Abstract
Myc synergizes with Ras and PI3-kinase in cell transformation,
yet the molecular basis for this behavior is poorly
understood. We now show that Myc recruits TFIIH,
P-TEFb and Mediator to the cyclin D2 and other target
promoters, while the PI3-kinase pathway controls formation
of the preinitiation complex and loading of RNA
polymerase II. The PI3-kinase pathway
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