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UMC Repository: Recent submissions

  • Heinen, Rutger; Vlegels, Naomi; de Bresser, Jeroen; Leemans, Alexander; Biessels, Geert Jan; Reijmer, Yael D.; Utrecht Vascular Cognitive Impairment study group (2018-01-01)
    Background and purpose: Mechanisms underlying cognitive impairment in patients with small vessel disease (SVD) are still unknown. We hypothesized that cognition is affected by the cumulative effect of multiple SVD-related ...
  • Groenewoud, Eva R.; Cohlen, Ben J.; Al-Oraiby, Amani; Brinkhuis, Egbert A.; Broekmans, Frank J.M.; de Bruin, Jan Peter; van Dool, Grada; Fleisher, Katrin; Friederich, Jaap; Goddijn, Mariëtte; Hoek, Annemieke; Hoozemans, Diederik A.; Kaaijk, Eugenie M.; Koks, Caroliene A.M.; Laven, Joop S.E.; van der Linden, Paul J.Q.; Manger, A. Petra; van Rumste, Minouche; Spinder, Taeke; Macklon, Nick S. (2018-07-01)
    Introduction: Pregnancy after frozen-thawed embryo transfer (FET) is a multifactorial process. Although embryo quality is a key factor in determining pregnancy, other factors, including maternal determinants, are also ...
  • van Oers, Anne M.; Mutsaerts, Meike A.Q.; Burggraaff, Jan M.; Kuchenbecker, Walter K.H.; Perquin, Denise A.M.; Koks, Carolien A.M.; van Golde, Ron; Kaaijk, Eugenie M.; Broekmans, Frank J.; De Bruin, Jan Peter; van der Veen, Fulco; Nap, Annemiek W.; Gondrie, Ed T.C.M.; Mol, Ben W.J.; Groen, Henk; Hoek, Annemieke; on behalf of the LIFEstyle study group (2018-03-01)
    Background Obesity in women of reproductive age has deleterious effects on reproductive and offspring health. In this study, we aimed to evaluate the association between the magnitude of periconceptional body-mass index ...
  • Weiss, Nienke S.; Nahuis, Marleen J.; Bordewijk, Esmee; Oosterhuis, Jurjen E.; Smeenk, Jesper M.J.; Hoek, Annemieke; Broekmans, Frank J.M.; Fleischer, Kathrin; De Bruin, Jan Peter; Kaaijk, Eugenie M.; Laven, Joop S.E.; Hendriks, Dave J.; Gerards, Marie H.; Van Rooij, Ilse A.J.; Bourdrez, Petra; Gianotten, Judith; Koks, Carolien; Lambalk, Cornelis B.; Hompes, Peter G.; Van Der Veen, Fulco; Mol, Ben Willem J.; Van Wely, Madelon (2018-05-01)
  • van Rijswijk, Joukje; van Welie, Nienke; Dreyer, Kim; van Hooff, Machiel H.A.; de Bruin, Jan Peter; Verhoeve, Harold R.; Mol, Femke; Kleiman-Broeze, Kimiko A.; Traas, Maaike A.F.; Muijsers, Guido J.J.M.; Manger, Arentje P.; Gianotten, Judith; de Koning, Cornelia H.; Koning, Aafke M.H.; Bayram, Neriman; van der Ham, David P.; Vrouenraets, Francisca P.J.M.; Kalafusova, Michaela; van de Laar, Bob I.G.; Kaijser, Jeroen; van Oostwaard, Miriam F.; Meijer, Wouter J.; Broekmans, Frank J.M.; Valkenburg, Olivier; van der Voet, Lucy F.; van Disseldorp, Jeroen; Lambers, Marieke J.; Peters, Henrike E.; Lier, Marit C.I.; Lambalk, Cornelis B.; van Wely, Madelon; Bossuyt, Patrick M.M.; Stoker, Jaap; van der Veen, Fulco; Mol, Ben W.J.; Mijatovic, Velja (2018-05-09)
    Background: Tubal pathology is a causative factor in 20% of subfertile couples. Traditionally, tubal testing during fertility work-up is performed by hysterosalpingography (HSG). Hysterosalpingo-foam sonography (HyFoSy) ...
  • Kuper, Willemijn F.E.; van Alfen, Claudia; Rigterink, Roeliene H.; Fuchs, Sabine A.; van Genderen, Maria M.; van Hasselt, Peter M. (2018-03-01)
    Background: CLN3 disease is a major cause of childhood neurodegeneration. Onset of visual failure around 6 years of age is thought to precede cognitive deterioration by a few years, but casuistic reports question this ...
  • de Rooy, R. L.P.; Halbertsma, F. J.; Struijs, E. A.; van Spronsen, F. J.; Lunsing, R. J.; Schippers, H. M.; van Hasselt, P. M.; Plecko, B.; Wohlrab, G.; Whalen, S.; Benoist, J. F.; Valence, S.; Mills, P. B.; Bok, L. A. (2018-07-01)
    Aim: In pyridoxine dependent epilepsy (PDE), patients usually present with neonatal seizures. A small subgroup is characterized by late-onset beyond 2 months of age. We aim to analyze the observation of relatively good ...
  • Polm, P. D.; Beyerlein, S.; Klijn, A. J.; de Jong, T. P.V.M.; Dik, P. (2018-06-01)
    Introduction: A tubularized conduit from an open 2-cm vascularized ileal segment is a frequently used technique to create a continent catheterizable channel in cases of an inappropriate or absent appendix. In the long term, ...
  • Momozawa, Yukihide; Dmitrieva, Julia; Théâtre, Emilie; Deffontaine, Valérie; Rahmouni, Souad; Charloteaux, Benoît; Crins, François; Docampo, Elisa; Elansary, Mahmoud; Gori, Ann Stephan; Lecut, Christelle; Mariman, Rob; Mni, Myriam; Oury, Cécile; Altukhov, Ilya; Alexeev, Dmitry; Aulchenko, Yuri; Amininejad, Leila; Bouma, Gerd; Hoentjen, Frank; Löwenberg, Mark; Oldenburg, Bas; Pierik, Marieke J.; Vander Meulen-De Jong, Andrea E.; Van Der Woude, C. Janneke; Visschedijk, Marijn C.; Lathrop, Mark; Hugot, Jean Pierre; Weersma, Rinse K.; De Vos, Martine; Franchimont, Denis; Vermeire, Severine; Kubo, Michiaki; Louis, Edouard; Georges, Michel; Abraham, Clara; Achkar, Jean Paul; Ahmad, Tariq; Ananthakrishnan, Ashwin N.; Andersen, Vibeke; Anderson, Carl A.; Andrews, Jane M.; Annese, Vito; Aumais, Guy; Baidoo, Leonard; Baldassano, Robert N.; Bampton, Peter A.; Barclay, Murray; Barrett, Jeffrey C.; Bayless, Theodore M.; Bethge, Johannes; Bitton, Alain; Boucher, Gabrielle; Brand, Stephan; Brandt, Berenice; Brant, Steven R.; Büning, Carsten; Chew, Angela; Cho, Judy H.; Cleynen, Isabelle; Cohain, Ariella; Croft, Anthony; Daly, Mark J.; D'Amato, Mauro; Danese, Silvio; De Jong, Dirk; Denapiene, Goda; Denson, Lee A.; Devaney, Kathy L.; Dewit, Olivier; D'Inca, Renata; Dubinsky, Marla; Duerr, Richard H.; Edwards, Cathryn; Ellinghaus, David; Essers, Jonah; Ferguson, Lynnette R.; Festen, Eleonora A.; Fleshner, Philip; Florin, Tim; Franke, Andre; Fransen, Karin; Gearry, Richard; Gieger, Christian; Glas, Jürgen; Goyette, Philippe; Green, Todd; Griffiths, Anne M.; Guthery, Stephen L.; Hakonarson, Hakon; Halfvarson, Jonas; Hanigan, Katherine; Haritunians, Talin; Hart, Ailsa; Hawkey, Chris; Hayward, Nicholas K.; Hedl, Matija; Henderson, Paul; Hu, Xinli; Huang, Hailiang; Hui, Ken Y.; Imielinski, Marcin; Ippoliti, Andrew; Jonaitis, Laimas; Jostins, Luke; Karlsen, Tom H.; Kennedy, Nicholas A.; Khan, Mohammed Azam; Kiudelis, Gediminas; Krishnaprasad, Krupa; Kugathasan, Subra; Kupcinskas, Limas; Latiano, Anna; Laukens, Debby; Lawrance, Ian C.; Lee, James C.; Lees, Charlie W.; Leja, Marcis; Van Limbergen, Johan; Lionetti, Paolo; Liu, Jimmy Z.; Mahy, Gillian; Mansfield, John; Massey, Dunecan; Mathew, Christopher G.; McGovern, Dermot P.B.; Milgrom, Raquel; Mitrovic, Mitja; Montgomery, Grant W.; Mowat, Craig; Newman, William; Ng, Aylwin; Ng, Siew C.; Ng, Sok Meng Evelyn; Nikolaus, Susanna; Ning, Kaida; Nöthen, Markus; Oikonomou, Ioannis; Palmieri, Orazio; Parkes, Miles; Phillips, Anne; Ponsioen, Cyriel Y.; Potocnik, Uros; Prescott, Natalie J.; Proctor, Deborah D.; Radford-Smith, Graham; Rahier, Jean Francois; Raychaudhuri, Soumya; Regueiro, Miguel; Rieder, Florian; Rioux, John D.; Ripke, Stephan; Roberts, Rebecca; Russell, Richard K.; Sanderson, Jeremy D.; Sans, Miquel; Satsangi, Jack; Schadt, Eric E.; Schreiber, Stefan; Schulte, Dominik; Schumm, L. Philip; Scott, Regan; Seielstad, Mark; Sharma, Yashoda; Silverberg, Mark S.; Simms, Lisa A.; Skieceviciene, Jurgita; Spain, Sarah L.; Steinhart, A. Hillary; Stempak, Joanne M.; Stronati, Laura; Sventoraityte, Jurgita; Targan, Stephan R.; Taylor, Kirstin M.; Ter Velde, Anje; Torkvist, Leif; Tremelling, Mark; Van Sommeren, Suzanne; Vasiliauskas, Eric; Verspaget, Hein W.; Walters, Thomas; Wang, Kai; Wang, Ming Hsi; Wei, Zhi; Whiteman, David; Wijmenga, Cisca; Wilson, David C.; Winkelmann, Juliane; Xavier, Ramnik J.; Zhang, Bin; Zhang, Clarence K.; Zhang, Hu; Zhang, Wei; Zhao, Hongyu; Zhao, Zhen Z.; The International IBD Genetics Consortium (2018-12-01)
    GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by ...
  • Luteijn, Rutger David; Drexler, Ingo; Smith, Geoffrey L; Lebbink, Robert Jan; Wiertz, Emmanuel J H J (2018-06)
    Poxviruses comprise a group of large dsDNA viruses that include members relevant to human and animal health, such as variola virus, monkeypox virus, cowpox virus and vaccinia virus (VACV). Poxviruses are remarkable for ...
  • Peltenburg, Boris; Driessen, Juliette P.; Philippens, Marielle E.P.; Pameijer, Frank A.; Castelijns, Jonas; Dankbaar, Jan Willem; Dorgelo, Bart; Lange, Charlotte A.H.; Meijer, Frederick J.A.; Palm, Walter M.; Roosendaal, Stefan D.; Steens, Stefan C.A.; Verbist, Berit M.; Stegeman, Inge; Janssen, Luuk M.; de Bree, Remco; Terhaard, Chris H.J. (2018-08-01)
    Introduction: For the detection of local recurrences of head and neck squamous cell carcinomas (HNSCC) after (chemo)radiation, diagnostic imaging is generally performed. Diffusion weighted magnetic resonance imaging (DW-MRI) ...
  • Stamatelopoulos, Kimon; Mueller-Hennessen, Matthias; Georgiopoulos, Georgios; Sachse, Marco; Boeddinghaus, Jasper; Sopova, Kateryna; Gatsiou, Aikaterini; Amrhein, Carolin; Biener, Moritz; Vafaie, Mehrshad; Athanasouli, Fani; Stakos, Dimitrios; Pateras, Konstantinos; Twerenbold, Raphael; Badertscher, Patrick; Nestelberger, Thomas; Dimmeler, Stefanie; Katus, Hugo A.; Zeiher, Andreas M.; Mueller, Christian; Giannitsis, Evangelos; Stellos, Konstantinos (2018-06-19)
    Background: Amyloid- (1-40) (A40) is implicated in mechanisms related to plaque destabilization and correlates with adverse outcomes in stable coronary artery disease. Objective: To determine the prognostic and reclassification ...
  • Campbell, Frederick; Bos, Frank L.; Sieber, Sandro; Arias-Alpizar, Gabriela; Koch, Bjørn E.; Huwyler, Jörg; Kros, Alexander; Bussmann, Jeroen (2018-03-27)
    Up to 99% of systemically administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells), although significant nanoparticle ...
  • Chen, Chen; Soto-Gutierrez, Alejandro; Baptista, Pedro M.; Spee, Bart (2018-04-01)
    The incidence of liver disease is increasing globally. The only curative therapy for severe end-stage liver disease, liver transplantation, is limited by the shortage of organ donors. In vitro models of liver physiology ...
  • Nguyen, Phong Dang; Currie, Peter David (2018-04-01)
    Stem cells are undifferentiated cells that play crucial roles during development, growth and regeneration. Traditionally, these cells have been primarily characterised by histology, cell sorting, cell culture and ex vivo ...
  • Alemany, Anna; Florescu, Maria; Baron, Chloé S.; Peterson-Maduro, Josi; Van Oudenaarden, Alexander (2018-04-05)
    Embryonic development is a crucial period in the life of a multicellular organism, during which limited sets of embryonic progenitors produce all cells in the adult body. Determining which fate these progenitors acquire ...
  • Martinez-Sanchez, Aida; Nguyen-Tu, Marie Sophie; Cebola, Ines; Yavari, Arash; Marchetti, Piero; Piemonti, Lorenzo; De Koning, Eelco; Shapiro, A. M.James; Johnson, Paul; Sakamoto, Kei; Smith, David M.; Leclerc, Isabelle; Ashrafian, Houman; Ferrer, Jorge; Rutter, Guy A. (2018-05-01)
    AMPK is a critical energy sensor and target for widely used antidiabetic drugs. In β cells, elevated glucose concentrations lower AMPK activity, and the ablation of both catalytic subunits [β-cell-specific AMPK double-knockout ...
  • Roerink, Sophie F.; Sasaki, Nobuo; Lee-Six, Henry; Young, Matthew D.; Alexandrov, Ludmil B.; Behjati, Sam; Mitchell, Thomas J.; Grossmann, Sebastian; Lightfoot, Howard; Egan, David A.; Pronk, Apollo; Smakman, Niels; Van Gorp, Joost; Anderson, Elizabeth; Gamble, Stephen J.; Alder, Chris; Van De Wetering, Marc; Campbell, Peter J.; Stratton, Michael R.; Clevers, Hans (2018-04-26)
    Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of ...
  • Pichol-Thievend, Cathy; Betterman, Kelly L.; Liu, Xiaolei; Ma, Wanshu; Skoczylas, Renae; Lesieur, Emmanuelle; Bos, Frank L.; Schulte, Dorte; Schulte-Merker, Stefan; Hogan, Benjamin M.; Oliver, Guillermo; Harvey, Natasha L.; Francois, Mathias (2018-05-01)
    Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine ...
  • Pogoda, Hans Martin; Riedl-Quinkertz, Iris; Löhr, Heiko; Waxman, Joshua S.; Dale, Rodney M.; Topczewski, Jacek; Schulte-Merker, Stefan; Hammerschmidt, Matthias (2018-05-01)
    Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-inactivating enzyme Cyp26b1 develop a hyper-mineralized spine with gradually fusing vertebral body precursors (centra). However, the ...