Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries

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Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries
 
Yang, Xin; Beroske, Lucas P.; Kemmink, Johan; Rijkers, Dirk T.S.; Liskamp, Rob M.J.
(2017) Tetrahedron Letters, volume 58, issue 48, pp. 4542 - 4546
(Article)
Abstract
The synthesis of a bicyclic tripeptide that mimics the ABC ring system of vancomycin is described by using a ring closing metathesis (RCM) – peptide coupling – ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) strategy.
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Keywords: Macrocycles, Peptides, Peptidomimetics, Ring-closing metathesis, Ru-based azide-alkyne cycloaddition, Biochemistry, Drug Discovery, Organic Chemistry
DOI: https://doi.org/10.1016/j.tetlet.2017.10.046
ISSN: 0040-4039
Publisher: Elsevier
(Peer reviewed)
 
 
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