• Sediment deficit and morphological change of the Rhine–Meuse river mouth attributed to multi-millennial anthropogenic impacts 

  Cox, J. R.; Leuven, J.R.F.W.; Pierik, H. J.; van Egmond, M.; Kleinhans, M. G. (Elsevier Limited, 2022-07-15)

  Many delta systems worldwide are becoming increasingly urbanized following a variety of processes, including land reclamation, embanking, major engineering and port constructions, dredging and more. Here, we trace the ...
• Stability and Asymmetry of Tide-Influenced River Bifurcations 

  Iwantoro, A. P.; van der Vegt, M.; Kleinhans, M. G. (Wiley, 2022-06)

  Bifurcations are important geomorphological features in tide-influenced deltas. At bifurcations, river flow and tides distribute sediment over the channel network and determine the morphodynamic evolution of the entire ...
• Effects of Sea-Level Rise on Dredging and Dredged Estuary Morphology 

  Cox, J. R.; Lingbeek, J.; Weisscher, S.A.H.; Kleinhans, M. G. (Wiley, 2022-10)

  Estuaries and deltas worldwide are facing land loss and drowning due to sea-level rise (SLR). Commonly home to ports, their channels are dredged and deepened for navigation. However, little is known about how such sediment ...
• Mass Mortality Caused by Highly Pathogenic Influenza A(H5N1) Virus in Sandwich Terns, the Netherlands, 2022 

  Rijks, Jolianne M; Leopold, Mardik F; Kühn, Susanne; In 't Veld, Ronald; Schenk, Fred; Brenninkmeijer, Allix; Lilipaly, Sander J; Ballmann, Mónika Z; Kelder, Leon; de Jong, Job W; Courtens, Wouter; Slaterus, Roy; Kleyheeg, Erik; Vreman, Sandra; Kik, Marja J L; Gröne, Andrea; Fouchier, Ron A M; Engelsma, Marc; de Jong, Mart C M; Kuiken, Thijs; Beerens, Nancy (Centers for Disease Control and Prevention (CDC), 2022-12)

  We collected data on mass mortality in Sandwich terns (Thalasseus sandvicensis) during the 2022 breeding season in the Netherlands. Mortality was associated with at least 2 variants of highly pathogenic avian influenza ...
• Correction: Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context 

  Healthy Brain Study consortium (Public Library of Science, 2022-04)

  [This corrects the article DOI: 10.1371/journal.pone.0260952.].
• No evidence for social factors in the overestimation of individuals from minority groups 

  Gayet, Surya; Sahakian, Andre; Paffen, Chris L E; Van der Stigchel, Stefan (National Academy of Sciences, 2022-11-22)
• Mandatory requirements for pediatric drug development in the EU and the US for novel drugs-A comparative study 

  Christiansen, Helle; De Bruin, Marie L; Hallgreen, Christine E (Frontiers Media S.A., 2022-10-31)

  Mandatory pediatric legislation has been implemented in the European Union (EU) and the United States (US) to increase research and the availability of drugs for the pediatric population. Differences in the legislative ...
• Direct Action of Non-Digestible Oligosaccharides against a Leaky Gut 

  Mavrogeni, Maria Eleni; Asadpoor, Mostafa; Henricks, Paul A J; Keshavarzian, Ali; Folkerts, Gert; Braber, Saskia (MDPI AG, 2022-11-07)

  The epithelial monolayer is the primary determinant of mucosal barrier function, and tight junction (TJ) complexes seal the paracellular space between the adjacent epithelial cells and represent the main "gate-keepers" of ...
• Pioglitazone use in Australia and the United Kingdom following drug safety advisories on bladder cancer risk: An interrupted time series study 

  Kemp-Casey, Anna; Mintzes, Barbara; Morrow, Richard L.; Dormuth, Colin R.; Souverein, Patrick C.; Roughead, Elizabeth E. (John Wiley and Sons Ltd, 2022-10)

  Purpose: National regulators in Australia and the United Kingdom issued safety advisories on the association between pioglitazone use and bladder cancer in July 2011. The Australian advisory noted that males were at higher ...
• Domain‐specific and domain‐general neural network engagement during human–robot interactions 

  Hogenhuis, A.; Hortensius, R. (Blackwell Publishing Ltd, 2022-11)

  To what extent do domain-general and domain-specific neural network engagement generalize across interactions with human and artificial agents? In this exploratory study, we analysed a publicly available functional MRI ...
• Human Milk Oligosaccharide 2′-Fucosyllactose Modulates Local Viral Immune Defense by Supporting the Regulatory Functions of Intestinal Epithelial and Immune Cells 

  Ayechu-Muruzabal, Veronica; Poelmann, Bente; Berends, Alinda J.; Kettelarij, Nienke; Garssen, Johan; van’t Land, Belinda; Willemsen, Linette E.M. (MDPI AG, 2022-09-19)

  Human milk contains bioactive components that provide protection against viral infections in early life. In particular, intestinal epithelial cells (IEC) have key regulatory roles in the prevention of enteric viral infections. ...
• HARmonized Protocol Template to Enhance Reproducibility of Hypothesis Evaluating Real-World Evidence Studies on Treatment Effects: A Good Practices Report of a Joint ISPE/ISPOR Task Force 

  Wang, Shirley V.; Pottegård, Anton; Crown, William; Arlett, Peter; Ashcroft, Darren M.; Benchimol, Eric I.; Berger, Marc L.; Crane, Gracy; Goettsch, Wim; Hua, Wei; Kabadi, Shaum; Kern, David M.; Kurz, Xavier; Langan, Sinead; Nonaka, Takahiro; Orsini, Lucinda; Perez-Gutthann, Susana; Pinheiro, Simone; Pratt, Nicole; Schneeweiss, Sebastian; Toussi, Massoud; Williams, Rebecca J. (Elsevier Ltd, 2022-10)

  Objectives: Ambiguity in communication of key study parameters limits the utility of real-world evidence (RWE) studies in healthcare decision-making. Clear communication about data provenance, design, analysis, and ...
• Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles 

  Marinelli, Lisa; Ciulla, Michele; Ritsema, Jeffrey A S; van Nostrum, Cornelus F; Cacciatore, Ivana; Dimmito, Marilisa Pia; Palmerio, Ferdinando; Orlando, Giustino; Robuffo, Iole; Grande, Rossella; Puca, Valentina; Di Stefano, Antonio (American Chemical Society, 2022-09)

  The encapsulation of peptides and proteins in nanosystems has been extensively investigated for masking unfavorable biopharmaceutical properties, including short half-life and poor permeation through biological membranes. ...
• P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure 

  Wang, Jing; Susam, M Merve; Gan, Changpei; Sparidans, Rolf W; Lebre, Maria C; Beijnen, Jos H; Schinkel, Alfred H (MDPI AG, 2022-09-08)

  EAI045 is a fourth-generation allosteric tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). It targets T790M and C797S EGFR mutants in the treatment of non-small cell lung cancer (NSCLC). EAI045 ...
• Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation 

  Madella, Avra Melina; Bergenhenegouwen, Jeroen Van; Garssen, Johan; Masereeuw, Rosalinde; Overbeek, Saskia Adriana (MDPI AG, 2022-09-18)

  Uremic metabolites, molecules either produced by the host or from the microbiota population existing in the gastrointestinal tract that gets excreted by the kidneys into urine, have significant effects on both health and ...
• Pandemic Preparedness: Maintaining Adequate Immune Fitness by Attaining a Normal, Healthy Body Weight 

  kiani, pantea; Mulder, Kiki; Balikji, Jessica; Kraneveld, Aletta; garssen, johan; Verster, Joris (MDPI AG, 2022-07-01)

  In addition to developing effective medicines and vaccines, pandemic preparedness also comprises general health-related, behavioral, and psychological aspects related to being more resis-tant in the case of future pandemics. ...
• Inattention, Impulsivity, and Hyperactivity among Individuals with Self-Reported Impaired Wound Healing 

  Balikji, Jessica; Hoogbergen, Maarten M.; garssen, johan; Verster, Joris (Multidisciplinary Digital Publishing Institute (MDPI), 2022-08)

  Background: Inattention and impulsivity are common causes of accidents and injury. The aim of the current study was to examine the level of attention deficit (AD), hyperactivity, and impulsivity (HI) in individuals with ...
• Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region: ACS Chemical Biology 

  Pascha, Mirte N.; Thijssen, Vito; Egido, Julia E.; Linthorst, Mirte W.; van Lanen, Jipke H.; van Dongen, David A. A.; Hopstaken, Antonius J. P.; van Kuppeveld, Frank J. M.; Snijder, Joost; de Haan, Cornelis A. M.; Jongkees, Seino A. K. (American Chemical Society, 2022-09-16)

  Influenza A viruses pose a serious pandemic risk, while generation of efficient vaccines against seasonal variants remains challenging. There is thus a pressing need for new treatment options. We report here a set of ...
• Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19. 

  Pongracz, T; Nouta, J; Wang, Wenjun; van, Meijgaarden KE; Linty, F; Vidarsson, G; Joosten, SA; Ottenhoff, THM; Hokke, CH; de, Vries JJC; Arbous, SM; Roukens, AHE; groups, COVID-19 (Elsevier BV, 2022-04)

  Background: Immunoglobulin G1 (IgG1) effector functions are impacted by the structure of fragment crystallizable (Fc) tail-linked N-glycans. Low fucosylation levels on severe acute respiratory syndrome coronavirus 2 ...
• Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex 

  Hurdiss, Daniel L.; El Kazzi, Priscila; Bauer, Lisa; Papageorgiou, Nicolas; Ferron, François P.; Donselaar, Tim; Van Vliet, Arno L.W.; Shamorkina, Tatiana M.; Snijder, Joost; Canard, Bruno; Decroly, Etienne; Brancale, Andrea; Zeev-Ben-Mordehai, Tzviya; Förster, Friedrich; Van Kuppeveld, Frank J.M.; Coutard, Bruno (American Association for the Advancement of Science, 2022-01-07)

  Enteroviruses are globally prevalent human pathogens responsible for many diseases. The nonstructural protein 2C is a AAA+ helicase and plays a key role in enterovirus replication. Drug repurposing screens identified ...

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