Most psychiatric and neurological disorders are characterized by a complex genetic background where many common variants (single-nucleotide polymorphisms, SNPs) show an association to disease. Nowadays, we are able to ...
Massive numbers of new prediction models have been published over the past two decades and the number of developed prediction models increases every week. Numerous guidelines and books have proposed a stepwise process in ...
The involvement of the immune system has been implicated in the aetiology of schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Although previous research supports immune alterations in SCZ, ...
A particular group of white blood cells, better known as phagocytes, play a crucial role in the host defense against bacterial infections. However, Staphylococcus aureus is a major human bacterial pathogen that is able to ...
Schizophrenia spectrum disorders, or psychotic disorders, are considered among the most serious life shortening, burdening mental illnesses worldwide, at a personal, familial and societal level, with approximately a 2- to ...
van Oers, C.A.M.M.(Utrecht University, 2019-02-21)
Stroke is a leading cause of disability worldwide. Even in case of severe brain damage neuronal plasticity may contribute to functional recovery. Understanding the underlying mechanisms could improve prognostication and ...
Locked-In Syndroom (LIS) is een situatie waarin iemand wel bij bewustzijn is, maar niet kan bewegen en niet kan spreken. Dit kan veroorzaakt worden door bijvoorbeeld een hersenstaminfarct of door neurodegeneratieve ...
Rayego-Mateos, Sandra; Rodrigues-Diez, Raúl R.; Morgado-Pascual, José Luis; Valentijn, FA; Valdivielso, Jose M; Goldschmeding, R; Ruiz-Ortega, Marta(2018-12-23)
Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive fibrosis, ultimately leading to end-stage renal disease. Although many studies have investigated the factors involved in the progressive ...
Antoinette Groenewegen, W.; Van De Putte, Elise M.(2018-01-01)
As of May 2018, the use of personal data in medical research is regulated under the General Data Protection Regulation (GDPR). While, as before, in principle patients’ consent for the use of their personal data is still ...
den Harder, Annemarie M; de Boer, Erwin; Lagerweij, Suzanne J; Boomsma, Martijn F; Schilham, Arnold M R; Willemink, Martin J; Milles, Julien; Leiner, Tim; Budde, Ricardo P J; de Jong, Pim A(2018-11-07)
BACKGROUND: Computed tomography (CT) emphysema quantification is affected by both radiation dose (i.e. image noise) and reconstruction technique. At reduced dose, filtered back projection (FBP) results in an overestimation ...
van Wessem, Karlijn J.P.; Leenen, Luke P.H.(2018-07-01)
Background: Haemostasis assessment is essential to determine the early need for massive transfusion in the treatment of polytrauma. Strategies to guide correction of coagulopathy vary widely. In order to evaluate ...
Longoni, A; Knežević, L; Schepers, K; Weinans, H; Rosenberg, A J W P; Gawlitta, D(2018-11-29)
Tissue engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. Such constructs typically consist of multipotent mesenchymal stromal ...
van der Naald, N.; van der Naald, M.; Schuurman, A.(2018-06)
CASE:Fracture of a sesamoid bone of the thumb is rare. We report a case of such a fracture after hyperextension of the thumb in a 26-year-old woman. After a volar plate injury was excluded, she was treated nonoperatively ...
van Hövell tot Westerflier, Claire V.A.; Stegeman, Inge; Muradin, Marvick S.M.; Smit, Adriana L.; Breugem, Corstiaan C.(2018-03-01)
Objectives The aim of our study was to investigate subjective information concerning parental experiences and preferences with regard to the initial information that is provided right after the birth of a child with microtia. ...
Cairat, Manon; Fournier, Agnès; Murphy, Neil; Biessy, Carine; Scalbert, Augustin; Rinaldi, Sabina; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Arveux, Patrick; Boutron-Ruault, Marie Christine; Cadeau, Claire; Fortner, Renée Turzanski; Kaaks, Rudolf; Boeing, Heiner; Aleksandrova, Krasimira; Peeters, Petra H.M.; Van Gils, Carla H.; Wareham, Nicholas J.; Khaw, Kay Tee; Aune, Dagfinn; Riboli, Elio; Gunter, Marc J.; Dossus, Laure(2018-10-01)
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was ...