Abstract
The preparation is described of a range of neoglycoproteins containing synthesised fragments of the capsular polysaccharide of Streptococcus pneumoniae type 3, that is beta-D-GlcpA-(1->4)-beta-D-Glcp-(1->O)-(CH2)3NH2 (1), beta-D-Glcp-(1->3)-beta-D-GlcpA-(1->4)-beta-D-Glcp-(1->O)-(CH2)3NH2 (2), and beta-D-GlcpA-(1->4)-beta-D-Glcp-(1->3)-beta-D-GlcpA-(1->4)-beta-D-Glcp-(1->O)-(CH2)3NH2 (3). A blockwise approach was developed for the synthesis of the protected carbohydrate chains, in which the carboxylic groups were introduced
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