Flores Dourojeanni, Jacques Paul(Utrecht University, 2019-07-09)
Animals, including humans, display a range of impulsive behaviours. For example, sometimes we are unable to withhold ourselves from carrying out certain actions, even though we are aware that such actions will incur negative ...
The majority of chronic diseases are likely to be the result of the combination of environmental exposures and human genetics. The exposome concept was proposed to increase our knowledge regarding the potential role of ...
A subarachnoid hemorrhage is a bleeding in the space around the brain. In a part of the cases, the bleeding is caused by a rupture of a bulge in a blood vessel, also called an aneurysm (aSAH). It is a life-threatening ...
The main objective of this project was to develop a cost-effectiveness model for policymakers to specifically target the disease burden of Respiratory Syncytial Virus (RSV) bronchiolitis in late premature children. Within ...
Oudeman, Eline Anna(Utrecht University, 2019-07-04)
Nonfocal transient neurological attacks (TNAs) are episodes with an acute onset of unexplained nonfocal symptoms that cannot be attributed to a specific territory of the brain, such as unsteadiness or bilateral weakness. ...
The lymphoid system is essential to maintain normal physiology, but also provides a major route for the spread of cancer cells. Consequently, it is an important target during gastrointestinal oncologic surgery. Adequate ...
This thesis consists of two parts. In the first part, we investigated current practices with regard to the identification of young patients with colorectal cancer potentially due to hereditary disease as well as measures ...
Chromosomal instability (CIN) is at the heart of genome destabilisation, but so far, many questions about its role in tumorigenesis remained unanswered. This was partly due to technical limitations and difficulties to ...
The main aim of this thesis was to evaluate the influence of maternal life style habits during pregnancy on the neurodevelopment of the child. In the first part, the reproducibility of fetal brain structure volume measurements ...
Breast cancer is one of the most common types of cancer worldwide. Despite advances in systemic treatment leading to increased survival rates, a substantial number of patients still dies of the disease. A personalized ...
Respiratory tract infections remain a leading cause of childhood morbidity and mortality worldwide. In this thesis, we have demonstrated that in childhood AOMT the nasopharyngeal microbiota considerably resembles and ...
For a small patient group with type 1 diabetes (T1D), standard treatment with insulin is very difficult, and donor pancreas or islet transplantation is an option. Nonetheless, limited donor organs mean that alternative ...
In the present work, liposomes loaded with glucocorticoids or proteasome inhibitors were studied in two clinically more relevant mouse tumor models: A spontaneous MMTV/neu mouse model of breast cancer. In this model, mouse ...
Individuals that have experienced profound stress during childhood can develop deficits in behavioral inhibition and social behavior, two core features of several stress related psychiatric disorders. However, not all ...
Many cerebrovascular diseases are complex and treatment is often based on experience and relatively small studies. A mathematical blood flow model might aid in better treatment decisions and might lead to more personalised ...
In several countries, lung cancer screening programs are being implemented, in which heavy cigarette smokers are regularly invited for a CT scan of their lungs (chest CT). This scan can help detect lung cancer in an early ...
Large-scale data processing and analysis offers the promise of personalizing health and biomedicine. In order to realize this promise, growing numbers of patients and citizens are contributing data to health research. The ...
In conclusion, the studies presented in this thesis contributed to the field of cell fate dynamics in human CRC and its metastasis. We developed novel reporters and strategies to study functional intratumoral heterogeneity ...
Biomarkers are frequently used in the diagnosis of cardiovascular diseases. In this thesis, different cardiovascular biomarkers were studied in various clinical settings. The first part focuses on troponin elevation after ...