Protein tyrosine phosphatases (PTPs) have a central role in cell signaling, by dephosphorylating other proteins. PTPs are highly susceptible to oxidation, due to the low pKa of their active sites. Their reactive cysteine ...
Sinds de eerste allogene hematopoëtische stamceltransplantatie (HSCT) in 1957 zijn de behandelingen verbeterd, maar HSCT-patiënten worden nog steeds geconfronteerd met levensbedreigende complicaties. In de periode 1957 - ...
Steege, Eline Johanna ter(Utrecht University, 2023-12-19)
Breast cancer is the most common cancer in women and despite advancements in diagnostics and treatment methods that have led to lower mortality rates, it remains one of the leading causes of cancer death among women. In ...
Vaan, Maria Dimphena Theodora de(Utrecht University, 2023-12-21)
The aim of this thesis was to further investigate obstetrical and perinatal safety outcomes of induction of labour with a balloon catheter in comparison to other induction agents in a general pregnant population as well ...
This thesis described the current state of longitudinal data analysis in the pediatric gastrointestinal (GI) surgical literature. Studies on two procedures were performed to gather the best available evidence for minimally ...
Ainsworth, Madison Jade(Utrecht University, 2023-12-19)
The persistent societal challenge of organ donor shortage, driven by factors such as population growth, increased lifespan, and higher disease prevalence, leaves thousands awaiting life-saving transplants. Tissue Engineering ...
Psoriasis is a complex autoimmune disease characterized by dysregulated interactions between keratinocytes and immune cells. Over the past decade, various antimicrobial peptides, chemokines, and cytokines have been discovered ...
This thesis describes new insights in sarcomeric cardiomyopathies, focusing on biomarkers, early detection and prognosis. The sarcomere constitutes the basic contractile unit of cardiomyocytes. Variants in genes that encode ...
Wakker, Simonides Immanuel van de(Utrecht University, 2023-12-15)
Extracellular vesicles (EVs) are small vesicles naturally produced by cells to transfer bioactive content to other cells. This thesis addresses key challenges in translating EV therapeutics in the context of cardiac repair. ...
Psoriasis is a chronic skin condition affecting approximately 60 million people worldwide, significantly impacting their lives. Its origins are complex, involving genetic and environmental factors, as well as immune system ...
Bronchiectasis is a heterogenous disease and is diagnosed in patients of all ages, with geographic variability around the globe. The prevalence of bronchiectasis worldwide rose by 40% between 2004 and 2014, and still ...
Braat, Maria Nicole Gerardine Johanna Aleida(Utrecht University, 2023-12-14)
Radioembolization is an established antitumoral treatment for both primary liver tumors and liver metastases. Contrary to normal liver tissue, hepatic tumors are almost solely fed by branches of the hepatic artery, allowing ...
Traditional biomarkers of breast cancer are dependent on invasive sampling of the areas suspicious of malignancy. In contrast, MRI not only investigates the whole tumor in vivo, but also evaluates the surrounding tissues ...
Glucocorticoids, such as dexamethasone and prednisone, play a crucial role in the treatment of childhood acute lymphoblastic leukemia (ALL). Dexamethasone is currently the preferred glucocorticoid and is administered during ...
Every year about 75 children in the Netherlands undergo an allogeneic stem cell transplantation (SCT) as an ultimate treatment for leukemia for instance. Unfortunately, often the complication acute Graft-versus-Host disease ...
In 2021, approximately 122,651 people in the Netherlands were diagnosed with cancer, and one in five of these cases were classified as rare cancers. This research focuses on penile cancer, with 178 new patients in the ...
Heijden, Lisa Tamara van der(Utrecht University, 2023-12-12)
In recent years, drug development in oncology switched focus from conventional cytotoxic drugs to targeted therapies. Despite this change in focus, dose selection of anticancer drugs in early drug development is still often ...
Drijver, Evert Pieter Marie den(Utrecht University, 2023-12-05)
Antibiotic resistance poses a global threat to public health in both humans and animals. Recently, attention has been focused on bacteria that produce Extended-spectrum Beta-lactamases (ESBL) or carbapenemases, rendering ...
Nurses are frequently confronted with situations in which they must deviate from organizational rules and regulations when these rules do not align with their professional standards and beliefs concerning delivering ...
Pure fruit juice (without added sugars or other additives) has similarities with both whole fruit and sugar-sweetened beverages. Like whole fruit, pure fruit juice contains vitamin C and flavonoids, but has the low satiety ...