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Now showing items 8681-8700 of 95693

Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges

Ramazani, Farshad; Chen, Weiluan; van Nostrum, Cornelis F; Storm, G; Kiessling, Fabian; Lammers, Twan; Hennink, Wim E; Kok, Robbert J (Elsevier bedrijfsinformatie b.v., 2016-01-12)

Poly(lactide-co-glycolide) (PLGA) microspheres are efficient delivery systems for controlled release of low molecular weight drugs as well as therapeutic macromolecules. The most common microencapsulation methods are based ...
Amphiphilic phthalocyanines in polymeric micelles: a supramolecular approach toward efficient third-generation photosensitizers

Setaro, Francesca; Wennink, Jos W H; Mäkinen, Petri I; Holappa, Lari; Trohopoulos, Panagiotis N; Ylä-Herttuala, Seppo; van Nostrum, Cornelus F; de la Escosura, Andres; Torres, Tomas (Royal Society of Chemistry, 2020-01-14)

In this paper we describe a straightforward supramolecular strategy to encapsulate silicon phthalocyanine (SiPc) photosensitizers (PS) in polymeric micelles made of poly(ε-caprolactone)-b-methoxypoly(ethylene glycol) ...
Are energy drinks unique mixers in terms of their effects on alcohol consumption and negative alcohol-related consequences?

Johnson, Sean J.; Alford, Chris; Stewart, Karina; Verster, Joris C. (Dove Medical Press Ltd., 2018-01-28)

Introduction: Previous research has suggested that consuming alcohol mixed with energy drinks (AMED) increases overall alcohol consumption. However, there is limited research examining whether energy drinks are unique in ...
Hangover resistance in a Canadian University student population

Kruisselbrink, L Darren; Bervoets, Adriana C; de Klerk, Suzanne; van de Loo, Aurora J A E; Verster, Joris C (Elsevier, 2017-06)

Background: Resistance to alcohol hangover may be a risk factor for alcohol use disorder. Previous research to establish the prevalence of hangover resistance in a drinking population has either not used comparable ...
The Impact of Having a 15-min Break With and Without Consuming an Energy Drink on Prolonged Simulated Highway Driving

Verster, Joris C.; van de Loo, Aurora J. A. E.; Bervoets, Adriana C.; Mooren, Loes; Roth, Thomas (Springer, 2017-12-01)

Purpose: To examine whether consuming an energy drink while having a break is effective in reducing the number of lapses of attention during prolonged highway driving. Methods: In a double-blind crossover study, N = 21 ...
The impact of alcohol hangover symptoms on cognitive and physical functioning, and mood

van Schrojenstein Lantman, Marith; Mackus, Marlou; van de Loo, Aurora J.A.E.; Verster, Joris C. (John Wiley and Sons Ltd, 2017-09-01)

Hangover research often records the presence and severity of symptoms experienced the day after heavy alcohol consumption. However, usually no information is gathered on the impact of experiencing these symptoms on mood, ...
Development of a definition for the alcohol hangover: Consumer descriptions and expert consensus

van Schrojenstein Lantman, Marith; van de Loo, Aurora J. A. E.; Mackus, Marlou; Verster, Joris C. (Bentham Science Publishers B.V., 2016-01-11)

Up to now, there is no adequate definition of the alcohol hangover. The purpose of the current study was to develop a useful definition, and consensus among those who will use it in scientific publications. A survey was ...
Domestication of the floating fern symbiosis Azolla

Schluepmann, Henriette; Bigot, Ivan; Rijken, Niels; Correas Griffol, Anna; Gudde, Peter; Dijkhuizen, Laura; Güngör, Erbil (Springer, 2021)

Ferns from the Azolla genus are highly productive without nitrogen fertilizer because filamentous cyanobacteria, Nostoc azollae, associated with the shoot stem cells, invade leaf cavities for N2-fixation, and reproductive ...
Interfacially Hydrazone Cross-linked Thermosensitive Polymeric Micelles for Acid-Triggered Release of Paclitaxel

Shi, Yang; Van Nostrum, Cornelus F.; Hennink, Wim E. (American Chemical Society, 2015-12-14)

Polymeric micelles are widely studied as drug carriers, but their poor in vivo stability and, as a consequence, premature drug release hampers their use for targeted drug delivery. Reversible cross-linking of polymeric ...
Biocompatibility of poly(d,l-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection

Kazazi-Hyseni, F.; Zandstra, J.; Popa, E. R.; Goldschmeding, R.; Lathuile, A. A R; Veldhuis, G. J.; Van Nostrum, C. F.; Hennink, W. E.; Kok, R. J. (Elsevier bedrijfsinformatie b.v., 2015-03-30)

Poly(d,l-lactic-co-hydroxymethyl glycolic acid) (PLHMGA) is a biodegradable copolymer with potential as a novel carrier in polymeric drug delivery systems. In this study, the biocompatibility of PLHMGA microspheres (PLHMGA-ms) ...
Relationship between polarities of antibiotic and polymer matrix on nanoparticle formulations based on aliphatic polyesters

Ritsema, J A S; Herschberg, E M A; Borgos, S E; Løvmo, C; Schmid-Fetzer, R.; Te Welscher, Y M; Storm, G; van Nostrum, C F (Elsevier bedrijfsinformatie b.v., 2018-09-15)

In the field of nanomedicine, nanoparticles are developed to target antibiotics to sites of bacterial infection thus enabling adequate drug exposure and decrease development of resistant bacteria. In the present study, we ...
The Effect of Formulation and Processing Parameters on the Size of mPEG-b-p(HPMA-Bz) Polymeric Micelles

Bagheri, Mahsa; Bresseleers, Jaleesa; Varela Moreira, Aida; Sandre, Olivier; Meeuwissen, Silvie A; Schiffelers, Raymond M; Metselaar, Josbert M; van Nostrum, Cornelus F; van Hest, Jan C M; Hennink, Wim E (American Chemical Society : Division of Carbohydrate Chemistry, 2018)

Micelles composed of block copolymers of poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) have shown great promise as drug delivery carriers due to their excellent stability and high ...
Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery

Wang, Yan; van Steenbergen, Mies J; Beztsinna, Nataliia; Shi, Yang; Lammers, Twan; van Nostrum, Cornelus F; Hennink, Wim E (Elsevier, 2020-12-10)

To avoid poly(ethylene glycol)-related issues of nanomedicines such as accelerated blood clearance, fully N-2-hydroxypropyl methacrylamide (HPMAm)-based polymeric micelles decorated with biotin for drug delivery were ...
Proceeding of the 9th alcohol hangover research group meeting

Merlo, Agnese; Adams, Sally; Benson, Sarah; Devenney, Lydia; Gunn, Craig; Iversen, Jacqueline; Johnson, Sean J.; Mackus, Marlou; Scholey, Andrew; Stock, Ann Katrin; van de Loo, Aurora J.A.E.; Lantman, Marith van Schrojenstein; Versprille, Livia J.F.Wilod; Verster, Joris C. (Bentham Science Publishers B.V., 2017-01-01)

Background: Alcohol hangover is a common occurrence among individuals who have experienced an episode of heavy alcohol consumption the previous night. Until now defined as the general feeling of misery that develops once ...
Urban Growth, Resident Welfare, and Housing Markets: Evidence from China

Cai, Yuanyuan (Utrecht University, 2023-05-10)

Cities have become the principal platform of economic growth and residents’ settlements. The importance of urban growth in residents’ quality of life is increasingly evident, because of the intimate interaction between ...
Proceeding of the 8th alcohol hangover research group meeting

Mackus, Marlou; Adams, Sally; Barzilay, Amir; Benson, Sarah; Blau, Lauren; Iversen, Jacqueline; Johnson, Sean J.; Keshavarzian, Ali; Scholey, Andrew; Smith, Gordon S.; Trela, Constantine; Vatsalya, Vatsalya; Verster, Joris C. (Bentham Science Publishers B.V., 2016)

Alcohol hangover is one of the most commonly experienced consequences of alcohol consumption. An alcohol hangover develops as the blood alcohol concentrations (BAC) approaches zero, and is characterized by a general feeling ...
Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries

Yang, Xin; Beroske, Lucas P.; Kemmink, Johan; Rijkers, Dirk T.S.; Liskamp, Rob M.J. (Elsevier, 2017-11-29)

The synthesis of a bicyclic tripeptide that mimics the ABC ring system of vancomycin is described by using a ring closing metathesis (RCM) – peptide coupling – ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) strategy.
Synthesis of nisin AB dicarba analogs using ring-closing metathesis: Influence of sp<sup>3</sup>versus sp<sup>2</sup> hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity

Slootweg, Jack C.; Van Herwerden, Eric F.; Van Doremalen, Mark F M; Breukink, Eefjan; Liskamp, Rob M J; Rijkers, Dirk T S (Royal Society of Chemistry, 2015-06-07)

Herein the synthesis of two nisin AB dicarba analogs is described, focusing on amino acid modifications at positions 2 and 5. The nisin mimics were synthesized by a combination of solid phase synthesis of the linear peptides, ...
The Green Light on Ketamine: Considerations for On-Road Safety

Hayley, Amie C; Stough, Con; Verster, Joris C; van de Loo, Aurora J A E; Downey, Luke A (Bentham Science Publishers B.V., 2015)
Delayed Differentiation Makes Many Models Compatible with Data for CD8+ T Cell Differentiation

Pandit, Aridaman; Boer, Rob J. De (Springer, 2021-01-05)

Upon antigen stimulation, naïve CD8+ T cells differentiate into short-lived effectors and longer-lived memory T cells. The kinetics of expansion of antigen-specific CD8+ T cells is highly reproducible at the population ...

Now showing items 8681-8700 of 95693