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Now showing items 3441-3460 of 95693

Modeling Brain Representations of Words' Concreteness in Context Using GPT-2 and Human Ratings

Bruera, Andrea; Tao, Yuan; Anderson, Andrew; Çokal, Derya; Haber, Janosch; Poesio, Massimo (Wiley-Blackwell, 2023-12)

The meaning of most words in language depends on their context. Understanding how the human brain extracts contextualized meaning, and identifying where in the brain this takes place, remain important scientific challenges. ...
Introduction Disruptieve Technologie

LS Moral Psychology & Social Philosophy; OFR - Ethics Institute; Hopster, Jeroen (2023-04-01)
De mantelzorgwaardering: een waardevol cadeau of een doekje voor het bloeden?

de Kievit, Femke (2024-02)

Mantelzorgers hebben in Nederland recht op een jaarlijkse blijk van waardering van de gemeente (de mantelzorgwaardering). Te denken valt aan een cadeaubon, een bosje bloemen of een klein geldbedrag. Hoewel de waardering ...
Hassel, Anke & Wegrich, Kai (2022). How to Do Public Policy

't Hart, Paul (2023)

n dieser Rezension wird „How to Do Public Policy“ von Anke Hassel und Kai Wegrich als ein originelles und hervorragend geeignetes Lehrbuch für Studierende und (angehende) Führungskräfte der öffentlichen Verwaltung, des ...
Escaping Wonderland

Husted, Emil; Mikołajewska-Zając, Karolina; Rahmouni Elidrissi, Yousra (2023-08)
On the assessment of adverse drug reactions from spontaneousreporting systems: the influence of under-reporting on oddsratios

Van der Heijden, P.G.M.; Puijenbroek, Eugene van; van Buuren, Stef; Van der Hofstede, Jacques W. (John Wiley and Sons Ltd, 2002)

A well-known problem in spontaneous reporting systems (SRSs) for adverse drug reactions (ADRs)is under-reporting, that is, the problem that not all occurrences of ADRs are reported to the SRS. Welook at the question of how ...
Case note: ECLI:NL:RVS:2023:1938: Intrekking Nederlanderschap: Syrieganger ondanks vrijspraak rechtbank in strafprocedure:hoorplicht

Bex - Reimert, Viola (2023-10-10)
RECLAME CODE COMMISSIE (COLLEGE VAN BEROEP) 6 juni 2023 (Gendertwijfel) m.nt. B.B. Duivenvoorde

Duivenvoorde, Bram (2023)
Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers

Clarke, Emily; Varela, Laura; Jenkins, Rosalind E; Lozano-Andrés, Estefanía; Cywińska, Anna; Przewozny, Maciej; van Weeren, P René; van de Lest, Chris H A; Peffers, Mandy; Wauben, Marca H M (Elsevier BV, 2024-03)

Osteoarthritis causes progressive joint deterioration, severe morbidity, and reduced mobility in both humans and horses. Currently, osteoarthritis is diagnosed at late stages through clinical examination and radiographic ...
Ethical and legal challenges of automated driving: The prioritization of socio-political values

Diaz-Piedra, Carolina; Liedo, Belen; Prado-Gordillo, Miguel Núñez de; Caurcel, M Jesus; Stasi, Leandro L. Di (Elsevier BV, 2023)

Much research on the ethics of automated driving (AD) focusses on moral decision-making processes in extreme traffic situations. However, more likely scenarios involving daily trade-offs among different values in the design ...
Broken wills and ill beliefs: Szaszianism, expressivism, and the doubly value-laden nature of mental disorder

Prado-Gordillo, Miguel Núñez de (Springer, 2024-01-05)

Critical psychiatry has recently echoed Szasz’s longstanding concerns about medical understandings of mental distress. According to Szaszianism, the analogy between mental and somatic disorders is illegitimate because the ...
Wederkerigheid en maatwerk in didactiek voor onderwijs voor professionals

ten Berge, Hanne; Lam, Ineke (2023-07-17)

Het hoger onderwijs heeft een rol in het ontwikkelen van onderwijs voor professionals (OvP). Voor veel docenten is de professional een nieuwe doelgroep. Zij vragen zich af 1) hoe ze een cursus voor master¬studenten kunnen ...
Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease

Shubhakar, Archana; Jansen, Bas C.; Adams, Alex T.; Reiding, Karli R.; Ventham, Nicholas T.; Kalla, Rahul; Bergemalm, Daniel; Urbanowicz, Paulina A.; Gardner, Richard A.; Wuhrer, Manfred; Halfvarson, Jonas; Satsangi, Jack; Fernandes, Daryl L.; Spencer, Daniel I.R. (Oxford University Press, 2023-06-01)

Biomarkers to guide clinical decision making at diagnosis of inflammatory bowel disease [IBD] are urgently needed. We investigated a composite serum N-glycomic biomarker to predict future disease course in a discovery ...
Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins

Roefs, Marieke Theodora; Bauzá-Martinez, Julia; van de Wakker, Simonides Immanuel; Qin, Jiabin; Olijve, Willem Theodoor; Tuinte, Robin; Rozeboom, Marjolein; Snijders Blok, Christian; Mol, Emma Alise; Wu, Wei; Vader, Pieter; Sluijter, Joost Petrus Gerardus (Springer Nature, 2023-12)

Extracellular vesicles (EVs) are cell-derived lipid bilayer-enclosed particles that play a role in intercellular communication. Cardiac progenitor cell (CPC)-derived EVs have been shown to protect the myocardium against ...
Novel canonical and non-canonical viral antigens extend current targets for immunotherapy of HPV-driven cervical cancer

Peng, Xu; Woodhouse, Isaac; Hancock, Gemma; Parker, Robert; Marx, Kristina; Müller, Julius; Salatino, Silvia; Partridge, Thomas; Nicastri, Annalisa; Liao, Hanqing; Kruppa, Gary; Hellner, Karin; Dorrell, Lucy; Ternette, Nicola (Elsevier, 2023-03-17)

Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and alternative reading frame (ARF)-derived sequences presented on ...
Large-Scale Immunopeptidome Analysis Reveals Recurrent Posttranslational Splicing of Cancer- and Immune-Associated Genes

Levy, Ronen; Regev, Tal Alter; Paes, Wayne; Gumpert, Nofar; Shvefel, Sapir Cohen; Bartok, Osnat; Dayan-Rubinov, Maria; Alon, Michal; Shmueli, Merav D.; Levin, Yishai; Merbl, Yifat; Ternette, Nicola; Samuels, Yardena (American Society for Biochemistry and Molecular Biology Inc., 2023-04)

Posttranslational spliced peptides (PTSPs) are a unique class of peptides that have been found to be presented by HLA class-I molecules in cancer. Thus far, no consensus has been reached on the proportion of PTSPs in the ...
Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Barczak, Wojciech; Carr, Simon M.; Liu, Geng; Munro, Shonagh; Nicastri, Annalisa; Lee, Lian Ni; Hutchings, Claire; Ternette, Nicola; Klenerman, Paul; Kanapin, Alexander; Samsonova, Anastasia; La Thangue, Nicholas B. (Nature Publishing Group, 2023-12)

Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating ...
Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

in collaboration with the UMC COVID-19 S3/HCW study group; Fatebenefratelli-Sacco Infectious Diseases Physicians group; Radboud University Medical Center (RUMC) and COUGH1 study group (Elsevier, 2023-09-15)

IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both are influenced by the composition of the conserved N-linked glycan located in the ...
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

Amsterdam UMC COVID-19 Biobank (Rockefeller University Press, 2023-11)

Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and ...
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer

Bhin, Jinhyuk; Yemelyanenko, Julia; Chao, Xue; Klarenbeek, Sjoerd; Opdam, Mark; Malka, Yuval; Hoekman, Liesbeth; Kruger, Dinja; Bleijerveld, Onno; Brambillasca, Chiara S.; Sprengers, Justin; Siteur, Bjørn; Annunziato, Stefano; van Haren, Matthijs J.; Martin, Nathaniel I.; van de Ven, Marieke; Peters, Dennis; Agami, Reuven; Linn, Sabine C.; Boven, Epie; Altelaar, Maarten; Jonkers, Jos; Zingg, Daniel; Wessels, Lodewyk F.A. (Rockefeller University Press, 2023-08-29)

Targeting the PI3K–AKT–mTOR pathway is a promising therapeutic strategy for breast cancer treatment. However, low response rates and development of resistance to PI3K–AKT–mTOR inhibitors remain major clinical challenges. ...

Now showing items 3441-3460 of 95693