovery 60 years ago, we have greatly improved our knowledge of RSV disease. Many risk factors for development of serious disease have been identified that include prematurity, pre-existing medical conditions, ...
  • Westendorp, Hendrik (Utrecht University, 2017-05-18)
    The aim of 125I prostate brachytherapy is to cover the prostate with an adequate dose to control local disease and, at the same time, limit dose to healthy structures to minimize toxicity of the treatment. The AAPM, ABS ...
  • Govaert, K.M. (Utrecht University, 2017-04-06)
    In chapter 2 an overview is given of the factors involved in surgery-stimulated tumour growth in the context of liver surgery for (metastatic) cancer. Most of the data is based on an overwhelming amount of pre-clinical ...
  • Jacob, K.A. (Utrecht University, 2017-04-18)
    Heart surgery is a frequently performed type of surgery and is associated with an inflammatory response throughout the body. This inflammation can injure several organs, including the heart itself and the kidneys. This ...
  • Aguilera-Gomez, Angelica (Utrecht University, 2017-04-13)
    During the last decade, a novel concept of cellular architecture and organization has re-emerged with the recognition of high-order compartmentalization via non membrane-bound macromolecular structures. These membrane-less ...

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