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Now showing items 3421-3440 of 95693

Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents

Moreno, Lucas; Dubois, Steven G.; Glade Bender, Julia; Mauguen, Audrey; Bird, Nick; Buenger, Vickie; Casanova, Michela; Doz, François; Fox, Elizabeth; Gore, Lia; Hawkins, Douglas S.; Izraeli, Shai; Jones, David T.W.; Kearns, Pamela R.; Molenaar, Jan J.; Nysom, Karsten; Pfister, Stefan; Reaman, Gregory; Smith, Malcolm; Weigel, Brenda; Vassal, Gilles; Zwaan, Christian Michel; Paoletti, Xavier; Iasonos, Alexia; Pearson, Andrew D.J. (American Society of Clinical Oncology, 2023-06-20)

PURPOSEThere is an increasing need to evaluate innovative drugs for childhood cancer using combination strategies. Strong biological rationale and clinical experience suggest that multiple agents will be more efficacious ...
CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy

Möckel, Diana; Bartneck, Matthias; Niemietz, Patricia; Wagner, Maike; Ehling, Josef; Rama, Elena; Weiler, Marek; Gremse, Felix; Eulberg, Dirk; Pola, Robert; Pechar, Michal; Etrych, Tomas; Storm, Gert; Kiessling, Fabian; Tacke, Frank; Lammers, Twan (Elsevier, 2024-01)

Blood vessel functionality is crucial for efficient tumor-targeted drug delivery. Heterogeneous distribution and perfusion of angiogenic blood vessels contribute to suboptimal accumulation of (nano-) therapeutics in tumors ...
Simulation of dual-purpose chicken breeding programs implementing gene editing

Chuang, Edward Y.S.; Wellmann, Robin; Meijboom, Franck L.B.; Tetens, Jens; Bennewitz, Jörn (BioMed Central, 2024-01-17)

Background: In spite of being controversial and raising ethical concerns, the application of gene editing is more likely to be accepted when it contributes to improving animal welfare. One of the animal welfare and ethical ...
Immunoglobulin A Glycosylation Differs between Crohn’s Disease and Ulcerative Colitis

IBD-BIOM Consortium (American Chemical Society, 2023-10-06)

Inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC), are chronic and relapsing inflammations of the digestive tract with increasing prevalence, yet they have unknown origins or cure. ...
Factors affecting IgG4-mediated complement activation

Oskam, Nienke; Damelang, Timon; Streutker, Marij; Ooijevaar-de Heer, Pleuni; Nouta, Jan; Koeleman, Carolien; Van Coillie, Julie; Wuhrer, Manfred; Vidarsson, Gestur; Rispens, Theo (Frontiers Media S.A., 2023-01-26)

Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system. Regardless, in IgG4 related disease (IgG4-RD) and in autoimmune ...
The Influence of Human IgG Subclass and Allotype on Complement Activation

Damelang, Timon; de Taeye, Steven W.; Rentenaar, Rosa; Roya-Kouchaki, Kasra; de Boer, Esther; Derksen, Ninotska I.L.; van Kessel, Kok; Lissenberg-Thunnissen, Suzanne; Rooijakkers, Suzan H.M.; Jongerius, Ilse; Mebius, Mirjam M.; Schuurman, Janine; Labrijn, Aran F.; Vidarsson, Gestur; Rispens, Theo (American Association of Immunologists, 2023-10-16)

Complement activation via the classical pathway is initiated when oligomeric Igs on target surfaces are recognized by C1 of the complement cascade. The strength of this interaction and activation of the complement system ...
Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level

de Graaf, Erik L.; Larsen, Mads Delbo; van der Bolt, Nieke; Visser, Remco; Verhagen, Onno J.H.M.; Hipgrave Ederveen, Agnes L.; Koeleman, Carolien A.M.; van der Schoot, C. Ellen; Wuhrer, Manfred; Vidarsson, Gestur (Blackwell Publishing Ltd, 2024-03)

The type and strength of effector functions mediated by immunoglobulin G (IgG) antibodies rely on the subclass and the composition of the N297 glycan. Glycosylation analysis of both bulk and antigen-specific human IgG has ...
Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy

Nimmerjahn, Falk; Vidarsson, Gestur; Cragg, Mark S. (Nature Publishing Group, 2023-07-06)

Humoral immune responses are characterized by complex mixtures of polyclonal antibody species varying in their isotype, target epitope specificity and affinity. Posttranslational modifications occurring during antibody ...
New hermit crab species (Anomura, Paguroidea) from the upper Miocene St. Marys Formation of Maryland (USA), preserved in their host shells

Wallaard, Jonathan J.W.; Fraaije, René H.B.; van Bakel, Barry W.M.; Nance, John R.; Lindholm, Adam; Jagt, John W.M. (Magnolia Press, 2023-01-06)

Two new species of hermit crab are recorded from the upper Miocene (Tortonian) St. Marys Formation of Maryland, named Pagurus hazenorum n. sp. and Paguristes timoni n. sp. and assigned to the families Paguridae Latreille, ...
Temperature-Dependent Twist of Double-Stranded RNA Probed by Magnetic Tweezer Experiments and Molecular Dynamics Simulations

Dohnalová, Hana; Seifert, Mona; Matoušková, Eva; Klein, Misha; Papini, Flávia S.; Lipfert, Jan; Dulin, David; Lankaš, Filip (American Chemical Society, 2024-01-25)

RNA plays critical roles in the transmission and regulation of genetic information and is increasingly used in biomedical and biotechnological applications. Functional RNAs contain extended double-stranded regions, and the ...
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and single-molecule experiments

Kolbeck, Pauline J.; Tišma, Miloš; Analikwu, Brian T.; Vanderlinden, Willem; Dekker, Cees; Lipfert, Jan (Oxford University Press, 2024-01-11)

DNA stores our genetic information and is ubiquitous in applications, where it interacts with binding partners ranging from small molecules to large macromolecular complexes. Binding is modulated by mechanical strains in ...
Miocene decapod crustacean faunas from Cyprus – Part 1. Geographical-stratigraphical setting and Anomura

Wallaard, Jonathan J.W.; Fraaije, René H.B.; van Bakel, Barry W.M.; Jagt, John W.M. (Texas A & M University, 2023)

Study of high-diversity Miocene decapod crustacean faunas has resulted in the recognition of several new species from a range of localities across Cyprus. Anomuran taxa collected comprise Paguristes joecollinsi, Dardanus ...
Rogueus belgodereae, a new raninoid crab (Crustacea: Brachyura: Raninoidea) from the Upper Palaeocene (Thanetian) of Southern France, with comments on early palaeocene decapod crustacean faunules

van Bakel, Barry W.M.; Ossó, Àlex; Téodori, Dominique (Texas A & M University, 2023)

Palaeocene crabs are rare globally; crab faunules of this period are mostly described from reefal environments, and little is reported about non-reefal environments. A new raninoid crab is described and formally named from ...
New genera and species of glaessneropsid crabs from the Lower and Middle Jurassic of France and Germany-Austria, and reconsolidation of Charassocarcinus Van Straelen, 1925

van Bakel, Barry W.M.; Guinot, Danièle (Elsevier Masson, 2023-08-01)

A new genus, Meroncarcinus, and two new species, M. boursicoti and Verrucarcinus marsae, are described from Callovian (Middle Jurassic) deposits of Calvados and Maine-et-Loire, France. New material of the type species of ...
Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia

Szittner, Zoltán; Bentlage, Arthur E.H.; Temming, A. Robin; Schmidt, David E.; Visser, Remco; Lissenberg-Thunnissen, Suzanne; Mok, Juk Yee; van Esch, Wim J.E.; Sonneveld, Myrthe E.; de Graaf, Erik L.; Wuhrer, Manfred; Porcelijn, Leendert; de Haas, Masja; van der Schoot, C. Ellen; Vidarsson, Gestur (Frontiers Media S.A., 2023-10-05)

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only ...
Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence

Hoefsmit, Esmee P; Völlmy, Franziska; Rozeman, Elisa A; Reijers, Irene L M; Versluis, Judith M; Hoekman, Liesbeth; van Akkooi, Alexander C J; Long, Georgina V; Schadendorf, Dirk; Dummer, Reinhard; Altelaar, Maarten; Blank, Christian U (2023-04)

UNLABELLED: The response rates upon neoadjuvant immune checkpoint blockade (ICB) in stage III melanoma are higher as compared with stage IV disease. Given that successful ICB depends on systemic immune response, we ...
An Aptian sponge-associated decapod crustacean assemblage from Cal Cassanyes (Catalonia, north-east Iberian Peninsula): Taxonomy and palaeoecological implications

Ossó, Àlex; van Bakel, Barry W.M.; Artal, Pedro; Moreno-Bedmar, Josep anton; Sánchez-Beristain, Francisco; Bover-Arnal, Telm (Academic Press Inc., 2024-02)

A highly diverse decapod crustacean fauna is described from the classic Aptian outcrop of Cal Cassanyes (Castellet i la Gornal) in Catalonia. Although decapod crustaceans are a minor component of the rich invertebrate ...
A reconsideration of the palinuroid family Synaxidae (Crustacea, Decapoda), with a new member from the Upper Jurassic of southern Poland

Fraaije, René H.B.; van Bakel, Barry W.M.; Jagt, John W.M.; Krobicki, Michał; Ossó, Àlex; Palero, Ferran; Wallaard, Jonathan J.W. (Texas A & M University, 2023)

Representatives of the family Synaxidae, commonly referred to as furry lobsters, are rare constituents of modern-day marine communities, while their fossil record suggests that they were more common in the past, in reefal ...
Future costs of key emerging offshore renewable energy technologies

Santhakumar, Srinivasan; Meerman, Hans; Faaij, André (Elsevier BV, 2024-02)

A detailed understanding of the technological development pathways of energy technologies will reduce the risks of public energy policy and private investment actions. However, such assessments for emerging technologies, ...
Self-organization as a mechanism of resilience in dryland ecosystems

Kéfi, Sonia; Génin, Alexandre; Garcia-Mayor, Angeles; Guirado, Emilio; Cabral, Juliano S.; Berdugo, Miguel; Guerber, Josquin; Solé, Ricard; Maestre, Fernando T. (National Academy of Sciences, 2024-02)

Self-organized spatial patterns are a common feature of complex systems, ranging from microbial communities to mussel beds and drylands. While the theoretical implications of these patterns for ecosystem-level processes, ...

Now showing items 3421-3440 of 95693