Radiotherapy aims to deliver a lethal radiation dose to cancer cells immersed in the body using a high energetic photon beam. Due to physiologic motion of the human anatomy (e.g. caused by filling of internal organs or ...
Enterococcus faecium is a commensal of the gastrointestinal tract. However, E. faecium can also cause a large number of hospital-acquired enterococcal infections in humans and has rapidly acquired resistance to several ...
Randomised controlled trials (RCTs) are considered the gold standard for the identification and estimation of causal effects and thus for establishing causal conclusions. Most RCTs are designed based on the implicit ...
Puberty is a period characterized by major changes in hormone levels, physical appearance, cognition, brain structure and function. The teenage brain undergoes considerable reorganization on a structural and functional ...
Lower respiratory tract infection (LRTI) is one of the leading reasons for consulting in primary care. Today, a general practitioner faces the challenge of distinguishing between patients with a mild self-limiting disease ...
Resistant hypertension, uncontrolled blood pressure despite use of ≥3 antihypertensives including a diuretic or use of ≥4 antihypertensives regardless of blood pressure (BP), was studied. In this thesis, 1/3 of patients ...
van den Elzen, M.T.(Utrecht University, 2017-07-04)
The occurrence of wheals, angioedema or both for at least 6 weeks is diagnosed as chronic spontaneous urticaria in (inter) national guidelines - after excluding other illnesses. The underlying mechanism of angioedema without ...
With an overall incidence of 29 to 64 per 100.000 people a year, clavicle fractures are one of the most common fractures around the shoulder girdle. They account for 2.6% to 4% of all fractures in adults. About 80% of all ...
Alloreactivity due to HLA mismatches between donor and recipient remains the major limiting factor in successful graft outcome after solid organ transplantation. However, the immunogenicity of individual HLA mismatches is ...
Mitral valve disease is one of the most prevalent valvular heart diseases. This thesis aims to investigate and optimize the management of mitral valve disease, focusing on the improvement of current diagnostic and treatment ...
Background The Knowledge about Older Patients-Quiz (KOP-Q) is designed as a unidimensional scale measuring knowledge of hospital nurses about older patients. Furthermore, the KOP-Q measures a second unidimensional construct, ...
Hofman, Cynthia S.; Lutomski, Jennifer E.; Boter, Han; Buurman, Bianca M.; De Craen, Anton J M; Donders, A Rogier T; Rikkert, Marcel G M Olde; Makai, Peter; Melis, René J.F.; Bleijenberg, N.; Blom, J. W.; Kempen, G. I J M; Krabbe, P. F M; Moll van Charante, E.P.; Muntinga, M. E.; Steyerberg, Ewout W.; Gussekloo, J.; van der Horst, H.E.; Olde Rikkert, Marcel G M; de Rooij, S.E.J.A.; Schols, Jos M. G. A.; Schuurmans, M. J.; Smilde, D. A.; Van Den Brink, D.; Qin, L.; TOPICS-MDS research consortium, Steering Committee, Working group(2017-03-01)
Background Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey Composite ...
Lutomski, Jennifer E.; Krabbe, Paul F M; Bleijenberg, N.; Blom, Jeanett; Kempen, Gertrudis I J M; MacNeil-Vroomen, Janet; Muntinga, Maaike E.; Steyerburg, Ewout; Olde Rikkert, Marcel G M; Melis, René J.F.; Bleijenberg, N.; Blom, J. W.; Melis, R.J.F.; Muntinga, M. E.; Steyerberg, Ewout W.; Gussekloo, J.; Olde Rikkert, Marcel G M; van den Brink, D.; Lutomski, J.E.; Qin, L.; Kempen, G. I.J.M.; Krabbe, P. F M; Buurman, B.M.; van der Horst, H.E.; de Rooij, S.E.J.A.; Schols, Jos M. G. A.; Schuurmans, M. J.; Smilde, D. A.; TOPICS Consortium(2017-03-03)
Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D ...
Stalpers, Dewi; Van Der Linden, Dimitri; Kaljouw, Marian J.; Schuurmans, Marieke J.(2017-06-01)
Aims: To examine nurse-perceived quality of care, controlling for overall job satisfaction among critical care nurses and to explore associations with work environment characteristics. Background: Nurse-perceived quality ...
de Sain-van der Velden, Monique G M; van der Ham, Maria; Gerrits, Johan; Prinsen, Hubertus C M T; Willemsen, Marcel; Pras-Raves, Mia L; Jans, Judith J; Verhoeven-Duif, Nanda M(2017-08-01)
Diagnosis and treatment of inborn errors of metabolism (IEM) require the analysis of a variety of metabolites. These compounds are usually quantified by targeted platforms. High resolution mass spectrometry (HRMS) has the ...
Johansson, Lennart F.; De Boer, E. N.; De Weerd, H. A.; van Dijk, F.; Elferink, M. G.; Schuring-Blom, G. H.; Suijkerbuijk, Ron F; Sinke, Richard J.; Te Meerman, G. J.; Sijmons, Rolf H.; Swertz, Morris A.; Sikkema-Raddatz, B.(2017-12-01)
Non-invasive prenatal testing (NIPT) of cell-free DNA in maternal plasma, which is a mixture of maternal DNA and a low percentage of fetal DNA, can detect fetal aneuploidies using massively parallel sequencing. Because of ...
Sameith, Katrin; Amini, Saman; Groot Koerkamp, Marian J A; van Leenen, Dik; Brok, Mariel; Brabers, Nathalie; Lijnzaad, Philip; van Hooff, Sander R.; Benschop, Joris J.; Lenstra, Tineke L.; Apweiler, Eva; van Wageningen, Sake; Snel, Berend; Holstege, Frank C P; Kemmeren, Patrick(2015-12-23)
Background: Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these genetic interactions has hardly been characterized. ...
van Osch, Dirk; Nathoe, Hendrik M.; Jacob, Kirolos A.; Doevendans, Pieter A.; van Dijk, Diederik; Suyker, Willem J.; Dieleman, Jan M.(2017-06)
Background: Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the ...
Hoff, Benjamin A; Pompe, Esther; Galbán, Stefanie; Postma, Dirkje S; Lammers, Jan-Willem J; Ten Hacken, Nick H T; Koenderman, Leo; Johnson, Timothy D; Verleden, Stijn E; de Jong, Pim A; Mohamed Hoesein, Firdaus; van den Berge, Maarten; Ross, Brian D; Galbán, Craig J(2017-06-07)
Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and quantification of non-emphysematous air trapping component, referred to as ...