Weele, Linda Jacqueline van(Utrecht University, 2022-05-25)
Actively self-renewing tissues need to maintain a delicate balance between providing sufficient cells to maintain the integrity of a tissue and preventing excessive proliferation resulting in tumorigenesis. Consequently, ...
Magnetic resonance imaging (MRI) provides superior soft tissue contrast compared with computed tomography (CT) imaging. Image guidance during radiotherapy treatments is of pivotal importance to ensure accurate deposition ...
Boosman, René Johan(Utrecht University, 2022-05-30)
In the current era of precision medicine in oncology, the tailoring of treatment of patients on the (molecular) characteristics of the tumor is widely performed. However, for many drugs, the full spectrum of precision ...
A stenosis in one of the pulmonary branches affects the hemodynamics of the pulmonary circulation. It causes an unequal flow distribution over the right and left lung and increases the pressure load of the right ventricle ...
To better understand cardiovascular diseases, patient data from the electronic health record can be used in research. In this thesis, I captured these data manually in clinical registries and developed a research data ...
Hasaart, Karlijn Anna Leonarda(Utrecht University, 2022-05-31)
In this thesis, we aimed to define the processes initiating pediatric leukemia by studying
mutation accumulation during embryonic and fetal development in non-cancerous stem
cells. Moreover, we investigated the molecular ...
Winter, Maria Adriana de(Utrecht University, 2022-05-24)
Anticoagulation is the cornerstone of treatment for venous thromboembolism (VTE; deep vein thrombosis and pulmonary embolism). After an initial treatment of at least 3 months, a decision must be made to stop treatment or ...
Uveitis is a severe and potentially blinding eye disease and is characterized by inflammation of the iris, choroid and retina. Uveitis can lead to complications resulting in severe vision loss or even blindness. Over the ...
The general aim of this thesis is to investigate wheter anti-inflammatory therapy improves outcomes in patients with coronary disease, based on a methodology that combines sustainable collection of evidence with the highest ...
This thesis aimed to better understand the function and relevance of the GFAP protein in glioma biology. We have shown that GFAP plays a dual role in glioma cell invasion. First of all, we show that GFAP isoforms distinctively ...
People differ remarkably in their response to traumatic events: some develop post-traumatic stress disorder (PTSD), while others are resilient and adapt successfully. PTSD is a debilitating condition that –among other ...
Native SERPINs are currently the treatment of choice for diseases driven by excessive serine protease activity. Nonetheless, their lack of specificity and potency as well as the short half-life of their recombinant ...
Chronic limb-threatening ischemia (CLTI) is a significant facet of atherosclerotic disease that has major medical and functional consequences. With the number of diabetic patients on the rise and improved life expectancy, ...
The first part of this thesis focused on the individual perspective of healthy and sustainable diets. Here, we investigated the association between adherence to various healthy and/or sustainable dietary patterns in relation ...
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Improvements in the treatment made over the last decades have resulted in increased overall survival, now reaching 90%. However, around 10% of ...
Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiomyopathy which is characterized by progressive fibro-fatty replacement of the myocardium. Clinically, this disease may lead to life-threatening arrhythmias and heart ...
Stelt, Femke van der(Utrecht University, 2022-05-12)
Improvements in surgery and care for children born with single ventricle physiology have increased their survival. This leads to a growing population of patients with this congenital heart defect who often suffer from ...
Achieving an appropriate individualization of treatment in older patients with cancer remains challenging. Identifying someone’s frailty is an important aspect to guide treatment decisions. Frailty can be identified by ...
Tas, Michelle Louise(Utrecht University, 2022-04-26)
Neuroblastoma is a common pediatric malignancy of the developing autonomic nervous system. Neuroblastoma tumors arise from neural crest cells of the developing autonomic nervous system. The clinical course is variable, ...
Eijkeren, Robert Johannes van(Utrecht University, 2022-05-17)
Fat tissue is more than just fat cells that store lipids. It is a highly complex tissue with a large variety of different cells that have different functions both locally and throughout the whole body. Fat cells for example, ...