Abstract
In the framework of studies towards oligosaccharide-conjugate-based vaccines against Streptococcus pneumoniae, the synthesis is reported of several spacer-containing oligosaccharides that represent parts of the capsular polysaccharide of S. pneumoniae serotype 6B, namely α-L-rhamnopyranosyl-(1→4)-5-O-(3-aminopropyl hydrogen phosphate)-D-ribitol, 3-aminopropyl D-ribitol-(5→hydrogen phosphate→2)-α-D-galactopyranoside, 3-aminopropyl α-L-rhamnopyranosyl -(1→4)-D-ribityl-(5→hydrogen phosphate→2)-α-D-galactopyranoside, and 3-aminopropyl D-ribityl-(5→hydrogen phosphate→2)-α-D-galactopyranosyl-(1→3)-α-D-glucopyranoside. Phosphorylations were carried out
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