Columnar cell lesions of the breast are proposed as the earliest recognizable precursor lesions of low grade breast cancer. The lesions are characterized by cystically enlarged terminal duct lobular units with monotonous ...
Hond, Titus Arnoldus Paulus de(Utrecht University, 2023-07-06)
Sepsis is a clinical condition in which an infection causes organ damage. This organ damage is caused by an excessive response of the immune system. Globally, sepsis incidence rates are estimated at 50 million people and ...
Awareness increases that tumors are not a homogenous collection of cells but instead form a micro-environment together with non-cancer cells. Novel anti-cancer therapies such as immunotherapy target this micro-environment ...
Bone conduction devices (BCDs) are an important option for hearing rehabilitation. The surgery for implantation of percutaneous BCDs has been evolved to more minimally invasive procedures. The most widespread used procedure ...
Beenker, Wouter Antonius Gerardus(Utrecht University, 2023-06-26)
Antibiotic resistance is a growing problem, leading to ineffective antibiotic treatments, causing bacterial infections to be lethal again. Therefore, new alternatives are needed to fight bacterial infections. Targeting ...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy associated with an increased risk of ventricular arrhythmias (VA) and sudden cardiac death. The current cornerstone of ARVC management ...
Adult stem cell (ASC)-derived organoids are miniature replicas of human epithelial organs. These organoids represent the molecular characteristic of their epithelium of origin, and thus, they can be used as proxies to study ...
Richthofen, Helen Juliette von(Utrecht University, 2023-06-28)
The strength of the immune response needs to be tightly regulated: an immune response which is too strong can damage healthy tissue, while an immune response which is too weak can lead to the survival of pathogens or cancer ...
Groot, Evianne Laura de(Utrecht University, 2023-06-29)
In this thesis we explored the clinical and genetic risk factors for idiopathic multifocal choroiditis (MFC). MFC is a rare ocular disease affecting the choroid in the posterior pole of the eye. This relapsing disease ...
Oosten, Anne Floortje van(Utrecht University, 2023-06-22)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal 5-year survival of 10%. Currently, the only chance at long-term survival is surgical resection combined with chemotherapy. Approximately 30 to ...
There are few experiences as trying as preterm birth. For both the parent and the child, the first few weeks of life are mired by uncertainty, adversity, and (subjective) stress. The complex and diverse effects of postnatal ...
Ouden, Hendrik den(Utrecht University, 2023-06-22)
This dissertation concerns various aspects of modern diabetes treatment, namely ‘personalised medicine’ based on the biological characteristics of the individual patient, and ‘patient-centred’ diabetes care with shared ...
The interaction of a myriad of molecular factors is necessary for proper development of mDA circuitry. Although significant progress has been made in uncovering the mechanisms involved in mDA neuron development, our ...
This Ph.D. thesis delved into the intricate engineering of extracellular vesicles (EVs) for optimized protein-based drug delivery. The clinical utilization of EVs for drug delivery was contingent upon efficient drug loading ...
Boogaard, Winnie Martina Clara van den(Utrecht University, 2023-06-19)
Every year about 600 children are diagnosed with cancer in the Netherlands. The different forms of cancer can be divided into three main subtypes: haematological, solid or neurological tumours. Different treatment modalities ...
The electrocardiogram (ECG) plays an important role in systematically assessing cardiac electrical function, but the standard 12-lead ECG only provides only a distant view on cardiac electrical activity. Using non-invasive ...
Assouly, Kelly Kérène Simy(Utrecht University, 2023-05-25)
Tinnitus is the perception of sound without an external stimulus, often experienced as a ringing, buzzing sound. It has a prevalence ranging from 10 to 30% of the general population with up to 3% of people with tinnitus ...
This thesis is about compression neuropathies of the upper extremity. Compression neuropathies often occur in patients with a genetic and/or systemic predisposition for such a syndrome or after a trauma. In each chapter ...
Moorsel, Marc Vincent Adriaan van(Utrecht University, 2023-06-09)
Cardiovascular diseases are the leading cause of death globally, accounting for approximately 32% of all deaths. These diseases, such as ischemic heart disease, stroke, and venous thromboembolism, are characterized by ...
The 1.5 Tesla magnetic resonance (MR) imaging with a linear accelerator (Linac), MR-Linac, is being implemented worldwide. It enables online and real-time, soft-tissue imaging
and targeted MRI-guided radiotherapy (MRgRT). ...