Exercise is an increasingly recognized effective strategy to counteract cancer-related symptoms, such as cancer-related fatigue, during and shortly after chemotherapy. However, if exercise during chemotherapy has lasting ...

Our brain is a richly vascular organ, with a complex network of small blood vessels. These blood vessels pulsate with the heartbeat, briefly increasing the blood volume in our brains. These pulsations result in local ...

Even after successful cancer treatment, many people experience fear of cancer recurrence (FCR), which decreases quality of life. In our individual participant data study (n=9,311), 39.6% of cancer patients and survivors ...

Similar to adults, children can also develop arthritis. The most common type of chronic arthritis in children is called juvenile idiopathic arthritis (JIA) and affects roughly 1 in every 1,000 children in the Netherlands. ...

Minimally invasive approaches to cancer treatment are intended to decrease surgical morbidity and thus reduce the negative impact on the quality of life for patients. This thesis focuses on evaluating the minimally invasive ...

The uniqueness of human sagittal spinal alignment, and its link to the distinct phenomenon of idiopathic scoliosis are studied in this thesis, with an emphasis on contemporary imaging techniques. Spinal ultrasound is ...

Due to the increasing longevity of patients, the number of elderly individuals in need of cardiovascular surgery rises. However, elderly patients often present with frailty, which is associated with postoperative complications ...

Laboratory testing plays a major role in internal medicine, especially in diagnosing diseases. In order to use laboratory testing most effectively, several conditions need to be met. Firstly, only tests that contribute ...

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide with an increasing prevalence up to 20% in children and 10% in adults in developed countries. Atopic dermatitis is associated with many ...

Human chromosomes are centimeters in length, but are structured to fit into a micrometer- scale nucleus. Key to this organization are structural maintenance of chromosomes complexes, which includes the cohesin complex. ...